Showing 68 results for Rahimi
Nasim Ebrahimi, Sadegh Vallian Borujeni,
Volume 19, Issue 6 (9-2016)
Abstract
Background: Niemann-Pick disease (NPD) refers to a group of lysosomal storage diseases that causes abnormal metabolism of lipids. One of the genes that play a role in the pathogenesis of this disease is SMPD1. To date, more than hundred disease- causing mutations have been identified in SMPD1 gene. Due to the large number of mutations in this gene, direct analysis of the mutations is costly and time-consuming. Therefore, indirect linkage analysis using polymorphic markers as an alternative method for molecular diagnosis of the mutations has been recommended. In the present study, allele frequency of rs1542705 genetic marker was analyzed in the Iranian population. The aim was to determine the polymorphic information content (PIC) and the possibility of its application in indirect diagnosing of NPD.
Materials and Methods: After bioinformatics analysis of the SMPD1 gene region, rs1542705 marker was selected for genotyping in Isfahan population. In order to calculate the allele and genotype frequency of the marker, molecular tests were done on 113 DNA samples of unrelated healthy individuals by using ARMS-PCR technique. Finally, the information related to the genotype of the individuals was statistically analyzed using Powermarker and Genepop software.
Results: The analyses showed that the studied population was in accordance with Hardy-Weinberg equilibrium. Allele frequency of rs1542705 marker for T and C alleles was 71.24% and 28.76%, respectively, and the heterozygosity of the marker was 43.36%. Also, polymorphic information content (PIC) was 0.325.
Conclusion: The results of this study showed that rs1542705 marker could be considered as an informative marker for molecular diagnosis of Niemann- Pick disease using linkage analysis in the studied population.
Shekoofeh Rahimi, Mahboobeh Nasiri, Saeideh Arian Nia, Reza Farrokh Seresht,
Volume 19, Issue 9 (12-2016)
Abstract
Abstract
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with broad clinical manifestations, but unclear etiology. Extensive tissue damage occurs due to the production of auto-antibody against nuclear and cytoplasmic antigens. Regarding the involvement of GADD45A gene in cell cycle control, T-cell proliferation suppression, and genome epigenetic regulation, this case-control study was done for the first time to evaluate the association of rs581000 polymorphism in 5’ near gene with the risk of SLE among patients in south of Iran.
Materials and Methods: This study was performed on 102 patients with SLE in comparison with 118 healthy controls. Genotyping of the GADD45A rs581000 polymorphism was performed using T-ARMS PCR.
Results: The T allele was significantly more frequent in the controls (0.13) than in the patients (0.01) with SLE (p<0.001). The frequency of genotypes carrying at least one C allele (CC+CG) was higher in control group (14.4%) compared to patient group (1%), and this allele showed protective effect against the risk of SLE (p<0.001, CI: 0.009-0.5, OR=0.06)
Conclusion: It seems that GADD45A rs581000 polymorphism involved in the SLE pathogenesis.
Mohsen Ebrahimi Monfared, Mehdi Sadegh, Zahra Gohari,
Volume 19, Issue 12 (3-2017)
Abstract
Abstract
Background: Melatonin regulates the sleep-wake cycle and is protected against oxidants. Vitamin E has antioxidant effect. The aim of this study was to investigate effect of melatonin and/or vitamin E on the EEG, sleep quality and quality of life of female nurses working in hospitals in Arak.
Materials and Methods: 60 female nurses were randomly selected from hospitals in the Arak city. Participants divided into three groups (melatonin3 mg/day, vitamin E 200 IU/day and melatonin and vitamin E groups) and a control group. Before and two months after the baseline, PSQTI and the quality of life of 26 questions questionnaire were completed and EEG was recorded. Finally, the findings for both groups before and after the intervention were compared with each other.
Results: The average of sleep quality showed an improvement in groups receiving melatonin and melatonin+vitamin E (p>0.05). While data of life quality did not show any significant change between groups. In EEG activity, α waves in the range of 8-10 Hz showed maximum increase in melatonin group and minimum increase in vitamin E group. Also, α wave in the range of 10-12 Hz revealed the most decrease in the melatonin group.
Conclusion: It seems simultaneous administration of melatonin and vitamin E is able to improve sleep quality. In addition, melatonin could improve alpha-waves of brain activity.
Mojtaba Rahimi Varposhti, Darioush Moradi Farsani, Babak Ali Kiaei, Behzad Nazem Roaya, Seyed Hosein Moosavi,
Volume 20, Issue 3 (6-2017)
Abstract
Abstract
Background: The aim of this study is to evaluate the impact of preemptive adding topical Ketorolac to Tetracaine drop on pain intensity and hemodynamic parameters during and after cataract surgery.
Materials and Methods: Eighty patients scheduled for elective cataract surgery under sedation and topical anesthesia, were randomly allocated to two equal groups: group T received Tetracaine 0.5%, and group TK received Tetracaine with ketorolac eye drops. One drop of each ophthalmic drug was applied every 10 minutes from 30 minutes before surgery. Pain intensity and hemodynamic parameters were assessed just before starting the operation and 5, 10, 15and 20 minutes during the operation, and then 0, 5, 10, 15 and 20 minutes after arrival of the patient to the recovery room.
Results: Mean pain intensity was significantly lower in TK group (1 ± 0.128) compared with T group (2 ± 1.54) during the surgery (p = 0.003), but there was no significant difference between the two groups in this regard during the recovery time (p =0.157). The number of patients requiring additional analgesic was not significantly different between the groups. There was no significant difference between the two groups regarding hemodynamic parameters except at 20th minutes and 15th and 20th minutes (heart rate and respiratory rate) after arrival to the recovery room.
Conclusion: Preemptive adding topical Ketorolac to Tetracaine drop is more effective than Tetracaine alone to reduce pain during cataract surgery.
Paria Nikpey, Tahereh Nazari, Shadi Khalili, Ahmad Ebrahimi,
Volume 20, Issue 4 (7-2017)
Abstract
Abstract
Background: Uterine myomas are benign tumors of the uterus which are derived from smooth muscle cells of the myometrium. Genetic factors play a major role in the progression of the disease. One of the most important genes which have impression in the mechanism of formation of the myoma is epidermal growth factor receptor (EGFR) that plays a basic role in the process of cell growth, differentiation, proliferation and mitogenesis. The aim of this study is survey of EGFR gene common mutations in Iranian women with uterine myomas. In this test, the common mutations of the exon 21 and 19 in the EGFR gene were surveyed.
Materials and Methods: In this case-control study, 80 women with myoma and 80 healthy women were studied as control. For checking deletion mutation of the Exon 19 (rs121913438), the Tetra ARMS/PCR method has been used and also for checking point mutation of the exon 21(rs121434568), the ARMS/PCR method has been used and results of the experiments were analyzed via χ 2 test.
Results: The comparison of the genotypes frequency of exon 21 (TT, TG, GG) and exon 19 (WW, WD, DD) related to EGFR gene in two groups of patients and control with using statistical test respectively represents the significant difference (p=1.320e-16) and (p=3.053e-13) in the different genotypes frequency among the patients and control groups.
Conclusion: The results of research indicate a significant relationship between EGFR gene mutations in exon 19 and exon 21 and potential for myoma in the studied population.
Zahra Sadeghi, Ahmad Ebrahimi, Fatemeh Davari Tanha, Sayed Yousef Seyedena,
Volume 20, Issue 7 (10-2017)
Abstract
Abstract
Background: Ectopic pregnancy is a type of pregnancy in which implantation of zygote occurs out of the uterine cavity. One of the most important problems is bleeding. On the other hand, Plasminogen Activator Inhibitor-1(PAI-1) gene is one of the involved factors in unsuccessful pregnancies, and 4G/5G polymorphism is the most common changes of this gene. So, it is important to study the prevalence of these changes in this gene in women with ectopic pregnancy.
Materials and Methods: In this case-control study, 100 Iranian women with ectopic pregnancy and 101 Iranian women with the normal pregnancy were selected. After blood sampling, ARMS PCR method has been used for detection 4G/5G polymorphism and data were analyzed by statistical analysis.
Results: In this study, 4G allele with 70.79% prevalence and 5G allele with 63.5% prevalence are the most common alleles for the control and case group, respectively. 4G/4G and 4G/5G genotypes in the control group and 4G/5G and 5G/5G genotypes in the case group are prevalent. An Armitage test found p<0.05 for both alleles, showing 4G allele (p= 1.524e-10; OR= 0.262) has decreasing effect and 5G allele (p= 1.524e-10; OR= 3.822) has increasing effect in ectopic pregnancy.
Conclusion: According to the findings, 5G allele and 4G/5G and 5G/5G genotypes have increasing effect, 4G allele and 4G/4G genotype have decreasing effect in ectopic pregnancy. So, we could consider 5G allele as a risk factor of ectopic pregnancy in this study.
Zahra Rahimi, Ahmad Rahbar, Fatemeh Kheyrollahi, Ali Ebraze, Zabihollah Gharlipour,
Volume 20, Issue 7 (10-2017)
Abstract
Abstract
Background: The evaluation of the amount and type of edible oils can significantly help to raise the people’s awareness about how to use this type of food product. The aim of this study was to determine consumption pattern of various edible oils and its related factors based on PRECEDE model.
Materials and Methods: This cross sectional descriptive analytic study was performed on 300 urban and rural women referring to health centers in Qom province. The participants were selected via multi-stage sampling method. The data were collected using standard questionnaire of PRECEDE model and analyzed by SPSS V.20 using independent t-test, paired t-test, ANOVA, and Pearson correlation coefficient.
Results: The results of this study showed that 46.4% of urban women and 53.6% of rural women used solid oil. There was a significant difference between urban and rural households in terms of the consumption of tallow oil (p<0.05), as the consumption of tallow oil was more prevalent in rural households than in urban households. Also, there was a statistically significant difference between the two groups of urban and rural women in terms of the mean score of consumption of healthy edible oils and reinforcing factors (p<0.05), as the mean scores of urban women were better than those of rural women.
Conclusion: Implementation of training programs using training models such as the PRECEDE model can help to modify and correct the pattern of consumption of edible oils, especially in rural areas and promote the level of health of the community.
Mojtaba Rahimi Varposhti, Darioush Moradi Farsani, Kamran Montazeri, Fatemeh Tanha,
Volume 20, Issue 8 (11-2017)
Abstract
Background:
This study aimed to compare the effect of cold eye irrigation solution (BSS) and viscoelastic gel with their combination in room temperature on the dosage of sedative drugs which we use in Phacoemulsification cataract surgery.
Material and methods:
190 patients scheduled for cataract surgery under sedation were randomly divided into two equal groups. During surgery we used cold (4c) and warm (room temperature) BSS and viscoelastic gel in the first and second group respectively. For all patients we started sedation with Midazolam and Fentanyl and in case we needed additional drug we used Sodium Thiopental till we reached desired sedation level. Ramsay sedation scores (before, during and after surgery) and total sedative drug consumption were evaluated and compared between two groups and at the end of the surgery we checked the satisfaction score of patients and surgeon about the quality of sedation.
Results:
The average dosage of Midazolam wasn’t significantly different between the two groups, while the average dosage of Sodium Thiopental was significantly lower in Cold group. Also the average time of which we reached desired Ramsay sedation score and the level of Ramsay score were significantly different between the two groups.
Conclusion:
Using cold BSS and viscoelastic gel in cataract surgery in comparison of their combination in room temperature will reduce the dosage of sedative drugs which we use during surgery and help us getting a more effective sedation and gaining both a satisfied patient and surgeon.
Darioush Moradi Farsani, Khosro Naghibi, Mojtaba Rahimi Varposhti, Bahador Malekipoor, Tahereh Fasihi,
Volume 20, Issue 9 (12-2017)
Abstract
Abstract
Background: Postoperative nausea and vomiting (PONV) is one of the most common complications in the patients undergoing strabismus surgery. The aim of current study was comparing supplemental 80% and 40% oxygen on reducing postoperative nausea and vomiting in the pediatrics undergoing strabismus surgery.
Materials and Methods: In this clinical trial study, 100 pediatric patients scheduled for strabismus surgery under general anesthesia were allocated randomly into two parallel supplemental 80% and 40% oxygen groups during surgery. PONV in patients was compared until 24hrs after operation.
Results: In the first 6hrs postoperatively, PONV in the supplemental 40% and 80% oxygen groups were 48.8% and 30.6% respectively, also were 20.8% and 12.2% in the 6 to 24hrs postoperatively. Therefore, there were no significant differences between both groups in regarding of PONV in 6hrs and 6 to 24hrs postoperatively (p values were 0.18 and 0.25, respectively).
Conclusion: According to our results, there is no any difference between 40% and 80% oxygen postoperatively in the pediatrics undergoing strabismus surgery.
Moein Rahimi Sadegh, Amir Rashidlamir, Ali Akbar Haddad Mashhad Rizeh, Mohammad Soukhtanloo,
Volume 20, Issue 12 (3-2018)
Abstract
Abstract
Background: Recent Research has pointed to the involvement of lysyl oxidase (LOX) in the muscle development. Despite the fact, there is currently no direct evidence that lox is involved in the myogenic factors and exercise-induced hypertrophy. Therefore, the purpose of this study was to investigate the effect of lysyl oxidase inhibition on exercise-induced hypertrophy, as well as the gene expression of MyoD1, myogenin, TGF-β and LOX in FHL muscle of wistar rats.
Material and Methods: In this experimental research, 32 male Wister rats with an average weight of 220±15 were divided into four groups: resistance training, normal control, treated control and treated resistance training. Rats performed a resistance training for 8 weeks in which animals climbed a vertical ladder of 1m and inclined at 85° with weights attached to their tails. In order to inhibit lysyl oxidase, treatment group rats received daily injection of intraperitoneal β-aminopropionitrile (120 mg/kg/day). FHL muscle was extracted to measure relative muscle weight, as well as genes expression of MyoD1, myogenin, TGF-β and LOX by real time-PCR.
Results: Relative weight of FHL muscle was decreased significantly in the treated groups with BAPN, compared with normal groups (p<0.05). Lysyl oxidase showed a significant increase compared to the normal control group following a resistance training (p<0.05). LOX gene expression in treatment groups showed a significant increase compared to normal control group (p<0.05). TGF-β gene expression in BAPN-treated groups significantly was increased (p<0.05) and Myogenin in treatment groups showed a significant decrease compared to normal control groups (p<0.05). The expression of MyoD1 gene in treatment groups was only decreased significantly in the treated control groups compared to normal control groups (p<0.05).
Conclusion: Results showed that inhibiting the lysine oxidase enzyme could affect the genes involved in hypertrophy and reduce the hypertrophy induced by resistance training.
Shahla Shahsavandi, Mohammad Majid Ebrahimi, Mohammad Reza Samiee,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: The inactivated vaccines are formulated with adjuvant to direct the host immune responses and also increase stability of the antigen. In recent years, the development of biological adjuvants and the evaluation of their ability in elicitation of immune responses against influenza virus have been considered. Hemokinin-1 (HK-1) activates T and B cells for differentiation into plasma cells, and antibody production. In this study, the effect of HK-1 for inducing humoral immune response against influenza chitosan based-nano vaccine was investigated.
Materials and Methods: Chitosan nanoparticle containing inactivated influenza antigen and chitosan nanoparticle containing the inactivated antigen formulated with HK-1 were prepared. Immune response following influenza nanoparticles vaccinations with and without the adjuvant was assessed in SPF chickens after prime and boost immunizations. Specific antibody levels against influenza were evaluated in serum samples of treatment and control groups by serological tests.
Findings: The chickens immunized with the HK-1 adjuvanted nano vaccine produced higher specific antibody titers that were sustained until the end of experiment comparable either with inactivated antigen alone or the H9N2 nanoparticles without HK-1 adjuvant. Administration of boosting had no effect on the enhancing of antibody titer.
Conclusion: The data show that the chitosan nanoparticles provide better absorption conditions and more stability and release of the influenza antigen in the presence of HK-1 biological adjuvant.
Mersedeh Fatemeh Yazdanbakhsh, Aboo Saeed Rashidi, Mohammad Karim Rahimi, Ramin Khajavi, Hamed Shafaroodi,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: The purpose of this research is to provide nanofibers from cellulose with Wheat bran as an agricultural residue and its antimicrobial activity by dipping ciprofloxacin hydrochloride on Staphylococcus aureus.
Materials and Methods: In this experimental study, cellulose disks were prepared from nano-impregnated fiber. Subsequently, these disks were placed on Staphylococcus aureus with standard paper disks and the results were measured as a non-growth zone after 24 hours. The amount of ciprofloxacin hydrochloride adsorbed in cellulose by comparing the effect of cellulosic discs containing different concentrations of antibiotics and standard ciprofloxacin disks was determined. Subsequently, the evaluation of the time of recovery of the ulcer in the skin of the rats was carried out with the drug-mediated formulation and without drug.
Findings: The disk (nano alpha-cellulosic) dipped by ciprofloxacin hydrochloride created a non-growth zone in Staphylococcus aureus. Measuring the size of the wound was done by digital imaging and the ImageJ software. The results of the recovery process were analyzed by ANOVA and pathological tests in five days.
Conclusion: The results showed that the nano-fibers disk could be useful in controlling bacteria in the culture medium, and the area of the wounds in rats (rats) dressed with nano-fibers impregnated with the drug was significantly less than the control group (p <0.05). |
Mis Mahnaz Najafi, Mohammad Reza Asad, Mostafa Rahimi, Rahman Souri, Ali Ahvar,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: The aim of study was to investigate the effect of 8 weeks of moderate-intensity continuous training (MICT) and high intensity interval training (HIIT) on the GLUT4 gene expression in skeletal muscle of obese male rats.
Materials and Methods: Twenty-eight male Wistar rats with 150 ± 25 grams body weight were divided into base control (n = 6), obese control (n = 6), MICT (n = 8), and (n = 8) HIIT groups as study sample. At the beginning of the study, base control group rats were sacrificed. In other groups, rats underwent high fat regime diet for 8 weeks. After one week of familiarization, rats in training groups run on treadmill for 8 weeks and 5 days per week. Forty-eight hours after the last session, the rats were scarified and gastrocnemius muscle tissue sample were removed. GLUT4 gene expression was measured by Real-Time PCR methods.
Findings: Results indicated that high fat diet for 8 weeks significantly increased rats body weight (p= 0.001), whereas both of MICT and HIIT training significantly decreased body weight (p= 0.001). Moreover, the MICT and HIIT had significant increase in GLUT4 gene expression in gastrocnemius muscle of obese rats (p = 0.001). Although, there were no differences between two experimental groups (p = 0.99).
Conclusion: According to the results, the MICT and HIIT increase gene expression of GLUT4 in mixed muscle fibers in obese rats. |
Maryam Rahimi Tesiye, Farhad Valizadegan, Shahrbanoo Oryan,
Volume 22, Issue 1 (4-2019)
Abstract
Background and Aim: Working memory is a dynamic neural system for temporarily maintaining and processing of information. Prefrontal cortex (PFC) is the main processing center of Working memory by using different neurotransmitter systems communicate with other brain structures such as Basolateral Amygdala (BLA). In this study, we investigated the role of Opioidergic system in medial PFC and Dopaminergic system of BLA nucleus in working memory based on RAM test.
Materials and Methods: In this study, The male Wistar rats were used. Rats were cannulated with stereotaxic surgery in mPFC and BLA sites. After a recovery period, they were microinjected. Parameters such as working and reference memory errors were calculated with DSWS protocol.
Ethical Considerations: This study with research ethics code IR.UMZ.REC.1397.23 has been approved by Bioethics Committee at Mazandaran University, Iran.
Findings: High doses of Morphine (2 µg/rat) intra mPFC and Chloropromazine (2 µg/rat) intra BLA have improving effects on working and reference memory (p≤0.05). Low (0.005 µg/rat) and high dose (0.5 µg/rat) of Apomorphine had improving {(p≤0.05), (p≤0.01)} and the moderate dose (0.05 µg/rat) of it had decreasing effect on working and reference memory (p≤0.01). Microinjection of Morphine (0.5 µg/rat) with triple doses of Chloropromazine had no significant change on working and reference memory errors. Interaction of Morphine (0.5 µg/rat) with different doses of Apomorphine could change Apomorphine different effects. Coadministration of different doses of Apomorphine with effective dose of Chloropromazine (2 µg/rat) and Morphine (2 µg/rat) decreased the working and reference memory errors.
Conclusion: Our findings showed that in processing of working and reference memory, opioidergic system in mPFC and dopaminergic system in BLA, are interacting reciprocally.
Mahsa Kavousi, Ehsan Rahimi, Jalil Fallah Mehrabadi,
Volume 22, Issue 2 (6-2019)
Abstract
Background and Aim: Lung cancer is one of the most contagious cancers in all of the world. Recently, several potential oncogenes and carcinogens have been identified, including EGFR, BRAF, KRAS and ALK genes. With due attention to the high prevalence of lung cancer, its death rate, the complications of chemotherapy and the efforts to find effective and less effective drugs, this study was done to investigate the effect of a plant extract so that results are available to manufacturing centers.
Materials and Methods: In this study, the effect of Eucalyptus extract and cisplatin on the expression of KRAS gene in A549 lung cancer cell line was investigated. To determine the cell survival, MTT was used and IC50 was determined. After determining IC50, the cells were exposed to less than IC50 concentrations of the extract and drug for 48 hours. Then, the amount of β-ACTIN and KRAS genes expressions in control and extract treated and drug treated groups were determined. For this purpose, a specific primers were designed for β- ACTIN and KRAS, and Real-Time PCR was be done.
Ethical Considerations: This study with research ethics code IR.IAU.East Tehran.REC.1396.3 has been approved by research ethics committee at Islamic Azad University, Tehran- East Branch, Iran.
Findings: The results showed that the amount of IC50 of the extract and drug was 8.75 and 1.77 mg/ml, respectively. In addition, the expression of genes in control and treated cells with extract and drug was compared. The expression of the KRAS gene relative to the reference gene in the cancer cell line treated with extract and drug, for 48 hours, was significantly decreased 2.89 and 9.25, respectively (p = 0).
Conclusion: Regarding the reduction of the relative gene expression in the A549 treated group, future studies on targeted lung cancer treatment can be promising and the potential for the use of plant compounds is more evident.
Reyhaneh Khoshchehreh, Mehdi Totonchi, Hossein Baharvand, Marzieh Ebrahimi,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: There is increasing evidence that cancer cells in addition to multiple genetic mutations, also acquire epigenetic abnormalities during development, maintenance, and progression. By utilizing the reprogramming technology as a tool to introduce the ‘pressure’ to alter epigenetic regulations, we might be able to clarify the epigenetic behavior that is unique to cancer cells. So far, iPSCs have been generated from normal primary cells, but it is unclear whether human primary cancer cell can be reprogrammed. We investigated the production of the iPS cells from the pancreatic adenocarcinoma cells using defined transcription factors.
Materials and Methods: We sought to reprogram patient derived xenograft from human PDAC, by introducing lentiviral mediated induction of Yamanaka Factors (OSKM) and characterized of induced cells by Alkaline Phosphatase staining, Real-Time PCR and immunostaining.
Ethical Considerations: This study with research ethics code EC/93/1025 has been approved by research ethics committee at Royan Institute.
Findings: Alkaline Phosphatase staining, Real-Time PCR and immunostaining showed that induction with the OSKM results in generating iPS cell line from fibroblast cells but not from PDAC PDX cells .We showed that, PDAC cells could not fully reprogrammed by the expression of 4 transcription factors.
Conclusion: This study demonstrated that the PDAC-PDX cancer cells were distinct from PDAC induced cells with regard to their epigenetic modifier genes expression pattern, although the expression of pluripotency genes did not increased significantly in the induced PDAC cells.
Narges Ensan, Isaac Rahimian Boogar, Siavash Talepasand, Fariborz Estilaee,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim Multiple Sclerosis (MS) is an unpredictable disease that can change individuals' lifestyle. The purpose of this study was to investigate the effect of a Mindfulness-Based Stress Reduction (MBSR) program on functional disability of patients with MS.
Methods & Materials The is an experimental study with pre-test/post-test/follow up design using control group. The study population consisted of all male and female patients with MS living in Neyshabur county, Iran. Of these, 47 were selected using a convenience sampling technique and randomly assigned into two groups of intervention (n=22) and control (n=25). The intervention group received MBSR therapy for 8 sessions, while the control group received no intervention. The follow-up was performed after one month. Subjects’ functional disability was measured by using the World Health Organization Disability Assessment questionnaire. The collected data were analyzed using SPSS v.21 software usingrepeated measurements Analysis of Variance (ANOVA).
Ethical Considerations This study obtained its ethical approval from the Research Ethics Committee of Neyshabur University of Medical Sciences (code: IR. NUMS.REC.1397.004)
Results The results of univariate ANOVA showed the significant effect of time and the interaction effect of time and group on functional disability of samples. The results of between-group ANOVA a significant difference between the intervention and control groups in functional disability (p <0.05). Pairwise comparison of the interaction effect of time and group showed a significant difference between the pre-test, post-test and follow-up scores (P = 0.001), but no significant difference was reported between the post-test and follow-up scores.
Conclusion The MBSR program could reduce the functional disability in patients with MS due to ease of treatment, faster patient education, and the short duration of intervention sessions.
Zeinab Abdolhosseini, Isaac Rahimian Boogar, Siyavash Telepasand,
Volume 22, Issue 6 (February & March 2020)
Abstract
Background and Aim: Physical complaints that have no clear cause are a process that is commonly seen in patients with Somatic Symptom Disorder (SSD). The increasing number of patients with this disorder and its related chronic symptoms including changes in quality of life and loss of individual efficiency has created social and psychological economic costs for these patients and their families.
Methods & Materials: This descriptive cross-sectional study conducted on 70 patients with SSD having digestive symptoms and chronic pain referred to the health centers in Semnan, Iran in winter 2018. They were selected using a convenience sampling method. The data collection tools were 15-item Patient Health Questionnaire Physical Symptoms (PHQ-15) and Rorschach test (Exner’s Comprehensive System). In order to analyze the collected data, multiple linear regression analysis, logistic regression analysis, and multivariate ANOVA were performed in SPSS v. 22 software.
Ethical Considerations: The present study was approved by the Research Ethics Committee of Semnan University of Medical Sciences (code: IR.SEMUMS.REC.1397.029).
Results: Perceived location indices including D and Dd scores in Rorschach test were able to significantly differentiate the SSD patients from controls (P<0.05). In the logistic regression model, 70% of participants were classified properly.
Conclusion: There is difference in projective responses between SSD patients and controls, and patients were less holistic. Anxiety and psychiatric symptoms were also higher in patients with SSD.
Anahita Khodabakhshi-Koolaee, Mohammad Pourebrahimi,
Volume 23, Issue 3 (August & September 2020)
Abstract
Background and Aim: Myasthenia Gravis (MG) is a neuromuscular disorder and auto-immune disease that is associated with symptoms of fluctuating muscle fatigue and dysfunction of the neuromuscular junction system. This disease greatly affects various aspects of the patient's life and impacts the person's perception of the quality of life. The aim of this study was to explain and analyze life experiences with myasthenia gravis disease in a young girl.
Methods & Materials: This report is a qualitative case with interpretive phenomenological approach that examines the life experiences of a young girl with myasthenia gravis in 2019. Data were collected through semi-structured interviews and analyzed using Van Manen's phenomenological approach.
Ethical Considerations: This study was registered in the Research Ethics Committee of Khatam University (Code: 3299/100/P/98).
Results: Thematic analysis indicated that myasthenia gravis disease affects all aspects of person's life world. These four aspects include living and feelings with time, body, space, and others. Eventually, three interrelated themes emerged from the patient's perception of the world around her, including physical weakness, future ambiguity, and frustration.
Conclusion: The present study shows a clear image and understanding of the problems of living with MG in a young girl. The phenomenological world of mixed by physical weakness, ambiguity in the future, and frustration that indicating the suffering and distress that the patient experiences following the illness. The results of this study contribute to the awareness of health and rehabilitation specialists in the field of work and research in myasthenia gravis as a neurological disease.
Leila Dehghan, Hamid Dalvand, Sadegh Samadi, Mohsen Ebrahimi Monfared, Fatemeh Rafiei,
Volume 23, Issue 4 (October & November 2020)
Abstract
Background and Aim: Musculoskeletal disorders are mainly prevalent among college students who experience direct contact with patients. This study aimed to determine the prevalence of musculoskeletal pains among Rehabilitation, Dentistry, and Nursing students at Arak University of Medical Sciences in 2017-2018.
Methods & Materials: In this cross-sectional descriptive study, 538 students of Arak University of Medical Sciences were recruited using the convenience sampling approach. Variables included age, sex, body mass index, study field, hours of using smartphone per day, and nine symptom sites being neck, shoulders, upper back, elbows, low back, wrist/hands, hips/thighs, knees, and ankles/feet. The researchers assessed the musculoskeletal pain by using the Nordic questionnaire and demographic questionnaire. Statistical analysis was performed using SPSS V. 18.
Ethical Considerations: The Research Ethics Committee of Arak University of Medical Sciences approved this study (Code: IR.ARAKMU.REC.1397.253).
Results: In this study, 538 students (205 males and 333 females) were studied with Mean±SD age of 22.04±2.53 years old. The results showed that the prevalence of musculoskeletal pain in the spine (neck 29.4%, upper 24.3%, and lower back 37.2%) was higher than in upper and lower extremities. Musculoskeletal pain in the shoulder, upper, lower back, and thigh were significantly different based on sex. Also, musculoskeletal pain in the neck and ankle, and foot were significantly different based on age (P<0.05). There was a significant difference between musculoskeletal pain of back and ankle based on smartphone use hours per day.
Conclusion: This study suggested that rehabilitation, nursing, and dentistry students are at risk for musculoskeletal pain, especially in the lumbar, cervical, and upper back.
