Showing 24 results for Safa
Sedigheh Safaeian Titkanlou, Toktam Maleki Shahmahmood, Zahra Ghayoumi-Anaraki, Fatemeh Haresabadi, Majid Haddadi Avval, Mohaddeseh Soltani, Mohsen Rajati Haghi,
Volume 23, Issue 6 (February & March 2020)
Abstract
Background and Aim: Phonological awareness skills, as part of phonological processing abilities, can predict the extent of success in acquiring written and reading skills. Phonological awareness skills are of concern in children with severe and profound hearing loss, which has been less studied in this population. Thus, this study aimed to evaluate these skills in Cochlear-Implanted (CI) children and compare them with their healthy counterparts.
Methods & Materials: The study population included 25 CI children and 25 healthy children, aged 4-6 years, who were monolingual Persian speakers. The selected CI and healthy children were selected from the Rehabilitation Center of Naqmeh and the Kindergartens in Mashhad, City, Iran, respectively. After selecting each participant, the test of phonological awareness was administered. To compare the mean scores of each subtest, the obtained data were analyzed in SPSS v. 21 using the Mann-Whitney U test.
Ethical Considerations: This study was approved by the Research Ethics Committee of Mashhad University of Medical Sciences (Code: IR.MUMS.REC.1396.263).
Results: The mean scores of CI children were significantly lower than that of their healthy peers in all phonological awareness subscales (P<0.05).
Conclusion: The obtained data suggested that healthy children presented better performance than the CI children in the phonological awareness test. Poor phonological awareness skills in CI children seem to be associated with hearing deprivation before cochlear implantation; thus, it requires to speed up surgery at an early age and the implementation of an effective rehabilitation program.
Fatemeh Sharafi Bajgan, Reza Safari, Maryam Nejat Dehkordi,
Volume 24, Issue 4 (October & November 2021)
Abstract
Background and Aim: Tamoxifen is a group of drugs of selective estrogen receptor modulators, and is one of the drugs effective in the prevention and treatment of some cancers (such as breast cancer). In this study, the interaction of tamoxifen with DNA is investigated experimentally. Also, the electronic structure (at atomic scale) of the molecular system of tamoxifen was theoretically investigated, using atom in molecule (AIM) theory.
Methods & Materials: First, in the experimental section of this study, the interaction of Tamoxifen with DNA were investigated by UV-ViS technique and hydrodynamic method (Viscometry). In addition, the analysis of the experimental results shows the obvious effect of concentration on the mechanism of how the tamoxifen molecule binds to DNA. Then, in the theoretical part of this research, using computational biophysical chemistry methods, some properties of tamoxifen molecular system, such as electronic Density of States (DOS), boundary orbital’s energy (HOMO/LUMO), Electrostatic Potential Energy (EPS) and electronic contour maps of the electron density and its Laplacian, will be calculated.
Ethical Considerations: This article is a meta-analysis with animal sample.
Results: Result of the UV-ViS spectroscopy technique and viscometry indicated hyperchromism and hypochromism effect. In addition, the result were depend on the concentration of the drug and affected the kind of binding of Tamoxifen to DNA. the analysis of computational studies on the drug tamoxifen suggests that the mechanism of the local charge/energy distribution in the molecular system of tamoxifen plays an important role in how this drug binds to DNA.
Conclusion: Based on the experimental results of UV-ViS technique and viscometry, as well as the electronic/vibrational properties of the tamoxifen molecular system, it was defined that the Tamoxifen interacts significantly with all the binding sites of DNA.
Farideh Barghi, Sahar Safarzadeh, Faremah Sadat Marashian, Saeed Bakhtiarpour,
Volume 25, Issue 6 (February & March 2023)
Abstract
Introduction: Since a more appropriate psychological treatment has not yet been found in the treatment of autism to be a definite solution in autism, in this research, two more common psychological methods have been compared. Objectives The aims of this study were to compare the effectiveness of ABA and Fluortime play therapy on sensory processing in children with autism spectrum disorder in Qom in 1401.
Methods: The method of this quasi-experimental study was pre-test-post-test and follow-up with a control group. The statistical population of the research included all the children with autism in land Qom at Golhay Behesht Autism Center. The statistical sample of this research was 45 people who were selected by available sampling, and randomly divided into three experimental groups using the ABA method (15 people Fluortime method (15 people) and the control group (15 people) were placed. The first experimental group was treated with the method of ABA in the designated sessions. 23 20-minute sessions were presented to the subject group. During experimental group Fluortime was treated with the method of 23 sessions of 20 minutes, it was presented to the subject group, then it was analyzed using analysis of variance with repeated measurements. Ethical Considerations: This article is approved by the ethics committee of Islamic Azad University Ahvaz branch IR.IAU.AHVAZ.REC.1401.032.
Results: The results of the analysis showed that the Flortime play therapy training in sensory processing was significantly at the level of the effect of the implementation of independent variables on the registration components down (P = 0.02) Sensory seeking (P = 0.001) Sensory sensitivity (P = 0.019) Sensory avoidance (P = 0.004) is significant. On the other hand, the average difference of sensory processing components in the applied behavior analysis and game group is significant. Fluortime treatment is significant with the control group. So that the mean of the components of sensory processing in both experimental groups has a significant0.05 ≥ P decrease compared to the control group.
Conclusions: This finding, in line with the change trend of the mean of the components of sensory processing, shows that functional ABA and Fluortime play therapy during the implementation period. And three months after the completion of the implementation period, it has led to a significant decrease in the average scores of sensory processing components. Sensory processing in children with autism spectrum disorder. It should be mentioned that in comparison, the scores of sensory seeking, sensory sensitivity and sensory avoidance in the Fluortime were higher than in the ABA method, and low registration was higher in the ABA method, but the results of the Ben Feroni test show that although each method was significant separately in sensory processing, the difference in effect Functional behavior analysis and Fluortime play therapy on sensory processing components of p>0/05 is not significant.
Dr Mehdi Asghari, Dr Gholamabbas Fallah Ghalhari, Dr Marzieh Abbasinia, Dr Farbod Ebadifard Azar, Dr Fahimeh Shakeri, Dr Mohammad Javad Ghanadzade, Mr Gholam Heidar Teimori, Dr Sanaz Karpasand, Dr Hossein Safari,
Volume 26, Issue 3 (August & September 2023)
Abstract
Introduction: One of the biggest environmental challenges of the 21st century is the phenomenon of climate change and global warming, which can cause numerous health problems. One significant health issue associated with climate change is the increase in the prevalence of heat stress, particularly in occupational encounters in hot outdoor environments. So this study aimed to predict and model temperature and humidity indices in the coming decades in a dry climate.
Methods: This study obtained daily atmospheric parameters, including minimum temperature, maximum temperature, and relative humidity of Kerman station, representing a dry climate, for a period of 30 years (1965 to 2005) from the meteorological organization. Modeling of these parameters and calculation of the Temperature and Humidity Index (THI) were performed using the atmospheric general circulation model HadGEM2-ES and the CORDEX dynamic microscaler model. Three different radiative forcing scenarios, including optimistic (RCP 2.6), intermediate (RCP 4.5), and pessimistic (RCP 8.5), were considered for the coming decades (three 30-year periods from 2011 to 2099). The Ethics Committe of Iran University of Medical Sciences (IUMS) approved the present study (Code: IR.IUMS.REC.1400.020).
Results: The results of the study showed an increasing trend for minimum and maximum temperature parameters in all three time periods using the three scenarios considered. Moreover, the increase in temperature in the decades of 2099-2071 was more pronounced compared to the previous decades. The results also demonstrated an increasing trend in the THI index based on all three scenarios. The average results obtained using these scenarios showed an increase of 2.11, 2.53, and 3.3 degrees Celsius, respectively, in this index until the end of the last century compared to the base decades.
Conclusions: Overall, the increase in temperature and the investigated THI index in the studied station, based on all three scenarios, will lead to changes in thermal comfort. Higher levels of thermal discomfort will not only occur in hot months and seasons but also in other seasons. Therefore, proper planning should be implemented to address the adverse effects of climate change on people's health.