Showing 28 results for Aerobic
Shahnaz Shahrjerdi, Nader Shavandi, Rahman Sheikh Hoseini,
Volume 12, Issue 4 (2-2010)
Abstract
Background: Diabetes Mellitus is a heterogeneous group of different metabolic disorders that are characterized by chronic increase of blood glucose and proteins, lipids and carbohydrates metabolism disorder. The aim of this study was to investigate the effect of 8 weeks of aerobic exercise on metabolic factors, quality of life and mental health of women with type II diabetes. Materials and Methods: In this semi-experimental investigation, 18 women with type П diabetes referring to Arak Petroleum Company Clinic were selected and divided into two groups: aerobic (10 participants) and control (8 participants). Aerobic group performed selected exercises in 8 weeks (three 30-50 min sessions per week). In this investigation, we used metabolic factors (such as total cholesterol, triglycerides, HDL, VLDL, LDL, FBS, HbA1c and Insulin serum) and SF-36 quality of life (QOL) and GHQ mental health (MH) questionnaires. The level of significance was considered to be 95% (P<0/05). Results: There were significant differences between the means of pre-test and post-test measures of FBS, HbA1C, Insulin serum, QOL and MH in aerobic group. There were no significant differences between the means of pre-test and post-test measures of TC, HDL, LDL, VLDL and triglycerides in aerobic group and all factors in the control group (P<0/05). Conclusion: Aerobic exercise affects metabolic factors, QOL and MH in type П diabetic patients and it results in their improvement.
Nader Shavandi, Abbas Sarami, Mohammad Parastesh, Akbar Ghorbani, Rahmat Alah Hidarpur,
Volume 13, Issue 2 (6-2010)
Abstract
Background: The aim of the present study was to determine the response of lung function indices to aerobic and anaerobic exercises in polluted air. Materials and Methods: In this quasi-experimental study, 20 healthy men were randomly divided into two equal groups experiment and control. The experiment group initially had one session of aerobic exercise and after a three-week break, received one session of anaerobic exercise on ergometer bicycle in polluted air. The control group did the same kind of exercise in healthy clean air. Lung function tests were run before, right after (the first post-test), and 24 hours after the exercises (the second post-test). Results: Aerobic exercise in unhealthy polluted air resulted in the significant reduction of FEV1, FVC, and FEF25-75% indices in the first and second post-tests. Following anaerobic exercises in polluted air, a significant decrease was observed in FVC and FEF25-75% indices in both the first and second post-tests. FEV1 and FEF25-75% indices in the first and second post-tests, and FEV1 and FVC indexes in the second post-tests underwent a remarkably greater reduction following aerobic exercise. Conclusion: While aerobic physical exercise in polluted air caused a reduction in the lung function indices (FEV1, FVC and FEF25-75%) in the first and second post-tests, it seemed that anaerobic exercises in polluted air induced a significantly smaller reduction in FEV1 and FEF25-75% in the first and second post tests, and FEV1/FVC in the second post test.
Nader Shavandi, Abbas Saremi, Akbar Ghorbani, Mohammad Parastesh,
Volume 14, Issue 2 (5-2011)
Abstract
Background: Adiponectin is a protein which is initially secreted exclusively by adipocytes but its secretion decreases in obese and overweight individuals. With its anti-inflammatory properties, adiponectin acts as an agent which can decrease the risk of type II diabetes and cardiovascular diseases. The aim of this study was to determine adiponectin serum levels in type II diabetic men and explore its relationship with insulin resistance following aerobic exercise.
Materials and Methods: In this semi- experimental study, 30 men with type II diabetes were randomly assigned to training and control groups. The training group went through an 8-week training program which consisted of three 40-50 minute aerobic exercise sessions a week (running on treadmill at intensities corresponding to 30to 75% of maximal heart rate (35-75% HR max)). For measuring adiponectin and insulin serum levels, blood samples were obtained through ELISA technique in 2 stages, weeks zero and eight. For determining insulin resistance, insulin resistance index was utilized. In order to evaluate the results, dependent and independent t-tests and Pearson correlation coefficient were used.
Results: The results did not indicate the presence of a significant relationship between adiponectin and insulin resistance following training (P=0, r=-0.14). In comparison with the control group, training induced a 39% decrease in adiponectin serum levels, a 10% decrease in BMI and bodyweight, and a 48% decrease in insulin resistance (P>0.001)
Conclusions: The findings of this study showed that in response to the 8-week aerobic training program, adiponectin serum levels significantly increased while insulin resistance got decreased. In addition, there was not a significant relationship between adiponectin serum level changes following training and insulin resistance index.
Abbas Saremi, Nader Shavandi, Neda Bayat,
Volume 15, Issue 1 (4-2012)
Abstract
Background: Physiological studies suggest that sleep deprivation may influence bodyweight through affecting appetite (decreasing leptin and increasing ghrelin). The aim of this study was to evaluate the effects of 12 weeks of aerobic training on obesity indices, serum levels of ghrelin and leptin, and sleep quality in overweight and obese men.
Materials and Methods: In this quasi-experimental study, 22 overweight and obese men with low sleep quality were randomly assigned to aerobic training (n=12) and control (n=10) groups. Aerobic training was performed (50-60 min/day, 3 day/week) for 12 weeks. Serum ghrelin and leptin and obesity and sleep quality indices were measured before and after the intervention. Changes in dependent variables resulting from the training intervention were assessed by dependant t-test using SPSS software.
Results: After aerobic training, weight (p<0.03), body mass index (p<0.04), visceral fat (p<0.04), total abdominal fat (p<0.03), and sleep quality (p<0.001) significantly improved. However, ghrelin and leptin serum levels did not change in response to aerobic training (p<0.05) during the same period.
Conclusion: Short-term aerobic training improved obesity indices and sleep quality in obese/overweight men, yet this improvement was not accompanied by changes in ghrelin and leptin serum levels.
Bayan Fayazi, Abdolhossein Parnow, Behroz Ahsan, Zeynab Yousefvand,
Volume 16, Issue 1 (4-2013)
Abstract
Background: Multiple sclerosis is a chronic disease of the central nervous system which leads to myelin destruction. The aim of this study was to examine the effect of aerobic training on functional capacity and percent body fat in women with moderate multiple sclerosis.
Materials and Methods: In this clinical trial, 15 women with multiple sclerosis (aged 33.68±8.22 years) with EDSS<4 were randomly divided into experimental (n=8) and control (n=7) groups. An aerobic program prolonged for 8 weeks, 3 days/week, 20-40 minutes/day, with 60-80% of HRmax was run in the experimental group. Some functional capacities, such as speed running, walking endurance, balance, and VO2 Max, as well as BF% were measured before and after the training program in both groups.
Results: The results showed that aerobic training led to significant increases in walking endurance, walking speed, balance, and VO2max (p<0.001). These indices, however, decreased significantly in the control group (p<0.05). Additionally, after the training program, percent body fat decreased significantly in the experimental group (p=0.005), but it increased significantly in control group (p=0.002).
Conclusion: Considering the findings of this study, it can be stated that aerobic training can improve functional capacity and decrease percent body fat in multiple sclerosis patients
Ahmad Rahmani, Mahmood Sheikh, Rasool Hemayat Talab, Naser Naghdi,
Volume 16, Issue 1 (4-2013)
Abstract
Background: Exercise can counteract the negative effects of stress, but variations in exercise protocols and intensities have generated different results. The purpose of this study was to investigate the effect of immobilization stress on cognitive performance and the moderating role of exercise.
Materials and Methods: In this experimental study, adult Albino-Wistar rats were randomly assigned to 5 groups. The animals underwent immobilization stress (2 hours per day×7 day), exercise (30 minutes per day×7 day), or no intervention. The rats were trained and tested using Morris water maze.
Results: The control group had better performance than the stress group in acquisition (p<0.01) and recall (p<0.05) in Morris water maze. There was not a significant difference between exercise-stress and control groups in water maze performance. Stress increased corticosterone levels (p<0.001), but exercise had a significant effect on decrement of corticosteron levels (p<0.001). Also, despite the absence of a significant difference between sham and exercise groups in the acquisition stage, the exercise group had a better performance in the recall stage (p<0.05).
Conclusion: Immobilization stress can impair acquisition and mild exercise has a protective effect against stress-induced negative effects. Corticosterone may be a major mediator in the protective effect of exercise against stress-induced cognitive impairment. In addition, the role of exercise in retrieval of past experiences is more prominent than their acquisition.
Ali Khajehlandi, Hosein Jafarei, Amin Mohammadi Demieh, Parvin Barzideh,
Volume 16, Issue 5 (8-2013)
Abstract
Background: Heat shock proteins (HSP) are from proteins family playing crucial role in maintaining cellular hemostats and protecting cells in an acute and chronic stressful conditions. The object of this study is to investigate the alternation of heat shock proteins (HSP70) levels after Wingate and Strand tests in female students.
Materials and Methods: In this semi- experimental study, 40 female (20 athletics and 20 non-athletics) with the mean age 22.3±3 & 23.2±2, Height 159.2±5 & 161.2±4 cm and mean weight of 59.3±3 & 65.4±2 kg (respectively) were selected randomly and underwent training protocols of Wingate and Strand tests with 3 days intervals. 5 cc brachial vein blood samples were taken immediately before and after performing tests in order to analyze the data using repeated measure method.
Results: The findings showed significant increase after aerobic Strand test between athletics and non-athletics Female (p<0.01). But, after aerobic Wingate test, a significant increased was observed only in Athletes' group (p>0.05). But there was an insignificant reduction in non-athlete group.
Conclusion: The results showed that exercise duration is more important than exercise intensity in HSP70 production.
Zeinab Aminilari, Farhad Daryanoosh, Maryam Koshkie Jahromi, Mohammad Mohammadi,
Volume 17, Issue 4 (7-2014)
Abstract
Background: Derived hormones from Adipokines include leptin, adiponectin, resistin, apelin, omentin.The aim of present study was to investigate the effect of 12 weeks aerobic exercise on plasma levels of Apelin, Omentin and glucose in obese older women with diabetes type 2.
Materials and Methods: In this study, 30 obese older women were chosen. They were also divided in to two groups: control (n=15 Age: 53.3+5.88 BMI: 28.7+2.2) and experimental (n=15 Age: 52.6+ 7.12: BMI: 30.03+3.6) according to their fat percentage and BMI. The training program included aerobic exercises which were conducted increasingly, 3 times a week for 12 weeks. Blood samples were taken before starting the exercise training and also 24 hours after the last training session. U Mann-Whitney Test was used to evaluate the data and in order to compare each group's pretest and posttest, Wilcoxon test was used at the significance level of p&le 0.05.
Results: There were significant changes in apelin and glucose plasma levels in the training group (p=0.001 and p=0.006 respectively). Furthermore, no significant difference was observed between each group's omentin levels.
Conclusion: It was finally concluded that exercise training can facilitate the process of glucose entrance into a cell because of the continuous muscle contractions and also decrease the plasma glucose. Also each adipokine response might be depend on the intensity and duration of exercise training, separately.
Mohammad Mehdi Rafiei, Nader Shavandi, Abbas Saremi, Abbas Shavandi,
Volume 17, Issue 4 (7-2014)
Abstract
Background: There are few studies related to effects of exercise training, including concurrent training, on hormonal changes in children. Hence, the aim of this study was to Compare theeffects of 6 weeks of resistance training and concurrent resistance and endurance training on aerobic power (VO2peak) and resting levels of growth hormone and cortisol in healthy children.
Materials and Methods: The subjects ofthis quasi-experimental study were 35 healthy boys between 9-11 years old, which were randomly divided into three groups of concurrent training (n=12), resistance training (n=11), control (n=12). Experimental groups were trained during 6 weeks 3 times a week.Control group were performed only their routine activities. VO2peak test was taken 48 hours before and after implementation of 6-weeks protocols and samples were selected from all subjects.Measurement of resting levels of GH and cortical was performed with ELISA method. For data analysis, one way ANOVA and paired t-test were used.
Results: The results showed that VO2peak and resting levels of GH increased significantly in concurrenttraining group (p=0.001, p=0.003, respectively). Resting level of cortisol in concurrent group was significantly lower than the other groups (p<0.05) and it was reducedsignificantlyin concurrent training and resistance training groups (p=0.001, p=0.036).
Conclusion: It seems a concurrent training period has greater benefits on VO2peak and resting levels of GH and cortical in children in comparison with resistance training.
Seyede Marzieh Ketabi Poor, Maryam Koushkie Jahromi,
Volume 17, Issue 8 (11-2014)
Abstract
Background: Regarding the importance of prevention of cardiovascular disease during menopause the purpose of present study was evaluating the influence of eight weeks progressive aquatic exercise on serum Apoproteins of A and B and lipoproteins in obese and normal weight menopause women.
Materials and Methods: This was a semi-experimental study in which 29 menopause women from Isfahan (age: 57.4 ±4.68 years) voluntarily participated in it. According to body mass index (BMI), participants were divided to obese (n=15, BMI= 30.21 ±3.90) or normal weight (n=14, BMI=22.44 ±2.25) groups. Subjects of both groups participated in 8 weeks aquatic exercise, three times a week, by progressive intensity of 50 to 70% of maximal heart rate and duration of 45 minutes.
Results: Findings of study indicated a significant influence of exercise on VLDL, Apo A and B and ApoB/ApoA in in obese group. In normal weight group, exercise caused significant changes in LDL, VLDL, Apo A and B and ApoB/ApoA, but there was no significaut difference between groups in none of study variables.
Conclusion: According to our findings, progressive aquatic aerobic exercise induces similar reduction of some cardiovascular risk factors especially ApoB and ApoB/ApoA and increasing ApoA in obese and normal weight menopause women.
Mozhgan Aghamohammadi, Abdolhamid Habibi, Roohollah Ranjbar,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Irisin, a recently identified myokine that seems had important role in hemostasis regulatation and improving insulin resistance. The effect of exercise training on serum irisin levels in type 2 diabates (T2D) is controversial. This study aims to investigate the effect of 6 weeks selective aerobic training on serum irisn levels and insulin resistance in women with T2D.
Materials and Methods: This research is a semi experimental study with pre-and post-test design. Research subjects were 20 women with T2D (mean age 47.4±5.6 years and BMI 29.92±3.42). Subjects were randomly divided into 2 groups: exercise group (n=12) and control group (n=8). Training protocol performed in 6 weeks (4 times a weeks, 40-65 min per session) and main training intencity and time were increased per week (50%-80% Hrmax). Main aerobic training was performed in 6 blocks, each block consisted of 32. Blood sample was collected before the and after end of training protocol.
Results: The results showed significant decrease in blood glucose, insulin and insulin resistance index and significant increase in serum irisin levels in exercise group compared with the control group (p≤0.05), but there is no significant correlation between serum irisin levels and insulin resistance.
Conclusion: It seems that aerobic training can have considerable impact on serum irisin levels, fasting blood glucos and insulin resistance index in women with T2D.
Parvin Farzanegi, Masoumeh Habibian, Hadi Alinejad,
Volume 19, Issue 3 (6-2016)
Abstract
Background: Chronic kidney disease as an important risk factor is associated with some disorders which are key causes of death and disability in older people. Therefore, the aim of this study was to assess the combined effect of regular aerobic exercise with garlic extract on renal apoptosis regulatory factors in aged rats with chronic kidney disease.
Materials and Methods: In this experimental research, 42 aged male Wistar rats(48-52 weeks) were selected and randomly divided into 6 groups: control, doxorubicin, doxorubicin-salin, doxorubicin- garlic, doxorubicin - exercise, doxorubicin –garlic-exercise(combined). Chronic kidney disease was induced by a single subcutaneous injection 8.5 mg/kg of doxorubicin. Swimming training was programmed 3 days /week, 30 min/day for 8 weeks. Both the doxorubicin garlic and combined groups with garlic extract were administered by garlic gavage at a dose of 2.5 g/kg. The renal Bax and Bcl-2 levels were evaluated by ELIZA method. A one-way analysis of variance was used to data analysis (p<0.05).
Results: The results showed that induced chronic kidney disease was associated with a significant increase on Bax and a decrease on Bcl-2 in aged rats. Also, 8 weeks swimming training, garlic supplementation and the combined intervention significantly reversed these changes. Furthermore, no significant difference have been observed in the effect of these interventions on Bax and Bcl-2 in aged rats with chronic kidney disease.
Conclusion: It seems that the use of non-pharmacological treatment methods such as exercise training, garlic extract supplement, and combination of the both interventions may be effective in reducing apoptosis resulted from chronic kidney disease in aged rats.
Rohullah Ranjbar, Abdolhamid Habibi, Farzaneh Abolfathi, Najeme Nagafian,
Volume 19, Issue 7 (10-2016)
Abstract
Background: Known inflammatory factors in type II diabetes and complications are delaying adjustment this factor, it is an effective approach in preventing complications.The aim of this study was to evaluate the effect of eight weeks aerobic interval training on interleukin-6 and interleukin-10 serum levels, in women with type II diabetes.
Materials and Methods: In this study, 18 patients with type II diabetes in Ahvaz city, were randomly divided into the two experimental group (n=10) and control group (n=8). The experimental group did the aerobic interval training and pedaling on the ergometer bicycle with 65 to 80 percent of their maximum leg power for three times a week during the eight weeks. The blood samples were prepared in two pre-test and post-test steps to measure the interleukin-6 and interleukin-10 serum levels through ELISA method.
Results: Statistical analysis showed that after eight weeks of aerobic interval training, interleukin-6 and interleukin-10 serum levels, related to the experimental group had no significant difference in comparison with control group (p>0.05).
Conclusion: The results indicate that doing the aerobic interval training for three times a week during eight weeks with 65 to 80 percent of maximum leg power, it has no effect on inflammatory and anti-inflammatory indices, in women with type II diabetes.
Abbas Saremi, Shahnaz Shahrjerdi, Atefe Kavyani,
Volume 19, Issue 9 (12-2016)
Abstract
Abstract
Background: Sirtuin-1 regulates important cellular processes, including apoptosis, cellular senescence, and metabolism. Therefore, sirtuin-1 may be a novel therapeutic target for type 2 diabetes. The aim of this study was to investigate the effect of 8 weeks aerobic training on sirtuin-1 level and cardiometabolic parameters in women with type 2 diabetes.
Materials and Methods: In this semi-experimental study with pretest – posttest design, twenty diabetic women (aged 43.92±5.2 y) were randomly assigned to aerobic training or non-exercising control groups. Aerobic training program was performed 50-60 min/d, 3d/wk, for 2 months. Serum levels of sirtuin-1, body composition and metabolic parameters were assessed before and after the training period. Data were analyzed by paired T test.
Results: Adiposity indices, total cholesterol, triglyceride, LDL- cholesterol,blood glucose and insulin resistance index were significantly reduced in the intervention group compared to the control (p<0.05). Also, sirtuin-1 level was increased in the intervention group compared to the control (p<0.05).
Conclusion: These findings show that aerobic exercise is associated with an improvement in siruin-1 levels and metabolic indices in women with type 2 diabetes.
Rahman Soori, Fardin Fardin Sohrabi, Sirous Choobineh, Ali-Asghar Ravasi, Kazem Baesi, Sadegh Abbasian,
Volume 19, Issue 11 (2-2017)
Abstract
Abstract
Background: Protein tyrosine phosphatase 1B (PTP1B) is a key enzyme in dephosphorylation of the insulin receptor (IR) and it is a central factor to induce the insulin resistance. The purpose of this study was to evaluate the effect of 12-week aerobic training on protein tyrosine phosphatase 1B gene expression and insulin resistance in diabetic rats.
Materials and Methods: In this study, 16 Wistar rats were divided into aerobic training and control groups. After inducing diabetes intra protaneally, aerobic training group performed training protocol for 12 weeks and 5 session/week. The duration and speed of each session increased progressively as 18 to 26 m/min and 10 to 55 min, respectively. Then, blood and tissue (from gastrocnemius) sampling were carried out in diabetic rats. Insulin resistance markers and PTP1B gene expression were evaluated by commercial kits and Real-Time PCR method, respectively.
Results: Findings showed that PTP1B significantly was decreased in diabetic rats of aerobic training group (p=0.0001). Also, glucose and insulin resistance significantly was decreased in aerobic training groups (p=0.02 and p=0.006, respectively). However, insulin in control rats was significantly increased (p=0.015).
Conclusion: It seems that, current aerobic training protocol has capability to decrease PTP1B and insulin resistance in diabetic rats. Furthermore, the direct correlation between PTP1B and insulin illustrated that any changes in insulin resistance due to exercise training associated with diminution of negative regulation of insulin signaling pathway.
Bahloul Ghorbanian, Ahmad Barani,
Volume 20, Issue 1 (4-2017)
Abstract
Abstract
Background: Diabetes mellitus is a common disease in human societies that dealing with its complications imposes enormous cost to the health system. The previous studies have shown that bone biochemical markers can be used for evaluation of bone metabolism in response to physical activity. The purpose of this study was to examine the effect of increasing 10-week aerobic exercise (AE) on serum osteocalcin, PTH and glycemic and anthropometric indices in postmenopausal women with type II diabetes.
Materials and Methods: In this semi-experimental study, 40 postmenopausal women with type II diabetes (40-60 years) as available subjects were selected and randomly assigned into two exercise (20) and control (20) groups. Exercise protocol was AE and walking activity for 10 weeks (3d/wk, 45 to 60 min/d with 45% to 60% HRRmax intensity). Blood samples were taken before and after exercise to measure serum variables. Data were analyzed by T-test and statistical significance criterion was set as p<0.05.
Results: AE makes a significant increase in osteocalcin levels and a decrease in insulin resistance index, insulin and fasting blood glucose in the experimental group (p<0.05). Changes in other variables such as PTH, HbA1c and anthropometric indices were not significant (p>0.05).
Conclusion: Due to the favorable effects of AE on osteocalcin and glycemic indices, it seems that this training method can be recommended as a non-invasive treatment for maintaining bone density and controlling blood glucose in diabetic patients.
Ali Heidarianpour, Zahra Razavi, Masoomeh Seif,
Volume 20, Issue 1 (4-2017)
Abstract
Abstract
Background: The aim of this study was to investigate the effect of aerobic exercise and GnRH agonist on the levels of apelin and insulin resistance index in girls with central precocious puberty.
Materials and Methods: In this study, twenty-five girls (7.44±0.34 years) with precocious puberty were included. They were randomly divided into three groups (drug, n=10, exercise+drug, n=8, and exercise, n=7) and one control group (healthy, n=10). In the experimental group, aerobic exercise for 12 weeks, 3 days/week was done, duration intensity of exercise gradually increased 5 minutes and 5% respectively every 2 week. Also, the GnRH agonists were used as medicine. BMI, the apelin and insulin resistance index were assessed before and after exercise.
Results: Insulin resistance index and apelin serum levels in experimental group (exercise and exercise+ drug) were significantly decreased(p=0.05), while these factors were unchanged in control group (p=0.05). Additionally, BMI in exercie groups was significantly decreased (p=0.000), while it was increased in experimental group (drug group) (p=0.06).
Conclusion: Considering to current data, it could demonstrate that aerobic training and GNRH agonists at the same time can lead to a decrease in BMI and apelin and an improvement in insulin resistance index.
Azam Zarneshan, Mohammadreza Zolfaghari, Mahdia Gholamnejad, Mehdi Yousefi,
Volume 20, Issue 8 (11-2017)
Abstract
Abstract
Background: IL-4 plays a key role in the pathogenesis of asthma and the increased serum level of that is positively correlated with asthma severity and obesity. IL-4 induces IgE secretion by B cells. Previous studies suggesting an anti-inflammatory effect of exercise training on asthmatic lungs. The aim of the present study was to investigate the effect of 12 weeks of aerobic exercise training on serum levels of IL-4 and IgE in overweight and obese asthmatic women.
Materials and Methods: 21 overweight and obese asthmatic women were selected and divided into two groups including experimental (n=12) and control (n=9) groups. The experimental group performed aerobic exercise training, three times a week, 60 minutes each session. Fasting blood samples were collected before and 2 days after completion of the course. The data were analyzed by using SPSS22 software
Results: A significant decrease in serum IL-4 (p = 0.015, t = - 2.68), BMI (p = 0.014, t = - 2.72) and weight (p = 0.001, t = -3.99) was shown following the 12 weeks of training in the experimental group compared to the control group. There were no significant correlations between the obesity changes and the Inflammatory Marker Changes (p>0.05).
Conclusion: The present study indicates that aerobic exercise training reduced the serum levels of IL-4 independent of obesity changes in overweight and obese asthmatic women.
Mirza Hossein Norouzi Kamareh, Mohammad Reza Zolfaghari, Firouz Ghaderi Pakdel, Javad Tolouei Azar,
Volume 20, Issue 9 (12-2017)
Abstract
Abstract
Background: Telomerase activity was reduced by aging, leading to decrease in telomere length and cell death. Evidence suggests that physical activity as well as green tea has a positive effect on the prevention of cellular aging. The aim of this study was to evaluate the effect of 12 weeks aerobic training combined with green tea extract on cardiac telomerase enzyme in aged male rats.
Materials and Methods: In this study, 32 aged male rats were randomly divided into 4 groups: control, exercise, green tea and exercise + green tea. Exercise groups performed moderate intensity aerobic exercise for 12 weeks and 5 days per week; meantime, the supplementary groups consumed green tea extract. Sandwich ELISA method was used to measure the amount of telomerase.
Results: The results show that telomerase enzyme in exercise group was significantly higher than control group (p= 0.001), green tea group was significantly higher than control group (p= 0.016) and in exercise + green tea group significantly higher than control group (p= 0.001) was observed.
Conclusion: According to the results of this study, 12 weeks of moderate-intensity aerobic exercise with green tea extract can increased the amount of telomerase enzyme and Prevent telomere length shortening and cellular aging.
Farhad Azimi, Marefat Siahkouhian, Farnaz Seifi-Skishahr, Roghayeh Afroundeh,
Volume 20, Issue 12 (3-2018)
Abstract
Abstract
Background: H2S plays a key role in the pathogenesis of the Alzheimer’s disease. The aim of the present study was to investigate the effects of 4 weeks of the special aerobic training after induction of Alzheimer’s disease by Aβ1-42 injection on CBS and SAM levels in hippocampus of Wistar male rats.
Materials and Methods: Twenty male Wistar rats (8 weeks old and weight 195 ± 20 g) were divided into four groups including: healthy control, Alzheimer’s control, Alzheimer’s + training and sham. To induce Alzheimer’s disease, Aβ1-42 was infused into the hippocampus of rats. Training group trained for 4-week. For data analysis, one-way ANOVA was used and Eta and Omega squared tests were used to determine the effect size (p<0.05).
Results: Findings revealed that 4 weeks of special aerobic training increased significantly the CBS and SAM levels in hippocampus of Alzheimer’s rats compared to the control Alzheimer’s rats ( ES=53; p= 0.007, ES= 92.22; p= 0.001). Also, we showed 4 weeks of special aerobic training increased CBS level in hippocampus of Alzheimer’s rats compared to the healthy cotrol group (ES= 44.07;
p= 0.014).
Conclusion: It seems that the special aerobic training can be used as a useful non-pharmacologically effective therapeutic treatment for Alzheimer's patients through positive regulation of hydrogen sulfide via CBS and SAM enzymes.
