---

Dermatoglyphic patterns are formed during the first and the second fetal development trimesters and they remain unchanged afterwards. At the end of the fourth month of fetal development, fingertips are formed along with brain and other derived ectodermia developments. In the 19th century, the mystery of human fingertips was discovered, and it was realized that fingertips consist of tiny network lines in the epiderms of the skin, and are exclusive to every individual, even to twins. In this study, through library research, by reviewing quantitative and qualitative dermatoglyphic patterns, the miracle of fingertips was considered based on Quran and Islamic commandments. Much research has been done comparing individual dermatoglyphic patterns of hands among various races, and the quantitative and qualitative relationship between dermatoglyphic patterns and diseases such as schizophrenia, nervous disorders, Down syndrome, diabetes I, Alzheimer, multiple sclerosis, congenital spinal abnormalities, and psoriasis disease has been shown. Accordingly, finger prints are used for identifying individuals, detecting criminals, and studying disease of genetic background. They can also be used as clues in determining the etiology of diseases. Fingertip sign is unique for every individual. Quran, in response to those who deny the resurrection after decomposition of the body and bones (Saffat, 37: 16), declares that Allah almighty, is not only capable of recreating them, but also is able to make human fingertips again (75: 3-4). The study shows the importance of human’s fingertips as the miracle of human creation, and reveals why Quran emphasizes on them as one indication of resurrection.

---

Background: Tuberculosis is an old problem that is currently considered a great challenge. Noticing Iran’s borders with Afghanistan and Pakistan, which are among the 22 high burden countries around the world, the present study was conducted to analyze the current molecular epidemiology of TB and survey genetic diversity of Mycobacterium tuberculosis strains in Markazi province, Iran. Materials and Methods: In this experimental study, 57 sputum specimens from smear positive patients admitted to health centers in Markazi province were cultured on specific mycobacterial culture media. Genomic DNA was extracted by standard protocols of WHO and digested separately by PvuII and AluI. Electrophoresis was performed and DNA fragments were transferred to positively charged nylon membrane by southern blotting method and hybridization by PGRS probe. The hybridized strains were subsequently detected by enzymatic reaction and analyzed. Results: Genotyping of the isolates by PGRS-RFLP with Pvu II and AluI displayed a wide range of genetic diversity so that 50 and 45 genotypes were identified, respectively. Conclusion: Noticing the great diversity of PGRS in the Mycobacterium tuberculosis strains, it can be concluded that in the study population, the majority of the patients hadtuberculosis with different etiologies. Therefore, it seems that reactivation of latent infection has had the main role in the spread of tuberculosis