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Introduction: Peptic ulcer is a condition in which there is an ulcer in the stomach or duodenum. The incidence of peptic ulcer is 5 to 10% and is more prevalent in men. Infection with helicobacter pylori, NSAIDS, smoking and alcoholism are of the most important risk factors. Another risk factor is the O blood group. Since most research in this field are done abroad this study is done with the aim of determining the relation between ABO blood group and Rh with peptic ulcer. Materials and Methods: In this case-control study, 325 persons with dyspepsia were investigated. These individuals were referred for endoscopy. The case group consisted of 110 persons in whom endoscopy had revealed a peptic ulcer and control group 215 persons in whom endoscopy had showed no sign of ulcer. Blood grouping was performed by slide and tube methods .Chi square test was used for data analysis. Results: Based on the results, patients’ age was between 18-75 years. 68.6% of samples were women because they had more referrals. There was a significant relation between age and sex with peptic ulcer. 25.5% of patients were single and 72.5% married. Among all samples 32.9% had A blood group, 18.5% B, 11.1% AB and 37.5% O and 88% were Rh positive and 12% Rh negative. There was no significant relation between ABO blood group and Rh with peptic ulcer. The gathered data was analyzed using odds ratio, relative risk and Chi square test. Conclusion: Although some investigations have showed correlations between ABO blood group and peptic ulcer, our data showed no correlation. This may be due to the prevalence of helicobacter pylori infection among patients with peptic ulcer which needs more investigations. Other effective factors may be life style and nutrition.

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Background: Epidemiologic studies show the high prevalence of some infections and cancers in individual blood groups. Perhaps, level of immunity factors differs in people with individual blood group. The aim of this study is to compare the level of antibodies and complement factors in ABO blood groups.

Materials and Methods: In this descriptive study, peripheral blood samples from 40 male healthy individuals with different ABO blood groups (n=10 in each group) with similar age (18-25 years) and genetic background were collected. The serum levels of total IgG, IgM, IgA, C3, and C4 were analyzed by nephelometry method. All data were analyzed by SPSS software version 11.5.

Results: The levels of IgA, IgG, and C4 protein in individuals with O blood group were significantly higher than those of other groups (p=0.02, p=0.01, and p=0.004, respectively). Also, the mean concentration of IgM in individuals with AB blood group was significantly higher than that in other groups (p=0.02). There was a significant difference between the level of C3 in O blood group and those of other blood groups (p=0.01). The mean concentrations of all parameters (except IgG) in B blood group were lower than those in other blood group.

Conclusion: Generally, natural antibodies in O blood group were higher than those in other groups. This high level of total antibodies in O blood group may reduce susceptibility to some infections.