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Background: In recent decades, with the increasing use of devices generating electromagnetic fields in modern industrial societies, the study of biological effect of these waves on the many organisms development has been considered by government and scientific organizations all over the world. Many people in all hours of their life are exposed to boarding electromagnetic fields of devices in their life and work places, with different intensities and frequencies. This presence of a significant relationship between the increase of some diseases and genetic aberrations and electromagnetic fields is one of the most important issues for researchers that has created many concerns regarding the adverse effects of electromagnetic fields. The findings of some studies indicate that this field does not have enough energy to damage biological molecules, while other researchers believe that electromagnetic fields by affecting cellular stress response and other protective mechanisms cause genetic cell damage. Some studies express that the electromagnetic field are safe alone, but they enhance the genotoxic function of physical and chemical environmental pollutants.

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Introduction: Experimental Autoimmune Encephalomyelitis (EAE) is an immune-mediated inflammatory model of multiple sclerosis that induces axonal loss, demyelination and motor disabilities. Electromagnetic fields (EMFs) possess multiple biological capabilities that affect the nervous system. The aim of the present study is to investigate the beneficial effect of low-intensity electromagnetic field on clinical symptoms, histological structure and gene expression in the cerebral cortex.
Methods: Forty-eight female C57BL/6 mice were used for this study. Following model induction, with MOG immunization the animals exposed to the EMFs (1 mT,50 Hz) over a period of two weeks. At the end of experiments, the body weight, clinical score (paralysis score) and lymphocyte infiltration of the cortex were evaluated in experimental groups. Moreover, the mRNA expression levels Bcl2, BDNF and Nrf2 are also were studied by using quantitative polymerase chain reaction (qPCR).
Results: The EMFs, significantly reduced the clinical symptom scores, decreased lymphocytic infiltration. The applied EMF also upregulated the expression of Bcl2, BDNF and Nrf2 in the cerebral cortex in compared to EAE model.
Conclusions: Overall, the present study demonstrated that electromagnetic fields, as a complementary therapy, exert significant neuroprotective properties in EAE by inhibiting oxidative stress and reducing neural tissue inflammation.