Ms Shiva Molavi, Mr Mohammad Parastesh, Mr Abbas Saremi, Mr Mohammad Reza Bayatiyani,
Volume 25, Issue 6 (February & March 2023)
Abstract
Introduction: In recent years, the use of X-rays in medicine and industry has expanded significantly. X-rays can cause oxidative stress and subsequently induce destructive effects on the kidneys. On the other hand, it has been proven that according to the theory of hormesis, resistance exercises have antioxidant effects, which may be used to reduce the harmful effects of X-rays. This study investigated the effect of resistance training on oxidative stress factors and structural changes in kidney tissue in rats exposed to X-rays
Methods: Twenty-four male rats were randomly divided into 4 groups. The irradiated groups were exposed to 4Gy X-ray. The training groups were exercised 5 times per week for 10 weeks. 24 hours after the last training session, blood samples were collected for evaluation of oxidative and antioxidant factors, and kidney tissue was isolated for stereological studies. The data was analyzed by one-way ANOVA in SPSS 20 software.
Results: In this study, whole-body X-ray irradiation caused a significant increase in kidney volume (P=0.003), cortex volume (P=0.02), glomerular volume (P=0.039), and serum Malondialdehyde (MDA) level (P=0.03). Also, performing the training protocol significantly reduced kidney volume (P=0.03), cortex volume (P=0.04), glomerular volume (P=0.033), and serum MDA level (P=0.02).
Conclusions: Based on this research, it seems that resistance training can lead to a decrease in glomerular filtration by creating adaptation and increasing antioxidant defense and changes in the hemodynamics of the kidneys, and as a result, reducing the volume and number of glomeruli, reducing the volume of the cortex and kidney, and it can improve the structure of kidney tissue in rats exposed to X-ray radiation.
Mohammad Parastesh, Zahra Yousefvand, Behzad Aria, Majid Mardaniyan Ghahfarrokh, Jamileh Ahmadi,
Volume 28, Issue 3 (8-2025)
Abstract
Introduction: Cisplatin, a widely used chemotherapy agent, offers therapeutic benefits for cancer treatment but often leads to adverse effects on neurogenesis and oxidative stress. On the other hand, physical activity has been proposed as a potential strategy to counteract these side effects. Therefore, the aim of the present study was to investigate the effect of an endurance training period on oxidative stress markers in the brain tissue of rats induced with cisplatin.
Methods: In this study, 32 male rats with an average weight of 220 grams were divided into four groups: healthy control, cisplatin-injected control, endurance training, and cisplatin + endurance training. After 8 weeks of endurance training, the rats were dissected, and blood serum was separated to measure oxidant and antioxidant factors. Additionally, the brain was removed under sterile conditions for the examination of the desired markers. Data were analyzed using one-way ANOVA.
Results: The results showed that cisplatin significantly decreased MDA and significantly increased TAC and CAT in the cisplatin-receiving control group. On the other hand, 8 weeks of endurance training significantly decreased MDA and significantly increased TAC and CAT. Moreover, no significant change was observed in serum SOD levels. In brain tissue, MDA levels significantly increased, and TAC, CAT, and SOD levels significantly decreased in the cisplatin-receiving group. Conversely, 8 weeks of endurance training reduced MDA levels and increased TAC, CAT, and SOD levels.
Conclusions: Based on the findings of the present study, it appears that physical exercise has protective effects against cisplatin-induced oxidative stress in the brain, which may be attributed to its antioxidant capabilities
