Showing 5 results for Dexamethasone
Dr Afsaneh Norouzi, Dr Hushang Talebi, Ms Farzaneh Jahani,
Volume 8, Issue 4 (12-2005)
Abstract
Introduction: Postoperative nausea and vomiting is one of the most common problems in postoperative period. Patients' who are at high risk of PONV, may receive anti-nausea and vomiting drugs. The most common drug is Metoclopramide, but it,s extrapiramidal signs and side effects such as lethargy, dizziness and headache especially in children lead us to perform this study, in order to compare Dexamethasone and Metoclopramide effects in PONV prevention. Materials and Methods: This study was a double-blind randomized controlled clinical trial. 262 patients (2-25 years) in ASA class I,II which were candidates for ENT, eye and laparatomy surgeries, divided into two groups randomly. One group received 0.1 mg/kg Dexamethasone IV and the other group received 0.1mg/kg Metoclopramide IV, 10-15 minuets before operation ending time. During recovery, the frequency of PONV was assessed. Data was analyzed by Pearson test. Results: PONV frequency in the two groups had no significant difference. Also PONV rate in the two groups had no significant difference in male and female. Conclusion: In prevention and treatment of PONV, Dexamethasone effect was same as Metoclopramide. Considering low expense, avalibility and low side effects, Dexamethasone is a proper substitute for Metoclopramide in surgeries with high risk of PONV.
Shahin Fateh, Mahmoud Amini, Somaie Daliri, Faeze Zahedian,
Volume 10, Issue 3 (6-2007)
Abstract
Introduction: Post operative pain, nausea and vomiting are common complications after hemorrhoidectomy and cause unpleasant expriences for patients. Today, scientists are increasingly moving forward to find new drugs with fewer side effects and costs to control these complications. So this study was planned to evaluate the effect of Dexamethasone on post operative pain, nausea and vomiting. Materials and Methods: This study was a double blind randomized controlled clinical trial that carried out on 112 patients scheduled for hemorrhoidectomy. Patients were diveded into two groups. Case group received 8mg Dexamethasone and control group received 2 ml normal saline intramuscularly 30 minutes before the operation. The method of surgery and general anesthesia were the same in all patients. Pain and nausea score were recorded using visual analog scale (VAS) and vomiting was recorded by asking of them at 0, 2, 4, 6 hours after operation. The patients were followed for 6 hours after the end of the operation and data was analyzed using t and chi square tests. Results: There was a significant difference between the two groups regarding prevention of post operative pain and nausea (p=0.00001). But there was no significant difference between the two groups regarding prevention of post operative vomiting. Conclusion: The result of this study suggested that injection of Dexamethasone before hemorrhoidectomy can decrease incidence of postoperative pain and nausea but dose not have any effects on postoperative vomiting. Therefore Dexamethasone is recommended before hemorrhoidectomy.
Hakimeh Koohpayma, Iran Goudarzi, Mahmood Elahdadisalmani, Kataneh Ebrari, Taghi Lashkarbolouki,
Volume 18, Issue 9 (12-2015)
Abstract
Background: Corticosteroids as dexamethasone are used for treating non-specific inflammatory diseases, however, may result in delayed wound healing due to its catabolic effects in skin. Thus, the purpose of the present study was to investigate the effect of quercetin on delayed wound healing in dexamethasone-treated rats.
Materials and Methods: In this experimental study, 40 male Wistar rats were used. After dermal incisions within a distance of 1.5 mm to the spinal column (30 mm length), rats were treated with 0.17 mg/kg dexamethasone, 50 mg/kg quercetin or both until 21 days. Wound healing was evaluated by measuring surface area, percentage of healing, wound length, duration of healing, and wound tensile strength.
Results: Our results showed that the duration of wound healing was significantly increased in dexamethasone treated rats in comparison with control group. In contrast, the rate of healing and skin tensile strength in dexamethasone treated rats receiving quercetin was significantly greater than dexamethasone treated group. In addition, the duration of wound healing in the dexamethasone treated group receiving quercetin was less than dexamethasone group.
Conclusion: This study provides some evidence to support the use of quercetin to accelerating wound healing in dexamethasone treated animals. However, Further research is needed to determine the quercetin mechanisms in acceleration of wound healing.
Fatemeh Dorreh, Anahita Namdari,
Volume 19, Issue 9 (12-2016)
Abstract
Abstract
Background: Acute bronchiolitis is the most common lower respiratory tract infection in infant and one of their hospital admission reasons. Due to the high prevalence of the disease and unclear effectiveness of existing treatments, the present study was designed to evaluate the therapeutic effect of single dose of injected dexamethasone and inhaled epinephrine in patients with acute bronchiolitis treated with inhaled salbutamol.
Materials and Methods: In this double-blinded clinical trial, 90 infants with age of 2-24 months who were admitted to hospital with acute bronchiolitis were studied. All patients received inhaled salbutamol (0.15 mg/kg) and then were randomly assigned to three groups (n=30) of dexamethasone (0.6 mg/kg), inhaled epinephrine (0.15 mg/kg) and control (distillated water). Heart rate (HR) and respiratory rate (RR), arterial blood oxygen saturation (O2 sat) and respiratory distress scores (RDS) of children at baseline, 30, 60,120 minutes and, 24 hours after intervention were recorded and compared between groups.
Results: The mean of HR, RR and RDS had significant improvement and the mean of O2 sat had significant rising trend and improvement during the study in all groups (p<0.05). The mean of HR in epinephrine group was upper than placebo in all measurements (p<0.001). RDS in epinephrine group was significantly upper than dexamethasone (p=0.002, CI95%=0.58- 2.69) and placebo (p=0.014, CI95%=0.27-2.8)
Conclusion: Based on the result of present study, it seems that inhaled epinephrine or injected dexamethasone have no superiority to placebo in treating infantile acute bronchiolitis and their administration is not recommended.
Darioush Moradi Farsani, Khosro Naghibi, Zahra Rezayinezhad,
Volume 20, Issue 7 (10-2017)
Abstract
Abstract
Background: Up to now, there is no single opinion on how to control pain after surgery and clinical research in this area has been continuing. This study aimed to compare the effect of intravenous Acetaminophen, Dexamethasone and placebo on postoperative pain after cataract surgery under sedation and topical anesthesia.
Materials and Methods: In a clinical trial study, 120 patients undergoing cataract surgery under sedation and topical anesthesia were distributed into three equal groups. 10 minutes before the end of surgery, the first group received 0.01 mg/kg Dexamethasone, the second group received 15 mg/kg Acetaminophen and third group received the same volume on normal saline as placebo. Pain intensity and additional analgesic consumption were assessed during operation and recovery and compared between the three groups.
Results: In the three groups of Acetaminophen, Dexamethasone and control groups, 6, 10 and 18 patients had postoperative headache (16.7%, 27% and 47.4% respectively) and there was a significant difference between the three groups(p=0.014). Also, pain intensity was significantly higher in control group compared with other two groups from 30 minutes after arrival to the recovery room until 24 h postoperatively (p<0.05). Also, the incidence of headache was higher in Dexamethasone group compared with Acetaminophen group, but there was no statistical difference between the two groups in this regard (p>0.05).
Conclusion: Intravenous Acetaminophen administration is more effective than Dexamethasone and placebo to reduce pain and analgesic requirements after cataract surgery.
