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Showing 7 results for Haghighi

Sepideh Mortaji, Anousheh Haghighi, Farzad Pakdel,
Volume 17, Issue 5 (8-2014)
Abstract

Background: Rheumatoid arthritis is the most common inflammatory arthritis. Keratoconjunctivitis sicca, scleritis, and episcleritis are ocular complications of this disease. The aim of this study is to evaluate Sjogren’s syndrome in subjects with rheumatoid arthritis.

Materials and Methods: In this cross-sectional study, ninety patients diagnosed as rheumatoid arthritis that followed up in rheumatology clinic of Rasool Akram hospital for six months and no definite cause was found for their dry eye, enrolled in the study. Rheumatoid arthritis activity was evaluated by DAS28 index and the severity of dry eye was assessed by Japanese dry eye diagnostic criteria.

Results: Mean activity of disease according to DAS28 was 2.9±1.56 and 88.9% of patients had dry eye based on Japanese dry eye diagnostic criteria. Twelve patients (13.3%) had secondary Sjogren's syndrome. SSA antibody was positive in 13.3% patients and 10% patients had positive SSB antibody. There was significant correlation between rheumatoid arthritis activity based on DAS28 and severity of dry eye according to Japanese dry eye diagnostic criteria in the both Sjogren (p=0.045) and non Sjogren groups (p=0.001).

Conclusion: We found significant correlation between rheumatoid arthritis activity and dry eye in the both sjogren and non-Sjogren groups. Most of rheumatoid arthritis subjects do not have Sjogren’s syndrome but dry eye is common even in rheumatoid arthritis patients without Sjogren's syndrome.


Masoumeh Sayahi, Mehrnoosh Zakerkish, Mohammad Hossein Haghighizadeh, Sara Ziagham,
Volume 17, Issue 10 (1-2015)
Abstract

Background: Menopause is a critical period in the women life which is associated with different neurophysiological and cognitive changes. This study aimed to determine the relationship between menopausal symptoms with metabolic syndrome in postmenopausal women.

Materials and Methods: This descriptive - analytical study was conducted on 165 postmenopausal women referred to health centers in Ahvaz. Data collection tools were standardized questionnaire menopausal rating symptoms (MRS), questionnaire to record demographic information and the results of experiments and measurements (blood pressure, Waist circumference). The data were analyzed by Pearson correlation coefficients, Mann-Whitny in by SPSS version 19.

Results: The results showed that the overall mean of MRS in this study was 11.85±5.4. The mean of metabolic syndrome was 36±4.8 percent and we found significant association between blood pressure (p=0.04), blood sugar (p=0.02),HDL-C(p=0.02) and urogenital symptoms. But there werent significant relationship between other metabolic syndrome components and other menopausal symptoms (somatic and psychological Dimensions).

Conclusion: The relationship was observed between metabolic syndrome and urogenital symptoms, therefore, as a preventative health strategy women with urogenital complaints should examin for metabolic syndrome.


Javad Nakhzari Khodakheir, Amir Hossein Haghighi, Mohammad Reza Hamedinia,
Volume 21, Issue 3 (6-2018)
Abstract

Background and Aim: Physical activity and exercise are as the methods stimulating the secretion of nerve growth factors in MS patients. Therefore, the purpose of this study was to investigate the effects of combined exercise training with aerobic dominant and supplementation of coenzyme Q10 on serum BDNF and NGF levels in patients with multiple sclerosis.
Materials and Methods: In the semi-experimental research, twenty-eight MS patients (EDSS=3-5) were selected by using available sampling method and randomly divided into three experimental groups (combined exercise training + Q10 supplementation, combined exercise training + placebo, and Q10 supplementation) and one control group. two experimental groups performed a combined exercise program include two sessions of aerobic training and one session of resistance training three sessions per week for eight weeks. 200 mg of Q10 supplement was prescribed per day. Blood samples (after 10 hours fasting) were collected 24 hours before the first and 24 hours after the last session of exercise for evaluation of serum levels of BDNF and NGF. Data were analyzed with analysis of covariance at a significance level of p<0.05.
Findings: The results showed no significant changes in serum levels of BDNF and NGF in the three experimental groups compared to the control group (p≥0.05).
Conclusion: Combined exercise training with coenzyme Q10 supplementation cannot lead to changes in serum concentration of nerve growth factors (BDNF, NGF) in patients with MS. Therefore, it is necessary to change the duration and severity of this type of training as well as dose of Q10 supplementation.

Ms Nastaran Haghighi Naghani, Dr Mohammad Fathi, Mohammad Reza Tabandeh,
Volume 26, Issue 2 (June & July 2023)
Abstract

Introduction: Diabetes is a chronic and progressive metabolic disorder that causes heart tissue damage and changes in its protein levels. The purpose of this study was to investigate the effect of an incremental training period on MMP-2 and MEF2C protein in cardiac muscle tissue of diabetic Wistar rats.
Methods: In this experimental study, 40 male Wistar rats (age 10 weeks and average weight 245 ± 9.5 grams) were randomly divided into 4 groups of 10: diabetes-control (DC), diabetes-exercise (DT), healthy-exercise (HT) and healthy-control (HC). Intraperitoneal injection of streptozotocin (45 mg/kg) was used to cause diabetes. The training protocol was implemented for 6 weeks. 24 hours after the last training session, heart tissue was extracted. Western blot method was used to evaluate MMP-2 and MEF2C protein expression. Data analysis was done using one-way analysis of variance test.
Results: The results showed that diabetes causes a significant increase in MMP-2 protein expression levels and a significant decrease in MEF2C in the DC group compared to the HC group (P<0.05). although a period of increased training leads to a significant decrease in MMP-2 protein expression levels and a significant increase in MEF2C in the DT group compared to the DC group (P<0.05).
Conclusions: The findings of this research show that increasing aerobic exercise moderates the effects caused by diabetes in the expression of these two proteins, which seems to be a protective effect against cardiomyopathy changes caused by diabetes. 


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