Background: Pediatricians frequently confront with elevated body temperature in children and subsequent anxious parents. They practice several approaches in management of fever. A recently addressed issue is administration of alternating doses of acetaminophen and Ibuprofen. This method is relatively common , despite lack of sufficient evidence in this field.

Materials and Methods: This study is a randomized clinical trial. A total of 240 children, aged 6 months to 12 years suffering from gastroenteritis was recruited in this research. Children were classified in 3 groups. First group received Acetaminophen, second group received Ibuprofen and third group were treated with acetaminophen – Ibuprofen every other day alternately.

Results: 240 child were taken apart in this research . 112 ones were female (46.66%) and 128 were male (53.33%). The mean time of lowering fever in the first group was 2.07 days. This figure in the second and third groups were 1.82 and 1.87 respectively. Average doses in the first, second and third groups were (in order) 9, 8.17 and 7.13 doses. Medication in the first group minimum effectiveness rather than two other groups.

Conclusion: The alternating regimen of Acetaminophen – Ibuprofen is more effective than monotherapy in reduction of fever in infants and children between 6 months to 12 years.

Background: Q fever is a zoonotic agent that is endemic in the many parts of the World. It has animal origin as considered as an emerging and re-emerging zoonose in many countries, including Iran. Cattle, sheep, and goats are the primary reservoirs for Q fever. Organisms are excreted in milk of infected animals. This study was conducted to determine the prevalence rate of Coxiella burentii in raw samples obtained from sheep in Bonab.

Materials and Methods: This study was carried out from Autuman 2014 to Winter 2014. Overall, 120 milk samples were collected from 100 dairy cattle breeding complexes and the diagnosis of Coxiella burnetii was confirmed by Nested-PCR method.

 Results: In this study, in total, 26 samples (21.66%) were found to be positive for the presence of Coxiella burnetii.

 Conclusion: Considering the importance of the bacterium, Coxiella burnetii, rapid and accurate diagnosis is of great significance. Due to high accuracy and high speed, molecular techniques are mostly effective in the diagnosis. Thus, the localization of molecular techniques in the diagnosis of Q fever is highly recommended. The results indicated that Cattle's milk could be a potential reservoir of Coxiella burnetii in Iran.