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Background and Aim: Type 2 diabetes is one of the effective and inhibiting factors in controlling blood glucose and vascular disorders. The aim of this study was to investigate the changes in the gene expression of vascular endothelial growth factor and its type 1 receptor in cardiac tissue of type 2 diabetic rats following three different training methods.
Materials and Methods: In this study, 60 rats were randomly divided into 5 equal groups: healthy control, diabetic control, and diabetic groups with endurance, resistance, and combined exercise training. Type 2 diabetes mellitus was induced by intraperitoneal injection of streptozotocin and exercises were performed 5 sessions per week for 8 weeks. Evaluation of the levels of gene expression of vascular endothelial growth factor and its receptor 1 was performed by RT-qPCR.
Findings: The results showed a significant reduction in the expression of vascular endothelial growth factor in diabetic control, endurance training and resistance training groups, as well as a significant increase in expression of its receptor in diabetic control group and all training groups compared to healthy control group (p <0.001). Comparisons with the diabetic control group showed that in all training groups, the vascular endothelial growth factor gene expression increased, but in the its receptor 1 it was significantly decreased (p <0.001).
Conclusion: The findings suggest that different training exercises are effective in improving angiogenesis, but combined exercises have a certain superiority compared to other exercises.
 

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Background and Aim: Coronavirus Disease 2019 (COVID-19) pandemic has reduced the physical activity of people worldwide. The purpose of this study is to provide a practical guide for performing physical activities at home during the COVID-19 pandemic.
Methods & Materials: The study was conducted by using library method and reviewing the books and articles on home-based physical activity, to provide a scientific basis for performing physical activity at home. In this regard, various physical activities with and without equipment at homes were examined.
Ethical Considerations: This article is a review article with no human or animal sample.
Results: Home-based practical suggestions for staying active and cope with its physical and psychological consequences of the COVID-19 pandemic were reported walking or running on a treadmill, the use of stationary bikes, and body weight resistance exercise, in addition to aerobic exercise.
Conclusion: This proposed physical activity programs can be used during the pandemic at home by people with sedentary lifestyle. 

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Background and Aim: This study aimed to investigate the effect of exercise timing on elevated postprandial glucose and after brief interval exercises in women with obesity.
Methods & Materials: Ten women with obesity (Mean±SD age = 40.41±3.97 years; weight = 86.66±7.26 kg; and BMI = 33.22±2.20 kg/m2) participated in a crossover design exercise intervention: 1) postprandial aerobic exercise, 2) pre-prandial aerobic exercise, 3) brief periodic exercise, and 4) control. Pre- and postprandial exercise included 30 min of moderate-intensity walking on the treadmill before and after each main meal (1 minute of exercise -30 seconds rest). The brief periodic exercise had three one-minute reps of activity every 30 min for 20 times during the day. Twelve-hour continuous glucose monitoring and two-hour postprandial glucose levels were calculated to examine changes in blood glucose levels.
Ethical Considerations: This study was approved by the institutional review board of the University of Isfahan (Ethics Code: IR.UI.REC.1397.119) and conducted in agreement with the ethical principles for biomedical research involving human subjects outlined in the declaration of Helsinki.
Results: The findings of this study suggested that brief periodic exercise resulted in a significant decrease in continuous glucose monitoring levels and postprandial glucose compared to the control group as well as pre-prandial exercise (P˂0.05). However, pre- and postprandial exercise did not result in significant changes in continuous glucose monitoring (P˃0.05). In addition, postprandial exercise led to a significant decrease in postprandial glucose compared to the control group (P˂0.05).
Conclusion: It seems that brief periodic exercise can have more beneficial effects on postprandial glucose levels, probably due to improved glucose metabolism in skeletal muscle.

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Background and Aim: Patellofemoral Pain Syndrome is one of the most common musculoskeletal problems in the elderly that Can affect their daily activity. This study aims to compare the effectiveness of a period strengthening core stabilization exercise with the Knee strengthening exercises on improving pain in female athletes with Patellofemoral Pain Syndrome.
Methods & Materials: In this study, 20 female athletes with Patellofemoral Pain Syndrome participated. They were accidentally divided into two groups: strengthening core stabilization exercise (10 people( and strengthening knee exercise (10 people). A visual analog scale measured patients’ pain before and after eight weeks of practice interventions. Paired t-test and independent t-test were used at the significant level of (P<0.05) to analyze the results.
Ethical Considerations: This study was approved by the Research Ethics Committee of Bu Ali Sina University Hamedan (Code: IR.BASU.REC.1398.032).
Results: The results showed that the pain level in both groups decreased significantly after strengthening core stabilization exercises (P=0.006) and the Knee strengthening exercises (P=0.000). Although intergroup comparison did not show a significant difference in the results (P̀=0.064), the calculation of the effect showed a more significant effect of strengthening knee exercise [ES=1.8) on the improvement of pain compared to the strengthening core stabilization group (ES=0.7).
Conclusion: The results showed that knee strengthening and core stabilization exercises reduced the pain. But due to the higher effectiveness of knee strengthening exercises in improving pain, it is recommended to use this protocol to reduce the pain of these patients.

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Background:  Rotator cuff injuries are one of the most common causes of shoulder pain.
There are different therapeutic approaches in this disease. The evidence of the positive effect of exercise therapy in this pathology is inconclusive. This study aimed to investigate the effect of a complete exercise protocol on improvement of the patients with rotator cuff injuries.
Methods: The patients with shoulder pain received the 12-week exercise protocol in 4 phases if they had confirmed rotator cuff injuries in clinical examination and shoulder MRI. 
Pain was measured by visual analog scale (VAS) and function was measured by two questionnaires; disabilities of the arm, shoulder and hand (DASH) and western Ontario rotator cuff index (WORC). Range of shoulder joint motion (ROM) was measured in five directions by goniometry. All of the outcomes were evaluated before intervention and in 6, 12, 24 weeks after starting the intervention.
Ethic: This study was registered in Iranian Registry of Clinical Trials (IRCT20100718004409N13). A written consent was taken from All participants before the study. 
Results: In this study Twenty-four patients with rotator cuff tendinopathy and tear were analyzed finally in terms of effectiveness of exercise therapy. The average of their age was 51.7 years old. 14 patients (53.8%) with Supraspinatus tendinopathy, 6 patients (23%) with Supraspinatus tear, 3 patients (12.5%) with Supraspinatus plus biceps tendinopathy, and one patient (4.16%) with Subscapularis plus Biceps tendinopathy were assessed. The pain score (Visual Analog Scale) decreased at all fallow-ups specially after 24 weeks (3±0.1) versus before intervention (8±0.1) (P value < 0.001). Shoulder range of motions by goniometer and also the patients function based on WORC and DASH Questionnaires were improved after 24 weeks versus before intervention that was significant statistically and clinically (P value < 0.001). 
Conclusion: A 12- week exercise protocol including strengthening, stretching, PNF and dynamic stabilizer exercises was effective on pain reduction and improvement of function and shoulder joint range of motion improvement in the patients with shoulder rotator cuff tendinopathy and partial tear. The improvement of the variables lasted 6 months.
 

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Background and purpose: Anti-cytokine considerations in covid-19 patients can play a significant role in preventing death, therefore, physical activity by reducing risk factors, as well as saffron with anti-inflammatory and antioxidant properties, are considered as anti-cytokine solutions. Therefore, the purpose of this research is to investigate the effect of saffron supplementation and endurance training on the concentration of interleukin-6, interleukin-10 and cysteine in outpatients with coronavirus.
Materials and methods: The statistical population of this research is outpatients with coronavirus, 36 of whom were randomly selected. Cytokines and cysteine were measured using a special kit and ELISA method. The research hypotheses were checked using SPSS software at a significance level of P<0.05 using ANOVA test with repeated measurements with between-group factor.
Results: The results showed that endurance activity and saffron supplementation caused a significant decrease in IL-6 levels and the ratio of interleukin 6 to interleukin 10 (P≥0.05). Also, endurance activity along with saffron supplementation caused a significant increase in serum L-cysteine concentration (P=0.035). The results showed that there is no interaction effect between the measurement stages and the group, as well as intra-group and inter-group differences in interleukin-10 variables (P=0.511).
Conclusion: The levels of IL-6 and IL-10 decrease due to saffron supplementation and endurance training, and the amount of cysteine increases, which helps the recovery of covid-19 patients.
 

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Abstract
Introduction: Resistance training (RT) is an important part of athletes' preparation exercises with the aim of strengthening physical fitness, creating neuro-muscular adaptations and improving sports performance. The aim of this study was to investigate the effect of resistance training with weight on NCV of tibial and peroneal nerves, muscle strength, agility, flexibility and performance of half-back, half-turn and angel balance skills in seven- to ten-year-old gymnasts.
Methods: In this semi-experimental study, 24 children with two years of experience in gymnastics (age: 8.5±1.5 years, weight: 32.10±9.40 kg, height: 135±13 cm) voluntarily Participated. Subjects were randomly divided into two groups including gymnastics training and gymnastics training + resistance training with weights. And they trained for 10 weeks. During the research, one group did general gymnastics exercises, and the other group did resistance training with weights three times a week in addition to gymnastics exercises. Before and after the exercises, NCV test, Sargent's jump muscle power tests, agility of 9x4m back-and-forth run, Wells' flexibility, and performing half-back, half-turn and balance skills of Angel were performed. Independent t-test was used to analyze the data. And a significance level of P<0.05 was considered.
Results: The results showed that the NCV in the tibial and peroneal nerves increased significantly in the weight resistance training group compared to the general gymnastics training group. Also, muscle strength in Sargent's jump, agility in 4x9m back and forth running, and the performance of half-back and half-turn skills increased significantly (P<0.05). However, no significant change was observed in the flexibility with the Wells test (P=0.870) and execution of Angel's balance skill (P=0.552).
conclusion: 10 weeks of resistance training with weights significantly increases neuromuscular adaptations, NCV, muscle power, agility, and implementation of half-back and half-varus skills in gymnast children. Therefore, it is suggested to use resistance exercises with weights to improve the performance of children athletes in the field of gymnastics and fields where nerve conduction speed, muscle power and agility are effective in the success of athletes.

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Introduction: The thickness of the molecular and pyramidal layers in the hippocampus represents a pivotal aspect of Alzheimer's research. This study was conducted to investigate the effect of swimming endurance, resistance, and combined exercises on the molecular and pyramidal layers of the hippocampus tissue thickness of Alzheimer's rats.
Methods: In this experimental study, 40 large white Wistar laboratory rats (6 weeks old; Weight 180-200 g) were randomly and equally divided into five groups: healthy control, Alzheimer's control, endurance, resistance, and combined. Alzheimer's disease was induced by intraperitoneal injection of trimethyltin chloride (8 mg/kg). Two weeks after the injection and confirmation of Alzheimer's induction, the training protocols of endurance (5-sessions/week, the first to the fourth week incrementally from 5-15-min to 45-min of swimming, the fifth to the twelfth week 60-min of swimming), resistance (5-sessions/week, The first week of familiarization with the exercise, week 2; 30%, week3-5; 70-90%, week6-8; 100-110%, week9-10; 120-130%, and week11-12; 140-150% of body weight), combined (2 resistance sessions/week and three endurance sessions/week) was performed for 12 weeks. Forty-eight hours post-intervention, animals were dissected, and hippocampus tissue was harvested. Finally, the data were analyzed at the significance level of P < 0.05.
Results: The thickness of the molecular and pyramidal layers of the hippocampal tissue of Alzheimer's animals decreased compared to healthy animals, and all three endurance, resistance, and combined exercise protocols increased layers (P < 0.001). However, the increase in the molecular and pyramidal layers thickness of the hippocampal tissue of combined group rats compared to the endurance and resistance group had a greater increase (P < 0.01).
Conclusions: These findings highlight the changes in the thickness of the hippocampal tissue layers concerning Alzheimer's pathology and the effect of combined exercises on this parameter. While exercise may have positively affected hippocampal volume and synaptic plasticity, more research is needed to fully understand the impact of exercise on hippocampal layer thickness in Alzheimer's.

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Introduction: Exercise and physical activity have always been recommended as a core treatment for knee osteoarthritis. However, it is unclear which types of exercises have the most splendid effect on this condition. This study aimed to evaluate the impact of two methods of water exercise (Traband exercise and NASM exercise) on pain and motor function in women with knee osteoarthritis.
Methods: In this semi-experimental study, with a design pre and post-test and a control group, 45 women with knee osteoarthritis with an average age = 56.5 years and a BMI = 29.04 kg/m2 were purposefully selected and divided into three groups (n = 15); Water Exercise with Theraband, Water Exercise with the NASM Approach and Control randomly. An exercise protocol with Theraband and NASM approach (approved by the Medical College of Georgia for patients with knee osteoarthritis) was performed for eight weeks, three sessions per week, and each session lasted about 60 minutes in the water. Visual Analog Scale (VAS) and physical performance tests of the Osteoarthritis Research Society International (OARSI) were used to estimate the study variables. MANCOVA and post hoc Bonferroni tests were conducted to analyze the data at a significant level (P ≤ 0.05).
Results: The results showed that, similarly, in both experimental groups, the amount of pain and the time of tests TUG, 40MW, and SCT decreased significantly (P≥  0.05). In addition, in both experimental groups, there was a significant increase in the scores of the 30-S-CS and 6MWT tests (P≥  0.05).
Conclusions: These results showed the beneficial effects of training in water with the traband and training in water with the NASM approach on pain and motor performance indicators. Therefore, the use of these training methods is recommended as a suitable prevention and treatment method for knee osteoarthritis.

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Introduction: Different training methods increase performance capabilities in addition to metabolic changes in body organs. The present study aimed to compare the effect of endurance and strength training on anthropometric indicators, glucose changes, fat metabolism, and irisin levels of young male students.
Methods: Thirty-six obese students (age: 21.19 ± 2.43 years; weight: 88.59 ± 6.20 kg; height: 175.41 ± 12.96 cm; body mass index: 30.45; fat percentage: 25.73%) were randomly placed in one of control, endurance, and strength training groups (n= 12). The strength training group trained for 8 week/3 session/4 sets/10 repetitions/ from 50 to 70% of the one repetition maximum (incremental manner, every 2 weeks), and the endurance training group trained for 30 minutes of aerobic jogging with 60 to 80% heart rate maximum. Plasma irisin, glucose, insulin, insulin resistance, fat percentage, body mass index, weight, waist circumference, and hip circumference were measured. The data were analyzed by one-way analysis of variance and Tukey's test at 0.05.
Results: Body weight (P = 0.03), fat percentage (P = 0.04), and body mass index (P = 0.04) significantly decreased in the post-test of endurance training group. Irisin level in the post-test in the control group had a significant difference with endurance and strength training (P = 0.01 and P = 0.02, respectively). Insulin in the post-test of the control group was significantly different from the endurance and strength group (P = 0.00 and P = 0.00, respectively). The level of insulin resistance in the post-test of the endurance and strength group had a significant difference compared to the control (P = 0.00 and P = 0.00, respectively).
Conclusions: Eight weeks of aerobic treadmill training and strength training with free weights can improve body composition, increase irisin levels, and reduce insulin resistance in obese male adolescents.