Showing 44 results for Ratio
Habib Rezaei, Soad Mahfoozpour, Somayeh Hesam, Eiravan Masoodi Asl,
Volume 27, Issue 2 (5-2024)
Abstract
Introduction: Traffic accidents are a principal challenge in the injury and death of people in Iran and many other countries, which has made the formulation of necessary strategies and planning for inter-sectoral cooperation to prevent and reduce traffic accidents undeniable. Therefore, this research was conducted to investigate the dimensions of inter-sectoral collaboration in preventing traffic accidents in Iran.
Methods: This research is a qualitative study that was conducted in 2023. In this study, sampling was done in a targeted manner, and 15 people from the statistical population were interviewed. The statistical population of the research at this stage included executive managers, traffic police, field activists, and public institutions active in the field of traffic accidents in Central Province and Tehran, who, due to the relevance of their job field, were informed or participated in intersectoral cooperation in line with the management of accidents and traffic accidents were included in the study. Data were collected and analyzed through structured interviews, and their coding was done with the help of MAXQDA 11 software.
Results: The study identified and extracted eight main dimensions of intersectoral cooperation in preventing traffic accidents. These dimensions include laws and law enforcement, research and development, information and data management, internal and external coordination, crisis management, education and awareness, roads, and vehicles.
Conclusions: Providing platforms for promoting the development and expansion of inter-sectoral cooperation in accident prevention and traffic accidents can have various benefits, including long-term social, political, economic and, well-being. Therefore, based on the findings of the research, it is suggested to design an intersectoral cooperation model for the prevention of accidents and traffic accidents so that traffic accidents can be reduced to the minimum possible with proper planning and design so that we can witness the highest level of effectiveness and efficiency in this area.
Atefeh Khaki, Maryam Baazm, Mohamad Bayat,
Volume 27, Issue 5 (12-2024)
Abstract
Introduction: Glyphosate is the most popular broad-spectrum herbicide globally due to the growing demand for glyphosate-resistant crops. Glyphosate exhibits harmful properties, including cytotoxicity, neurotoxicity, and reproductive toxicity. This study aimed to investigate the detrimental effects of glyphosate on ovarian histopathology in mice and the in vitro maturation (IVM) of oocytes following superovulation.
Methods: In this study, thirty-two female NMRI mice were randomly divided into the following groups: control, glyphosate, superovulation, and superovulation-glyphosate. Animals received glyphosate (0.5%) continuously through drinking water for three weeks. HMG and HCG were used to induce superovulation. Oocytes were collected from the ampulla, and the quantity and quality of oocytes were analyzed. Then, in vitro maturation (IVM) of oocytes was performed. At the end of the study, ovarian histopathology was analyzed.
Results: Compared to the control group, the glyphosate-treated group exhibited a significant decrease in secondary and Graafian follicles while demonstrating a concomitant increase in atretic follicles (P < 0.05). Additionally, the superovulation-glyphosate group showed fewer germinal vesicle breakdown (GVBD) and MII oocytes than the superovulation group. In the superovulation-glyphosate group, there was a notable reduction in GVBD and MII oocytes following in vitro maturation (IVM).
Conclusions: Glyphosate has the potential to damage ovarian tissue and adversely affect IVM and oogenesis.
Rouhollah Hemmati Bushehri, Mahmoud Reza Jaafari, Ghasem Mosayebi, Ali Ghazavi, Ali Ganji,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: Nowadays, plant-derived compound is widely used in medical treatment as complementary therapies. Rosemary is one of these plants that have anti-angiogenic and anti-tumor effects. However, low solubility and low bioavailability lead to limited use of this compound. To overcome this limitation, the use of liposomes is beneficial. So, this study aimed to prepare liposomes containing rosemary alcoholic extract to obtain the best formulation with best properties to use in the antitumor study.
Methods: Liposomes were prepared by Thin-Film-Hydration method in different ratios of rosemary extract, hydrogenated-soybean-phosphatidylcholine (HSPC), Cholesterol, and mPEG2000 (F1-F6). The characterization of nanoliposomes includes size, PDI (Poly dispersity index), zeta potential, encapsulation efficiency, and release rate was measured.
Results: The results showed that the average particle size and zeta potential were 113.4 nm and -10.8 mV, respectively. Encapsulation efficiency showed a range of 60- 90%. The average release rate of the extract was about 60%. Also, the results showed that the F1 formulation was transparent, had appropriate properties, and did not precipitate. F2 formulation was not transparent. F3-F4 formulations were precipitated, and F5-F6 formulations did not achieve the appropriate size.
Conclusions: This study proved that F1 formulation in a ratio of 55:30:5 HSPC/chol/mPEG2000 is the best formulation for the preparation of nanoliposomes containing rosemary alcoholic extract to achieve the best properties for use in cancer studies.
Mehdi Mikelani Akhoreh Ouliaei, Farnaz Farhad, Hamid Sarlak,
Volume 28, Issue 2 (4-2025)
Abstract
Introduction: Considering parents' preferences and opinions is an important factor in dentists' choice of treatment techniques. Despite the relatively low attitude of parents towards the use of the "parental presence/absence" technique, dentists still use this technique during pediatric dental treatment. The present study was conducted with the aim of simultaneously investigating the dentists' attitudes regarding the "presence/absence of parents" technique during the treatment of 4-10-year-old children and determining the factors affecting this attitude.
Methods: In this cross-sectional study, the attitudes of 83 dentists regarding the "presence/absence of parents" technique were evaluated using an investigator-designed questionnaire. The questionnaire scored dentists' attitudes regarding the above technique and evaluated the background factors affecting the child's attitude. Data were analyzed with a significance level of 0.05.
Results: The mean attitude score of the participants was 60.61±12.99. Also, 55.4% of participants considered this technique "unsuccessful". The factors "type of treatment", "child's age", "child's behavior", "parental behavior" and "implementation of the presence/absence technique", significantly affected the participants' attitudes.
Conclusions: Dentists do not hold a highly positive attitude toward the "presence/absence of parents" technique. According to dentists working in pediatric dentistry, this technique has low success in guiding children’s behavior.
