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Showing 4 results for Cervical

Dr Nayereh Ghomian, Dr Marzeieh Lotfalizadeh,
Volume 9, Issue 1 (3-2006)
Abstract

Introduction: Diagnosing parturients in risk of cesarean section early in the beginning of active phase of labor, is very important. This may let take necessary action to accelernate labor (delivery) and prevent maternal mortality and morbidity due to late cesarean section. Materials and Methods: During a period of 8 months from July 2004 to March 2005, 216 primiparous women, with term pregnancy and cephalic single fetus, referred to Imam Reza hospital in (during) active phase of labor, were studied. Changes of cervical dilatation and descent of the conceptus were observed. Parturients were devided to two groups, vaginal delivery and cesurean section. Protraction or arrest disorders were the indications of cesarean deliveries. Findings were analysed through using T-Test, unilateral variance and Chi square test. Results: The more changes in cervical dilatation in the first 2 hours of active phase of labor, the less possibility of cesarean delivery (p<0.001). Also the more rate of the conceptus descent in the first 2 hours of active phase of labor, the less rate of cesarean section (p<0.001). There was no significant statistical relationship between condition of membranes at the onset of active labor and method of delivery, however there was a significant relationship between oxytocin augmentation and method of delivery (p<0.001). Conclusion: In primiparous women with term pregnancy, vaginal delivery would be fairly predictable by observing changes of cervical dilatation and conceptus descent during the first 2 hours of active phase of labor.
Noorosadat Kariman,
Volume 12, Issue 2 (9-2009)
Abstract

Background: Cervical cancer is a preventable disease and we can determined preventive methods by discovering ethiology of disease. There are no appropriate research about the relation between coitus during menstruation and cervical cancer in Iran. This study is done to investigate the relationship between coitus during menstruation and cervical cancer in women referring to health care centers of Shahid Beheshti University of Medical Sciences in 2007-2008. Methods and Materials: This case-control study was carried out on 100 patients with cervical cancer (case) and 100 healthy women (control). All participates were Moslem with Iranian nationality and habitant in Iran. They had no previous history of frequent pelvic radiotherapy and alcohol consumption. Two groups were matched with age, age of first coitus, age of first vaginal delivery, parity and type of delivery. Data was collected through structured interview and analyzed using Chi-square and logistic-regression. Result: The study showed that 40% of case group and 10% of control group had coitus during menstruation. Coitus during menstruation in case group was 6 times more than control group (p<0.0001, odds ratio =6.0, CI= 2.7-12.9). Discussion: Coitus during menstruation may increase the risk of cervical cancer. A research is recommended to find out the best educational method which to prevent this disease.
Fathollah Mohaghegh, Mojtaba Ahmadlou,
Volume 18, Issue 4 (7-2015)
Abstract

Background: Cervical cancer is the third most common genital malignancy in women. In majority of developing countries the prevalence of this malignancy is high. The aim of this study was to determine the prevalence of cervical cancer among married wemon in Arak.

Materials and Methods: This cross-sectional and analytical study was carried out on 1000 married women. Demographic variables involving age, literacy, history of hysterectomy, nutrition statute, marriage age, history of abortion, smoking habits, etc were filled by questioners. Then Pap smear was done in all subjects and specimens were sent to the pathobiology laboratory. The data were analyzed with SPSS statistical software.

Results: The mean age of studied subjects was 39.38±10.1, the most freqrency of marriage once was 459(45%), the mean age of marriage was17.9±10.3, the mean age of first sexual intercourse was 15.1 (9.2%), the most frequency of the numbers of peregnancy was 2.6±2.1, and the mean times of abortion once was 153(15.3%). In this study, the prevalence of cervical cancer was 0.004(4 per 1000). There was a significant correlation between age, hysterectomy the time of marriage and painful sextual intercourse and cervical cancer (p<0.005). There was no statistically significant relation between smoking, food diet, pregnancy prevention drugs and the other variables of the study of cervical cancer (p>0.005).

 Conclusion: With attention to high prevalence of cervical cancer, promoting education and knowledge about the importance and necessity of pap smear and risk factors of cervical cancer and encouraging marriaged women to take part in screening programs is necessary.


Tahere Azimi, Malihe Bagheri, Mahdi Pariyan, Behzad Khansarinejad, Ashraf Zamani, Mahdieh Mondanizadeh,
Volume 23, Issue 3 (8-2020)
Abstract

Background and Aim: Cervical Cancer (CC) is the third most common malignancy in the women, the main cause of which is human papillomavirus (HPV). Both E6 and E7 oncogenes of the virus play an important role in its tumorigenesis. Today, methods available for screening CC are not capable of detecting the disease at an early stage. Therefore, it is important to identify new biomarkers for early detection of this cancer. For this purpose, in the present study, miRNAs targeting the two oncogenes E6 and E7 of human papillomavirus (types 16 and 18) were studied in CC by bioinformatics.
Methods & Materials: First, using the NCBI database, the E6 and E7 gene sequences were obtained for both human papillomavirus types 16 and 18. Then, using the miRBase and RNA22 bioinformatics databases, the most appropriate targeting miRNAs for these genes were selected.
Ethical Considerations: This study was approved by Ethics Committee of Arak University of Medical Sciences.
Results: Based on the P obtained from bioinformatics databases, miRNA including miR-92a-5p (P=7.51e-2), miR-195-3p (P=2.24e-1), miR-34a-5p (P=2.73e-1) and miR-155-5p (P=4.95e-2) were introduced for the two genes E6 and E7.
Conclusion: Results from bioinformatics studies revealed that of the four miRNAs identified, miR-155-5p and miR-92a-5p are probably the targeting miRNAs specific for the E6 and E7 genes, respectively. Therefore, it seems that these miRNAs can be a suitable candidate for in vitro studies in CC patients.


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