Showing 30 results for Multiple Sclerosis
Esmail Asadpour, Saeed Veisi,
Volume 20, Issue 7 (10-2017)
Abstract
Abstract
Background: The aim of this study was to investigate the effectiveness of emotionally focused couple therapy on sexual self-esteem and sexual function in women with multiple sclerosis in the city of Tehran.
Materials and Methods: This was a quasi experimental study with pretest-posttest, a month follow-up and control group. The statistical population included women with multiple sclerosis in the city of Tehran. 30 patients with the age range of 20-50 years old were chosen as samples and randomly were divided in 2 groups of individuals as control and emotionally focused therapy. The experimental groups practiced the emotionally focused therapy for a month, 9 step and 60 minutes in each session. Then, post-test was performed for them. For data collecting, the sexual self-esteem and sexual function questionnaires were used. Data analysis was done by using multivariate analysis of covariance by SPSS 23 software at a significant level less than 0.05.
Results: Statistical data analysis illustrated that the amounts of sexual self-esteem of life after emotionally focused couple therapy intervention were significantly increased in experimental than control group (p<0.05). Also, of emotionally focused therapy was significant increase on sexual function of women with multiple sclerosis (p<0.05).
Conclusion: According to the findings of this study, emotionally focused couple therapy has affected on sexual self-esteem and sexual function in women with multiple sclerosis Thus, emotionally focused couple therapy can be a good approach to improve the sexual problems in women with multiple sclerosis.
Abbas Alimoradian, Mohsen Shamsi, Fardin Faraji, Mehdi Ahmadi, Sayyed Ebrahim Sayyedi,
Volume 21, Issue 2 (5-2018)
Abstract
Abstract
Background: Multiple sclerosis (MS) is a myelinating inflammation and an impairment of neuronal cell regeneration in the central nervous system with unknown causes. The aim of this study was to evaluate serum melatonin levels in the treatment of patients with multiple sclerosis.
Materials and Methods: A prospective study and a Cohort were conducted on 40 MS patients with multiple sclerosis patients referring to instituate MS in Arak city for one year. In this study, patients who were treated with interferon-moderating drugs and who had not been treated for more than one year were randomly selected. A questionnaire containing demographic information and clinical information and separation of interacting factors was completed and completed. Clinical information included MRI, VEP, EDSS (Expanded Disability Status Scale) score, and clinical symptoms. The patients also received peripheral blood samplers 3 times in 6 months intervals to measure melatonin and their melatonin levels, and then the relationship between the data obtained from the patient's clinical data, EDSS, serum melatonin levels using the software SPSS with ANOVA and Post-hoc statistical analyzed.
Results: In patients with MS, in spite of receiving drug treatment, the level of melatonin as an antioxidant decreased in second order sampling, which is consistent with the deterioration of the patient's clinical condition (EDSS test), and this is not observed in the control group.
Conclusion: According to the findings of this study, it can be argued that the level of melatonin is a measurable objective and measurable variable (with the help of ELISA) that can be used in the follow-up of these patients, along with clinical evaluations and questionnaires.
Farshid Farzin, Masoud Golpayegani, Fardin Faraji, Shahnaz Shahrjerdi, Parastoo Ghasemi,
Volume 21, Issue 2 (5-2018)
Abstract
Background: Multiple sclerosis (MS) is caused by thedestruction of myelin in central nervous system which leads to functional disabilities. Balancing problems are the most common dysfunctions and dizziness is known as its first sign in these patients.This study aimed to assessthe effects of vestibular rehabilitation by Cawthorne & Cooksey exercises on balance and the following disabilities caused by dizziness in patients with MS.
Materials and Methods: This study was a semi-experimental research with pre-test and post-test. Subjects of this study were 30 women with Multiple sclerosis regardless of the type of MS and dizziness that were divided into control and experimental groups. Experimental group performed the exercise protocol for a 12 week period and 3 times per day for 5-15 minutes. Berg balance scale (BBS) was used to access the balance and (Dizziness Handicap Inventory) DHI questionnaire was used to accessing the dizziness before and after intervention.
Results: The results showed that, after finishing exercise protocol, in experimental group there was a significant difference in patient with MS, whereas there was no significant difference between pre and post-test in control group.
Conclusion: Cawthorne & Cooksey exercises as a non-invasive method can be an effective therapy to improving the balance and disability caused by dizziness in patients with MS.
Javad Nakhzari Khodakheir, Amir Hossein Haghighi, Mohammad Reza Hamedinia,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: Physical activity and exercise are as the methods stimulating the secretion of nerve growth factors in MS patients. Therefore, the purpose of this study was to investigate the effects of combined exercise training with aerobic dominant and supplementation of coenzyme Q10 on serum BDNF and NGF levels in patients with multiple sclerosis.
Materials and Methods: In the semi-experimental research, twenty-eight MS patients (EDSS=3-5) were selected by using available sampling method and randomly divided into three experimental groups (combined exercise training + Q10 supplementation, combined exercise training + placebo, and Q10 supplementation) and one control group. two experimental groups performed a combined exercise program include two sessions of aerobic training and one session of resistance training three sessions per week for eight weeks. 200 mg of Q10 supplement was prescribed per day. Blood samples (after 10 hours fasting) were collected 24 hours before the first and 24 hours after the last session of exercise for evaluation of serum levels of BDNF and NGF. Data were analyzed with analysis of covariance at a significance level of p<0.05.
Findings: The results showed no significant changes in serum levels of BDNF and NGF in the three experimental groups compared to the control group (p≥0.05).
Conclusion: Combined exercise training with coenzyme Q10 supplementation cannot lead to changes in serum concentration of nerve growth factors (BDNF, NGF) in patients with MS. Therefore, it is necessary to change the duration and severity of this type of training as well as dose of Q10 supplementation.
Farzaneh Fuladi Targhi, Fardin Faraji, Ali Akbar Maleki Rad, Keyvan Ghassami, Afsoon Talaei,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Multiple Sclerosis is (MS) is a common demyelinating disease of CNS that inflammation and stress oxidative processes have an important role in clinical courses and progression of it. The aim of the present study was to determine the anti-inflammatory effects of Melatonin on fatigue in MS.
Materials and Methods: In a double-blind clinical trials study, 62 patients with relapsing remitting MS were randomized to oral Melatonin 3 mg or placebo daily for 8 weeks. Scale of Fatigue in MS was studied by assessing FSS (Fatigue Severity Scale) on weeks 1 and 8.
Findings: 47 patients in intervention group and 15 patients in placebo group completed the study. In intervention group, treatment with Melatonin produced a significant decrease in FSS vs placebo group (before intervention: the average of FSS in patient group was 32.04±13.97 and in control group was 35.86±15.44; after intervention: the average of FSS in patient group was 30.42±12.40 and in control group was 41±12.66). Although in control group, the average of FSS was 35.866 and it was 41 after intervention. Because the score of placebo patient is near or upper than 36, this study suggested that Melatonin has a significant effect on improving and decreasing fatigue in MS.
Conclusion: The use of melatonin alongside of First-line drugs such as mitoxantrone, IFN – B or glatimer acetate can improve fatigue and disability in patient with MS.
Nima Sanadgol, Parisa Maleki,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Ellagic acid (EA) is a natural antioxidant with phenolic structure. In this study, we evaluate the effects of EA consumption on population and activation of neuroglia cells in the animal model of MS under oxidative stress.
Materials and Methods: Mature male mice with age of between 8 to 9 weeks were kept in the standard conditions. For model induction, animals received powder normal diet containing 0.2% Cuprizone (Cup) for six weeks. Mice were divided into eight groups containing control, control receiving three doses of EA (20, 40 and 80 mg/kg), Cup and Cup receiving three doses of EA. Finally, specific glial cell markers in the animal brain tissues were analyzed by molecular methods such as immunohistochemistry (IHC), western blotting (WB) and Real Time-PCR (RT-PCR).
Findings: IHC and WB analysis have shown that only high concentration of EA is able to reduce protein expression of GFAP (activated astrocytes marker), Mac-3 (activated microglial marker), increase protein expression of Olig-2 (oligodendrocytes precursor marker) and ultimately significant reduction on APC (mature oligodendrocytes marker)/Olig-2 ratio in comparison with Cup group. In addition, RT-PCR evaluation indicated that changes in the mRNA expression of target markers were consistent with observed changes in their protein expression and therefore, IHC and WB results were confirmed.
Conclusion: Consumption of 80 mg/kg of EA effectively decreased activation of astrocytes and microglial and so appropriates environment for migration of oligodendrocyte precursor cells to the lesion area and shifting from damage course into the repair progressions.
Nima Sanadgol , Mohammad Sharifzadeh , Parisa Maleki ,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: Regarding the importance of new treatments to control and treat multiple sclerosis (MS), in this study we investigated the role of Benzoaric acid (BA) on the neuro-inflammation and apoptosis processes in the cuprizone (cup)-induced animal model of MS.
Materials and Methods: In this experimental study, 35 males C57BL/6 mice were divided into five groups. The study groups were included, control: received six weeks of normal powdered food beside intraperitoneal (i.p.) injection of BA solvent (100 µL per day PBS) for the last two weeks, cup: received six weeks of powdered food contains 0.2% cup beside i.p. injection of BA solvent for the last two weeks and cup-treatment: received six weeks of powdered food contains 0.2% cup beside i.p. injection of 20, 40 and 80 mg/kg BA for the last two weeks. Eventually, the medial corpus callosum area of the animal’s brain was evaluated via western blot and Real-Time PCR methods.
Ethical Considerations: Ethical points were observed according to the declaration of Helsinki and relevant code of ethics, regarding minimizing harms during animal experimentation (UOZ-GR-9517-13).
Findings: Molecular studies have shown that BA-80 decreased mRNA (p <0.01) and protein expression of NF-KB and consequently increased I-KB/NF-KB ratio (p <0.05) and decreased inflammation in compare to cup group. Moreover, BA-80 decreased caspase-9 mRNA (p<0.01) and caspase-8 mRNA (p <0.05) and subsequently increased caspase-8/caspase-9 ratio (p<0.01) and decreased apoptosis in compare to cup group.
Conclusion: The dose of 80 mg/ml BA via decreasing cup-induced neuro-inflammation and neuro-apoptosis has protective effects in this model.
Narges Ensan, Isaac Rahimian Boogar, Siavash Talepasand, Fariborz Estilaee,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim Multiple Sclerosis (MS) is an unpredictable disease that can change individuals' lifestyle. The purpose of this study was to investigate the effect of a Mindfulness-Based Stress Reduction (MBSR) program on functional disability of patients with MS.
Methods & Materials The is an experimental study with pre-test/post-test/follow up design using control group. The study population consisted of all male and female patients with MS living in Neyshabur county, Iran. Of these, 47 were selected using a convenience sampling technique and randomly assigned into two groups of intervention (n=22) and control (n=25). The intervention group received MBSR therapy for 8 sessions, while the control group received no intervention. The follow-up was performed after one month. Subjects’ functional disability was measured by using the World Health Organization Disability Assessment questionnaire. The collected data were analyzed using SPSS v.21 software usingrepeated measurements Analysis of Variance (ANOVA).
Ethical Considerations This study obtained its ethical approval from the Research Ethics Committee of Neyshabur University of Medical Sciences (code: IR. NUMS.REC.1397.004)
Results The results of univariate ANOVA showed the significant effect of time and the interaction effect of time and group on functional disability of samples. The results of between-group ANOVA a significant difference between the intervention and control groups in functional disability (p <0.05). Pairwise comparison of the interaction effect of time and group showed a significant difference between the pre-test, post-test and follow-up scores (P = 0.001), but no significant difference was reported between the post-test and follow-up scores.
Conclusion The MBSR program could reduce the functional disability in patients with MS due to ease of treatment, faster patient education, and the short duration of intervention sessions.
Negar Tagipor, Ali Zeinali,
Volume 25, Issue 4 (9-2022)
Abstract
Introduction: Sleep quality is one of the effective variables in other psychological characteristics, especially in multiple sclerosis patients. As a result, the present study was conducted with the aim of determine the role of interpersonal problems and illness perception in predicting sleep quality with mediating distress tolerance in multiple sclerosis patients.
Methods: This was a cross-sectional correlational study. The research population was all patients who were members of the Multiple Sclerosis Association of Urmia township in the first quarter of 2021 year. The sample size was estimated 315 people who were selected by available sampling method. The research data were collected by Barkham et all short version of interpersonal problems inventory (1996), Broadbent et all brief illness perception questionnaire (2006), Buysse et all Pittsburgh sleep quality index (1989) and Simons & Gaher distress tolerance scale (2005) and were analyzed by Pearson correlation coefficients and path analysis methods in SPSS-19 and PLS-3 software. This research with the IR.IAU.URMIA.REC.1400.022 ethics code is approved by the ethics committee in biomedical research of Islamic Azad University of Urmia branch.
Results: The results showed that the increase of interpersonal problems and negative perception of illness led to decrease the distress tolerance and loss of sleep quality and an increase of distress tolerance improved sleep quality. In addition, the decrease of interpersonal problems and negative perception of illness with mediating distress tolerance led to improved sleep quality (P<0.01).
Conclusions: According to the results, to improve the sleep quality of multiple sclerosis patients can be increased the rate of their interpersonal problems and illness perception and decreased their distress tolerance.
Hadis Tahmasbi Arashloopour, Daryoush Khajavi, Fardin Faraji,
Volume 28, Issue 2 (4-2025)
Abstract
Introduction: Multiple sclerosis (MS) is the most common neurological disorder in young adults and balance problems due to MS may result in disturbances in upright posture, limitations in walking and turning, and ultimately falls in patients. The aim of this study was to investigate the effects of a combined physical exercises and cognitive-behavioral stress management intervention program on static, dynamic balance and balance confidence in PwMS.
Methods: The statistical population included MS patients (aged 20–60 years with Expanded Disability Status Scale [EDSS] scores of 2–4) referred to the Arak MS Association. Thirty participants were selected via convenience sampling and randomly assigned to experimental and control groups. Participants underwent pretests using the Timed Up and Go (TUG) test, single-leg stance test, and the Activities-Specific Balance Confidence (ABC) Scale. Then, they participated in the combined motor and cognitive intervention program, and finally performed a post – test. Data were analyzed by Independent and Paired Student T-tests.
Results: According to the results, the mean score of the experimental group in the TUG test (P ≤ 0.002), and standing on one-foot tests increased significantly in the post-test (P ≤ 0.001). There were no significant differences in mean ABC scores between the experimental and control groups on the post-test (P ≤ 0.153).
Conclusions: The findings suggest that a combined motor and cognitive intervention program can effectively improve agility, dynamic and static balance in people with MS. Improving balance confidence may require a longer duration of training due to its subjective nature.
