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Background and Aim: The new Coronavirus Disease 2019 (COVID-19) outbreak initiated from China in late December 2019, has posed a great global health threat. Since patients with high blood pressure, diabetes, and cardiovascular diseases are at high risk of COVID-19, this study aims to investigate the prevalence, severity, clinical manifestations, and mortality rate in COVID-19 patients with underlying diseases compared to those without underlying diseases.
Methods & Materials: This study was performed on 1408 patients with COVID-19 admitted to Golestan, Hajar, Khanevadeh and Besat hospitals in Tehran, Iran. Required data including disease prevalence, severity, clinical manifestations and mortality rate in patients with and without underlying diseases were collected and then analyzed using statistical tests in SPSS software, considering a significance level of P<0.05.
Ethical Considerations: This study was approved by the AJA University of Medical Sciences (Code: IR.AJAUMS.REC.1399.091). Ethical principles have been observed in accordance with the guidelines of the National Ethics Committee and the COPE regulations.
Results: Patients were 912 men (64.8%) and 496 women (35.2%) aged 18-98 years (Mean age= 57.8 years). Results reported that 27% of patients were intubated and 21.9% were died. Blood oxygen level in 53.7% of patients was less than 93 mg/dL; 36.1% had a history of hypertension, 24.1% had a history of diabetes, and 21.7% had a history of cardiovascular disease.
Conclusion: The severity, clinical manifestations, and mortality rate of COVID-19 patients with cardiovascular disease, diabetes and hypertension are significantly different compared to those without underlying diseases.

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Background and Aim: Concerns are increasingly raised about the impact of social media use on depression in adolescents. This article aimed to summarize and synthesize quantitative studies addressing the association between social media and depression in adolescents.
Methods & Materials: This systematic review and meta-analysis included studies on the impact of the internet and social media use on depression in adolescents using Persian and English databases. In total, 15 studies met the inclusion criteria and were included in the analysis.
Ethical Considerations: All ethical principles are considered in this article. 
Results: The obtained data revealed a slight (0.18) statistically significant correlation (P<0.000) between social media use and depression in adolescents. However, this relationship was complex and associated with multiple psychosocial, behavioral, and individual factors, necessitating further investigation of mediating and moderating variables. Notably, most explored studies were cross-sectional; thus, they failed to infer the causal relationship between social media use and depression. In Iran, research has only investigated internet dependence. Further research is required in this area.
Conclusion: Overall, the mechanism of the impact of social media on depression should be further investigated through qualitative and longitudinal studies.

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Introduction: Beyond the members of the charter board, the horizon of Amedwar Kanandah for the sake of Bimaran Niyazmand, the member of the board of the board. In parallel, there is a new medical science in New Mutrah, in the opinion of specialists who claim that it is a model and that they have a source for beyond the organs with children. Definitively The current issue is that of new topics and the question of programs in the possession of jurisprudence and rights, which must be carefully selected from the angles that are the subject of jurisprudence debate.
Methods: This is a book in the form of a textbook and a description - an analysis with the use of the books of science and jurisprudence of his room.
Results: This type of child is based on the basis of investigations, which are believed to be valid, according to the permissibility of the organs that are nozadan with severe cranial defects, i.e., in the womb of a mother, or from a cutaneous period, but from birth in the middle of my heart; A defensible issue.
Conclusions: The use of the nostril organs affected by the cornea with limitations of the cervical spine, but with a significant meaning in the development of Rastafarian, and the use of non-main organs based on multiple rational and legal evidences; Milabashed project. The parts of my life are afflicted with severe corneal ulcers, based on the inevitability and inevitability of the disease, and the reason for the fact that the situation is similar to the meaning of the disease. Develop a legitimate development in the most vigorous manner, and the issue of the necessity of preserving human dignity This is an issue that cannot be denied. But from the point of view of the role that is not a conditional legality, it is a present issue with conditional auspices in no severe form.
 

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Introduction: Physical activity is one of the important lifestyle factors that can have positive or negative effects on the reproductive system, and more research is needed to reflect the effect of inactivity on fertility in order to provide safe lifestyle recommendations to help couples achieve pregnancy is required. Therefore, this study was conducted with the aim of describing and comparing the physical activity status of fertile and infertile men in Arak city in 2022.
Methods: The present study is a case-control study that was conducted on 220 fertile and infertile men (22 to 40 years old) referred to Arak University Jihad infertility centers that were selected through available sampling. Participants completed self-test questionnaires on socio-demographic characteristics, lifestyle, physical activity, and sedentary behaviors. Anthropometric characteristics and body composition were also measured. Multivariate logistic regression was used to analyze the association of infertility with physical activity level, sedentary behavior, and body composition.
Ethical Considerations: This study was approved by the Ethics Committee of the University of Arak University (Code: IR.ARAKMU.REC.1401.046).
Ethical Considerations: The present research has been registered with the code IR.ARAKU.REC.1401.015 in the Ethics Committee of Arak University.
Results: In this study, it was observed that the amount of physical activity (P=0.02) and body composition (P=0.001) in fertile men is more favorable than infertile men. In men with a low level of physical activity, the risk of infertility increases 2.97 times (odds ratio 2.97 and 95% CI: 1.03, 8.61, and P=0.04). On the other hand, in men with moderate level of physical activity, the risk of infertility decreases (odds ratio 0.27 and 95% CI: 0.08, 0.92, and P=0.03). Also, in men who sit for more than 6 hours a day, the chance of infertility increases by 3.02 times (odds ratio 3.02 and 95% CI: 1.28, 7.10, and P=0.01). An increase in body mass index increases the risk of infertility by 1.61 times in men (odds ratio 1.61 and 95% CI: 1.23 and 2.11 and P=0.001).
Conclusions: Since obesity, physical inactivity and infertility in Iranian men are increasing at the same time, so there should be more focus and seriousness on the issue of lifestyle modification and especially physical activity regarding reproductive health.

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Background and Aim: Diabetes is a type of metabolic disease and one of the most common endocrine diseases. Oxidative stress and inflammation play an important role in the development and progression of diabetes. mTOR signaling pathway play an important role in glucose homeostasis and proliferation of pancreatic beta cells. In the present study, the therapeutic effects of p-cymene on oxidative stress markers and expression of the mTOR gene in diabetic male Wistar rats were investigated.
Materials and Methods: Diabetes was induced by injecting 55 mg/kg body weight of streptozotocin. Biochemical analyses of pancreatic tissue and real-time PCR were done to investigate the effects of metformin (55 mg/kg body weight) and p-cymene (25, 50, and 100 mg/kg body weight) on the activities of catalase and glutathione peroxidase enzymes and mTOR gene expression.
Findings: Streptozotocin decreased catalase and glutathione peroxidase enzymes and decreased the expression of the mTOR gene in pancreatic tissue. Treatment with metformin or p-cymene improved the activities of catalase and glutathione peroxidase enzymes and the expression of the mTOR gene in a dose-independent manner.
Conclusion: Results indicate that p-cymene has antioxidant properties and can regulate the mTOR signaling pathway. Therefore, p-cymene may be effective for the treatment of diabetes alone or in combination with metformin.

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Introduction: Nurses have a prominent position in providing healthcare services. There is an undeniable relationship between nurses' professional self-concept and providing care to patients. This study was conducted to investigate the relationship between professional self-concept and the lifestyle of nurses in selected hospitals of Mazandaran cities.
Methods: This descriptive study was conducted using a stratified sampling method with a proportional allocation of 200 nurses working in hospitals affiliated with Mazandaran University of Medical Sciences in 2015. Data collection tools included a demographic information form, a nurse professional self-concept questionnaire, and a nurses' lifestyle questionnaire. Data analysis was done with a significance level of P ≤ 0.05. Pearson's correlation coefficient was used to determine the relationship between professional self-concept and nurses' lifestyle.
Results: The mean score of nurses' professional self-concept and a lifestyle was 156.55 ± 19.37 and 216.42 ± 5.88, respectively. There was also a significant direct relationship between professional self-concept and nurses' lifestyle.
Conclusions: Considering the confirmation of positive correlation between professional self-concept and the lifestyle of nurses, nursing managers can promote healthy lifestyles in nurses by promoting professional self-concept.

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Introduction: Sociodemographic factors and perceived anxiety have a significant impact on the development of somatic symptom disorder. This study aimed to investigate the role of demographic characteristics, social isolation, and perceived anxiety in predicting somatic symptom disorder.
Methods: In a cross-sectional descriptive study among adults aged 18 to 60 in Tehran in 2023, 437 participants were selected based on convenience sampling. The participants completed the Somatic Symptom Disorder Questionnaire (SSEQ), Social Isolation Questionnaire, and Perceived Anxiety Questionnaire. Data were analyzed using Pearson’s correlation and multiple regression analysis.
Results: The results indicated that social isolation and perceived anxiety have a positive and significant correlation with somatic symptoms disorder (P < 0.01). There was no correlation between demographic characteristics (age, gender, marital status, education, and employment status) and somatic symptoms (P  <0.01). Multiple correlation and regression coefficients among research variables were statistically significant (P < 0.01).
Conclusions: The examined model was almost able to predict 22% of the somatic symptoms of the disorder. The results have implications for formulating interventions based on social isolation and perceived anxiety in controlling somatic symptoms. It is essential to pay attention to social isolation and perceived anxiety in the formulation and implementation of interventions and educational programs for the prevention and improvement of somatic symptom disorder.