Showing 7 results for Epilepsy
Mohammad Mehdi Arab, Amirabolfazl Suratgar, Alireza Rezaei Ashtiani,
Volume 11, Issue 3 (9-2008)
Abstract
Background: Epileptic seizures are manifestation of epilepsy. Understanding of the mechanisms causing epileptic disorder needs careful analyses of the electroencephalograph (EEG) records. The detection of epileptic form discharges (spike wave) in the EEG is an important component in the diagnosis of epilepsy. Approximately one in every 100 persons will experience a seizure at some time in their life. Already intelligence spike detection method discucsed but purpose of this research is diagnosis of different kind of epilepsy (grandmal and Petitmal) by design of an intelligence diagnosis processing. Methods and Materials: In this descriptive study, 100 EEG signals of brain hemispheres from different person in healthy, interictal and ictal conditions were used. Fifty Hz noise and artifact signals were removed by soft ware procedure then signals separated by expert neurologist to three categories, healthy (frequency band 8-12 Hz), petitmal seizures (typical 3 Hz), grandmal seizures (clonic stage with 4 Hz frequency) and divided each of them to 6 seconds segments. Information of this signals (background alpha, spike and slow, poly spike and poly sharp) were extracted by wavelet transform and classified by soft ware procedure neural network to there groups healthy, ptitmal and grandmal epilepsy. Results: In designed software accuracy of diagnosis ptitmal and grandmal epilepsies was obtained about 80% Conclusion: This method introduced intelligent diagnosis of epilepsy (ptitmal and gradmal) and automatically detected healthy person from epileptic patients. One of the other advantages is help to neurologist for detection of sickness clearly and expendable different kinds of other epilepsy
Entezar Mehrabi Nasab, Mozafar Khazaei, Saber Khazaei,
Volume 12, Issue 4 (2-2010)
Abstract
Background: Clinical research suggest a relationship between epilepsy and hypogonadism. The aim of this study is to identify the impact of epilepsy induced by kindling with pentylenetetrazol (PTZ) on hormones and some reproductive parameters in male rats.
Materials and Methods: Adult male rats (NMRI strain) were divided into control and kindling groups. Kindling was induced by 40 mg/kg PTZ with a 48 hour interval through intraperitoneal injection. Each animal received 13 doses. At the end of the thirteenth dose, animals were weighed and uthenaized with ether and blood samples, collected from their hearts, were used for testosterone, prolactin and FSH, LH assay. In order to examine motility and morphology of sperms, tissue samples from epidydimis were isolated and minced in DMEM/F12 culture medium and were incubated for 15 minutes. Then sperm morphology and motility were studied. Testis were also isolated and weighed.
Results: Kindling with PTZ decreased serum levels of testosterone and LH, but it increased rolactin. However, there was no difference in serum level of FSH between the two groups. Sperm motility in kindling group decreased significantly. There were no significant differences in testis weight, but the amount of animal weight losses in the kindling group was more than that of the control group.
Conclusion: By changing the serum level of sexual hormones and decreasing sperm motility, PTZ kindling induced epilepsy exerts diminishing negative effects on reproduction.
Razieh Javaheri, Hamid-Taher Neshat-Doost, Hossein Molavi, Mohammad Zare,
Volume 13, Issue 2 (6-2010)
Abstract
Background: Psychological interventions may improve the quality of life in females with temporal lobe epilepsy through affecting their bio-psycho-social dimensions. This aim of this study was to aim assess the efficacy of cognitive-behavioral stress management (CBSM) group education on improvement of quality of life in epileptic patients. Materials and Methods: This was a case-control study with pre-post-and follow-up tests. The sample population included 26 patients, already diagnosed with temporal lobe epilepsy by neurologist and through electro-encephalography, that were randomly selected and assigned to experimental and control groups. Data were collected through the Quality Of Life Questionnaire for Epileptic patients (QOLIE- 89) that was administered in the pre-test, post-test, and follow-up test. CBSM group education was given to the experimental group in ten sessions during two months. Results: The mean of QOLIE-89 score in the experimental group showed a significantly higher increase in comparison to that in the control group (p<0.05). Conclusion: The results demonstrated the effectiveness of CBSM group education on the improvement of quality of life in females with temporal lobe epilepsy.
Mahdi Tohidipour, Amir Aboulfazl Suratgar, Mohammad Reza Arab, Ali Reza Rezaei Ashtaini,
Volume 16, Issue 1 (4-2013)
Abstract
Background: The general method for paraclinic diagnosis of epilepsy is electroencephalography that is performed by visual analysis by experienced neurologist. However, due to false detection and impossibility of evaluating electrodes and brain areas coherence, it is not uniquely used for seizure detection. In recent years, Quantitative Electroencephalogram (QEEG) has become a strong instrument for detection of brain disorders. Hence, studies in the field of EEG performance improvement and brain mapping images analysis corresponding to new methods that contain 2-D and 3-D output images and automatic epilepsy diagnosis are necessary.
Materials and Methods: In this cross-sectional study, through extracting epilepsy feature by computing the energy of each EEG channel, brain map pattern of each patient was plotted using cubic interpolation and generalized and partial patterns and potential center of epilepsy were diagnosed by LVQ artificial neural network using image processing combination methods.
Results: In the proposed algorithm, 11 epilepsy brain mapping patterns, including 1 generalized and 10 partial seizure patterns, were automatically diagnosed.
Conclusion: Since seizure detection in the EEG signals is a complex procedure and the number of expert neurologists is small, this schema can be used for epilepsy diagnosis as an intelligent diagnosis method so that generalization of this method can help detect various brain disorders.
Simin Namvar Aghdash, Mansoure Mokhtari,
Volume 18, Issue 12 (3-2016)
Abstract
Background: Traditional medicinal herbs have remained as a component of disease treatment system of many societies in the world. Today, many scientists have paid attention to the use of medicinal herbs in the treatment of epileptic seizures, because epilepsy is one of the most common neuropsychological disorders in the world that have many serious physical, psychological, social, and economic consequences. The aim of this study was to investigate the effect of Chelidonium Majus extract in the treatment of seizure.
Materials and Methods: In this study 40 mice have been randomly chosen and divided into 5 groups including a control group that received only pentylenetetrazol, sham group that received distilled water and 3 experimental groups received aqueous extract of Chelidonium Majus in doses of 50,100 and 150 mg/kg for 4 weeks. 30 minutes after gavage with different doses of the extract or distilled water, pentylenetetrazol was injected to experimental and sham groups. Animals immediately were transferred to a special cage and the seizure behaviors and parameters were recorded by a camera. Then, the different phases of seizure, latency time for onset of seizure and seizure duration were evaluated.
Results: Data analysis indicated that the aqueous extract of Chelidonium Majus had a significant effect on PTZ-induced seizure. Therapy by this extract increases latency time for onset of seizure and prevents progress of seizure phases.
Conclusion: The attained results showed that Chelidonium Majus extract has anticonvulsant effect on PTZ-induced seizure. Thus, it may be used in seizure treatment.
Azam Alinaghipour, Marziyeh Tavassoli, Elahe Seyed Hosseini, Abolfazl Ardjmand,
Volume 20, Issue 7 (10-2017)
Abstract
Abstract
Background: Neuronal damage following seizures and epilepsy is one of the main causes of disabilities and mortality worldwide. In recent years, preconditioning has been introduced as a novel strategy for the prevention of brain damage. Preconditioning is a phenomenon in which a minor noxious stimulus protects from a subsequent more severe insult. The aim of present study was to examine the effect of ethanol (Eth) preconditioning on pentylenetetrazole (PTZ)-induced impairment memory in the inhibitory avoidance model.
Material and Methods: This study was carried out on 45 adult male Wistar rats (180-200 g). Animals were assigned into five groups: Control, Eth 0.25, Eth 0.5, PTZ and Eth (0.5) +PTZ (n=9, for all groups). Eth-preconditioning was induced 6 days before the injection of PTZ. The animals were tested in a single trial step-through inhibitory test in two sessions (train and test). Then locomotor activity of rats was recorded in the open-field apparatus and NR1 mRNA expression in the hippocampus was measured by real-time PCR technique.
Results: One-way ANOVA revealed that the Ethanol preconditioning did not impair inhibitory memory. Further, post-test analyses showed that Ethanol preconditioning significantly prevented from PTZ-induced memory impairment, and increased NR1 subunit mRNA expression in PTZ-induced memory impairment group. In addition, one-way ANOVA for the locomotor activity showed no significant difference between the groups.
Conclusion: Our results showed that a pre-conditioning treatment with Ethanol
(0.5g/kg/day), 6 days before PTZ-induced memory impairment may provide a kind of neuroprotection in rats.
Yousef Panahi, Davood Kiani Fard, Fatemeh Feyzi,
Volume 22, Issue 6 (1-2020)
Abstract
Background and Aim: The purpose of this study was to investigate the stimulatory and protective effects of Methylphenidate (MPD) on the experimental epilepsy induced by intraperitoneal injection of Pentylenetetrazole (PTZ) in adult male rats.
Methods & Materials: In this study, 15 male rats (weight, 200-250 gr) dividied into one control group (n=5) received normal saline and two treatment groups; the first group (n=5) received MPD with a dose of 2.5 mg/kg and the second group (n=5) received MPD with a dose of 5 mg/kg by gavage. After anesthesia with ketamine-xylazin combination and animal skull surgery, the recorded electrodes were inserted into the cranium in the stratum striatum layer of the CA1 region of the hippocampus, and epileptic activity was induced by intraperitoneal injection of PTZ (80 mg/kg) and the epileptiform activity was evaluated in terms of the number of spikes per time unit and their amplitudes by eTrace software.
Ethical Considerations: This study with an ethics code of FVMT.REC.1397.67 was approved by the Research Ethics Committee of the Faculty of Veterinary Medicine at University of Tabriz.
Results: Oral MPD at 2.5 and 5 mg/kg doses increased the number of spikes up to 576 and 613, respectively, compared to the control group (330 spikes), which were statistically significant. Amplitude of PTZ-induced epileptic activity after treatment with 2.5 and 5 mg/kg MPD reached 1254 and 1085 respectively compared to control group (1051), which were not statistically significant.
Conclusion: The doses of oral MPD used in this study potentiate seizure activity. Therefore, the use of this drug in people with a background of seizure or suffering from some types of seizure should be cautious, and the evaluation of its effect in these patients need further studies.
