Showing 4 results for Bdnf
Elham Vosadi, Hamed Barzegar, Mahboobe Borjianfard,
Volume 16, Issue 10 (1-2014)
Abstract
Introduction: This study was to examine the effects of endurance training and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus.
Materials and Methods: Twenty eight Wistar rats were divided into four groups: (1) Regular diet-sedentary (RD-Sed), (2) Regular diet-Exercise (RD-Exe), (3) HF-sedentary (HF-Sed), and (4) HF- Exercise (HF- Exe) RD-Sed group was regarded as control. Animals in exercise groups received 8-wk endurance training and animals in HF groups were exposed to the HF diet for 8-wk. Hippocampal BDNF protein was assessed using commercial ELISA kits and the data were analyzed by one-way ANOVA. Statistical differences were considered significant at p<0.05.
Results: The results showed that the endurance training had no significant increase in BDNF protein level comparison with the RD-Sd and HF-Sed groups moreover the high-fat diet had no significant effect in BDNF protein level.
Conclusion: According to results of present study, looks applications of endurance training can increase amount of hippocampus BDNF protein level.
Reavan Afshar, Masoud Rahmati, Rahim Mirnasouri,
Volume 28, Issue 1 (3-2025)
Abstract
Introduction: Considering the synthesis and secretion of irisin and BDNF from muscle tissue during exercise and the possible relationship of these factors with improving muscle strength and performance, the present study aimed to investigate the effect of 12 weeks of strength training on muscle strength, body fat percentage, irisin, and BDNF in inactive middle-aged women.
Methods: In a semi-experimental study, 20 inactive middle-aged women (mean age 37.70 ± 5.91 years, weight 79.80 ± 5.82 kg) were selected and randomly assigned to two strength training groups (n = 10) and control groups (n = 10). The training group performed 12 weeks of strength training, three sessions per week at an intensity of 65 to 80% of maximum strength. Then, blood samples were taken using ELISA to measure irisin and BDNF. Independent t-test and Pearson correlation test were used to analyze the data. The significance level (P ≤ 0.05) was considered.
Results: Strength training significantly increased serum irisin concentration (P = 0.035) and serum BDNF concentration (P = 0.058) and also considerably decreased body fat percentage (P = 0.058) in middle-aged women. There was also a positive and significant relationship between lower body strength and serum irisin levels (P = 0.040). The Results from the Pearson correlation test indicate a significant positive relationship between BDNF and upper body strength (P = 0.038).
Conclusions: Based on the results of the present study, it seems that increased secretion of serum irisin and BDNF hormones is related to increased muscle strength following strength training in middle-aged individuals.
Mohammad Parastesh, Ali Yasavoli Sharahi, Jalil Moradi, Behzad Aria,
Volume 28, Issue 6 (1-2026)
Abstract
Introduction: Physical and cognitive fitness are crucial in futsal, making the identification of effective training methods essential. This study aimed to investigate the effects of two high-intensity interval training (HIIT) protocols on plasma brain-derived neurotrophic factor (BDNF) levels, working memory, and selected physical fitness factors (aerobic and anaerobic capacity) in adolescent futsal players.
Methods: This semi-experimental study was conducted on 15–16-year-old futsal players from Arak city with at least three years of club experience (approved by Arak University Ethics Committee, code: IR.ARAKU.RCE.1401.027). Twenty-four participants were randomly assigned to HIIT1 (10×1-minute intervals with 1-minute rest) or HIIT2 (3×4-minute intervals with 2-minute rest) groups, training for eight weeks. Aerobic capacity, anaerobic capacity, plasma BDNF levels, and working memory were assessed pre- and post-intervention. Data were analyzed using Paired and Independent T-tests (p <0.05).
Results: The HIIT1 group showed significant improvements in aerobic capacity (p=0.001) and BDNF levels (p=0.001). Similarly, HIIT2 demonstrated significant increases in aerobic capacity (p=0.001), anaerobic capacity (p=0.014), and BDNF levels (p=0.001). Working memory showed no significant changes in either group (p=0.780), with no between-group differences observed.
Conclusions: Both HIIT protocols significantly improved aerobic capacity and BDNF levels, while only HIIT2 enhanced anaerobic capacity. Neither protocol affected working memory. HIIT appears effective for enhancing physiological and physical fitness factors in adolescent futsal players.
Ali Ganji, Iman Farahani, , , Mohammadhasan Sakhaie,
Volume 28, Issue 6 (1-2026)
Abstract
Introduction: Experimental Autoimmune Encephalomyelitis (EAE) is an immune-mediated inflammatory model of multiple sclerosis that induces axonal loss, demyelination and motor disabilities. Electromagnetic fields (EMFs) possess multiple biological capabilities that affect the nervous system. The aim of the present study is to investigate the beneficial effect of low-intensity electromagnetic field on clinical symptoms, histological structure and gene expression in the cerebral cortex.
Methods: Forty-eight female C57BL/6 mice were used for this study. Following model induction, with MOG immunization the animals exposed to the EMFs (1 mT,50 Hz) over a period of two weeks. At the end of experiments, the body weight, clinical score (paralysis score) and lymphocyte infiltration of the cortex were evaluated in experimental groups. Moreover, the mRNA expression levels Bcl2, BDNF and Nrf2 are also were studied by using quantitative polymerase chain reaction (qPCR).
Results: The EMFs, significantly reduced the clinical symptom scores, decreased lymphocytic infiltration. The applied EMF also upregulated the expression of Bcl2, BDNF and Nrf2 in the cerebral cortex in compared to EAE model.
Conclusions: Overall, the present study demonstrated that electromagnetic fields, as a complementary therapy, exert significant neuroprotective properties in EAE by inhibiting oxidative stress and reducing neural tissue inflammation.
