Showing 33 results for Jani
Aliasghar Farazi, Nader Zarrinfar, Farshideh Didgar, Mansoureh Jabbariasl, Parisa Mirzajani,
Volume 17, Issue 4 (7-2014)
Abstract
Background: Treatment failure and relapse is a major problem in the treatment and control of brucellosis. The present study directed to determine risk factors for failure of treatment and relapse in patients treated for brucellosis.
Materials and Methods: This study was a descriptive - analytic and prospective study and were conducted in 72 patients with acute brucellosis.Patients were followed up during treatment and for six months after completion of therapy, and patients with treatment failure or relapse were analyzed. All data analyzed using SPSS software and P-value of less than 0.05 was considered significant.
Results: The mean value of age in patients was 40.2 ± 16.5 years. Treatment failures was 6.9% and the relapse at the end of the ninth month was 12.5% that recurrence of symptoms were associated with increased titers of serological tests and 80.6 percent had successful treatment. In this study gender of male (P = 0.026), occupational exposure (P = 0.005), delayed treatment in less than two weeks (P = 0.016), hepatosplenomegaly (P = 0.003), thrombocytopenia (P = 0.023), CRP &ge +2 (P = 0.017) and Wright &ge 1/320 and 2-ME &ge 1.160 at the end of the sixth week of treatment (P = 0.004 and P = 0.010) were risk factors of treatment failure and relapse in brucellosis.
Conclusion: The diagnosis and treatment of relapse and treatment failure in acute brucellosis is not clear, therefore, the prediction of relapse may be useful in preventing recurrence and treatment of patients.
Malek Soleimani Mehranjani, Majid Mahdiyeh, Atena Sadat Azimi,
Volume 18, Issue 7 (10-2015)
Abstract
Background: Alpha-tocopherol, as a strong antioxidant, plays an important role in testraining free radicals. The aim of this study was to investigate the effect of Alpha-tocopherol on cell proliferation and restraining apoptosis in rat bone marrow mesenchymal stem cells.
Materials and Methods: In this research study, the rat bone marrow mesenchymal stem cells were extracted under sterile conditions using flashing-out method. At the end of the third passage, cells were divided into groups of control and Alpha-tocopherol with doses of 15 and 25 µM and were treated in the osteogenic media cell medium containing 10% fetal bovine serum, 10 mM β-glycerol phosphate, 10 nM dexamethasone and 50 µg/ml ascorbic 3-phosphate] for a period of 21 days. Then, cell proliferation, DNA damage, expression of Bcl-2 and Bax genes and the morphologic changes of the cells were investigated during the procedure of osteogenesis. Data were analyzed using one-way ANOVA and means difference was considered significant at p<0.05.
Results: Cell proliferation, the size of nuclei diameter and expression of anti-apoptotic Bcl-2 gene showed a significant increase in mesenchymel stem cells treated with Alpha-tocopherol (p<0.05) in a dose dependent manner compared to the control cells. Also, cytoplasm extension was seen in the cells treated with Alpha-tocopherol, compared to the control group. Since Alpha-tocopherol causes a significant decrease in DNA damage and the expression of apoptotic Bax gene, compared to the control group, therefore it can suppress apoptosis in bone marrow mesenchymal stem cells, in a dose dependent manner .
Fahimeh Farahani Dastjani, Mohsen Shamsi, Mahboobeh Khorsandi, Mohammadreza Rezvanfar, Mehdi Ranjbaran,
Volume 19, Issue 2 (5-2016)
Abstract
Background: Diabetes is one of the most common disease resulted from metabolism disorders. Thus, Studying medication adherence in patients to explain educational interventions to improve the health of these patients is necessary. Therefore, the present study aimed to assess the factors affecting medication adherence in diabetics patients based on health belief model in Arak 2014.
Materials and Methods: In this analytical study, 366 diabetic patients in Arak in 2014 were selected and data were collected through a researcher made questionnaire about patients behavior in the field of medication adherence and its influencing factors based on the health belief model. Linear regression model was used to determine the predictive power of structures.
Results: The mean knowledge score and the medication adherence was 31.34 and 84.34, respectively. In this study, perceived susceptibility, perceived barriers and internal action guide were as the strongest predictors of medication adherence behavior in patients and predicted their behavior variance 0.36. Between function and susceptibility and severity and perceived benefits and self- efficacy of manual internal and external action guides in the field of medication adherence with diabetes, there was a direct correlation that the highest correlation was related to the perceived susceptibility structure (r=0.42 , p<0.001).
Conclusion: The results showed that the educational interventions with an emphasis on building the perceived sensitivity of patients with diabetes for medication adherence and emphasis on internal incentives as motivators and incentives for patients to achieve better results in the field of medication adherence should be at the heart of educational interventions.
Mostafa Jani, Bahman Salehi, Seyed Ali Aleyasin, Hossein Davoudi,
Volume 20, Issue 3 (6-2017)
Abstract
Abstract
Background: The aim of this study was to determine the effectiveness of cognitive-behavioral group therapy on quality of life of patients with cardiovascalar diseases.
Materials and Methods: This semi-experimental study was done based on a pretest -posttest design with control group. Statistical population included all of the patients with cardiovascular diseases referred to Amir-Kabir educational and medical center of Arak, and sample included 30 persons who selected by screening and simple random sampling and assigned into two control and experimental groups. Research instrument included Mcnew quality of life scales which participants answered it during two pre-test and post-test steps; also, experimental group participated in 9 cognitive-behavioral therapy meetings.
Results: There was a significant difference between mean quality of life and its components in both experimental and control groups.
Conclusion: Results analysis showed that group-based cognition- behavior theray has an influence on life quality (emotional, physical and social domains)(p>0.05).
Foad Asjodi, Phd, Hamid Mohebi, Ebrahim Mirzajani, Azimeh Izadi,
Volume 20, Issue 4 (7-2017)
Abstract
Abstract
Background: The aim of this study was to evaluate the effects of supplementation of Branched-Chain Amino Acids (BCAAs) plus carbohydrate (CHO) and whey protein plus CHO on muscle damage indices after eccentric resistant exercise.
Materials and Methods: Twenty four untrained healthy males participated in this study. They were randomly divided into three groups, BCAA +glucose (0.1+0.1g/kg) supplement group (n=8), Whey+glucose (0.1+0.1g/kg) supplement group (n=8), and placebo (malto dextrin 0.2g/kg) group (n=8). Each subject consumed a carbohydrate beverage with addition of whey protein or branched-chain amino acid or placebo 30 minutes before exercise in a randomized,double-blind fashion. Serum levels of Creatine Kinase (CK), Lactate dehydrogenase (LDH), and muscle pain were measured before, 24, 48, 72 h after exercise. Follow-up analyses included 1-way repeated measures ANOVAs, and Bonferroni post hoc comparisons.
Results: 24 h after test, serum levels of CK, LDH and muscle pain in both supplement groups were increased less than placebo group (0.015, 0.001 and 0.001, respectively). Also, the levels of CK and LDH showed significant changes in both intervention groups compared to placebo group at 24 h (0.001, 0. 015, respectively). Similarly, significant differences in the levels of CK and LDH between groups were observed.
Conclusion: These data indicate that muscle damage and pain after resistant exercise were reduced by an ingestion of either BCAA drink or whey protein drink.
Mostafa Jani, Hamidreza Jamilian, Ahmad Aramoon,
Volume 20, Issue 9 (12-2017)
Abstract
Abstract
Background: The purpose of the present research was to compare the perceived stress, self-efficacy and mental health in patients with HIV and Hepatitis C.
Materials and Methods: The method of present research was causal-comparative research. Population included of all patients with acquired immune deficiency syndrome or AIDS referred to a behavioral disease counseling centers of Arak city and all patients of chronic hepatitis caused by the hepatitis C virus referred to Gastroenterology Research Center and private practice of digestive specialists in Arak city. The sample consisted of 200 people, including 100 HIV and 100 people with hepatitis C who participated in the study and were selected for screening. All participants responded to the three instruments including Cohen Perceived Stress, Kamark and Mrimlstyn, Sherer's Self-efficacy and Goldberg general health questionnaires. Data analysis was done in two descriptive and inferential levels using SPSS version 20.
Results: The results of MONOVA showed that two groups were different in the perceived stress, self-efficacy and mental health, physical symptoms, depression, anxiety, social dysfunction, at the level of 0.01.
Conclusion: It is suggested that workshops to be held to careful inform how much stress and self-efficacy had affected on physical and mental health of patients with acquired immune deficiency syndrome or AIDS.
Mojtaba Habibi, Nikzad Ghanbari, Moloud Sivandian, Hanieh Mahdizadeh Hanjani,
Volume 21, Issue 5 (10-2018)
Abstract
Background and Aim: Present study was conducted to investigate the prediction of juvenile delinquency based on individual vulnerability and the risk opportunity in the family, peers, school and neighborhood in high schools in Tehran
Materials and Methods: This is a coss-sectional study. The statistical population of this study included all the female and male students of 20 districts of Tehran who were studying in high school during the academic year 2013-2014. The sample size of the study was 1847 individuals (946 (51.2%) girls and 901 (48.8%) boys). The sampling was performed in a multi-stage cluster method due to the extent of the population, and the participants of this study completed the socio-mental protective and risk factors and behaviors scale. Data were analyzed using multiple regression analysis, stepwise method, and SPSS-24 statistical software.
Findings: Results of present study showed that among predictor variables, risk opportunity/availability (B=0.67, t=13.28, p<0.001), vulnerability/family (B=0.37, t=8.57, p<0.001), and vulnerability/school (B=1.14, t=6.7, p<0.001) have significant prediction effect on adjusted index of adolescents’ delinquent behavior, also adolescent boys do more delinquent behavior than girls (t (1823) =4.82, p<0. 01).
Conclusion: This study showed that the individual vulnerability and risk opportunity in the family, peers, school and neighborhood predict delinquent behavior in adolescents. So, it is necessary to take preventive measures and interventions for this age group, risk factors should be considered at individual, school and family levels.
Fatemeh Heidari Soureshjani, Majid Kheirollahi, Parichehreh Yaghmaei, Fattah Sotoodehnejadnematalahi,
Volume 23, Issue 4 (October & November 2020)
Abstract
Background and Aim: Alzheimer's Disease (AD) is a neurodegenerative brain disease that gradually destroys memory and cognitive skills. The disease is caused by the formation of beta-amyloid plaques, oxidative stress, dysfunctions in the cholinergic system, neuronal killing inflammation, and ultimately brain atrophy. Donepezil and hyoscyamoside have inhibitory effects on these pathogens; therefore, their impact on the learning process of Alzheimer’s rats in the Morris Water Maze was investigated.
Methods & Materials: In the present experimental study, 60 male rats of Wistar breed with approximately 7 weeks age within the control group (rats that received normal water and food), the PBS group (underwent surgery), PBS group (received solvent Aβ), the first Alzheimer›s group (animals that received beta-amyloid by Alzheimer’s surgery, second Alzheimer’s group (after Alzheimer’s surgery, they received 1 cc of normal saline daily, and treatment groups that treated the rats with beta-amyloid after Alzheimer. In the hyoscyamoside group, they received 10 mg/kg daily of hyoscyamoside for 28 days. The donepezil group received it 4 mg/kg daily for 28 days by gavage. The Morris Water Maze test was used to evaluate learning and memory. Data were analyzed by ANOVA statistical analysis and Post Hoc test.
Ethical Considerations: The Ethics Committee in Biomedical Research, Islamic Azad University, Science and Research Branch approved the research (Code: IR.IAU.SRB.REC 1397.057)
Results: Beta-amyloid injection caused extensive damage to memory. The treatment groups with hyoscyamoside and donepezil spent less time and distance with a significant level (P<0.001) than the group of Alzheimer’s patients to find the hidden platform. In the reminder phase, where the previously hidden platform was located, they spent more time, with a significant level (P<0.001) in the local quarter.
Conclusion: Treatment of rats with hyoscyamoside and donepezil improved spatial memory in Alzheimer’s rats. They appear to play a significant role in the prevention and treatment of Alzheimer’s disease.
Seifollah Aghajani, Sahar Khoshsorour, Sara Taghizadeh Hir,
Volume 24, Issue 1 (April & May 2021)
Abstract
Background and Aim: Breast cancer is among the most prevalent cancers in women with extensive associated biopsychological problems. The present study aimed to determine the effects of holographic reprocessing therapy on cognitive flexibility and posttraumatic growth in women with breast cancer.
Methods & Materials: This was a quasi-experimental study with pretest-posttest and a control group design. The statistical population included all patients with breast cancer who underwent mastectomy and who were being treated in the chemotherapy ward of Imam Khomeini Hospital in Ardabil City, Iran, in 2020.
By convenience sampling method, 30 women with breast cancer were selected and randomly divided into the experimental and control groups (n=15/group). The experimental group, while receiving pharmacotherapy, collectively underwent holographic reprocessing therapy in 9 one-hour sessions (two sessions per week) for 5 weeks; however, the control group received only pharmacotherapy. Both research groups were assessed in pretest and posttest phases by the Cognitive Flexibility Inventory (Dennis & Vander Wal, 2010) and the Posttraumatic Growth Inventory (Tedeschi & Calhoun, 1996). Finally, the obtained data were analyzed using Multivariate Analysis of Covariance (MANCOVA) in SPSS v. 23.
Ethical Considerations: All study subjects provided a signed written informed consent form. The Research Ethics Committee of Ardabil University of Medical Sciences approved this study (Code: IR.ARUMS.REC.1399.393).
Results: The current study results indicated that holographic reprocessing therapy was effective on cognitive flexibility (F= 42.319, P<0.01) and posttraumatic growth (F= 18.300, P<0.01) in women with breast cancer; this method also increased their cognitive flexibility and posttraumatic growth.
Conclusion: Considering psychological factors and information processing methods in patients with cancer is highly important. Thus, counselors and psychotherapists are advised to use holographic reprocessing therapy as a complementary treatment without adverse effects along with medical treatments to reduce the psychosocial problems caused by the disease.
Maliheh Rahmani, Zahra Zanjani, Abdollah Omidi,
Volume 25, Issue 1 (April & May- 2022)
Abstract
Background and Aim Various research studies have investigated the relationship between anxiety and worry. The present study aimed to examine the mediating role of cognitive emotion regulation and mindfulness in the relationship between anxiety and worry.
Methods & Materials The present study follows a correlational design study. The research sample included 248 students of Kashan universities in Iran studying in the 2017-2018 academic year. The study data were collected using the generalized anxiety disorder (GAD-7), Pennsylvania state worry questionnaire (PSWQ), the Persian short form of cognitive emotion regulation questionnaire (CERQ-P-short form), and five-factor mindfulness questionnaire (FFMQ). Then, the obtained data were analyzed using the SPSS v. 22 and AMOS v. 22 software.
Ethical Considerations The Ethics Committee of Kashan University of Medical Sciences approved the study (Code: IR.KAUMS.REC.1396.36).
Results The results showed a significant relationship between generalized anxiety and worry, worry and cognitive emotion regulation, worry and mindfulness, generalized anxiety and cognitive emotion regulation, and anxiety and mindfulness. The results of the structural equation modeling confirmed the mediating role of cognitive emotion regulation in the relationship between anxiety and worry. Also, the path coefficient of mindfulness and anxiety was removed from the model because it was not significant.
Conclusion Generally, cognitive emotion regulation plays a mediating role in the relationship between anxiety and worry. These findings seem applicable in the individual, family, educational, therapeutic, and interpersonal mental health fields.
Seyed Mohsen Madani Larijani, Zahra Salemi, Mohammad Reza Rezvanfar, Pegah Mohaghegh,
Volume 25, Issue 5 (December & January 2022)
Abstract
Introduction: Fetuin-A is a secreted protein from the liver, which plays a role in microvascular disorders of diabetes through insulin resistance and inflammation. The aim of this study is to investigate the amount of fetuin-A in diabetic patients without and with microvascular disorders.
Methods: 90 people in 4 groups, diabetic control, nephropathy, retinopathy and retinopathy-nephropathy participated in this research. Data were analyzed using Kruskal-Wallis and Pearson correlation tests. Measurement of parameters including VEGF, interleukin 8 (IL-8), insulin, interleukin 6 (IL- 6) and Fatuin-A was done by ELISA method. The concentration of C-reactive protein (CRP) was measured by nephrometric method.
Ethical considerations: This study was conducted after the approval of the protocol in the research ethics committee and receiving the ethical code number IR.ARAKMU.REC.1400.250 and according to the Declaration of Helsinki.
Results: The obtained results showed that the correlation between fetuin-A and VEGF in the control group was not significant (p=0.234), in the nephropathy group it was significant (p<0.01), in the retinopathy group it was significant (p<0.01) and in the retinopathy group - Nephropathy was significant (p=0.032). Also, the correlation between fetuin-A and interleukin-6 in the nephropathy group is not significant (p=0.285), in the retinopathy group is not significant (p<.075), in the retinopathy group is not significant (p<0.059) and in the retinopathy-nephropathy group. It was insignificant (p=0.113). The correlation between fetuin-A interleukin 8 in the control group is not significant (p=0.592), in the nephropathy group (p=0.592), in the retinopathy group (p=0.314) and in the retinopathy-nephropathy group (p= 0.362). The correlation between Fetuin-A and the homeostatic model of insulin resistance was significant in all groups (p<0.01). Fetuin-A and VEGF levels in the three groups of nephropathy and retinopathy increased significantly compared to the control group. The amount of interleukin 6, interleukin 8 and homeostatic model of insulin resistance in nephropathy, retinopathy and retinopathy-nephropathy groups has increased significantly compared to the control group.
Conclusions: Because fetuin-A is directly related to insulin resistance and VEGF production, its control can have an effect in preventing and controlling the development of microvascular disorders, especially in the early stages of diabetes. Although the results showed that fetuin-A level has no significant relationship with inflammatory factors such as interleukin 6 and interleukin 8, especially in the retinopathy-nephropathy group, but a significant increase of interleukin 6, interleukin 8 and CRP in patients with microvascular disorders to the diabetic control group, it shows the importance of inflammation in the development and progression of microvascular disorders and the importance of its control in diabetic patients.
Yasaman Noroozi, Parisa Janjani,
Volume 26, Issue 3 (August & September 2023)
Abstract
Introduction: Adolescents are one of the most vulnerable groups against risky behaviors. Therefore, this research was conducted with the aim of determining the relationship between attachment styles and rumination of anger in high-risk behaviors of adolescents by analyzing the mediating role of difficulty in emotion regulation.
Methods: The method of the current research is descriptive-analytical of the correlation-path analysis type. The statistical population of this research was all the students of the first secondary level in the marginal areas of Kermanshah city in the academic year of 2011-2014 and the sample included 530 people who They were selected by multi-stage cluster sampling method. To collect data, Iranian youth risk-taking questionnaire, Hazen and Shiver attachment scale, Sakodolski, Glob and Cromwell anger rumination scale, and Gertz and Roemer scale of difficulty in regulating emotions were used. The data obtained from the questionnaires were analyzed using the path analysis model and the statistical software Smart PLS version 3.3 and SPSS version 25. This study with ID IR.IAU.KSH.REC.1402. 014 has been approved by the Research Ethics Committee of Kermanshah Islamic Azad University.
Results: The path of attachment style to risky behaviors (β = 0.81 and t = 2.32), the path of anger rumination to risky behaviors (β = 0.45 and t = 2.32), the path of attachment style to risky behaviors with mediation Emotion regulation difficulty (β = 0.61 and t = 3.28), rumination to risky behaviors with the mediation of emotion regulation difficulty (β = 0.21 and t = 3.55), it was found that all values at the error level are less than 0.05 are significant.
Conclusions: Through the mediation of difficulty in emotion regulation, there is a positive and significant relationship between attachment styles and rumination of anger in high-risk behaviors of adolescent girls. These results emphasize the difficult role of brahmin in regulating emotions in high-risk behaviors of adolescent girls.
Saeed Pazhoohan, Fatemeh Abbasi Feijani, Abdollatif Moini , ,
Volume 26, Issue 6 (February & March 2024)
Abstract
Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating condition. People with COPD often experience exacerbations that may require hospitalization. Pattern analysis of respiratory variability can provide valuable insights into the complexity of the respiratory control system. Therefore, this study investigated respiratory pattern variability during stable and exacerbation phases in patients with COPD.
We analyzed respiratory signal data from 14 patients with COPD during exacerbations and stable phases and compared them with 12 age- and sex-matched control subjects. Respiratory pattern variability analysis of 30-minute inter-breath intervals (IBI) time series was performed using sample entropy and Detrended Fluctuation Analysis.
Sample entropy analysis of the IBI revealed that respiratory variability was more regular during both stable and exacerbation phases in patients with COPD. Also, the short-term (α1) and long-term fractal-like correlation (α2) significantly decreased during both exacerbation and stable phases compared to healthy controls.
The respiratory control system in patients with COPD shows less variability (lower entropy and fractal correlation). This reduction in respiratory signal variability indices in COPD patients is still lower than in healthy people, even when their disease status is stabilized.
