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Showing 109 results for درما

Jamal Ashoori,
Volume 18, Issue 2 (5-2015)
Abstract

Background: Meta-cognitive therapy and schema therapy are two important methods in treatment of mental disorders special in treatment of anxiety and depression. This study aimed to compare the effectiveness of meta-cognitive therapy and schema therapy on decrease symptoms of anxiety and depression in nursing and midwifery students.

Materials and Methods: This study was a quasi-experimental with a pre-test, post-test and 2 mounts follow-up design. The statistical population included all girl students of nursing and midwifery faculty that referred to counseling center of Islamic Azad University of Mashhad. Totally 60 students with anxiety and depression were selected through available sampling method and randomly assigned to three groups. The experimental groups educated 10 sessions of 70 minutes by meta-cognitive therapy and schema therapy methods. All groups completed the questionnaire of Cattell anxiety and Beck depression.The data were analyzed by using the SPSS-19 software and by multivariate analysis of covariance (MANCOVA) method.

Results: The findings showed in the post-test, schema therapy unlike meta-cognitive therapy significantly led to decrease symptoms of anxiety and depression. But in the follow-up state each two methods of meta-cognitive therapy and schema therapy significantly led to decrease symptoms of anxiety and depression and in the follow-up state, there wasn't any significant difference between two methods (p<0.05).

Conclusion: The results showed though the effect of schema therapy appears earlier than meta-cognitive therapy, but there is no significant difference between two treatments in long time Therefore, counselors and therapists can use meta-cognitive therapy and schema therapy for decreasing symptoms of anxiety and depression disorder.


Zahra Karimi, Ahmad Alipor, Tayebe Mohtashami,
Volume 18, Issue 3 (6-2015)
Abstract

Background: Premenstrual Syndrome (PMS) consists of repetitious physical and psychological symptoms that occurs in luteal phase of menstrual period and will be over when menstrual period starts. The goal of this study is to investigate the effect of calcium therapy plus vitamin D and cognitive behavioral therapy (CBT) on the parameters of PMS symptoms in women suffering from PMS.

Materials and Methods: This study has an experimental plan of pretest and post-test of the control group. The statistical society is 250 female staff of Tehran Universities in academic year 2013-2014. Premenstrual syndrome screening tool (PSST) questionnaire was used as an evaluation tool. The collected data were analyzed using the indexes of the descriptive statistics and covariance analysis (p<0.05).

Results: The minimum age of the statistical society was 24, 52.5 % of them held a master's degree and 60% were single. Cognitive behavioral therapy method, calcium and vitamin D therapy were significant in improving the parameters of symptoms at p<0.05 level of significance.

Conclusion: Combining cognitive behavioral therapy and calcium supplementation and vitamin D is significantly effective in improving components of PMS sympotoms and applying these methods is recommended by the consultants and gynecologists.


Mojtaba Hashemi, Javad Javaheri, Marjan Habibi, Parsa Yousefi Chaijan, Mahdyieh Naziri,
Volume 18, Issue 6 (9-2015)
Abstract

  Background: The prevalence of constipation in childhood is 0.7% to 29.6%. Inorganic causes are considered as the most common cause of constipation in children. Polyethylene glycol (PEG) is the most effective and safest laxatives which is usable in children in the long-term. This study was conducted to evaluate and compare the effect of PEG treatment and probiotic bacilluscoagulans and bifidobacterium and probiotic to enhance the growth of probiotics.

  Materials and Methods: In this double blind clinical trial study(interventional study), 120 children aged 2-16 years with chronic functional constipation enrolled the study based on ROME III criteria. The bowels became empty by using liquid paraffin. Then, children were randomly divided into three groups of polyethylene glycol+placebo and Probiotics+placebo and polyethylene glycol+probiotics recipients. After 6 weeks of treatment, treatment success rates between the three groups were compared before and after the study Data analyzed by SPSS 20 software.

  Results: The results of the study conducted on the three groups for treatment of constipation showed that the effect of polyethylene glycol and probiotic on treatment was considerable before and after treatment but the levels of effect was similar in the comparison of groups. The simultaneous use of two drugs was more effective than a single drug.

Conclusion: Overall, the results of our study showed that concurrent use of polyethylene glycol and probiotics is much more effective in the treatment of constipation.


Maryam Kazemipoor, Afrooz Hajighasemi, Sanam Mirbeigi,
Volume 18, Issue 6 (9-2015)
Abstract

  Background: Mandibular premolars, because of high anatomic variations, are among the most difficult teeth for root canal treatment.The aim of this study is to compare and evaluate root canal morphology of mandibular first premolars between males and famales in an Iranian population applying CBCT imaging.

  Materials and Methods: In this analytical-cross sectional study, 230 CBCT imaging belonged to 115 males and 115 females were evaluated in this study. Images were assessed in the three spatial planes and the difference in the number of canals and roots were compared and reported statistically. Data were analyzed using SPSS 17 software and Chi-square test.The significance level was set as p<0.05.

  Results: In total, of 460 mandibular first premolars, 85.7% had one root, 14.3% had two roots, 63.9% had one canal and 36/1% had two canals. In comparison between two genders, in the males the prevalence of one root was 78.7%, two roots 21.3%, one canal 60% and two canals 40%. In the females, the prevalence of one root was recorded as 92.6%, two roots 7.4%, one canal 67.8% and two canals 32.2%.

Conclusion: According to the results of this study the number of roots in the mandibular first premolars in males was statistically more than in females.


Narges Zamani, Mehran Farhadi, Hamidreza Jamilian, Mojtaba Habibi,
Volume 18, Issue 8 (11-2015)
Abstract

Background: The purpose of this study was to determine the effectiveness of dialectical behavior therapy in reducinng expulsive anger.

Materials and Methods: This is a pre-test and post-test semi-experimental study with control group. The study population included 32 patients with expulsive anger that reffered to Amir kabir remedial education center based on psychiatrist diagnosis and were randomely divided into case (dialectical behavior therapy) and control group. The case group was educated the dialectical behavior therapy skills for 16 sessions from 2 until 2.5 hours at teamly. To collect data, the patients filled Eysenk expulsive questionnaire before and after intervention. Considering no necessary assumptions were fulfilled to conduct the multivariate analysis of covariance and variance, so, the univariate analysis of variance was used.

Results: The results of variance analysis proved that dialectical behavior therapy significantly reduced expulsive angers.

Conclusion: With due attention to the results, it can be said that dialectical behavior therapy leads to reducing expulsive angers in treated patients, thus, this method can be included in interventional programs for target groups in psychotherapy centers. Aslo, it helps to improve the life of patients by reducing expulsive angers.


Marzieh Sadat Sajjadinezhad, Karim Asgari, Hosein Molavi, Peyman Adibi,
Volume 18, Issue 10 (1-2016)
Abstract

Background: Recently it is accentuated on the role of psychological symptoms in the course of chronic diseases and applying psychological interventions as complementary interventions. The aim of this study was to compare the effects of cognitive-behavioral stress management, optimism training and conevntional medical therapy on somatic symptoms, perceived stress, illness perception and quality of life in patients with ulcerative colitis.

Materials and Methods: In this study, thirty female patients were selected accidentally, and randomly assigned into three groups including cognitive-behavioral stress management(n=10), optimism training(n=10) and conventional medical therapy(n=10). All patients completed Perceived Stress Scale, Illness Perception questionnaire, WHO Quality of Life questionnaire, and Lichtiger Colitis Activity Index. Then, experimental groups participated in 9 sessions of  cognitive-behavioral stress management and optimism training group interventions. Thereafter, three groups answered to scales again. This course was repeated in a 6-mounth follow-up. Analysis of covariance (ANCOVA) was used to analyze the data.

Results:  The findings indicated that the effects of two interventions were significant on patient´s illness perception, perceived stress and quality of life however, these interventions did not change somatic symptoms.

Conclusion: Totally, it can be said that psychological interventions such as stress management and optimism training can be effective on improving the psychological symptoms in patients with ulcerative colitis and their cure.


Parsa Zargar, Esmaeel Ghani, Farideh Jalali Mashayekhi, Ebrahim Eftekhar,
Volume 19, Issue 3 (6-2016)
Abstract

Background: A small percent of patients with colorectal cancer (CRC) respond to 5-Fluorouracil (5-FU), as a first line of chemotherapy. In this study in, in order to design a new chemotherapy protocol, the effect of 5-FU and acriflavine (ACF) cotreatment on mortality rate of CRC cell lines was investigated.

Materials and Methods: Cytotoxicity of 5-FU and ACF against CRC cell lines (LS174T, SW480 and HCT116) was detected using MTT assay. Cells were treated with different concentrations of 5-FU (0.5-64 µM) or ACF (0.07-5 µM) for 72 hours and then cell viability and drugs IC50 was calculated. To assess the effect of ACF on anticancer activity of 5-FU, cells were cotreated with different concentrations of 5-FU and IC30 concentration of ACF.

Results: ACF and 5-FU suppress the viability of CRC cell lines in dose-dependent manner. 5-FU and ACF have most cytotoxic effect on LS174T and the lowest cytotoxic effect on SW480 cells. Cotreatment of ACF with 5-FU could not significantly change the sensitivity of cells against 5-FU (p>0.05).

Conclusion: In this study, the fatal and cytotoxic effect of ACF on three CRC cell lines was shown. However, cotreatment of ACF with 5-FU could not improve the anticancer activity of 5-FU.


Alireza Zarinara, Mohammad Mahdi Akhondi, Hojjat Zeraati, Koorosh Kamali, Kazem Mohammad,
Volume 19, Issue 6 (9-2016)
Abstract

Background: The prediction models for infertility treatment success have presented since 25 years ago. There are scientific principles for designing and applying the prediction models that is also used to predict the success rate of infertility treatment. The purpose of this study is to provide basic principles for designing the model to predic infertility treatment success.

Materials and Methods: In this paper, the principles for developing predictive models are explained and then the design of such models in infertility treatments is described in more details by explaining one sample.

Results: The important principles for models that firstly are described are: identifying and defining the purpose, expected function of model, input data that will be used to develop a model: type of intervention or diagnostic procedures that can lead to changes in the samples and output definition or expected result of model function. Further, characteristics of predictive factors in final model, drawing the information flowchart, internal and external validation and attention to the analysis programme of results are the important subjects that have been described.

Conclusion: If predictive models are used properly, can help treatment team and patients to achive best treatment in ART.


Hadis Alsadat Adl, Abdollah Shafi`abadi, Zabih Pirani,
Volume 19, Issue 10 (1-2017)
Abstract

Abstract

Background: Infertility is described as a loss that this event is serious tension in life and it makes extreme trauma on couples. This research aimed to investigate the effect of group psychotherapy based on life quality on marriage intimacy of infertile women.

Materials and Methods: This research method was in semi-test methodology with pre-test, post- test and follow-up test plan with control group and statistical sample was 32 persons (16 persons in test group and 16 persons in control group) that they were chosen in available sampling mode from Royan center in Arak and both two groups were peer in research standards. Test group received training for 5 sessions in 90 minute. For collecting data, Bagarozzi marital intimacy questionnaire was used. Data were analyzed by analysis of covariance by using SPSS software.

Results: Results showed that life quality training affected significantly on marriage intimacy of infertile women and improved it. Significant difference between pre-test, post-test and follow-up average scores of test and control groups showed effectiveness of life quality training on infertile women ( p=0.003<0.05 ,f=27.57).

Conclusion: The research showed that group therapy of life quality plan affected on marital intimacy and improved it. Therefore, it is recommended as a supplement.


Ehsan Bakhshi, Reza Kalantari, Nooshin Salimi,
Volume 20, Issue 2 (5-2017)
Abstract

Abstract

Background: Evaluation of performance is one of the hardest aspects of management responsibilities. Today, performance evaluation process is a characteristic of work world that can be useful in making workforce more effective. This study aimed to assess the job performance and its determinants in healthcare workers.

Materials and Methods: This cross sectional and descriptive –analytical study conducted in capitation way on all workers in healthcare centers and health houses of Islamabad-e Gharb city in 2016. Data collection tools were questionnaires of demographics and job performance of Hersey and Goldsmith. Descriptive statistics, one way ANOVA and Independent sample T-test used in order to data analysis.

Results: The mean and standard deviation of job performance score was 52.5± 9. There was a significant relationship between job performance with sex and education level (p<0.05). Also, there were significant relationships between feedback and environment with sex, and support aspect with type of employment (p<0.05).

Conclusion: Success and progress of each organization is based on high levels of job performance in its employees. Solutions such increasing salary and providing good physical environment, can be useful to improve job performance of employees.


Mostafa Jani, Bahman Salehi, Seyed Ali Aleyasin, Hossein Davoudi,
Volume 20, Issue 3 (6-2017)
Abstract

Abstract

Background: The aim of this study was to determine the effectiveness of cognitive-behavioral group therapy on quality of life of patients with cardiovascalar diseases.

Materials and Methods: This semi-experimental study was done based on a pretest -posttest design with control group. Statistical population included all of the patients with cardiovascular diseases referred to Amir-Kabir educational and medical center of Arak, and sample included 30 persons who selected by screening and simple random sampling and assigned into two control and experimental groups. Research instrument included Mcnew quality of life scales which participants answered it during two pre-test and post-test steps; also, experimental group participated in 9 cognitive-behavioral therapy meetings.

Results: There was a significant difference between mean quality of life and its components in both experimental and control groups.

Conclusion: Results analysis showed that group-based cognition- behavior theray has an influence on life quality (emotional, physical and social domains)(p>0.05).


Esmail Asadpour, Saeed Veisi,
Volume 20, Issue 7 (10-2017)
Abstract

Abstract
 Background: The aim of this study was to investigate the effectiveness of emotionally focused couple therapy on sexual self-esteem and sexual function in women with multiple sclerosis in the city of Tehran.
 Materials and Methods: This was a quasi experimental study with pretest-posttest, a month follow-up and control group. The statistical population included women with multiple sclerosis in the city of Tehran. 30 patients with the age range of 20-50 years old were chosen as samples and randomly were divided in 2 groups of individuals as control and emotionally focused therapy. The experimental groups practiced the emotionally focused therapy for a month, 9 step and 60 minutes in each session. Then, post-test was performed for them. For data collecting, the sexual self-esteem and sexual function questionnaires were used. Data analysis was done by using multivariate analysis of covariance by SPSS 23 software at a significant level less than 0.05.
 Results: Statistical data analysis illustrated that the amounts of sexual self-esteem of life after emotionally focused couple therapy intervention were significantly increased in experimental than control group (p<0.05). Also, of emotionally focused therapy was significant increase on sexual function of women with multiple sclerosis (p<0.05).
 Conclusion: According to the findings of this study, emotionally focused couple therapy has affected on sexual self-esteem and sexual function in women with multiple sclerosis Thus, emotionally focused couple therapy can be a good approach to improve the sexual problems in women with multiple sclerosis.

 

Atefe Azimi, Abdollah Omidi, Elham Shafiei, Arash Nademi,
Volume 20, Issue 10 (1-2018)
Abstract

  1. Abstract
  2. Background: Students face a lot of emotional problems and psychological stress that affect their individual and social adaptation as well as their quality of life. Therefore, examining treatment models for these problems is very important. One of these models, the Fractal Diagnostic Treatment Model, is based on emotional regulation skills for a wide range of emotional disorders that can be used properly. The purpose of this study was to investigate the effectiveness of integrated diagnostic therapy on individual and social adaptations and emotional adjustment.
  3. Materials and Methods: A total of 70 female students were selected and assigned into two diagnostic groups (35 patients) and control (35 people). The experimental group received 12 sessions of diagnostic diagnosis weekly. Data were gathered in this study by Social Compliance Scale and Graz's Regulatory Emotion Questionnaire. Data were analyzed using descriptive statistics and multivariate covariance analysis (MANCOVA).
  4. Results: The results showed that transdiagnostic treatment focused on the dimensions of emotional regulation, including: refusal of emotional responses (F = 120.69, p < 0.01), impulse control problems (F = 14.57, p < 0.01), lack of emotional awareness (F =104.82, p< 0.01), lack of emotional resolution (F=42.64, p< 0.01), participation problems (F = 41.00, p<0.01), and limitations in achieving emotional regulation (F = 85.33, p<0. 01) is effective. Also, the results showed that exacerbation-based fetal diagnostic therapy was effective on individual adaptations (F = 146.76, p < 0.01) and social (F = 85.02, p<0.01).
  5. Conclusion: Regarding the effect of Fract-Intervention therapy based on emotional adjustment on personal and social adaptation and student's emotional adjustment dimensions, these results are applicable to clinical practitioners, counselors and practitioners in academic counseling centers.

Javad Mesrabadi, Saeed Mohammadi Moulod,
Volume 21, Issue 1 (4-2018)
Abstract

Abstract
Background: Learning disorders is one of the most common problems of students, which attracted the attention of many psychologists and many studies have been conducted on the effectiveness of various interventions on different classes of learning disorder. The present study aimed to conclude general conclusions about the effectiveness of various educational and therapeutic interventions and the discovery of possible moderating variables.
Materials and Methods: In order to achieve the research purpose by using meta-analysis method, quantitative results of 128 selected researches which were obtained according to the criteria for entering and leaving and using keywords were used. In total, 623 primary effect sizes were obtained and analyzed by using CMA2 software.
Results: The results of the analysis showed that amount of combined effect size of the educational and therapeutic interventions on learning disorders was 1.13, and after dividing into multiple predecessor and consequence variables, the amounts of the combined effect size for educational interventions and therapeutic interventions for overall class of learning disabilities were respectively 0.74 and 1.26, for reading disorder 0.87 and 1.01, for writing disorder 1.20 and 1.22, and for mathematical disorder 1.29 and 1.26 that all of these effects size were significant (p≤0.001). Also, the results of independent t-test showed that the difference in the effectiveness of therapeutic interventions on reading disorder and educational interventions on mathematical disorder is significant (p≤0.001).
Conclusion: Based on the size of the effects obtained, it can be said that educational and therapeutic interventions have a very high effect on learning disabilities, and the use of therapeutic interventions for reading disorder and educational interventions for mathematical disorder is more effective.

 

Fatemeh Seif, Mohamad Reza Bayatiani,
Volume 21, Issue 4 (8-2018)
Abstract

Abnormal and uncontrolled growth of the cells can lead to cancer. In advanced countries, cancer is the second leading cause of death, and in our country, it is the third cause of death (after cardiovascular diseases and driving accidents). According to a report published by the Institute of Health and Evaluation (2015), for evaluating 32 cancers in 195 countries between 2005 and 2015, the prevalence of cancer has increased by 33% (1).
Radiotherapy is one of the most common cancer treatments that can be used alone or in combination with other therapies such as surgery, chemotherapy or hormone therapy. Approximately 52% of patients with cancer have to be treated by Radiotherapy with a 50% contribution to treatment (2). Radiation therapy uses gamma rays or x-rays or accelerated particles to destroy tumor cells (3). In the past, radiotherapy was done in a two-dimensional fashion, using rectangular fields based on conventional imaging that has now been replaced with 3D conformal radiotherapy. In Three‐dimensional treatment, based on CT or other imaging methods, the treatment volumes such as: GTV (Gross Tumor Volume), target with microscopic spread of tumor that is CTV (Clinical Tumor Volume), ITV (Internal Target Volume), PTV (Planning Target Volume) and also related organs at risk are defined with high accuracy for treatment planning (4). In recent years, with the advancement of computer sciences in treatment planning systems, as well as accelerator equipment for delivering the dose to the patient, treatment can be applied as Intensity Modulated Radiation Therapy (IMRT). In IMRT, each radiation field consists of a beamlets and produces different intensities. This treatment is especially useful for curved areas and when the organs at risk are in the vicinity of the tumor. IMRT can be delivered using linear accelerators with static or Dynamic MLCs, Intensity Modulated Arc Therapy (IMAT), Volumetric Arc Modulated Therapy (VMAT) or tomotherapy (5).
In determination of treatment volumes, the selection of appropriate margin is very important, because small margin may cause loos of the tumor and great margin can damage healthy tissues. The use of IGRT (Image Guide Radiotherapy) reduces these errors and increases the accuracy of treatment. Todays, in developed countries, SRT (Stereotactic Radiation Therapy) is used to destroy the non-surgical tumors, such as some of the brain tumors. In SRS, the prescribed dose is delivered to the tumor up to five sessions. In this method using imobilization devices is important, which usually involve the use of the relevant frames (6). In this regard, Cyber knife is actually a stereotactic system in which the x-ray source is mounted on a robot and can rotates in different angles. This treatment is based on three-dimentional imaging, so the tumor can be identified precisely with the guide of imaging. Cybernayev can be used to treat small tumors with high precision (7).
In addition to treatment with X-rays, ions such as proton can be used to kill cancer cells. One of the important features of treatment with proton is the deliver of the absorbed dose of the particles into the tissue. The absorbed dose curve of this beam in the tissue has a peak at a specified depth, depends on the energy used, called the Bragg peak which can give the highest dose of radiation in the tumor site (8).
There have been many advances in radiotherapy in Iran in recent years, but there is still lack of some advanced treatment equipment. On the other hand, with the regard of the significant cancer rate in the country, it is necessary to have proper information about the incidence of cancer at first. It should be noted that the use of registration systems based on just laboratory information (pathology) leads to a low number of cancer statistic, which this way is recorded in Iran. However, the cancer registry system in developed countries is based on clinical information and mortality in addition to collecting laboratory information.
Another factor causing errors in the cancer record statistics is the population coverage of cancer registries; for example, population coverage in the United States is 99%, Australia and New Zealand is 86%, and the European ::union:: is 57%, while coverage in South and central America is only 21% and in the African and Asian countries is 11 % and 8 %., respectively (1). Therefore, at first, it seems necessary to register the cancer properly in our country and then, based on the needs assessment for the different regions, establish and equipe radiotherapy centers.

Masoomeh Sofian,
Volume 21, Issue 5 (10-2018)
Abstract

Hepatitis C is one of the important causes of liver disease in the world. It seems that HCV will emerge as the leading cause of viral hepatitis-related advanced liver diseases and death in the near future. There are approximately 71 million chronically infected individuals worldwide, many of whom are unaware of their infection (1).
It has been estimated that the prevalence of HCV in the Iranian general population is less than 0.5%. In Iran, the average prevalence of HCV is among thalassemia patients (16.6%), hemophilia patient (54%), individuals under dialysis (8.3%) and among injection drug users (51.4 percent).
After screening of blood donors for HCV in Iran, the burden of HCV infection decreased significantly in hemophilia, thalassemia and patients on hemodialysis. Unfortunately, injecting illicit drugs still continues to be a major source of infection in Iran (2, 3).
Iran has the lowest prevalence for HCV infection in the Middle East. Countries such as Pakistan and Azerbaijan with high prevalence of HCV infection are neighbors of Iran (2).
The main populations at risk of HCV infection in Iran include intravenous drug users (IDUs) followed by people with tattoos, use of common razor, multi partner, homosexuality, receiving blood, and patients on hemodialysis (2).
Clinical care for patients with hepatitis c infection has advanced considerably thanks to an enhanced understanding of the pathophysiology of the disease and because of developments in diagnostic procedures and improvement in therapy and prevention, and HCV elimination has been considered by the World Health Organization till 2030 (2,3).
Screening and treating patients is necessary to eradicate HCV, So, EIA test is used for initial screening and detecting antibody against hepatitis C. Rapid diagnostic tests (RDTs) using serum, plasma, finger stick, whole blood or saliva as matrices can be used for initial screening. If anti-HCV antibodies are detected, the presence of HCV RNA or alternatively HCV core antigen in serum or plasma should be determined to identify patients with ongoing infection. Although the sensitivity of the core antigen assay is less than HCV RNA assay, but because of low cost and good sensitivity, it is a valuable test for HCV. The positive Anti HCV by EIA and negative PCR may be occurred by following reasons: 1-false positive 2-spontaneous viral clearance 3- treatment –induced viral clearance, 4- low levels of virus DNA in the Blood that is not determined by PCR. Following spontaneous or treatment –induced viral clearance, anti HCV antibodies may be persist lifelong. Thus, the follow of treated patient use of PCR or core Ag is necessary (1). HCV has a high rate of genetic heterogeneity (1-7 genotype), therefore, no vaccine to prevent this infection today. Genotype 1a and 3a are the most prevalent genotypes in Iran. HCV reinfection can occur after spontaneous or treatment induced viral clearance, essentially if patient at high risk of infection and re exposure (4).
Strategies to promote diagnosis, screening, and treatment should be targeted to high-risk groups rather than the general population. Annual screening is recommended for Individuals with a history of injecting illicit drug. In the past, treatment of HCV was interferon and ribavirin for 24 to 48 weeks. This treatment regimen associated with low response to treatment, high drug complication and high drug cost. In 2011, protease inhibitors, the first generation of DAAs (Telaprevir and Boceprevir), were emerged as the third component of the standard of care. These drugs had a lot of complications such as drug-drug interactions, severe skin rashes/pruritus and anemia. In 2013, Sofosbuvir, a new DAA, was introduced for treatment of HCV infection. SOF-containing regimens had a shorter duration of therapy, with fewer side effects in comparison with protease inhibitor-based triple therapy (5).
At present, in Iran, the basis of treatment is sofosbovir 400 milligram that combined with second drug daclatasvir (60 mg) or velpatasvir in pan genotype and or ledipasvir (90 mg) in genotype 1a. These drugs exist in separated or combination form with different brand names. In fact, the patient with hepatitis C in both treatment-naive and non-cirrhotic, taking a combination pill daily for 12 weeks associated with high treatment response. However, in cirrhotic patients or patients with previous treatment experience, treatment prolongs 24 weeks or ribavirin (1000 -1200 mg, 5-6 200mg tablets) is added to 12 weeks of treatment according patient weight. Accurate assessment of liver fibrosis and cirrhosis is essential for predicting prognosis and for planning treatment duration and adding RBV to the standard therapy of patients with chronic HCV infection. So, percutaneous liver biopsy or elastography non-invasive methods have been considered as the gold standard for assessing hepatic fibrosis. If biopsy or elastography not available, platelet count, liver sonography and liver enzyme level is helpful for determination of liver fibrosis (6).
In EASL Recommendations on Treatment of Hepatitis C 2018, other drugs of DAAs like pibrentasvir, glecaprevir, elbatasvir and grazoprevir are recommended. Also 8, 16 and 28 weeks of treatments are suggested in special cases and treatment without sofosbovir is mentioned (1).
Determination of viral load by quantitative PCR and genotyping of HCV recommend before the treatment, if viral load and genotyping is not available, qualitative PCR without genotyping is sufficient for treatment with pan genotyping drugs (1, 5).
New treatments are free-INF and these drugs have low cost and low adverse effect (5, 7). Todays, HCV is treated very simply by consuming only one pill daily for 12 weeks. Sustained viral response (SVR) that defined negative PCR 12-24 weeks after discontinuing treatment occurred in more than 90% of patients (1, 4). In patients with cirrhosis, despite SVR, sonography of liver and αFP level test for screening of liver malignancy is recommended every 6 months (1).
It seems that the best strategy for HCV prevention in the community is increasing case finding and therapy with the ultimate goal of stopping the vicious cycle in the community. Todays, there is no vaccine for HCV prevention yet. The incidence of HCV infection should be reduced by providing safe blood transfusion and medical procedures in hospitals and out-patient clinics, increasing people awareness and public education regarding the risks of exposure such as unsafe tattooing and unsafe sexual contacts and finally implementation of harm reduction for IDUs (1, 5).

Zahra Zare Bidaki , Mohammad Mahdi Jahangiri,
Volume 21, Issue 7 (2-2019)
Abstract

Background and Aim: The purpose of this study was to investigate the effectiveness of acceptance-based treatment on psychological flexibility of mothers of children with autism disorder.
Materials and Methods: This study was a quasi-experimental pretest-posttest with control group. The statistical population of the present study included mothers with autistic children referring to the autism community in Qom city at 2017. According to the semi-experimental design and Criteria for research, a sample of 30 patients (each group of 15) was selected voluntarily. Samples were randomly assigned to two experimental and control groups. The experimental group received 8 sessions of "acceptance and commitment therapy. The instrument for collecting information included the Acceptance and Action Questionnaire-II (AAQ-II). Data were analyzed by SPSS software using covariance.
Ethical Considerations: This study with research ethics code IR.IAU.ARAK.REC.1396.39 has been approved by research ethics committee at Islamic Azad University of Mahallat, Iran.
Findings: Based on study findings, the acceptance- and commitment-based therapy had significant impact on psychological flexibility in mothers of children with autism.
Conclusion: Based on the findings, it can be concluded that acceptance and commitment therapy is effective in improving the mental health of mothers with childhood autism.

Masoud Rezagholizamenjany, Parsa Yousefichaijan,
Volume 21, Issue 7 (2-2019)
Abstract

Nephrotic syndrome
Nephrotic syndrome is a manifestation of glomerular disease as a proteinuria in the nephrotic and triad of hypoalbuminemia, edema, hyperlipidemia, and high protein in the urine. Nephrotic proteinuria is defined as protein excretion of more than 40 mg/m2 of body surface per hour or protein to creatinine ratio of more than 2-3 at the first morning urine sample. Its annual incidence in most western countries is 2-3 cases per 100000 children per year, and in developing countries it is often higher due to malaria (1). New findings in this area are often about treatment, which are evaluated and reviewed in following.

Mohammad Khalili Kelaki, Ruholah Karimzadeh , Neda Soleimani, Seyed Masoud Hosseini, Maghsud Arshadi,
Volume 22, Issue 3 (8-2019)
Abstract

Background and Aim: Background and Aim: Photodynamic therapy is a minimally invasive approach to cancer, which is used to combine non-toxic photosensitizer and visible light to produce reactive oxygen species and destroy tumors. This study aimed to investigate the cytotoxicity effect of Graphene Oxide (GO)as an organic matter with many oxygen groups on photodynamic on destroying cancer cells.
Materials and Methods: This study was performed on breast cancer cells (MCF-7) in vitro. The study groups included the first group of drug with different concentrations of graphene oxide (333.3, 285.7, 230.7, 166.6, 90.9,
47.6 µg/ml), the second group co-drug and laser light irradiation and the control group consisted of cells treated only with laser irradiation and the control group was treated with no treatment. Cells were exposed to visible laser irradiation (405 nm) at 0.1 W / cm2. Cell viability was determined by MTT assay.
Ethical Considerations: This study with research ethics code SBU/S.1397.46A has been approved by research ethics committee at Shahid Behesht University of Tehran, Iran.
Findings: The results of in vitro experiments showed that the dark toxicity of graphene oxide at concentrations of less than the 90.9 μg / ml concentration had no significant effect on cancer cells. Also, laser light alone don’t has toxic effect on cells. But graphene oxide-mediated dynamic light therapy has reduced the bioavailability of cancer cells on average by 21% over dark toxicity. Results are presented as mean of three independent replications, standard error, and p< 0.05 was considered significant.
Conclusion: In this study, graphene oxide is fully biodegradable at concentrations below a certain value, but with increasing concentration, the toxicity effect increases. With exposure to light and graphene oxide, viability decreses that it is more effective for in vivio studies.

Khadijeh Mohsenpourian, Mostafa Nokani, Hamidreza Jamilian, Mohsen Ghasemi,
Volume 22, Issue 4 (9-2019)
Abstract

Background and Aim Obsessive-Compulsive Disorder (OCD) is the fourth most common psychiatric disorder. It consists of symptoms, including intrusive thoughts, rituals, behaviors, preoccupations, and compulsions. This study aimed to evaluate the effectiveness of attention bias modification and selective serotonin reuptake inhibitors in reducing the symptoms of OCD.
Methods and Materials study population comprised patients with OCD referring to the outpatient clinic of Amir Kabir Hospital in Arak City, Iran. Of them, 80 patients were randomly assigned to the two groups. The first group received the selective serotonin reuptake inhibitors, and the other group received the treatment modality to determine the effectiveness of the Yale-Brown OCD scale and dot-probe task tests.
Ethical Considerations The Research Ethics Committee of Arak University of Medical Sciences approved this study (Research Ethics Code: IR.ARAKMU.REC.1396.284). 
Results Treatment of attention bias modification in comparison with selective serotonin reuptake inhibitors did not show a significant difference in the reduction of attention bias (P=0.377). Also, a significant difference between the two groups in reducing the symptoms of OCD (P=0.007), indicates that selective serotonin reuptake inhibitors are more effective in diminishing the symptoms of OCD. Besides the attention bias modification decreased the symptoms of OCD, but these results were not significant (P=0.228)
Conclusion Attention bias modification is a significant improvement in reducing attention bias and can be used with other interventions. However, it appears that the reduction in the severity of OCD symptoms, as against this intervention, continues to be the preferred treatment for pharmacotherapy.


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