Journal of Arak University of Medical Sciences

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The Effects of Bilberry and Cinnamon on Blood Biochemical Parameters of Workers Exposed to Nickel and Chromium Contaminants

Neda Baghinia, Gholam Hassan Vaezi, Ali Akbar Malekirad, Mahmood Reza Baghinia,
Volume 17, Issue 11 (2-2015)

Abstract

Background: Nickel and chromium are heavy metals whieh after arriving in biological systems can produce highly reactive free radicals in the body and interact with macromolecules cause damage to them. The purpose of this study, the effect of bilberry and cinnamon extract on blood biochemical factors in workers exposed to nickel and chromium.

Materials and Methods: In this clinical trial, 99 workers were divided into 3 groups: group 1 (control), group 2 workers, welders exposed to nickel and chromium without extract (G) and group 3 workers, welders exposed to nickel and chromium with extracts (B). First biochemical parameters were measured in blood serum. Then the group 3, 2 times a day for four weeks, billberry juice and tea - Cinnamon received. Finally, Biochemical parameters in blood were measured and compared. SPSS software and descriptive statistics (mean±SD), T- independent and one-way ANOVA test were used to analyze the data.

Results: Between group Variance in some biochemical variables between the three groups, control, G and B showed statistically significant differences (p<0.05). Within-group variance was significant in some variables.

Conclusion: After consumption of billberry juice and tea-cinnamon positive changes in biochemical parameters in workers who are exposed to the toxic effects of nickel and chromium was obtained.

Effect of Chronic Aerobic/Resistive Exercises with Supplementation of Cinnamon on Insulin Resistance in Women with Polycystic Ovary Syndrome in Ahvaz City in 2017

Sahar Parseh, Saeid Shakerian, Ali Akbar Alizadeh,
Volume 22, Issue 1 (4-2019)

Abstract

Background and Aim: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine abnormalities that insulin resistance and obesity are among its main causes. The purpose of this study was to investigate the effect of chronic aerobic and resistive exercises along with supplementation of cinnamon on insulin resistance in women with polycystic ovary syndrome in Ahwaz in 2017.
Materials and Methods: In this semi-experimental study, 40 women with aged 18 to 30 years (BMI ≤24) were randomly divided into 4 groups. The intervention group performed 6 weeks, 3 sessions per week with intensity 50 to 75% of maximum heart rate for 50 to 85 minutes of exercise aerobic-resistance. Serum levels of insulin, glucose, and body composition indexes were evaluated. The t-test was correlated and ANCOVA was used.
Ethical Considerations: This study with research ethics code EE/ 96.24.3.77886/Scu.ac.ir has been approved by research ethics committee at Shahid Chamran University of Ahvaz, Iran.
Findings: Data analysis showed that body mass index, fat percentage and insulin resistance were decreased in exercise and supplementation exercises (p≤0.05). Cinnamon was also effective in combination with combined exercises in body composition and insulin resistance index (p≤0.05). Changes in fat free mass were not significant in any of the groups (p≤0.05).
Conclusion: It seems that this decrease in the difference in insulin resistance is more due to the combined exercise, and given the positive effect of cinnamon on reducing BMI, its use may be effective in the long term on insulin resistance.

Effect of Bioflora and Cinnamon Extract Consumption on Dyslipidemia and Cardiovascular Disease in a Diabetic Rat Model

Fatemeh Shahrestan, Parvaneh Jafari, Aram Gharebaghi, Iman Khani Farahani, Esmaeil Shahrestan,
Volume 23, Issue 2 (5-2020)

Abstract

Background and Aim: Diabetes mellitus is one of the leading causes of death, and its prevalence is increasing annually because of the change in lifestyle. Increased blood glucose level and dyslipidemia are the major symptoms of this metabolic disease. Currently, the main and effective treatment for diabetes is the use of medication such as insulin. Its control by using herbal products has received a lot of attention in the world. The aim of this study is to evaluate the effects of bioflora (a probiotic supplement) and aqueous extract of cinnamon in improvement of blood glucose level, dyslipidemia, and reduction of cardiovascular diseases in diabetic rats.
Methods & Materials: Thirty-five male Wistar rats were prepared and randomly divided into five groups of negative control, positive control, probiotic (treated with bioflora 3.2×108 CFUs/day for 30 days), cinnamon (treated with 200 mg/kg of cinnamon aqueous extract for 30 days), and probiotic + cinnamon. Diabetes was induced by intra-peritoneally injection of streptozotocin. The rats’ weight, blood glucose level, lipid profile, high sensitivity C-Reactive Protein (hs-CRP) and Atherogenic Index (AI) were measured at the end of experiment to predict the risk of cardiovascular diseases.
Ethical Considerations: This study ethically approved in Research Centre of Islamic Azad University of Arak (Code: IR.IAU.ARAKREC1397.005). All interventions performed in accordance with the Guide for Care and Use of Laboratory Animals prepared by the Institute of Laboratory Animal Resources.
Results: Induction of diabetes caused severe weight lost in rats, but the weight loss was lower in groups treated with probiotic. The blood glucose level in probiotic + cinnamon group was significantly reduced. Bioflora reduced triglyceride, cholesterol, and Low-Density Lipoprotein Cholesterol (LDL-C) levels, while cinnamon extract significantly reduced triglyceride and LDL-C levels compared to the positive control group. AI and hs-CRP values were reduced in the probiotic group compared to control groups. There was no synergistic effect by combined use of bioflora and cinnamon extract.
Conclusion: Bioflora effectively prevented dyslipidemia by improving intestinal microbiota, lowering blood glucose level, and improving lipid profile and, therefore, reduced the risk of cardiovascular diseases.

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