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Abstract

Background: Sirtuin-1 regulates important cellular processes, including apoptosis, cellular senescence, and metabolism. Therefore, sirtuin-1 may be a novel therapeutic target for type 2 diabetes. The aim of this study was to investigate the effect of 8 weeks aerobic training on sirtuin-1 level and cardiometabolic parameters in women with type 2 diabetes.

Materials and Methods: In this semi-experimental study with pretest – posttest design, twenty diabetic women (aged 43.92±5.2 y) were randomly assigned to aerobic training or non-exercising control groups. Aerobic training program was performed 50-60 min/d, 3d/wk, for 2 months. Serum levels of sirtuin-1, body composition and metabolic parameters were assessed before and after the training period. Data were analyzed by paired T test.

Results: Adiposity indices, total cholesterol, triglyceride, LDL- cholesterol,blood glucose and insulin resistance index were significantly reduced in the intervention group compared to the control (p<0.05). Also, sirtuin-1 level was increased in the intervention group compared to the control (p<0.05).

Conclusion: These findings show that aerobic exercise is associated with an improvement in siruin-1 levels and metabolic indices in women with type 2 diabetes.

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Background and Aim Apoptosis or programmed death is active biological process and reversible that the balance between growth and cell death in various tissues, particularly myocardial tissue is essential role. The aim of this study was the effect of 8 weeks High Intensity Interval Training (HIIT) with and without food restriction on gene expression of Caspase 3 and 9 in rats.
Methods & Materials: This study was experimental multi group design with control group which conducted on 30 rats with two months old male. Subjects were divided in to five homogenous groups including base control, control, caloric restriction, interval exercise training and caloric restriction+interval exercise training. Training groups five sessions in weeks were participated in interval exercise training for 8 weeks. The level of gene expression of the proteins Caspase 3 and 9 was evaluated by Real Time-PCR. Dates were analyzed using the 1-way ANOVA at the level of (P<0.05).
Ethical Considerations: The protocol of this study was approved by the Medical Committee of Sanandaj University of Medical Sciences (Code: IR.MYK.REC.1397.5022).
Results: The results showed that the training group had a significant decrease in gene expression of Caspase 3 in comparison with caloric restriction+exercise training (P<0.05). Also, exercise training and exercise training+caloric restriction significantly decrease in the gene expression of Caspase 9 compared to caloric restriction, base control and control (P<0.05) and significantly decrease in the gene expression of Caspase 3 compared to base control and control (P<0.05).
Conclusion: According to the results, it seems that high intensity interval training with and without calorie restriction provides the necessary adaptations to inhibit or stop apoptosis induced by aerobic exercise.