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Introduction: Secondary hyperparathyroidism (SHPT) is one of the serious complications in patients with chronic kidney disease (CKD). This study aimed to identify biochemical alterations of renal bone disease in hemodialysis patients of Qazvin province. Materials and Methods: In a descriptive study, fasting blood samples of arterio-venul shunt, before starting hemodialysis, were taken from all CKD patients and Ca++, P-- and ALP were measured by colorimetric methods and PTH by IRMA method. Descriptive statistics was used to present data. Results: In 4% of cases there were no abnormalities of mentioned parameters but in 96% of patients one or more parameters were abnormal. The most prevalent abnormality was related to P-- (increased) and the least one to ALP (increased). 51% of patients had raised PTH level (hyperparathyroidism) and higher abnormalities of other biochemical parameters. No differences were seen in the mean of age, duration and number of hemodialysis and also sex ratio of hyperparathyroid patients and all studied patients. Conclusion: The Biochemical and hormonal results revealed a predominance of mild to moderate secondary hyperparathyroidism and renal bone disease in CKD patients, so there is a need to control the disease with specific treatments.

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Introduction: Serum Alkaline Phosphatase (ALP) is a glycoprotein that is secreted from osteoblasts. In fractures, the rate of ALP will be changed. Low intensity pulsed ultrasound accelerates the growth and remodeling of fractures. However the relation between pulsed ultrasound and changing the rate of serum ALP in New Zeland rabbit is not studied yet. The aim of this study is to investigate the effect of pulsed ultrasound on serum ALP during bone healing of tibia in New Zealand rabbit. Materials and Methods: This is an experimental study. 54 male and mature New Zealand rabbits were randomly divided into six groups (3 experimentals and 3 controls). All of them were operated for inducing a model of experimental fracture. After repair of wounds, the right leg of experimental groups was exposed to pulsed ultrasound for 2, 4 and 6 weeks. The control groups were kept without any intervention during the same time. After experiment, the rabbits were anesthesied and blood samples were taken from their hearts for ALP serology, and then the rabbits were killed. Blood was centrifuged and serum ALP was read by spectrophotometer. Data was analyzed by Mann-Whitney U and Kruskal-Wallis tests. Results: Results showed that the mean serum ALP level in experimental group after 4 weeks exposing to pulsed ultrasound was significantly higher as compared to control group (p= 0.03). There was no significant difference between the other groups. Conclusion: The results of this study demonstrate that pulsed ultrasound wave increases serum ALP and accelerates the bone healing.

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Background: The purpose of the present study was to investigate the probable changes of HSP70 , liver enzymes & Cpk in professional athletes after a training season and participating in skating open world championship.

Materials and Methods: 10 elite female skaters were chosen. Eccentric exercise test were performed in three sections (24 hours before the beginning of the training, after six months of training (before participating in Skating World Championship) and 24 hours after the end of world championship). The training program consisted of 26 weeks of training, performed 5 times a week encompassing specialized skate trainings. Blood samples were taken before and after each eccentric exercise test.

Results: there was no significant change, in HSP70 concentration in response to eccentric exercise test, in pre exercise period (p>0.898). But, it illustrated a significant increase in after eccentric exercise test, in post exercise period (p<0.031). Moreover, in measuring down, it showed a significant increased in the amount of liver enzymes and Cpk after eccentric exercise test in second and third step compared to first step (p<0.05).

Conclusion: the results of the study illustrated that improving an athlete's physical fitness level during training season and matches leads to a significant increase in the protective level of the body (via the production of HSP70), depending also on the ability of the body of the individual in producing that protein. It can also be stated probably individual body fitness level, is an important factor in determining ALT, AST, ALP levels after performing eccentric exercise.

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