Sadegh Abbasian, Ali Asghar Ravasi, Rahman Soori, Sirous Choobineh,
Volume 25, Issue 2 (5-2022)
Abstract
Background and Aim Adropin is a new hormone plays an important role in improving lipid metabolism and vascular protection. The current study aims to determine the effect of eight weeks of high-intensity interval training (HIIT) on Adropin level and nitric oxide (NO) metabolites in overweight men.
Methods & Materials This is a quasi-experimental study with a pre-test/post-test design. Participants were 32 overweight men (Mean±SD age: 30.5±3.07 years, BMI: 27.93±4.2 kg/m2). They were randomly divided into two groups of HIIT (n=16) and control (n=16). The VO2max test was first conducted. Then, the HIIT group performed 8 weeks of HIIT (3 days per week) at 20 sessions of 30 seconds with a 13-s interval between each session. Body composition was measured using a bioelectrical impedance analyzer and the blood sampling was done for measuring Adropin and NO metabolites by ELISA kits in pre-test and post-test phases. The data analysis was done by repeated-measures ANOVA. The significance level was set at P<0.05.
Ethical Considerations This study was approved by the ethics committee of the University of Tehran (Code: IR.UT.REC.1395007). All procedures were in accordance with guidelines of the declaration of Helsinki.
Results There was a significant difference in Adropin between HIIT and control groups (0.88±0.256; 95% CI: 0.26-1.5 ng/mL). There was also a significant difference in NO metabolites between the two groups (7.5±3.03; 95% CI: 0.85-14.15 ng/ml). Moreover, there was a positive relationship between Adropin and NO metabolites in overweight men (r=0.498, P=0.0001).
Conclusion It seems that HIIT can attenuate cardiovascular diseases by increasing Adropin and NO and can improve cardiovascular fitness (VO2max) and body composition of men with overweight.
Seyed Sarmad Zahmatkeshan, Hamid Rajabi,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: The aim of this study was to investigate the relationship between serum adropin levels and markers of renal function in active and inactive young people.
Methods: The present research was conducted using a correlational method.Fifty young men and women with an average age of 28.22 ± 2.27 years, height 170 ± 8 cm, and body mass index 24.72 ± 4.88 kg/m² participated in the present study. Subjects were divided into active and inactive groups based on Beck's questionnaire, and 3 cc of blood was taken from their brachial vein to measure levels of adropin, urea, uric acid, creatinine, blood urea nitrogen (BUN), albumin, and total serum protein. The normality of the data was determined through the Kolmogorov-Smirnov test, and the independent t-test was used to compare the mean of the data, and the Pearson correlation coefficient was used to determine the correlation.
Results: Although a strong, positive (r = 0.78 +) and significant (p < 0.05) correlation was observed between adropin and physical activity, the renal function markers did not show a significant difference between the two active and inactive groups. No significant correlation was observed between renal function markers and adropin levels and between renal function markers and physical activity.
Conclusions: With increasing physical activity, the amount of adropin increases, but this increase does not change the levels of renal function markers in healthy people. Therefore, it seems that there is no relationship between adropin levels and renal function markers in healthy young people.
