Showing 3 results for Diabetic Neuropathy
Ali Reza Susan Abadi , Mansour Parvaresh , Keyvan Ghasaami, Mitra Sadat Rezaei ,
Volume 5, Issue 4 (12-2002)
Abstract
Introduction: Diabetic neuropathy is a common complication of diabetes, leading to great morbidity and mortality and resulting in a huge economic burden for care of the patient with diabetes. It is the most common of neuropathy in the developed countries of the world, accounts for more hospitalizations than all the other diabetic complications combined, and is responsible for 30% 1075% of nontraumatic amputations.
Materials and Methods: This investigation is a descriptive analytic, cross-sectional study among 40 diabetic patients without symptoms of peripheral neuropathy referred to Aruk Vali-Asr diabetes clinic from March to september of 2003. Patients were referred to one neurologist for study of peroncal and tibial motor nerves and sural sensory nerve conduction velocity in electrodiagnostic clinic of Arak Amir Kabir hospital. The results of this group were compared to the results of 70 age and Gender matched normal control subjects. Independent samples T-Test, Pearson correlation coefficient and Fisher's exact test were used in analysis.
Results: A total of 40 patients were studied with mean age of 42.6 years and mean duration after the first diagnosis of diabetes 5.72 years. Mean investigated nerves conduction velocity in the normal control group was meaningful more than in diabetic patients. Asymptomatic neuropathy was present in 27 (67.5%) of patients. In these patients mean duration after the first diagnosis of diabetes was 6.5±5.16 years.
Conclusion: Asymptomatic diabetic neuropathy is common (67.5%) sural sensory. Nerve conduction velocity is a sensitive test for early diagnosis of diabetic neuropathy.
Yahya Bigdeli , Ali Heidarianpour,
Volume 15, Issue 4 (9-2012)
Abstract
Background: Peripheral neuropathy is a common complication associated with diabetes mellitus. It has been shown that oxidative stress is an important etiological factor in neuropathy which contributes to its development however, the exact pathophysiology underlying this complication is not fully understood. This study was designed to examine the effect of regular exercise and vitamin C administration on pain threshold in rats. Materials and Methods: In this experimental study, 36 male Wistar rats (220±10 g) were allocated to control and diabetic (control, vitamin C, exercise, and exercise+ vitamin C) groups. Diabetes was induced by the subcutaneous administration of streptozotocin (60 mg/kg). A week after the induction of diabetes, the rats were subjected to swimming training and vitamin C treatment for 8 weeks. At the end of weeks 3, 5, and 8, Tail-Flick test was done on the rats to assess pain threshold. Data were analyzed using SPSS software. Results: Diabetes significantly decreased pain threshold in the rats. Diabetes-induced hyperalgesia was significantly decreased by training and vitamin C. Concurrent effects of training and vitamin C on thermal pain threshold were significantly higher than each of them alone. Conclusion: Regular exercise together with vitamin C administration can be a proper method for preventing thermal hyperalgesia associated with diabetes. Therefore, they can be effective in the treatment and management of pain
Ali Gomar, Abdolkarim Hosseini, Naser Mirazi, Mojtaba Gomar,
Volume 17, Issue 8 (11-2014)
Abstract
Background: Diabetes mellitus is a common metabolic disorder that is associated with many complications such as peripheral neuropathies. This study was designed to investigate the effect of Brassica juncea on peripheral neuropathic pain in diabetic rat.
Materials and Methods: In this experimental study, male Wistar rats (250±20 g) were divided randomly to normal and diabetic (control, B. juncea extract at doses 150 and 300 mg/kg) groups. Experimental diabetes was induced by the intraperitoneal injection of streptozotocin (60 mg/kg). After four weeks treatment, animals were subjected to Tail-flick test to evaluate pain threshold and data were analyzed using SPSS software. Statistical significance was considered at p<0.05.
Results: The results of this study showed that diabetes significantly decreased pain threshold in the rats. Also diabetes-induced hyperalgesia was significantly decreased by treatment with extracts of B. juncea at doses 150 and 300 mg/kg (p<0.05 and p<0.01, respectively).
Conclusion: Our observation indicates that B. juncea could be a therapeutic option for control and treatment of hyperalgesia associated with diabetic neuropathy in diabetic patients. However, further studies are required to elucidate the antinociceptive effects of B. juncea.
