Showing 74 results for Eta
Mitra Rahimzadeh, Behrooz Kavehie,
Volume 20, Issue 3 (6-2017)
Abstract
Abstract
Background: Heart attacks are the cause of 40% of deaths in Iran and due to its upswing in Iran and the world, the determination of its short-term survival rate in order to assess treatment methods is of great importance. The purpose of this study is to estimate patients’ short-term survival rate after heart attacks by Meta-analysis method.
Materials and Methods: This study is a systematic review. The analysis was based on data extracted from English and Persian data bases. To analyze the information obtained, including the average age of patients, and one-month and one-year short-term survival rates, the STATA 11.2 and the random effect model were used.
Results: The results of the study on 18 studies entering the Meta-analysis including 62486 patients, demonstrated that one-month and one-year short-term survival rate in Iran are respectively 87.7 and 85.2 percent and no significant difference was observed between the two genders. The average age of patients was reported 62.43 years and no significant difference was observed between the two genders in the occurance of health attack.
Conclusion: The results of this Meta-analysis showed that although the survival rate of an Iranian patient after a myocardial Infarction is the same as patients in developed countries, the average age of the patients in Iran is lower, which indicates that the load of disease in Iran is greater than in other countries regarding the years lost to the disease.
Darioush Moradi Farsani, Khosro Naghibi, Zahra Rezayinezhad,
Volume 20, Issue 7 (10-2017)
Abstract
Abstract
Background: Up to now, there is no single opinion on how to control pain after surgery and clinical research in this area has been continuing. This study aimed to compare the effect of intravenous Acetaminophen, Dexamethasone and placebo on postoperative pain after cataract surgery under sedation and topical anesthesia.
Materials and Methods: In a clinical trial study, 120 patients undergoing cataract surgery under sedation and topical anesthesia were distributed into three equal groups. 10 minutes before the end of surgery, the first group received 0.01 mg/kg Dexamethasone, the second group received 15 mg/kg Acetaminophen and third group received the same volume on normal saline as placebo. Pain intensity and additional analgesic consumption were assessed during operation and recovery and compared between the three groups.
Results: In the three groups of Acetaminophen, Dexamethasone and control groups, 6, 10 and 18 patients had postoperative headache (16.7%, 27% and 47.4% respectively) and there was a significant difference between the three groups(p=0.014). Also, pain intensity was significantly higher in control group compared with other two groups from 30 minutes after arrival to the recovery room until 24 h postoperatively (p<0.05). Also, the incidence of headache was higher in Dexamethasone group compared with Acetaminophen group, but there was no statistical difference between the two groups in this regard (p>0.05).
Conclusion: Intravenous Acetaminophen administration is more effective than Dexamethasone and placebo to reduce pain and analgesic requirements after cataract surgery.
Atabak Shahed, Ali Asghar Ravasi, Sirous Choubineh, Davar Khodadadi,
Volume 20, Issue 11 (2-2018)
Abstract
Abstract
Background: The aim of this study was to investigate the effect of four weeks exercise prior preparation before Alzheimer's induction on the levels of nerve growth factor and beta amyloid in the hippocampus of Wistar male rats
Materials and Methods: 84 male Wistar rats (8 weeks old) with a weighing average of 20 ± 195 grams from Pasteur Institute of Iran were prepared, and rats were randomly divided to two exercise (4 weeks aerobic training on a treadmill with a gradient of 0 degrees, 5 days a week for 4 weeks) and rest groups. Then, the rats of each group were randomly assigned to 3 sub groups of 14 numbers, injection Aβ1-42, control, and non-injected. 48 hours after the last exercise session, injections into the hippocampus amyloid beta or Dimethyl sulfoxide were performed. Seven days after surgery, the rats of each group were randomly sacrificed or subjected to behavioral testing. To determine the levels of of nerve growth factor and beta amyloid Sampling was performed from the hippocampus and plasma of animals, a Morris water maze test was used for spatial memory test. Kolmogorov-Smirnov test (KS) and analysis of variance were used to analyze the data.
Results: The results of one-way analysis of variance showed that there was a significant difference between the levels of amylohyd of hippocampus and NGF in different groups. Also, the results of the probe test for spatial memory showed that the time spent on the target circle in the Aβ1-42 injection group was significantly lower than the other groups (p≤ 0.01). Also, the exercise and exercise + sham groups had a significantly better performance than control group.
Conclusion: It seems that performing physical activity before induction of Alzheimer's in rats is a kind of countermeasures and preeclampsia with physiological disorders and progression of the disease.
Moein Rahimi Sadegh, Amir Rashidlamir, Ali Akbar Haddad Mashhad Rizeh, Mohammad Soukhtanloo,
Volume 20, Issue 12 (3-2018)
Abstract
Abstract
Background: Recent Research has pointed to the involvement of lysyl oxidase (LOX) in the muscle development. Despite the fact, there is currently no direct evidence that lox is involved in the myogenic factors and exercise-induced hypertrophy. Therefore, the purpose of this study was to investigate the effect of lysyl oxidase inhibition on exercise-induced hypertrophy, as well as the gene expression of MyoD1, myogenin, TGF-β and LOX in FHL muscle of wistar rats.
Material and Methods: In this experimental research, 32 male Wister rats with an average weight of 220±15 were divided into four groups: resistance training, normal control, treated control and treated resistance training. Rats performed a resistance training for 8 weeks in which animals climbed a vertical ladder of 1m and inclined at 85° with weights attached to their tails. In order to inhibit lysyl oxidase, treatment group rats received daily injection of intraperitoneal β-aminopropionitrile (120 mg/kg/day). FHL muscle was extracted to measure relative muscle weight, as well as genes expression of MyoD1, myogenin, TGF-β and LOX by real time-PCR.
Results: Relative weight of FHL muscle was decreased significantly in the treated groups with BAPN, compared with normal groups (p<0.05). Lysyl oxidase showed a significant increase compared to the normal control group following a resistance training (p<0.05). LOX gene expression in treatment groups showed a significant increase compared to normal control group (p<0.05). TGF-β gene expression in BAPN-treated groups significantly was increased (p<0.05) and Myogenin in treatment groups showed a significant decrease compared to normal control groups (p<0.05). The expression of MyoD1 gene in treatment groups was only decreased significantly in the treated control groups compared to normal control groups (p<0.05).
Conclusion: Results showed that inhibiting the lysine oxidase enzyme could affect the genes involved in hypertrophy and reduce the hypertrophy induced by resistance training.
Farhad Azimi, Marefat Siahkouhian, Farnaz Seifi-Skishahr, Roghayeh Afroundeh,
Volume 20, Issue 12 (3-2018)
Abstract
Abstract
Background: H2S plays a key role in the pathogenesis of the Alzheimer’s disease. The aim of the present study was to investigate the effects of 4 weeks of the special aerobic training after induction of Alzheimer’s disease by Aβ1-42 injection on CBS and SAM levels in hippocampus of Wistar male rats.
Materials and Methods: Twenty male Wistar rats (8 weeks old and weight 195 ± 20 g) were divided into four groups including: healthy control, Alzheimer’s control, Alzheimer’s + training and sham. To induce Alzheimer’s disease, Aβ1-42 was infused into the hippocampus of rats. Training group trained for 4-week. For data analysis, one-way ANOVA was used and Eta and Omega squared tests were used to determine the effect size (p<0.05).
Results: Findings revealed that 4 weeks of special aerobic training increased significantly the CBS and SAM levels in hippocampus of Alzheimer’s rats compared to the control Alzheimer’s rats ( ES=53; p= 0.007, ES= 92.22; p= 0.001). Also, we showed 4 weeks of special aerobic training increased CBS level in hippocampus of Alzheimer’s rats compared to the healthy cotrol group (ES= 44.07;
p= 0.014).
Conclusion: It seems that the special aerobic training can be used as a useful non-pharmacologically effective therapeutic treatment for Alzheimer's patients through positive regulation of hydrogen sulfide via CBS and SAM enzymes.
Javad Mesrabadi, Saeed Mohammadi Moulod,
Volume 21, Issue 1 (4-2018)
Abstract
Abstract
Background: Learning disorders is one of the most common problems of students, which attracted the attention of many psychologists and many studies have been conducted on the effectiveness of various interventions on different classes of learning disorder. The present study aimed to conclude general conclusions about the effectiveness of various educational and therapeutic interventions and the discovery of possible moderating variables.
Materials and Methods: In order to achieve the research purpose by using meta-analysis method, quantitative results of 128 selected researches which were obtained according to the criteria for entering and leaving and using keywords were used. In total, 623 primary effect sizes were obtained and analyzed by using CMA2 software.
Results: The results of the analysis showed that amount of combined effect size of the educational and therapeutic interventions on learning disorders was 1.13, and after dividing into multiple predecessor and consequence variables, the amounts of the combined effect size for educational interventions and therapeutic interventions for overall class of learning disabilities were respectively 0.74 and 1.26, for reading disorder 0.87 and 1.01, for writing disorder 1.20 and 1.22, and for mathematical disorder 1.29 and 1.26 that all of these effects size were significant (p≤0.001). Also, the results of independent t-test showed that the difference in the effectiveness of therapeutic interventions on reading disorder and educational interventions on mathematical disorder is significant (p≤0.001).
Conclusion: Based on the size of the effects obtained, it can be said that educational and therapeutic interventions have a very high effect on learning disabilities, and the use of therapeutic interventions for reading disorder and educational interventions for mathematical disorder is more effective.
Nasrin Shikhhossieni, Rohollah Nikooie, Mohsen Aminaie,
Volume 21, Issue 1 (4-2018)
Abstract
Abstract
Background: The aim of the present study was to investigate the effect of endurance training on the content of lactate dehydrogenase isoforms (LDHA and LDHB) and isozymes in cerebrospinal fluid of male wistar rats.
Materials and Methods: Seventeen animals (5 weeks old) were randomly divided into two groups according their body weight: control (C; n = 9) and trained (T; n = 8). The animals from the T group were underwent a training program for 12 weeks (started at 20 m/min for 30 min and finished at 26 m/min for 60 min at the last week). Cerebrospinal fluid (CSF) samples were collected from cisterna Magna 72 hours after the last exercise session. LDH Isoforms and isozymes were measured by ELISA and Electrophoresis techniques, and the comparisons between groups were evaluated by student t-test.
Results: Both LDHA and LDHB isoforms were found in the CSF of the C group; LDH1 and LDH5 had the highest and lowest content, respectively. Following the twelve-week training protocol, LDHB (p<0.01), LDH1 (p<0.01), and LDH2 concentrations (p<0.01) were significantly increased in the T group compared with those from the C group and LDH3 concentrations (p<0.01) and LDHA/LDHB ratio (p<0.01) were significantly decreased. Endurance training had no effect on LDHA and LDH4.
Conclusion: Endurance training is associated with oxidative shift of lactate dehydrogenase isoforms and isozymes in cerebrospinal fluid which could be considered as a prelude to aerobic metabolism of lactate in the brain.
Mahdi Bayati, Reza Gharakhanlou, Maryam Nikkhah, Sadegh Amani Shalamzari,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: Low-volume, high-intensity interval training (HIT) increase skeletal muscle aerobic capacity, yet little is known about the potential mechanisms in improvement of this adaptability. The purpose of present study was to examine the effect of four weeks of HIT on peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and vascular endothelial growth factor (VEGF) protein contents in skeletal muscle of active men.
Materials and Methods: Eight active male students voluntarily and purposefully participated in this study. One week before the experiment started; subjects were familiar with protocol of research. Needle biopsy samples vastus lateralis were obtained 48 h before training and 72 h after the final training session. HIT protocol consisted of 11-15 bouts of 1 min cycling at ∼85-90% of reserve heart rate separated by 1 min of active recovery between each, 3 sessions per week for 4 weeks. Variables were measured by ELISA. All data were analyzed using paired t-test and at the level of significance of p ≤ 0.05.
Findings: Results of study showed the four weeks of HIT lead to significant increase in PGC-1α and VEGF (p < 0.001).
Conclusion: Our findings suggest that activation of VEGF from PGC-1α pathway is part of cellular-molecular mechanisms of high-intensity interval training. So, probably angiogenesis in skeletal muscle is one of the most important factors in improving of aerobic performance, which requires more studies. |
Mis Mahnaz Najafi, Mohammad Reza Asad, Mostafa Rahimi, Rahman Souri, Ali Ahvar,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: The aim of study was to investigate the effect of 8 weeks of moderate-intensity continuous training (MICT) and high intensity interval training (HIIT) on the GLUT4 gene expression in skeletal muscle of obese male rats.
Materials and Methods: Twenty-eight male Wistar rats with 150 ± 25 grams body weight were divided into base control (n = 6), obese control (n = 6), MICT (n = 8), and (n = 8) HIIT groups as study sample. At the beginning of the study, base control group rats were sacrificed. In other groups, rats underwent high fat regime diet for 8 weeks. After one week of familiarization, rats in training groups run on treadmill for 8 weeks and 5 days per week. Forty-eight hours after the last session, the rats were scarified and gastrocnemius muscle tissue sample were removed. GLUT4 gene expression was measured by Real-Time PCR methods.
Findings: Results indicated that high fat diet for 8 weeks significantly increased rats body weight (p= 0.001), whereas both of MICT and HIIT training significantly decreased body weight (p= 0.001). Moreover, the MICT and HIIT had significant increase in GLUT4 gene expression in gastrocnemius muscle of obese rats (p = 0.001). Although, there were no differences between two experimental groups (p = 0.99).
Conclusion: According to the results, the MICT and HIIT increase gene expression of GLUT4 in mixed muscle fibers in obese rats. |
Nahideh Talebzadeh, Saeid Ghorbian,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: Metabolic syndrome (MS) was committed multiple disorders including diabetes, hypertension, and obesity, which were played influential effects on the mortality rates of patients suffering from of cardiovascular disorders. Vascular endothelial growth factor (VEGF) is a protein that stimulates vascular and angiogenesis. One of the most common epigenetic changes is methylation of the promoter regions of genes, which leads to the regulation of gene expression. We aimed to assess the methylation pattern of promoter regions of VEGF gene which may act a critical role in the pathogenesis of MS.
Materials and Methods: In this descriptive-analytical investigation, we have assessed a total of 100 subjects, which were included 50 of cases diagnosed as MS and 50 healthy individuals as a control group. Methyl specific polymerase chain reaction (MS–PCR) method was performed to analyzing of VEGF gene promoter methylatin patterns and data analysis was performed using Chi Square test and SPSS 23 software.
Findings: The frequencies of VEGF gene promoter methylation observed in 32% and 20% of case and control individuals, respectively. Our findings revealed that the frequencies of the gene methylated were not statistically different between two groups (p=0.239). In other hand, our findings revealed a statistically significant difference regarding to the clinical parametrics including, triglycired (p=0.050), cholesterol (p=0.046), suger blood (p=0.025) and HbA1C (p=0.016) between cases and control groups (p=0.05).
Conclusion: According to our findings, methylation alteration in VEGF gene did not show any critical role in the pathogenesis of MS and it is suggested that more evidence will be needed to approve the present results.
Farzaneh Jajarmi, Ahmad Jonidi Jafari, Majid Kermani, Mitra Gholami,
Volume 22, Issue 1 (4-2019)
Abstract
Background and Aim: Dust was considered by researchers as one of the most important forms of air pollution. The aim of this study was to identify the physical and chemical characteristics of dust storm sources in Tehran.
Materials and methods: This study was conducted in selected air sampling stations of Tehran, in the days of dust and ordinary from January 2016 for one year. The concentration of dust particles was determined by gravimetric. Heavy metal concentrations in samples after digestion were determined with graphite furnace atomic absorption spectrometry (AAS-GF). Mineralogy and morphology of the dust fall particles were inspected using X-ray diffraction and scanning electron microscopy and sources particles using Enrichment Factor Analysis and principal component analysis (PCA) were performed. For statistical analysis, R software was used.
Ethical Considerations: This study with research ethics code IR.IUMS.REC.1397.313 has been approved by research ethics committee at Iran University of Medical Sciences.
Findngs: The highest average particle concentration in normal days was related to the central station (122.63 µg / m3), and the lowest for the East Station (67.13 µg / m3). The highest concentrations of the elements measured in the particles are related to iron and aluminum and the lowest concentrations of chromium and nickel. Lowest amount of Enrichment Factor was obtained for iron, less than one.
Conclusion: The results of this study indicated that the concentration of dust in center was higher than other station. Natural and human resources both play a significant role in the release of metals. By conducting further studies on the source of dust in Tehran and using the results, effective control measures can be designed and implemented.
Mohammad Malekipoya, Bahram Abedi, Mohammad Reza Palizvan, Abbas Saremi,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: Extensive prevalence of myocardial infraction, and an increase of 36% in total deaths due to it by 2020, and attention to the causes and methods of alternative therapy is very important. There are different ways in treating these patients that endurance training is one of them. The aim of this study was to evaluate the effect of 8 weeks of incremental endurance training on serum levels of TSP-1 and MMP-1 in male Wistar rats with myocardial infarction.
Materials and Methods: In this controled experimental study with control group, 20 rats weighing 230 ±30 g (8-week-old) were randomly divided into incremental endurance training and control, after induction of infarction with Isoproteronol (150 mg/kg). The training group performed an 8-week training session (3 sessions a week, for 20 to 50 minutes at 12 to 18 meters per minute).Then, 24 hours later, the venous blood sample was collected to evaluate serum concentrations of TSP-1 and MMP-1 and transferred to the laboratory. Independent t-test was used to analyze the data at a significant level of p <0.05 to Graphed Pad software.
Ethical Considerations: This study with research ethics code IR.IAU.ARAK.REC.1397.007 was approved in Research Ethics Committee of Islamic Azad University, Arak branch, Iran.
Findings: The results showed that endurance training significantly increased serum MMP1 levels (p = 0.048) in rats with myocardial infraction, while there was no significant effect (p = 0.092) on the exercise program in serum TSP-1 levels.
Conclusion: the result of this study suggests that increasing endurance training may increase MMP-1 in rats with myocardial infraction, which can play an important role in angiogenesis and replacement of capillaries.
Seyed Ali Kazemi Rezaei, Sahar Khoshsorour, Robabeh Nouri,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim Obesity with its various physical and mental problems threatens public health. This study aimed to investigate the discriminative role of metacognitive beliefs, the difficulty in emotion regulation, and codependency in women with obesity.
Methods and Materials In this causal-comparative research, 40 obese women (BMI ≥30 kg/m2) and 40 normal-weight subjects were selected by convenience sampling method. The samples were evaluated by metacognitive questionnaire, difficulties in emotion regulation scale, and the Farsi version of codependency measurement tool. We used discriminant function analysis to analyze the obtained data.
Ethical Considerations All study subjects signed the written consent form. The Research Ethics Committee of Kharazmi University approved this study (Code: IR.KHU.REC.1397.41).
Results The discriminant function could correctly classify 95% of obese people and 97.5% of normal-weight people with 3 variables of metacognitive beliefs, difficulty in emotion regulation, and codependency. In other words, 96.25% of all participants had been classified correctly.
Conclusion Distinguishing the two groups of obese and normal people, the variables of metacognitive beliefs, difficulty in emotion regulation, and codependency have a significant role. Therefore, these variables are supposedly influential psychological factors in obesity. So they can be used for its prevention and treatment.
Leila Dehghan, Hamid Dalvand, Sadegh Samadi, Mohsen Ebrahimi Monfared, Fatemeh Rafiei,
Volume 23, Issue 4 (9-2020)
Abstract
Background and Aim: Musculoskeletal disorders are mainly prevalent among college students who experience direct contact with patients. This study aimed to determine the prevalence of musculoskeletal pains among Rehabilitation, Dentistry, and Nursing students at Arak University of Medical Sciences in 2017-2018.
Methods & Materials: In this cross-sectional descriptive study, 538 students of Arak University of Medical Sciences were recruited using the convenience sampling approach. Variables included age, sex, body mass index, study field, hours of using smartphone per day, and nine symptom sites being neck, shoulders, upper back, elbows, low back, wrist/hands, hips/thighs, knees, and ankles/feet. The researchers assessed the musculoskeletal pain by using the Nordic questionnaire and demographic questionnaire. Statistical analysis was performed using SPSS V. 18.
Ethical Considerations: The Research Ethics Committee of Arak University of Medical Sciences approved this study (Code: IR.ARAKMU.REC.1397.253).
Results: In this study, 538 students (205 males and 333 females) were studied with Mean±SD age of 22.04±2.53 years old. The results showed that the prevalence of musculoskeletal pain in the spine (neck 29.4%, upper 24.3%, and lower back 37.2%) was higher than in upper and lower extremities. Musculoskeletal pain in the shoulder, upper, lower back, and thigh were significantly different based on sex. Also, musculoskeletal pain in the neck and ankle, and foot were significantly different based on age (P<0.05). There was a significant difference between musculoskeletal pain of back and ankle based on smartphone use hours per day.
Conclusion: This study suggested that rehabilitation, nursing, and dentistry students are at risk for musculoskeletal pain, especially in the lumbar, cervical, and upper back.
Mina Vesal, Changiz Rahimi,
Volume 24, Issue 1 (3-2021)
Abstract
Background and Aim: Concerns are increasingly raised about the impact of social media use on depression in adolescents. This article aimed to summarize and synthesize quantitative studies addressing the association between social media and depression in adolescents.
Methods & Materials: This systematic review and meta-analysis included studies on the impact of the internet and social media use on depression in adolescents using Persian and English databases. In total, 15 studies met the inclusion criteria and were included in the analysis.
Ethical Considerations: All ethical principles are considered in this article.
Results: The obtained data revealed a slight (0.18) statistically significant correlation (P<0.000) between social media use and depression in adolescents. However, this relationship was complex and associated with multiple psychosocial, behavioral, and individual factors, necessitating further investigation of mediating and moderating variables. Notably, most explored studies were cross-sectional; thus, they failed to infer the causal relationship between social media use and depression. In Iran, research has only investigated internet dependence. Further research is required in this area.
Conclusion: Overall, the mechanism of the impact of social media on depression should be further investigated through qualitative and longitudinal studies.
Morteza Ghasemi, Hamidreza Jamilian, Mansoureh Nourizadeh Ab-Barik,
Volume 24, Issue 4 (9-2021)
Abstract
Background and Aim: The main purpose of this study was to compare the metacognitive beliefs of people with hypochondriasis Covid 19 and normal people.
Methods & Materials: In this research, the causal-comparative method has been used. The statistical population of the study included all people with hypochondriasis disorder Covid 19 in Arak, based on this, 30 people from the population with this disorder and 30 people from the normal population were selected by available sampling method and based on Age and education were matched. Data were collected based on the short form of the 1997 Wells Metacognition Questionnaire (MCQ-30). Multivariate analysis of variance was used to analyze the data.
Ethical Considerations: The present study has been registered with the code IR.IAU.ARAK.REC.1399.036 in the ethics committee of Islamic Azad University Arak branch.
Results: There was a significant difference between metacognitive beliefs in patients with hypochondriasis covid 19 and normal individuals (P<0.001). These patients were significantly different from normal individuals in the components of positive beliefs about worry, negative beliefs about thought control, self-awareness, cognitive uncertainty, and the need to control thoughts. And in the components of positive beliefs about anxiety, negative beliefs. They got higher scores on controlling thoughts and cognitive self but on the components of cognitive uncertainty and the need to control thoughts compared to normal people.
Conclusion: Hypochondriasis disorder causes many problems for the individual and the health system, so by recognizing the dysfunctional metacognitive beliefs of these patients, metacognitive therapy can be an effective treatment for this disorder.
Shahnaz Shahrjerdi,
Volume 24, Issue 4 (9-2021)
Abstract
Background and Aim: The aim of this study was to investigate the prevalence and associated factors of musculoskeletal pain in undergraduate students of Engineering and Humanities Faculties of Arak University in 1397-98.
Methods & Materials: This cross-sectional study of 464 students (humanities, 169 and engineering, 295 people) with mean age (20.56+1.51 years), Body Mass Index (22.29±3.35 kg/m2)). Was done at the undergraduate level of Arak University in the 2018-2019 years. Nordic questionnaire to assess musculoskeletal pain during the last 7 days, 12 months as well as functional disorders during the last 12 months in the neck, shoulders, wrists and hands, back, lower back, pelvis, thighs, legs and ankles were examined.
Ethical Considerations: This study was approved by the Ethics Committee of Research Projects of Hamadan University (Code: IR.BASU.REC.1398.013).
Results: The highest prevalence of musculoskeletal pain was in the spine (63.4%) which is in the back (27.6%), neck (23.5%) and then shoulders (21.8%), respectively. In software and chemical engineering, neck, shoulder, wrist, and hand pain were most common due to computer work and study time per day. Back and lower back pain were very common in psychology and Quranic sciences due to inactivity and increasing Waist-Hip ratio.
Conclusion: Musculoskeletal pain is one of the most serious problems in some fields of study in colleges, which can be found to reduce the complications by finding the causative factors and educating students.
Miss Zahra Mortezaei, Dr Somayeh Rajabi, Dr Sayyed-Javad Ziaolhagh,
Volume 26, Issue 3 (9-2023)
Abstract
Introduction: Methamphetamine increases the release of dopamine from nerve terminals. Binding of dopamine to dopamine receptors increases the phosphorylation of cyclic adenosine monophosphate responsive element (CREB) protein and changes the transcription of downstream genes.The purpose of this study is to investigate the effect of methamphetamine induction followed by aerobic training and Berberine on dopamine receptor 4 and CREB gene expression in the heart tissue of methamphetamine-addicted female rats during the withdrawal period.
Methods: 30 rats were randomly divided into 5 control groups, methamphetamine, methamphetamine + aerobic training, methamphetamine + Berberine, methamphetamine + aerobic training + Berberine. Intraperitoneal injection of 10 mg/kg of methamphetamine was performed for 5 days, and during the withdrawal period, aerobic training was performed for 4 weeks and simultaneously the consumption of berberine 100 mg/kg as a solution in drinking water was considered. Real Time PCR method was used to measure gene expression. Independent T-test, Kruskal-Wallis test and SPSS24 software were used at the level of 0.05 to analyze the data. The code of ethics in the research was received with number IR.IAU.SHAHROOD.REC.1402.015.
Results: The results showed that methamphetamine use caused a non-significant increase (97%) in CREB expression and a non-significant decrease (52%) in dopamine 4 receptor compared to the control group (P>0.05). The implementation of interventions during the withdrawal period, such as Berberine consumption and the combination of berberine with aerobic training, produced non-significant increasing and decreasing effects on dopamine 4 receptor gene expression and CREB in the heart of methamphetamine-addicted rats, respectively (P > 0.05).
Conclusions: Short-term induction of methamphetamine did not cause significant changes in the expression of dopamine 4 receptor and CREB genes in the heart. Therefore, these genes could not undergo a significant change as a result of interventions such as Berberine and exercise. More studies are needed to investigate exact genetic changes in heart tissue.
Akram Jokar, Homa Sheikhani Shahin, Mehrzad Moqaddasi, Alireza Jowhari,
Volume 26, Issue 5 (12-2023)
Abstract
On average, patients suffering from non-alcoholic steatohepatitis after about seven years, their disease turns into fibrosis and reversibility at this stage becomes very difficult because this disease is an irreversible stage of the disease. Fatty liver is non-alcoholic (2). Researches have come to the conclusion that liver inflammation and insulin resistance decrease and insulin sensitivity increases with sports activity (3). TNF-α has a high inflammatory effect; So that different agents and species of this family and their receptors play a role in NASH disease and liver fibrosis (5). However, exercise increases prostaglandins and cAMP. The mentioned hormones inhibit the function of TNF-α (6). On the other hand, anti-inflammatory cytokines increase due to exercise and inhibit the increase of TNF-α. With the increase in production and secretion of TNF-α, other inflammatory factors such as TGF-β1 signaling are activated and fibrosis signaling will start in liver cells (5). TGF-β1 (Transforming growth factor beta 1) is one of the members of the large family of transforming growth factors beta (TGF-β) and a key cytokine in obesity and insulin resistance (7). In a research, during 48 weeks of applying a high-fat diet to rats, they found that steatosis occurs in the liver of rats from the eighth week onwards, and the amount of TGF-β1 in them increased significantly. In the end, they came to the conclusion that this factor can be one of the main characteristics of determining the degree of liver fibrosis in patients with NASH (10). High-intensity interval training (HIIT) is one of the new training models whose positive effects have been identified in a variety of metabolic diseases (13). On the other hand, there are very few researches about the effect of aquatic environment and swimming on the improvement of metabolism and inflammation in NASH patients. Based on the results of a systematic review in 2018, it was shown that endurance exercise in water improved systemic inflammation and weight control (18). Despite the conflicting results in this field and the beneficial effects of exercise in water and also human's innate interest in water, the effect of high-intensity interval exercise in water in patients with non-alcoholic steatohepatitis has not been observed by the researchers of this study. Therefore, the effect of eight weeks of high-intensity interval training in water on inflammatory factors in patients with non-alcoholic steatohepatitis was investigated.
Materials and methods
In this study, eight-week-old rats were divided into two groups: healthy (n=20) and high-fat diet (HFD) (n=20). After eight weeks and proof of disease induction, the HFD group was randomly divided into two groups: control-disease (n=9) and exercise-disease (n=9); Also, the healthy group was divided into two groups: control-healthy (n=9) and exercise-healthy (n=9). The rats in the training group performed HIIT swimming training, including 20 times of 30 seconds of swimming with 30 seconds of rest between each time, for eight weeks (three days a week). One-way ANOVA and Bonferroni's post hoc test (P<0.05) were used to determine the difference between groups.
Ethical Considerations
The proposal of this study has been approved by the Ethics Committee of Shiraz University of Medical Sciences (IR.SUMS.REHAB.REC.1400.008).
Findings:
As shown in diagram 1; Based on the results of the one-way analysis of variance test, it can be said that there was a significant difference between the mean TNF-α blood serum (P=0.001). According to the results of Bonferroni's post hoc test, these differences in blood serum TNF-α variable between the control-healthy and control-disease groups (P=0.001), exercise-disease (P=0.001) and exercise-healthy (P=0.002), control-disease with exercise-disease (P=0.012) and exercise-healthy (P=0.001), exercise-healthy with exercise-disease (P=0.002) was.
According to graph 2, it can be seen that there is no significant difference in TGFβ1 variable in all four groups (p=0.068). However, by comparing the averages, it is found that the amount of TGFβ1 protein has decreased by 49.1968% in the patient-exercise group after high-intensity intermittent swimming exercise compared to the control-patient group. Meanwhile, this protein in the exercise-healthy group was reduced by 45.2741% compared to the control-patient. Figure 1 shows the protein bands related to TGFβ1 protein.
Discussion and conclusion: The results of the present research showed that high-intensity intermittent swimming exercises reduce inflammatory and fibrotic factors, and in general, it can be concluded that eight weeks of high-intensity intermittent swimming exercises improve the inflammatory and fibrotic factors associated with non-alcoholic steatohepatitis. . However, to obtain a definitive result, this type of exercise should be studied in human studies in this patient community.
Appreciation and thanks: This article is taken from the master's thesis in sports physiology (first author) of Zand Institute of Higher Education, Shiraz, with ethics code IR.SUMS.REHAB.REC.1400.008. In the end, we sincerely thank all friends and colleagues who helped us during the stages of this research.
Conflict of interest:The authors of this article have no mutual benefit from its publication.
Authors' share (participation rate): All four authors participated in the preparation of this article.
Key words: high-intensity swimming interval training, non-alcoholic steatohepatitis, tumor necrosis factor alpha, transforming growth factor beta
Saman Afrasiabi, Mahdi Goudarzvand, Amir Saeid Sedighi, Yazdan Shafikhani, Behrooz Ghanbari,
Volume 27, Issue 1 (3-2024)
Abstract
Introduction: Sequential word learning is a crucial aspect of memory research in cognitive neuroscience, emphasizing the importance of recalling words at the beginning (primacy) and end (recency) of a sequence. This study aims to investigate the extent of primacy and recency effects in patients with neglect syndrome caused by right parietal lobe damage.
Methods: This case-control study involved 18 patients with parietal lobe tumors, divided into two groups: 9 patients with neglect syndrome and nine without. Patients referred to the neurosurgery department of Shahid Tajrish Hospital with right parietal lobe lesions underwent neurological and psychological evaluations, including the cancellation test, line bisection test, copying test, and the 5-point test. Those diagnosed with neglect syndrome formed the syndrome group, while the rest constituted the control group. Both groups participated in immediate recall (short-term memory) and delayed recall (long-term memory) tests for sequential word learning, with results analyzed for primacy and recency effects.
Results: Among the 18 patients, 61% were men and 39% were women. Analysis of immediate and short-term memory tests for sequential word learning revealed no significant differences in primacy and recency effects between the two groups.
Conclusions: The findings suggest that patients with right parietal lobe damage and neglect syndrome do not exhibit significant differences in primacy or recency effects in verbal memory during sequential word learning compared to the control group. Consequently, immediate and short-term memory appears relatively unaffected in these patients.
