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Showing 83 results for Cancer

Ahmad Ameri, Jamshid Ansari, Majid Mokhtari, Ali Chehrei,
Volume 9, Issue 4 (12-2006)
Abstract

Introduction: Radiotherapy after breast cancer surgery will increase local control of the disease and also increase overall survival. Radiation have some side effects on lung function. In different radiotherapy techniques, these side effects are different. Pulmonary function tests and oxygen saturation are methods for evaluation of these complications. In this study we decide to campare pulmonary complications in two radiotherapy methods. Materials and Methods: In this clinical trial study fifty one patients with breast cancer in stage II and III according to TNM staging system, which were under modified radical mastectomy in Imam Hosein hospital and refered for adjuvant radiotherapy, randomly divided in two groups. In one group patients were treated with three field technique and in others with four field technique. All patients received total dose of 48-50 Gy. For patients, pulmonary function test and pulse oxymetery were done once before initiation of radiotherapy and then one and three months after radiotherapy. Results: Measurement of FEV1 , FVC and show that no significant statistical difference was present between the two groups one month and three months after radiotherapy, also in each of the two groups the amount of FEV1 , FVC and one month after radiotherapy had no significant statistical difference in comparison to baseline tests but FEV1 and FVC after three months was decreased and had significant statistical difference respectively (p<0.001, p<0.006). SO2 had no significant defference between the two groups and also in each group after one and three month of radiotherapy. Conclusion: Locoregional radiotherapy of breast and lymph nodes areas causes a decrease in some parameter of pulmonary function tests but no difference was present between three field and four field techniques.
Fathallah Mohaghegh, Ahmad Hamta, Mohammad Ali Shariatzade,
Volume 11, Issue 2 (6-2008)
Abstract

Introduction: Based on statistical and epidemiological studies, cancer is the third most common cause of death after heart diseases and accidents, therefore planning to control cancer is essential for public health. Cancer registration is an important part of cancer control, and the collected data could be useful in etiological studies, and health programming to prevent and treat the disease. In this study cancer incidence and cancer registration in Markazi province investigated. Materials and Methods: In this descriptive study, data related to cancer were collected from the health center of Markazi province, from 2001 to 2006. Then the prevalence and incidence of different kind of cancer were determined. Results: Results showed that the top ten cancers among women were: 1-Breast 2-Skin 3-Stomach 4-Colorectal 5-Lung 6-Uterus 7-Bladder 8-Lymphoma 9-Thyroid 10-Esophagus, and the ten most prevalent cancers among men were: 1-Skin 2-Bladder 3-Stomach 4-Lung 5-Prostate 6-Colon and Colorectal 7-Esophagus 8-Lymphoma 9-Testese 10-Gall bladder. Conclusion: In this investigation we also compared cancer incidence and distribution in Markazi province with national rates and our results showed that in some years, cancer statistics is different from national statistics which it may be due to different environmental and epidemiological factors.
Mahbobeh Sajadi Hezaveh, Bahman Salehi, Kamran Moshfeghi,
Volume 11, Issue 3 (9-2008)
Abstract

Background: Breast cancer is the most prevalent type of all cancer in women. In this study form various methods for treatment of depression due cancer. This study conducted for comparison drug therapy and drug-cognitive therapy on decreasing depression, effect of drug and cognitive theray on decreasing depression. Methods and Materials: This is a clinical trial study. Form patient refered to oncology clinic and ward of vali-e-Asr hospital 78 women were selected by simple sampling. Based on Beck depression test, 42 of them had depression. They randomly divided to case and control groups. Both groups received antideresant drug as usual. But case group had also cognitive- drug therapy. Afrer 6 Month treatment both group were tested again for depression. Data was analyzed by spss using independent and paired t tests. Results: The mean depression score hadnot signigiant difference between case and control grops beor and after treatment. The mean depression score in control group had no significant deference before and after treatment the mean depression score in the case group was significantly different after treatment (p<0.05). The mean score of depression in control group was more than case group after treatment. Conclusion: In the present study cognitive therapy cause a significant decrease in depression score of case group.
Mahbobeh Majadi Hezaveh, Mojgan Khademi,
Volume 12, Issue 1 (5-2009)
Abstract

Background: Breast Cancer is the most common malignancy and is the second largest cause of death among 35-55 years old women. The aim of this study is explore and to describe women's experiences with breast cancer for achieving a deeper comprehension of their individual experiences. Methods and Materials: This is a qualitative study with a phenomenological approach. Sampling method was purposive and continued till data saturation. Twenty two participants (patients,families and treatment team) attended in the study.Data were collected by using in-depth interviewing and were analyzed by “Parse”method. We tried to analyze qualitative data based on valid criteria. Results: The findings of this research were summarized into four core concepts:delay in diagnosis and treatment, treatment rejection, drowning in suffering (reaction to disease,facing with outcome of treatment,exposure to treatment system, ineffective care and disturbance in daily life of the family) and moving toward normal life. Conclusion: Knowledge of treatment team from the expriences of women suffering from breast cancer helps them to play a better role in their treatment. It seems, this is essential for make a shift from terminal treatment to early diagnosis. Also it emphasise to use of source for support of patients.
Noorosadat Kariman,
Volume 12, Issue 2 (9-2009)
Abstract

Background: Cervical cancer is a preventable disease and we can determined preventive methods by discovering ethiology of disease. There are no appropriate research about the relation between coitus during menstruation and cervical cancer in Iran. This study is done to investigate the relationship between coitus during menstruation and cervical cancer in women referring to health care centers of Shahid Beheshti University of Medical Sciences in 2007-2008. Methods and Materials: This case-control study was carried out on 100 patients with cervical cancer (case) and 100 healthy women (control). All participates were Moslem with Iranian nationality and habitant in Iran. They had no previous history of frequent pelvic radiotherapy and alcohol consumption. Two groups were matched with age, age of first coitus, age of first vaginal delivery, parity and type of delivery. Data was collected through structured interview and analyzed using Chi-square and logistic-regression. Result: The study showed that 40% of case group and 10% of control group had coitus during menstruation. Coitus during menstruation in case group was 6 times more than control group (p<0.0001, odds ratio =6.0, CI= 2.7-12.9). Discussion: Coitus during menstruation may increase the risk of cervical cancer. A research is recommended to find out the best educational method which to prevent this disease.
Mohammad Ali Shariat Zadeh, Ahmad Hamta, Malek Solimani, Zahra Rasoli,
Volume 12, Issue 2 (9-2009)
Abstract

Background: Skin cancer is one of the most important cancers in the world. This cancer is more common in men than women. We survey chromosomal changes in DMBA-induced skin cancer in SD rat strains. Methods and Materials: In this fundamental study, 20 SD rat strains were randomly divided into case and contal group. DMBA (2.5 mg) was injected to SD rat strains subcutaneously therefore skin cancer model for studies was created. Tumors became subjects for cell culture and metaphase chromosomal were prepared. Finally G-banding were stained. We have also transmitted genomic information from rat to human using suitable databases and Gene were determined. Results: Data showed numerical and frequent structural changes in different number of chromosomes. For example gain in chromosomes number 1, 15, 17 and loss in 1, 7, 15, and also structural changes like deletion was seen in chromosomes number 1, 4, 8, 10, 15, 17, and addition in chromosome number 15. Discussion: It is predicted that CST6، PRKCDBP، PTCH1، DKK3، ، BRMS1، CDKN1C، CD81، DMP1، CDKN2B ، EEF1A1 ، HRAS، CASP2، KLF4 probably cause skin cancer.
Shabanali Alizadeh, Kamran Moshfeghi, Mssoumeh Kalantari, Khadijeh Ebrahimi,
Volume 12, Issue 4 (2-2010)
Abstract

Background: The existence of estrogen and progesterone receptors, p53, human epidermal receptor-2(HER-2) and cathepsin-D are among the prognostic markers for breast cancer. In this study, we investigated the relationship between these factors and lymph-node involvement. Materials and Methods: In this case-control analytic study, 105 patients with breast cancer were investigated. After detecting breast mass, surgical biopsy was done and the status of the estrogen and progesterone receptors, p53, HER-2, and cathepsin-D were studied. Collected data were registered in a checklist and were subjected to analysis. Results: There was no relationship between lymph-node involvement and estrogen and progesterone receptors, p53, cathepsin-D and HER-2. Conclusion: In order to get more precise results about hormonal receptors, p53, HER-2 and cathespin-D, a similar research with a larger sample size over a longer period of time is needed.
Yalda Arast, Reza Solgui, Hamid Galedari, Heibatollah Kalantari, Mohsen Rezaei,
Volume 13, Issue 2 (6-2010)
Abstract

Background: Colorectal cancer is one of the most important and most common fatal types of cancer in the world. Identifying new agents which individually or in combination with other agents induce apoptosis in tumor cells is surely of great significance in treatment of colon cancer. The aim of the present study was to assess the effectiveness of applying lovastatin and α-tocopherol individually or in combination with each other in the induction of apoptosis in human colorectal cancer cells. Materials and Methods: In this trial, HT29 cells were exposed to various concenterations of lovastatin (5, 10, and 20 μmol) and/or alpha tocopherol (10, 20, and 25, and 30 μmol). After cell count, these cells were examined through trypan blue method and DNA fragmentation technique. Results: The findings of DNA fragmentation technique showed that each of the two drugs could induce apoptosis at all of the given concentrations. In the combination of 10 μmol concentration of lovastatin and 5 and 10 μmol concentrations of α-tocopherol, induction of apoptosis was not observed. Conclusion: Based on the extensive effects of statins, the concentration of lovastatin is seen as determining in its apoptosis function, and its combination with tocopheroles in high concentrations, by inducing apoptosis, can provide novel effective strategies for prevention of human colorectal cancer.
Zohre Yousefi, Fatemeh Homaei, Sara Rafiei,
Volume 14, Issue 5 (11-2011)
Abstract

Background:Breast cancer is one of the most common cancers in women worldwide and one of its most desirable treatments is tamoxifen. The reported side effect associated with tamoxifen is endometrial thickness and increased risk of endometrial cancer. The aim of this study was to assess the influence of tamoxifen on the endometrial thickness in amenorrhea breast cancer patients treated with tamoxifen. Materials and Methods: This descriptive-analytic, cross-sectional study was conducted in Radiotherapy Departments of Mashhad University of Medical Sciences over a period of seven years.162 patients treated with tamoxifen whose bleeding cycle had been disrupted were selected and the relationship between tamoxifen usage and endometrial thickness was investigated in them. In addition, the relationship between abnormal vaginal bleeding and the ultra sonographic findings was assessed. Data analysis was done by using t-test and Chi-square test. Results: There was a significant relationship between tamoxifen usage and abnormal endometrial thickness while the greatest relationship was observed in the first year of treatment. The relationship between abnormal vaginal bleeding and abnormal endometrial sonographic findings was significant (P=0.001). The incidence of endometrial cancer in tamoxifen users was more than general population (0.61% vs. 0.1%). Conclusion: Considering the findings of this study, in the presence of abnormal sonographic and clinical observations indicating abnormal vaginal bleeding, pathological evaluation of the endometrial biopsy should be carried out for patients who use tamoxifen.
Arash Shams, Sedighe Mehrabian, Nor-Amir Mozafari,
Volume 15, Issue 1 (4-2012)
Abstract

Background: Olive oil as a mjor source of fat in diet, besides having a high level of unsaturated fatty acid contains biological components, such as the antioxidant phenolic compounds that can prevent the destructive effect of free radicals and their resulting mutation on cellular structures. The main goal of this study was to investigate the antioxidant and anticancer effects of olive oil through Salmonella typhimurium and microsome. Materials and Methods: In this study, 16 Iranian olive oil samples and one Spanish sample were used. The determination test of anti-mutagenic potential was based on the method proposed by Ames et al. using mutant strain of Salmonella typhimurium TA100 and a well-known carcinogenic material (sodium azide) which by adding microsome of rat liver (S9), its anticancer effect was examined. Positive and negative controls which respectively contained sodium azide and distilled water were studied. Each test was simultaneously done three times and the percentage of inhibition was determined according to (1-T/M) × 100. Results: The inhibitory percentage in its highest level in darkness was equal to 63.64% based on the variety of olive oil and in light was equal to 60.70%. Conclusion: The findings of this study show that the antioxidant and anticancer properties of olive oil decrease with exposure to light
Saman Maroufizadeh, Ebrahim Hajizadeh, Ahmad Reza Baghestani, Seyed Reza Fatemi,
Volume 15, Issue 2 (6-2012)
Abstract

Background: Gastric cancer is a common and lethal disease throughout the world. This study was designed and carried out to determine the five-year survival rate of gastric cancer patients who had undergone surgical treatment at Taleghani Hospital of Tehran, and to assess its associated factors. Materials and Methods: In this historical-cohort study, information obtained from a total of 213 gastric cancer patients who underwent surgery at Taleghani Hospital of Tehran between 2003 and 2008 was included. In the analyses, Kaplan-Meier method, log-rank test, Cox proportional hazards model, and Lin-Ying additive hazards model were used. Results: The five-year survival rate and the median life expectancy in the studied patients were 14.6% and 29.6 months, respectively. Two covariates showed significant impacts on the gastric cancer patients’ data in both models: age at diagnosis and tumor size. We found that pathologic stage was significant under the Lin-Ying model (P=0.043) however, it was not significant under the Cox model (P=0.069). Other clinicopathological characteristics were not statistically significant (P>0.05). Conclusion: Since Cox and Lin-Ying models consider different aspects of the association between risk factors and the study outcome, it seems desirable to use both of them as complementary models but not as alternative models to obtain a more comprehensive understanding of data. This study showed that the early detection of patients in younger ages and in primary stages is important to decrease the risk of death in patients with gastric cancer and to increase the survival rate.
Sedigheh Mehrabian, Ahmad Majd, Ali Kheiri, Parisa Joniubi,
Volume 15, Issue 2 (6-2012)
Abstract

Background: Nowadays, cancer is one of the main causes of death in the world and mutagens cause death in millions of patients. Noticing the side effects of the drugs used to treat cancer, scientists are looking for drugs with fewer side effects and more therapeutic effects. Accordingly, the number of studies in this field is rapidly increasing. This study was done to evaluate the effects of antimutagenesis of aqueous and alcoholic extracts of A. vera leaf gel and latex by Ames test against the mutagenic substance named sodium azid in the presence and absence of microsomal homogenates of rat liver (S9). Materials and Methods:In this experimental study, after preparing different extracts of A. vera gel and latex, the antimutagenic effect of different extracts was assessed by Ames test, within which a mutant strain was grown on a culture containing mutagen substance (NaN3). Antimutagen (A. vera extract) reduced reversed mutation. The difference between the mean number of revertants per plate in relation to the mutagens was analyzed through one-way ANOVA using SPSS software. Results: The results showed that the ethanol extract of latex and aqueous extract of gel had the maximum (91%) and minimum (56%) percentages of inhibition, respectively. Conclusion: This assessment revealed strong antimutagenicity effect for all of the extracts due to the presence of different kinds of antioxidants substances such as various anthraquinones, flavonoids, and vitamins A, C, and E. The maximum inhibition of mutation was observed in ethanol extract of latex. This observation supports the results obtained from the application of microsome mixture as well as those reported by other researchers.
Zeinab Moghadami Fard, Jamilleh Abolghasemi, Mohsen Asadi Lari, Mehdi Mohammadi, Mahmood Reza Gohari, Masoud Salehi,
Volume 15, Issue 8 (1-2013)
Abstract

Background: There are various factors effective in the appearance of metastasis that have been surveyed and recognized in different studies. However, the appearance of metastasis by determination of these factors cannot be predicted. One of the models used for the analysis of recurrent data and consideration of heterogeneity between patients is frailty model. Materials and Methods: In this survival study, 133 women with breast cancer were treated in Fayazbakhsh Hospital, Tehran, during 2005-2007. All patients were followed until April 2011. Frailty model was employed for the analysis of data and gamma frailty distribution was assumed with the average one and Ө variance. All statistical methods were run in R software. Results: Disease-free survival rates for 3 and 5 years were 0.78 and 0.72, respectively. During the follow-up period, the risk of metastasis was estimated to be 43%. Two factors were identified as the prognostic factors in the appearance of metastasis: tumor malignancy grade and the number of positive lymph nodes. Frailty variance was 4.27 (P=0.001). Conclusion: The significant variance of frailty component in the model indicates that patients who have identical explanatory variables face different levels of risk experiencing metastasis. Also, specific characteristics of the patients are important in the incidence of metastasis.
Mahin Farahmand, Amir Almasi-Hashiani, Davood Mehrabani,
Volume 15, Issue 10 (3-2013)
Abstract

Background: Prostate cancer is one of the most common cancers in men which its incidence rate and associated mortality and morbidity are on the rise. The aim of this study was to investigate the epidemiology of prostate cancer in Fars province between 2003 and 2008 years. Materials and Methods: In this epidemiological study, using Fars province cancer registry data, the incidence rates were calculated per 100,000 people and age standardized incidence rate (ASR) was measured by direct method using the world standard population. Data were analyzed by SPSS, version 16, and Microsoft Excel, version 2007. Cochrane Armitage Test for linear trend was used for evaluation of the incidence trend by running Winpepi software. Results: Over a 6-year period, 1212 cases were recorded in Fars province. The ASR of prostate cancer in these six years was 4.69, 7.16, 15.09, 14.04, 16.65 and 16.02, respectively, which revealed significantly increasing trends. The highest incidence rate was observed in 80 and upper age group. Conclusion: The ASR of prostate cancer in Fars province is significantly lower than other parts of the world, especially in more developed countries. This can be due to absence of screening programs and/or cancer registry.
Hoda Noorkojuri, Ebrahim Hajizadeh, Ahmad Reza Baghestani, Mohammad Amin Pourhoseingholi ,
Volume 15, Issue 10 (3-2013)
Abstract

Background: Gastric cancer is the second leading cause of mortality due to cancer worldwide and it is the most common type of cancer in Iran. The aim of this study was to assess the effects of prognostic factors on the survival of patients with gastric cancer using the penalized spline in Cox model and compare it with Cox proportional hazards model. Materials and Methods: In this retrospective study, information obtained from a total of 216 gastric cancer patients who underwent surgery at Taleghani Hospital of Tehran between 2003 and 2008 years was included. Cox proportional hazards model and penalized spline in Cox model were used. R software was used for data analysis. The efficacy of these models was compared according to Akaike information criterion. Results: The five-year survival rate was 30% and the mean follow-up time was 16.60±15.28 months. Survival mean and median were 46 and 30 months, respectively. The analysis of Cox proportional hazards and penalized spline models resulted in age at diagnosis and tumor size as prognostic factors for survival time (P<0.05). Also, Akaike information criterion and survival curve for patients with a tumor size over 35 mm and age at diagnosis over 45 years were equal in both models. Conclusion: Cox proportional hazards and penalized spline models generated similar results thus, it is more appropriate to use Cox proportional hazards model because of its ease of interpretation and capability of modeling both continuous and discrete covariates. This study also showed if gastric cancer is diagnosed early, the relative risk of death will reduce.
Shahnaz Shahrjerdi, Sedighe Darvish Shafighi,
Volume 16, Issue 9 (12-2013)
Abstract

Background: Breast cancer is the most common cancer among women. An important goal for cancer patients is to improve the quality of life (QOL) by maximizing functions affected by the disease and its therapy. This study examined the effects of massage therapy on quality of life in women with breast cancer after surgery.

Materials and Methods: The study was quasi-experimental. Among the 53 women with breast cancer surgery and oncology clinic of Arak, 30 were randomly allocated in two groups of massage therapy (n=15) and 5 weeks (30 min, 2 sessions per week) and control (15 cases). Cortisol levels and quality of life questionnaire (SF36) was redirected and mental health groups. Data analysis software SPSS version 16 using paired t-test and one-way analysis of variance and a confidence level of 95% (p<0.05) was performed.

Results: The results showed a significant increase in the experimental group improved after the massage, physical (p=0.001) and psycho-social (p=0.002) were compared with control subjects. Massage also improves quality of life and mental health in breast cancer patients after surgery was (p<0.05). However, serum cortisol levels between the experimental and control groups were not significant (p>0.05).

Conclusion: The overall results of this study showed that massage therapy can be an effective intervention to improve quality of life and mental health in patients with breast cancer during radiotherapy is used.


Mahmood Reza Baghinia, Seyyed Mehdi Shariatzadeh, Neda Baghinia,
Volume 16, Issue 10 (1-2014)
Abstract

Background: Prostate cancer is one of the most prevalent type of cancer and the second cause of death among American men. Its prevalence has a direct relationship with increasing age. The present study was carried out to determine the level of prostate specific antigen (PSA) and calcium level in blood in men with prostate cancer and BPH in Arak.

Materials and Methods: In this prospective study, out of 400 Arak males, were selected from different inner-city areas through cluster sampling during a period of two years (august 2011-august 2012). After the population was approved to have the necessary criteria to be included in the study, their PSA and calcium level was measured and its mean in over 40 years. In order to determine mean difference among the seven groups T-test analysis and to determine "PSA", PSA Assay and Tandem-R kits were utilized and for measurement of serum calcium, pars azmoon kit was used.

Results: In this study, there was a markedly relationship between age and serum calcium and serum PSA in both groups.in this way that there was a negative relationship between age and serum calcium and a positive relationship between age and serum PSA.

Conclusion: With respect to the findings of the study, it could be confirmed that was a markedly relationship between serum PSA and serum calcium only in prostatic cancer patients,according to this study in future maybe we used serum calcium as a tumor-marker for screening for prostate cancer.


Ghodratollah Roshanaei, Azam Komijani, Abdolazim Sadighi Pashaki, Javad Fardmal,
Volume 16, Issue 11 (2-2014)
Abstract

Background: It can be used different models such as nonparametric, semi-parametric and parametric to estimation of survival. Depending on the nature of the data, some methods may be more appropriate. Using of appropriate model result more accuracy estimation of survival and it's affected. so the aim of this study estimation of survival and determination of its related risk factor. Materials and Methods: In this study, 169 patients with colorectal cancer who had treated in Hamadan MRI Center from March 2005 to Jun 2013 were evaluated. Survival time of patients is considered from diagnosis time to death or end of study. The effect of Demographic and clinical risk factors on survival is assessed by parametric model. follow up of patient Data were analyzed using Spss16 and R statistical software.

Results: The median survival was 4.3±40 months. Univariate analysis showed that the effect of staging of tumor, tumor grade, histology type of tumor, metastasis and relapse on survival were significant but in multivariate model histology type of tumor and metastasis were significant.

Conclusion: using of appropriate statistical model for detection of affected risk factor on patient with colorectal cancer can be prevented progression of disease and increased of survival of them.


Zahra Fazeli, Mahbobe Najafian Zade, Babak Eshtati, Amir Almasi Hashiani,
Volume 16, Issue 11 (2-2014)
Abstract

Background: The prevalence and incidence of cancer in different parts of the world have different patterns. To recognize the frequency of malignancies in different social groups according to climatic conditions is considered as the primary component of prevention programs at different levels. This study was conducted to investigate the epidemiology, survival rates and geographical epidemiology of breast cancer in Markazi province.

Materials and Methods: In this epidemiological study, needed data were obtained from cancer registration program and death registration data. The data were analyzed by using SPSS software version 16 and Winpepi and significant level was 0.05. And to draw a map to show the breast cancer incidence rate in Markazi district, Arc view software was used.

Results: Out of the 400 cases recorded during the 5-year, 8.5% died due to breast cancer. 5-year survival rate was 87% and there was a significant correlation between survival rate and age. Most records were related to the age group 49-40 years and the highest incidence rate was in Arak. The trends of incidence rate was not significant.

Conclusion: The results showed that 5-year breast cancer survival rate is more than some other places which could be due to new and improved methods of treatment and methods of screening and early detection of disease. Other aspects of the epidemiology of the disease is similar to other parts of Iran.


Azam Gholamian, Adeleh Divsalar, Mahboubeh Eslami Moghadam, Maryam Saiedifar, Ali Akbar Sabory ,
Volume 17, Issue 2 (5-2014)
Abstract

Background: Catalase is a basic antioxidant enzyme that exits in human organs, mainly in the liver. The liver as a main tissue in the body that plays a substantial role in the catabolism and detoxification of drugs is a target of toxic and carcinogenic effects of many drugs. In the present study, the side effects of an anti-cancer compound of oxali-palladium on the function and structure of liver catalase were investigated.

Materials and Methods: In this experimental study, changes in the enzyme activity were studied by conversion in substrate (hydrogen peroxide) absorption at wavelength of 240 nm, using UV-visible spectroscopy in the absence and presence of different concentrations of oxali-palladium at room temperature. Furthermore, the effect of oxali-palladium on the tertiary structure of catalase was investigated using fluorescence spectroscopy via studying the changes in the intrinsic enzyme emission in the absence and presence of different concentrations of oxali-palladiumat at both room and physiologic temperatures.

Results: Kinetics data showed that the Km value of bovine liver catalase was 26.8 mM. Moreover, in the presence of different concentrations of oxali-palladium‚ the enzyme activity showed a gradual decrease in a dose-dependent manner (p<0.001). Fluorescence data presented changes in the tertiary structure of the enzyme by quenching fluorescence emission‚ that indicated alteration in protein chromophore environment.

Conclusion: It could be concluded that inhibition of catalase enzyme by anticancer drug of oxali-palladium increases the content of reactive oxygen species. Increase in reactive oxygen species values is one of the chief mechanisms of different anticancer drugs.



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