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Showing 2 results for Colon Cancer
Evaluation of Anticancer Effect of Aqueous and Hydroalcoholic Extracts of Quercusin Fectoria Leaf against Colon Cancer HT29 Cell Line
Sahar Abdalan, Fahimeh Baghbani-Arani, Seyed Ataollah Sadat Shandiz,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: In traditional medicine and previous studies, Quercus infectoria plants have been suggested as a cancer treatment. The aim of the current study was to investigate the cytotoxic effect of aqueous and hydro alcoholic extracts of Quercus infectoria leaf against colon cancer HT29 cell line and to evaluate the Bax and Bcl-2 gene expression in treated cells.
Materials and Methods: In this study, aqueoFus and hydro alcoholic extracts of Quercus infectoria leaf were prepared. Then, the HT29 and HEK293 cell lines were treated by various concentrations of extracts for 24 hours and the cytotoxicity effect of extracts was estimated by colorimetric MTT (methyl thiazolyl tetrazolium) assay. Finally, the pro-apoptotic Bax and anti-apoptotic Bcl-2 gene expression in treated cells compared to GAPDH reference gene expression was evaluated using real time PCR technique.
Findings: According to the MTT results, the cytotoxic activity of aqueous extract has dose-dependent manner against both cell lines, therefore, the Bax and Bcl-2 gene expression levels in treated cells by aqueous extract were changed 2.8 (p˂0.05) and 2.2-fold (p˃0.05) compared to reference gene, respectively.
Conclusion: According to the results, it seems that the aqueous extract of Quercus infectoria leaf has the potential for apoptosis induction in colon cancer HT29 cell line and based on more studies, it can be used as a colon cancer treatment.

Assessment of One-, Three- and Five-Year Survival Rates in Patients with Colon Cancer in Hamedan Province from 2003 to 2017
Rasoul Najafi, Fatemeh Amiri, Ghodratoalleh Roshanaei, Mohammad Abbasi,
Volume 22, Issue 2 (6-2019)
Abstract
Background and Aim: Colon cancer is one of the most common cancers in the gastrointestinal tract. Colon cancer is the third death cause among cancers. The aim of this study was to estimate the survival rate and determine the effective factors in colon cancer patients.
Materials and Methods: In this study, 193 colon cancer patients referring to Hamadan Imam Khomeini Clinic during the years 2003-2017 in a retrospective cohort study were used. Follow up of all patients was done by referral and phone call up to 2017. The Kaplan -Meyer model was used to estimate the survival of patients. Also, the effect of prognostic factors on the survival of patients was obtained by Cox regression model. The software used to analyze the data was STATA 11 and the significance level was 0.05.
Ethical Considerations: This study with research ethics code IR.UMSHA.REC.1396.144 was approved in Research Ethics Committee of Hamadan University of medical sciences, Iran.
Findings: The mean age of the patients at diagnosis was 57.09 ± 12.9 years. The probability of survival of one-, three- and five-year was 0.82, 0.61 and 0.48 percent, respectively. Also, the cancer stage has a significant effect on survival time of the patients.
Conclusion: Based on the Cox model, only the stage of cancer was effective on the survival time of patients with colon cancer. Therefore, timely diagnosis also helps prevent disease progression, as well as increase the survival time of the patient, especially at an advanced age.

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