Showing 68 results for Rahimi
Darioush Moradi Farsani, Khosro Naghibi, Mojtaba Rahimi Varposhti, Bahador Malekipoor, Tahereh Fasihi,
Volume 20, Issue 9 (12-2017)
Abstract
Abstract
Background: Postoperative nausea and vomiting (PONV) is one of the most common complications in the patients undergoing strabismus surgery. The aim of current study was comparing supplemental 80% and 40% oxygen on reducing postoperative nausea and vomiting in the pediatrics undergoing strabismus surgery.
Materials and Methods: In this clinical trial study, 100 pediatric patients scheduled for strabismus surgery under general anesthesia were allocated randomly into two parallel supplemental 80% and 40% oxygen groups during surgery. PONV in patients was compared until 24hrs after operation.
Results: In the first 6hrs postoperatively, PONV in the supplemental 40% and 80% oxygen groups were 48.8% and 30.6% respectively, also were 20.8% and 12.2% in the 6 to 24hrs postoperatively. Therefore, there were no significant differences between both groups in regarding of PONV in 6hrs and 6 to 24hrs postoperatively (p values were 0.18 and 0.25, respectively).
Conclusion: According to our results, there is no any difference between 40% and 80% oxygen postoperatively in the pediatrics undergoing strabismus surgery.
Moein Rahimi Sadegh, Amir Rashidlamir, Ali Akbar Haddad Mashhad Rizeh, Mohammad Soukhtanloo,
Volume 20, Issue 12 (3-2018)
Abstract
Abstract
Background: Recent Research has pointed to the involvement of lysyl oxidase (LOX) in the muscle development. Despite the fact, there is currently no direct evidence that lox is involved in the myogenic factors and exercise-induced hypertrophy. Therefore, the purpose of this study was to investigate the effect of lysyl oxidase inhibition on exercise-induced hypertrophy, as well as the gene expression of MyoD1, myogenin, TGF-β and LOX in FHL muscle of wistar rats.
Material and Methods: In this experimental research, 32 male Wister rats with an average weight of 220±15 were divided into four groups: resistance training, normal control, treated control and treated resistance training. Rats performed a resistance training for 8 weeks in which animals climbed a vertical ladder of 1m and inclined at 85° with weights attached to their tails. In order to inhibit lysyl oxidase, treatment group rats received daily injection of intraperitoneal β-aminopropionitrile (120 mg/kg/day). FHL muscle was extracted to measure relative muscle weight, as well as genes expression of MyoD1, myogenin, TGF-β and LOX by real time-PCR.
Results: Relative weight of FHL muscle was decreased significantly in the treated groups with BAPN, compared with normal groups (p<0.05). Lysyl oxidase showed a significant increase compared to the normal control group following a resistance training (p<0.05). LOX gene expression in treatment groups showed a significant increase compared to normal control group (p<0.05). TGF-β gene expression in BAPN-treated groups significantly was increased (p<0.05) and Myogenin in treatment groups showed a significant decrease compared to normal control groups (p<0.05). The expression of MyoD1 gene in treatment groups was only decreased significantly in the treated control groups compared to normal control groups (p<0.05).
Conclusion: Results showed that inhibiting the lysine oxidase enzyme could affect the genes involved in hypertrophy and reduce the hypertrophy induced by resistance training.
Shahla Shahsavandi, Mohammad Majid Ebrahimi, Mohammad Reza Samiee,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: The inactivated vaccines are formulated with adjuvant to direct the host immune responses and also increase stability of the antigen. In recent years, the development of biological adjuvants and the evaluation of their ability in elicitation of immune responses against influenza virus have been considered. Hemokinin-1 (HK-1) activates T and B cells for differentiation into plasma cells, and antibody production. In this study, the effect of HK-1 for inducing humoral immune response against influenza chitosan based-nano vaccine was investigated.
Materials and Methods: Chitosan nanoparticle containing inactivated influenza antigen and chitosan nanoparticle containing the inactivated antigen formulated with HK-1 were prepared. Immune response following influenza nanoparticles vaccinations with and without the adjuvant was assessed in SPF chickens after prime and boost immunizations. Specific antibody levels against influenza were evaluated in serum samples of treatment and control groups by serological tests.
Findings: The chickens immunized with the HK-1 adjuvanted nano vaccine produced higher specific antibody titers that were sustained until the end of experiment comparable either with inactivated antigen alone or the H9N2 nanoparticles without HK-1 adjuvant. Administration of boosting had no effect on the enhancing of antibody titer.
Conclusion: The data show that the chitosan nanoparticles provide better absorption conditions and more stability and release of the influenza antigen in the presence of HK-1 biological adjuvant.
Mersedeh Fatemeh Yazdanbakhsh, Aboo Saeed Rashidi, Mohammad Karim Rahimi, Ramin Khajavi, Hamed Shafaroodi,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: The purpose of this research is to provide nanofibers from cellulose with Wheat bran as an agricultural residue and its antimicrobial activity by dipping ciprofloxacin hydrochloride on Staphylococcus aureus.
Materials and Methods: In this experimental study, cellulose disks were prepared from nano-impregnated fiber. Subsequently, these disks were placed on Staphylococcus aureus with standard paper disks and the results were measured as a non-growth zone after 24 hours. The amount of ciprofloxacin hydrochloride adsorbed in cellulose by comparing the effect of cellulosic discs containing different concentrations of antibiotics and standard ciprofloxacin disks was determined. Subsequently, the evaluation of the time of recovery of the ulcer in the skin of the rats was carried out with the drug-mediated formulation and without drug.
Findings: The disk (nano alpha-cellulosic) dipped by ciprofloxacin hydrochloride created a non-growth zone in Staphylococcus aureus. Measuring the size of the wound was done by digital imaging and the ImageJ software. The results of the recovery process were analyzed by ANOVA and pathological tests in five days.
Conclusion: The results showed that the nano-fibers disk could be useful in controlling bacteria in the culture medium, and the area of the wounds in rats (rats) dressed with nano-fibers impregnated with the drug was significantly less than the control group (p <0.05). |
Mis Mahnaz Najafi, Mohammad Reza Asad, Mostafa Rahimi, Rahman Souri, Ali Ahvar,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: The aim of study was to investigate the effect of 8 weeks of moderate-intensity continuous training (MICT) and high intensity interval training (HIIT) on the GLUT4 gene expression in skeletal muscle of obese male rats.
Materials and Methods: Twenty-eight male Wistar rats with 150 ± 25 grams body weight were divided into base control (n = 6), obese control (n = 6), MICT (n = 8), and (n = 8) HIIT groups as study sample. At the beginning of the study, base control group rats were sacrificed. In other groups, rats underwent high fat regime diet for 8 weeks. After one week of familiarization, rats in training groups run on treadmill for 8 weeks and 5 days per week. Forty-eight hours after the last session, the rats were scarified and gastrocnemius muscle tissue sample were removed. GLUT4 gene expression was measured by Real-Time PCR methods.
Findings: Results indicated that high fat diet for 8 weeks significantly increased rats body weight (p= 0.001), whereas both of MICT and HIIT training significantly decreased body weight (p= 0.001). Moreover, the MICT and HIIT had significant increase in GLUT4 gene expression in gastrocnemius muscle of obese rats (p = 0.001). Although, there were no differences between two experimental groups (p = 0.99).
Conclusion: According to the results, the MICT and HIIT increase gene expression of GLUT4 in mixed muscle fibers in obese rats. |
Maryam Rahimi Tesiye, Farhad Valizadegan, Shahrbanoo Oryan,
Volume 22, Issue 1 (4-2019)
Abstract
Background and Aim: Working memory is a dynamic neural system for temporarily maintaining and processing of information. Prefrontal cortex (PFC) is the main processing center of Working memory by using different neurotransmitter systems communicate with other brain structures such as Basolateral Amygdala (BLA). In this study, we investigated the role of Opioidergic system in medial PFC and Dopaminergic system of BLA nucleus in working memory based on RAM test.
Materials and Methods: In this study, The male Wistar rats were used. Rats were cannulated with stereotaxic surgery in mPFC and BLA sites. After a recovery period, they were microinjected. Parameters such as working and reference memory errors were calculated with DSWS protocol.
Ethical Considerations: This study with research ethics code IR.UMZ.REC.1397.23 has been approved by Bioethics Committee at Mazandaran University, Iran.
Findings: High doses of Morphine (2 µg/rat) intra mPFC and Chloropromazine (2 µg/rat) intra BLA have improving effects on working and reference memory (p≤0.05). Low (0.005 µg/rat) and high dose (0.5 µg/rat) of Apomorphine had improving {(p≤0.05), (p≤0.01)} and the moderate dose (0.05 µg/rat) of it had decreasing effect on working and reference memory (p≤0.01). Microinjection of Morphine (0.5 µg/rat) with triple doses of Chloropromazine had no significant change on working and reference memory errors. Interaction of Morphine (0.5 µg/rat) with different doses of Apomorphine could change Apomorphine different effects. Coadministration of different doses of Apomorphine with effective dose of Chloropromazine (2 µg/rat) and Morphine (2 µg/rat) decreased the working and reference memory errors.
Conclusion: Our findings showed that in processing of working and reference memory, opioidergic system in mPFC and dopaminergic system in BLA, are interacting reciprocally.
Mahsa Kavousi, Ehsan Rahimi, Jalil Fallah Mehrabadi,
Volume 22, Issue 2 (6-2019)
Abstract
Background and Aim: Lung cancer is one of the most contagious cancers in all of the world. Recently, several potential oncogenes and carcinogens have been identified, including EGFR, BRAF, KRAS and ALK genes. With due attention to the high prevalence of lung cancer, its death rate, the complications of chemotherapy and the efforts to find effective and less effective drugs, this study was done to investigate the effect of a plant extract so that results are available to manufacturing centers.
Materials and Methods: In this study, the effect of Eucalyptus extract and cisplatin on the expression of KRAS gene in A549 lung cancer cell line was investigated. To determine the cell survival, MTT was used and IC50 was determined. After determining IC50, the cells were exposed to less than IC50 concentrations of the extract and drug for 48 hours. Then, the amount of β-ACTIN and KRAS genes expressions in control and extract treated and drug treated groups were determined. For this purpose, a specific primers were designed for β- ACTIN and KRAS, and Real-Time PCR was be done.
Ethical Considerations: This study with research ethics code IR.IAU.East Tehran.REC.1396.3 has been approved by research ethics committee at Islamic Azad University, Tehran- East Branch, Iran.
Findings: The results showed that the amount of IC50 of the extract and drug was 8.75 and 1.77 mg/ml, respectively. In addition, the expression of genes in control and treated cells with extract and drug was compared. The expression of the KRAS gene relative to the reference gene in the cancer cell line treated with extract and drug, for 48 hours, was significantly decreased 2.89 and 9.25, respectively (p = 0).
Conclusion: Regarding the reduction of the relative gene expression in the A549 treated group, future studies on targeted lung cancer treatment can be promising and the potential for the use of plant compounds is more evident.
Reyhaneh Khoshchehreh, Mehdi Totonchi, Hossein Baharvand, Marzieh Ebrahimi,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: There is increasing evidence that cancer cells in addition to multiple genetic mutations, also acquire epigenetic abnormalities during development, maintenance, and progression. By utilizing the reprogramming technology as a tool to introduce the ‘pressure’ to alter epigenetic regulations, we might be able to clarify the epigenetic behavior that is unique to cancer cells. So far, iPSCs have been generated from normal primary cells, but it is unclear whether human primary cancer cell can be reprogrammed. We investigated the production of the iPS cells from the pancreatic adenocarcinoma cells using defined transcription factors.
Materials and Methods: We sought to reprogram patient derived xenograft from human PDAC, by introducing lentiviral mediated induction of Yamanaka Factors (OSKM) and characterized of induced cells by Alkaline Phosphatase staining, Real-Time PCR and immunostaining.
Ethical Considerations: This study with research ethics code EC/93/1025 has been approved by research ethics committee at Royan Institute.
Findings: Alkaline Phosphatase staining, Real-Time PCR and immunostaining showed that induction with the OSKM results in generating iPS cell line from fibroblast cells but not from PDAC PDX cells .We showed that, PDAC cells could not fully reprogrammed by the expression of 4 transcription factors.
Conclusion: This study demonstrated that the PDAC-PDX cancer cells were distinct from PDAC induced cells with regard to their epigenetic modifier genes expression pattern, although the expression of pluripotency genes did not increased significantly in the induced PDAC cells.
Narges Ensan, Isaac Rahimian Boogar, Siavash Talepasand, Fariborz Estilaee,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim Multiple Sclerosis (MS) is an unpredictable disease that can change individuals' lifestyle. The purpose of this study was to investigate the effect of a Mindfulness-Based Stress Reduction (MBSR) program on functional disability of patients with MS.
Methods & Materials The is an experimental study with pre-test/post-test/follow up design using control group. The study population consisted of all male and female patients with MS living in Neyshabur county, Iran. Of these, 47 were selected using a convenience sampling technique and randomly assigned into two groups of intervention (n=22) and control (n=25). The intervention group received MBSR therapy for 8 sessions, while the control group received no intervention. The follow-up was performed after one month. Subjects’ functional disability was measured by using the World Health Organization Disability Assessment questionnaire. The collected data were analyzed using SPSS v.21 software usingrepeated measurements Analysis of Variance (ANOVA).
Ethical Considerations This study obtained its ethical approval from the Research Ethics Committee of Neyshabur University of Medical Sciences (code: IR. NUMS.REC.1397.004)
Results The results of univariate ANOVA showed the significant effect of time and the interaction effect of time and group on functional disability of samples. The results of between-group ANOVA a significant difference between the intervention and control groups in functional disability (p <0.05). Pairwise comparison of the interaction effect of time and group showed a significant difference between the pre-test, post-test and follow-up scores (P = 0.001), but no significant difference was reported between the post-test and follow-up scores.
Conclusion The MBSR program could reduce the functional disability in patients with MS due to ease of treatment, faster patient education, and the short duration of intervention sessions.
Zeinab Abdolhosseini, Isaac Rahimian Boogar, Siyavash Telepasand,
Volume 22, Issue 6 (February & March 2020)
Abstract
Background and Aim: Physical complaints that have no clear cause are a process that is commonly seen in patients with Somatic Symptom Disorder (SSD). The increasing number of patients with this disorder and its related chronic symptoms including changes in quality of life and loss of individual efficiency has created social and psychological economic costs for these patients and their families.
Methods & Materials: This descriptive cross-sectional study conducted on 70 patients with SSD having digestive symptoms and chronic pain referred to the health centers in Semnan, Iran in winter 2018. They were selected using a convenience sampling method. The data collection tools were 15-item Patient Health Questionnaire Physical Symptoms (PHQ-15) and Rorschach test (Exner’s Comprehensive System). In order to analyze the collected data, multiple linear regression analysis, logistic regression analysis, and multivariate ANOVA were performed in SPSS v. 22 software.
Ethical Considerations: The present study was approved by the Research Ethics Committee of Semnan University of Medical Sciences (code: IR.SEMUMS.REC.1397.029).
Results: Perceived location indices including D and Dd scores in Rorschach test were able to significantly differentiate the SSD patients from controls (P<0.05). In the logistic regression model, 70% of participants were classified properly.
Conclusion: There is difference in projective responses between SSD patients and controls, and patients were less holistic. Anxiety and psychiatric symptoms were also higher in patients with SSD.
Anahita Khodabakhshi-Koolaee, Mohammad Pourebrahimi,
Volume 23, Issue 3 (August & September 2020)
Abstract
Background and Aim: Myasthenia Gravis (MG) is a neuromuscular disorder and auto-immune disease that is associated with symptoms of fluctuating muscle fatigue and dysfunction of the neuromuscular junction system. This disease greatly affects various aspects of the patient's life and impacts the person's perception of the quality of life. The aim of this study was to explain and analyze life experiences with myasthenia gravis disease in a young girl.
Methods & Materials: This report is a qualitative case with interpretive phenomenological approach that examines the life experiences of a young girl with myasthenia gravis in 2019. Data were collected through semi-structured interviews and analyzed using Van Manen's phenomenological approach.
Ethical Considerations: This study was registered in the Research Ethics Committee of Khatam University (Code: 3299/100/P/98).
Results: Thematic analysis indicated that myasthenia gravis disease affects all aspects of person's life world. These four aspects include living and feelings with time, body, space, and others. Eventually, three interrelated themes emerged from the patient's perception of the world around her, including physical weakness, future ambiguity, and frustration.
Conclusion: The present study shows a clear image and understanding of the problems of living with MG in a young girl. The phenomenological world of mixed by physical weakness, ambiguity in the future, and frustration that indicating the suffering and distress that the patient experiences following the illness. The results of this study contribute to the awareness of health and rehabilitation specialists in the field of work and research in myasthenia gravis as a neurological disease.
Leila Dehghan, Hamid Dalvand, Sadegh Samadi, Mohsen Ebrahimi Monfared, Fatemeh Rafiei,
Volume 23, Issue 4 (October & November 2020)
Abstract
Background and Aim: Musculoskeletal disorders are mainly prevalent among college students who experience direct contact with patients. This study aimed to determine the prevalence of musculoskeletal pains among Rehabilitation, Dentistry, and Nursing students at Arak University of Medical Sciences in 2017-2018.
Methods & Materials: In this cross-sectional descriptive study, 538 students of Arak University of Medical Sciences were recruited using the convenience sampling approach. Variables included age, sex, body mass index, study field, hours of using smartphone per day, and nine symptom sites being neck, shoulders, upper back, elbows, low back, wrist/hands, hips/thighs, knees, and ankles/feet. The researchers assessed the musculoskeletal pain by using the Nordic questionnaire and demographic questionnaire. Statistical analysis was performed using SPSS V. 18.
Ethical Considerations: The Research Ethics Committee of Arak University of Medical Sciences approved this study (Code: IR.ARAKMU.REC.1397.253).
Results: In this study, 538 students (205 males and 333 females) were studied with Mean±SD age of 22.04±2.53 years old. The results showed that the prevalence of musculoskeletal pain in the spine (neck 29.4%, upper 24.3%, and lower back 37.2%) was higher than in upper and lower extremities. Musculoskeletal pain in the shoulder, upper, lower back, and thigh were significantly different based on sex. Also, musculoskeletal pain in the neck and ankle, and foot were significantly different based on age (P<0.05). There was a significant difference between musculoskeletal pain of back and ankle based on smartphone use hours per day.
Conclusion: This study suggested that rehabilitation, nursing, and dentistry students are at risk for musculoskeletal pain, especially in the lumbar, cervical, and upper back.
Mehrdad Nasrollahzadeh Sabet, Mohammad Khanalipour, Milad Gholami, Abdolazim Sarli, Arefeh Rahimi Khorrami, Emran Esmaeilzadeh,
Volume 23, Issue 5 (December & January - Special Issue on COVID-19 2020)
Abstract
Background and Aim: The new Coronavirus Disease 2019 (COVID-19) outbreak initiated from China in late December 2019, has posed a great global health threat. Since patients with high blood pressure, diabetes, and cardiovascular diseases are at high risk of COVID-19, this study aims to investigate the prevalence, severity, clinical manifestations, and mortality rate in COVID-19 patients with underlying diseases compared to those without underlying diseases.
Methods & Materials: This study was performed on 1408 patients with COVID-19 admitted to Golestan, Hajar, Khanevadeh and Besat hospitals in Tehran, Iran. Required data including disease prevalence, severity, clinical manifestations and mortality rate in patients with and without underlying diseases were collected and then analyzed using statistical tests in SPSS software, considering a significance level of P<0.05.
Ethical Considerations: This study was approved by the AJA University of Medical Sciences (Code: IR.AJAUMS.REC.1399.091). Ethical principles have been observed in accordance with the guidelines of the National Ethics Committee and the COPE regulations.
Results: Patients were 912 men (64.8%) and 496 women (35.2%) aged 18-98 years (Mean age= 57.8 years). Results reported that 27% of patients were intubated and 21.9% were died. Blood oxygen level in 53.7% of patients was less than 93 mg/dL; 36.1% had a history of hypertension, 24.1% had a history of diabetes, and 21.7% had a history of cardiovascular disease.
Conclusion: The severity, clinical manifestations, and mortality rate of COVID-19 patients with cardiovascular disease, diabetes and hypertension are significantly different compared to those without underlying diseases.
Mina Vesal, Changiz Rahimi,
Volume 24, Issue 1 (April & May 2021)
Abstract
Background and Aim: Concerns are increasingly raised about the impact of social media use on depression in adolescents. This article aimed to summarize and synthesize quantitative studies addressing the association between social media and depression in adolescents.
Methods & Materials: This systematic review and meta-analysis included studies on the impact of the internet and social media use on depression in adolescents using Persian and English databases. In total, 15 studies met the inclusion criteria and were included in the analysis.
Ethical Considerations: All ethical principles are considered in this article.
Results: The obtained data revealed a slight (0.18) statistically significant correlation (P<0.000) between social media use and depression in adolescents. However, this relationship was complex and associated with multiple psychosocial, behavioral, and individual factors, necessitating further investigation of mediating and moderating variables. Notably, most explored studies were cross-sectional; thus, they failed to infer the causal relationship between social media use and depression. In Iran, research has only investigated internet dependence. Further research is required in this area.
Conclusion: Overall, the mechanism of the impact of social media on depression should be further investigated through qualitative and longitudinal studies.
Farzaneh Hajizadeh, Fatemeh Ebrahimi, Seyed Zia Tabatabaei,
Volume 25, Issue 3 (August & September 2022)
Abstract
Background and Aim The early years of life are the most critical stage in the growth and development of children. While the optimal development of children depends on a complex set of factors, the pattern of breastfeeding and complementary feeding of infants is of undeniable importance. Therefore, the present study conducted to investigate the factors related to the feeding patterns of one-year-old children referred to healthcare centers in Rafsanjan city.
Methods & Materials his descriptive study was performed on 600 mothers with one-year-old children under the auspices of healthcare centers in Rafsanjan city in 2017. Volunteered mothers with active health records were selected randomly. The required information was collected through a questionnaire containing demographic characteristics and questions related to the feeding of children and was analyzed by SPSS software, version 18.
Ethical Considerations The Ethics Committee of Rafsanjan University of Medical Sciences (RUMS) approved the present study (Code: IR.RUMS.REC.1396.179).
Results About 95% of mothers participating in this study started breastfeeding their children up to one hour after delivery, but 56.7% of them completed breastfeeding by one year of age. The results show that most mothers had started supplemental feeding with two or three spoons in each meal, and about 90% of them followed the health worker's advice. Also, the most important reasons for feeding children with powdered milk are disorders in the child's development (34%), inadequate breast milk (17%), maternal disease (14%), do not take the mother's breast (11%) and children being twins (8%).
Conclusion Despite face-to-face training for mothers in health care centers for feeding their children, still there are some difficulties in commencing complementary feeding and its continuation. Therefore, need for more health and nutrition education regarding the best ways for feeding children to mothers by personnel of Rafsanjan health care centers.
Mr Fathollah Ghorbani, Mohammad Rezaei, Dr Ebrahim Ebrahimi, Mis Lila Ghorbani, Dr Elham Rezaei,
Volume 25, Issue 5 (December & January 2022)
Abstract
Introduction: Beyond the members of the charter board, the horizon of Amedwar Kanandah for the sake of Bimaran Niyazmand, the member of the board of the board. In parallel, there is a new medical science in New Mutrah, in the opinion of specialists who claim that it is a model and that they have a source for beyond the organs with children. Definitively The current issue is that of new topics and the question of programs in the possession of jurisprudence and rights, which must be carefully selected from the angles that are the subject of jurisprudence debate.
Methods: This is a book in the form of a textbook and a description - an analysis with the use of the books of science and jurisprudence of his room.
Results: This type of child is based on the basis of investigations, which are believed to be valid, according to the permissibility of the organs that are nozadan with severe cranial defects, i.e., in the womb of a mother, or from a cutaneous period, but from birth in the middle of my heart; A defensible issue.
Conclusions: The use of the nostril organs affected by the cornea with limitations of the cervical spine, but with a significant meaning in the development of Rastafarian, and the use of non-main organs based on multiple rational and legal evidences; Milabashed project. The parts of my life are afflicted with severe corneal ulcers, based on the inevitability and inevitability of the disease, and the reason for the fact that the situation is similar to the meaning of the disease. Develop a legitimate development in the most vigorous manner, and the issue of the necessity of preserving human dignity This is an issue that cannot be denied. But from the point of view of the role that is not a conditional legality, it is a present issue with conditional auspices in no severe form.
Dr Abbas Saremi, Dr Mohammad Parastesh, Dr Sahar Ebrahimi,
Volume 25, Issue 6 (February & March 2023)
Abstract
Introduction: Physical activity is one of the important lifestyle factors that can have positive or negative effects on the reproductive system, and more research is needed to reflect the effect of inactivity on fertility in order to provide safe lifestyle recommendations to help couples achieve pregnancy is required. Therefore, this study was conducted with the aim of describing and comparing the physical activity status of fertile and infertile men in Arak city in 2022.
Methods: The present study is a case-control study that was conducted on 220 fertile and infertile men (22 to 40 years old) referred to Arak University Jihad infertility centers that were selected through available sampling. Participants completed self-test questionnaires on socio-demographic characteristics, lifestyle, physical activity, and sedentary behaviors. Anthropometric characteristics and body composition were also measured. Multivariate logistic regression was used to analyze the association of infertility with physical activity level, sedentary behavior, and body composition.
Ethical Considerations: This study was approved by the Ethics Committee of the University of Arak University (Code: IR.ARAKMU.REC.1401.046).
Ethical Considerations: The present research has been registered with the code IR.ARAKU.REC.1401.015 in the Ethics Committee of Arak University.
Results: In this study, it was observed that the amount of physical activity (P=0.02) and body composition (P=0.001) in fertile men is more favorable than infertile men. In men with a low level of physical activity, the risk of infertility increases 2.97 times (odds ratio 2.97 and 95% CI: 1.03, 8.61, and P=0.04). On the other hand, in men with moderate level of physical activity, the risk of infertility decreases (odds ratio 0.27 and 95% CI: 0.08, 0.92, and P=0.03). Also, in men who sit for more than 6 hours a day, the chance of infertility increases by 3.02 times (odds ratio 3.02 and 95% CI: 1.28, 7.10, and P=0.01). An increase in body mass index increases the risk of infertility by 1.61 times in men (odds ratio 1.61 and 95% CI: 1.23 and 2.11 and P=0.001).
Conclusions: Since obesity, physical inactivity and infertility in Iranian men are increasing at the same time, so there should be more focus and seriousness on the issue of lifestyle modification and especially physical activity regarding reproductive health.
Dr. Maryam Arabloei Sani, Dr. Zahra Hajebrahimi, Dr. Parichehreh Yaghmaei, Dr. Nasim Hayati Roodbari,
Volume 26, Issue 5 (December & January 2023)
Abstract
Background and Aim: Diabetes is a type of metabolic disease and one of the most common endocrine diseases. Oxidative stress and inflammation play an important role in the development and progression of diabetes. mTOR signaling pathway play an important role in glucose homeostasis and proliferation of pancreatic beta cells. In the present study, the therapeutic effects of p-cymene on oxidative stress markers and expression of the mTOR gene in diabetic male Wistar rats were investigated.
Materials and Methods: Diabetes was induced by injecting 55 mg/kg body weight of streptozotocin. Biochemical analyses of pancreatic tissue and real-time PCR were done to investigate the effects of metformin (55 mg/kg body weight) and p-cymene (25, 50, and 100 mg/kg body weight) on the activities of catalase and glutathione peroxidase enzymes and mTOR gene expression.
Findings: Streptozotocin decreased catalase and glutathione peroxidase enzymes and decreased the expression of the mTOR gene in pancreatic tissue. Treatment with metformin or p-cymene improved the activities of catalase and glutathione peroxidase enzymes and the expression of the mTOR gene in a dose-independent manner.
Conclusion: Results indicate that p-cymene has antioxidant properties and can regulate the mTOR signaling pathway. Therefore, p-cymene may be effective for the treatment of diabetes alone or in combination with metformin.
Ali Rahimi, Behzad Hamedani, Nasrin Rasoulzadeh,
Volume 27, Issue 1 (3-2024)
Abstract
Introduction: Nurses have a prominent position in providing healthcare services. There is an undeniable relationship between nurses' professional self-concept and providing care to patients. This study was conducted to investigate the relationship between professional self-concept and the lifestyle of nurses in selected hospitals of Mazandaran cities.
Methods: This descriptive study was conducted using a stratified sampling method with a proportional allocation of 200 nurses working in hospitals affiliated with Mazandaran University of Medical Sciences in 2015. Data collection tools included a demographic information form, a nurse professional self-concept questionnaire, and a nurses' lifestyle questionnaire. Data analysis was done with a significance level of P ≤ 0.05. Pearson's correlation coefficient was used to determine the relationship between professional self-concept and nurses' lifestyle.
Results: The mean score of nurses' professional self-concept and a lifestyle was 156.55 ± 19.37 and 216.42 ± 5.88, respectively. There was also a significant direct relationship between professional self-concept and nurses' lifestyle.
Conclusions: Considering the confirmation of positive correlation between professional self-concept and the lifestyle of nurses, nursing managers can promote healthy lifestyles in nurses by promoting professional self-concept.
Ahmad Ansarifar, Isaac Rahimian-Boogar, Siavash Talepasand,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: Sociodemographic factors and perceived anxiety have a significant impact on the development of somatic symptom disorder. This study aimed to investigate the role of demographic characteristics, social isolation, and perceived anxiety in predicting somatic symptom disorder.
Methods: In a cross-sectional descriptive study among adults aged 18 to 60 in Tehran in 2023, 437 participants were selected based on convenience sampling. The participants completed the Somatic Symptom Disorder Questionnaire (SSEQ), Social Isolation Questionnaire, and Perceived Anxiety Questionnaire. Data were analyzed using Pearson’s correlation and multiple regression analysis.
Results: The results indicated that social isolation and perceived anxiety have a positive and significant correlation with somatic symptoms disorder (P < 0.01). There was no correlation between demographic characteristics (age, gender, marital status, education, and employment status) and somatic symptoms (P <0.01). Multiple correlation and regression coefficients among research variables were statistically significant (P < 0.01).
Conclusions: The examined model was almost able to predict 22% of the somatic symptoms of the disorder. The results have implications for formulating interventions based on social isolation and perceived anxiety in controlling somatic symptoms. It is essential to pay attention to social isolation and perceived anxiety in the formulation and implementation of interventions and educational programs for the prevention and improvement of somatic symptom disorder.
