Background: Traditionally levels of cholesterol and triglyceride are used to identify individuals at risk of coronary artery disease (CAD). The aim of this study is examining the association of ApoA1 and ApoB with severity of coronary artery disease and whether these parameters are better predictor of CAD.

Materials and methods: This is a cross- sectional study. All patients that referred to ARAK amirallmomenin hospital and enrolled for coronary angiography was entered to study. Before angiography and after gathering informed consent, levels of apoA1 apoB, cholesterol, TG, LDL, VLDL, HDL and FBS were measured. The results of coronary angiography were reviewed by two experienced cardiologist separately. Severity of coronary artery disease involvement was determined by Gensini score (GS), the data were analyzed with statistical methods by SPSS software.

Results: There is a statistically significant correlation Between apoB and GS (r=0.127, p=0.047). Logistic regression model showed that among predictors for CAD entered model eg gender, age, cholesterol, TG, HDL, LDL , VLDL, ApoA1, ApoB and ApoB/Apo- A1 ratio, only ApoB and gender were proper predictors of coronary artery Disease( CAD) (p=0.002, , p=0.001). In comparison with angiography for diagnosis of CAD, ROC analysis represent that using ApoB can be useful test (p=0.047).

Conclusion: According to result of this study, using ApoB in addition to conventional parameters for assessing the patient at risk to having CAD would be reasonable and could be an independent risk factor for CAD.

Background: Cardiac accidents due to Coronary Artery Disease are the most common cause of mortality in the world. On the other hand, vitamin D deficiency is known as an emerging risk factor of this disease. Considering the high prevalence of vitamin D deficiency in Iran we investigated the prevalence of vitamin D deficiency in angioplasty patients, effect of gender and its relationship with Coronary Artery Disease severity.

Materials and Methods: In this cross sectional study serum level of 25(OH) D3 in was measured in 149 patients undergoing PCI between May and September 2013 in Baqiatallah hospital. Patients with renal failure (Cr>2mg/dl), liver disease, and those treated with glucocorticoids or anti-epileptic drugs were excluded. Data were analyzed with SPSS 21 software. Chi-square and T-Test were used and P value<0.05 was considered statistically significant.

Results: The prevalence of vitamin D deficiency in patients was 77.2% (men 86% and women 62.5%) (p=0.0005). Vitamin D deficiency severity was related to the number of involved vessels in men (p=0.046). Vitamin D deficiency was related with stent length in patients with right coronary angioplasty (p=0.041).

Conclusion: The effect of vitamin D deficiency on coronary artery disease seems to be different in men and women. Complementary studies are needed to elucidate this issue further.