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Background: Noise-induced hearing loss is a noticeable clinical issue. The aim of this study was to evaluate the effect of N-Acetylcysteine on the reduction of permanent noise-induced hearing loss in workers at Hepco Company. Materials and Methods: In this clinical trial, in a one-month period from October to November, 118 male 22-52 year-old workers with at least 5 years of experience working in places with permanent high tone noise (more than 850db) were selected and divided to experimental and control groups. The experimental group received Fluimucil (NAC) and the control group received vitamin B1. Hearing ability of the two groups was evaluated through audiometry after the one-month period. Results: In the control group, hearing loss was significant and it was in direct relationship with age and job experiment. The placebo (vitamin B1) did not have any significant effects on preventing hearing loss. In the experimental group, there was significant hearing loss in higher frequencies and at 6000, a relative improvement was observed, whereas with increases in age and job experience hearing loss became more significant which was rather low in comparison with the control group. Conclusion: The findings of this study shows that using N-Acetylcysteine has significant effects on NIHL (high tone loss) in higher frequencies. This study can be used as the basis for launching future studies on reducing the damages induced by noise

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Background: The importance of maintaining and enhancing the quality of life in (tuberculosis TB) patients is essential. The purpose of this study was to use N - acetylcysteine to improve the quality of life in patients with tuberculosis.

Materials and Methods: This study is a double-blind clinical trial that performed on 88 patients on anti-TB treatment that aged over 50 years in the central province of Iran within 15 months. Data collection tools included a demographic questionnaire and the Short Form Quality of life (SF12). Data were analyzed using SPSS software and t-test, Chi-square, Mann-Whitney, ANOVA and Pearson correlation analysis were used. p less than 0.05 was considered significant.

Results: This study showed that the two groups before the intervention in different features were not significantly different, but in quality of life at the end of the first month. The intervention group compared with the control group in physical subscale score (p=0.0068) and psychological subscale scores (p=0.0284) and quality of life score (p=0.0112) were better. Also, our study showed that age of patients (p=0.0331), duration of disease (p=0.0416), and serum CRP mean (p= 0.0234) and type of tuberculosis (p=0.0372) were significantly related to total score of quality of life at the end of the first month in the intervention group.

Conclusion: According to this survey results we hoped to combine the use of adjuvant therapy with N-acetylcysteine and standard tuberculosis treatment improves quality of life and increase life expectancy of patients.

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Background: Post ischemic myocardial reperfusion can impair CABG outcomes and cause increased mortality, hospital stay and costs. Then, increased oxygen free radicals lead to lipid peroxidation and sulfhydryl group oxidation. The aim of this study is to evaluate whether N-acetylcysteine and Vitamin C as antioxidants could effect postoperative outcomes of on-pump CABG.

Materials and Methods: In this clinical trial, patients who had undergone CABG were studied in 4 groups receiving Vitamin C, N-acetylcysteine, Vitamin C & N-acetylcysteine and traditional drugs. The study population consisted of 50 patients in each group. Data were recorded in a checklist and analyzed by using SPSS 20.

Results: Mean pump time, ICU stay, hospital stay, the distribution of troponin positive serum, arrhythmia and need for reoperation were significantly different between groups. Gender distribution, mean cross-clamp time, serum creatinine level before and after surgery, the need for inotropic drugs and required dose level of it, showed no significant differences between groups.

Conclusion: It seems that the combination of N-acetylcysteine and  Vitamin C had a stronger effect on the defference between the mean of pump time, hospital length stay and  length of ICU stay versus the administration of N-acetylcysteine or Vitamin C alone.