Showing 33 results for Arab
Valiollah Khadir Sharabiany, Saeed Oraii,
Volume 16, Issue 3 (6-2013)
Abstract
Background: Nowadays, many patients with cardiovascular diseases require pacemaker implantation that is associated with few complications such as cardiac and valvular insufficiency. This study aims to compare the development of tricuspid and mitral regurgitation in right ventricular outflow tract (RVOT) and right ventricular apex (RVA) pacing.
Materials and Methods: In this single-blind clinical trial, 164 candidates for permanent pacemaker (PPM) implantation due to sick sinus syndrome or atrioventricular block were randomly divided into 2 equal groups to receive either RVOT or RVA pacing. Patients with heart failure or valvular diseases were excluded from the study. Pre and post-procedural echocardiography after 6 months were performed and the results were compared for the development of mitral and tricuspid regurgitation and probable changes in the ejection fraction (EF).
Results: Age, gender, pacing mode, and baseline cardiac rhythm did not significantly differ between RVOT and RVA pacing groups. The incidence of mitral regurgitation was significantly higher in the RVA group (p=0.033), whereas the incidence of tricuspid regurgitation was similar in both groups (p>0.05). There was a trend toward less tricuspid regurgitation in the RVOT group however, it was not statistically significant. Ejection fraction was not significantly different between the study groups.
Conclusion: It seems that the incidence of mitral regurgitation in RVA pacing is significantly higher than RVOT although this needs further investigation in future studies.
Saeid Babaei, Reza Talebi, Mohammad Reza Darabi, Mahmood Reza Nakhaei, Mohammad Bayat, Parvindokht Bayat, Maryam Ba Azm,
Volume 16, Issue 8 (11-2013)
Abstract
Background: Pentoxifylline is a xantin derivative that causes deduction of blood viscosity, improves peripheral blood current and increases tissues oxygenization. In this study, considering special properties of this drug and inspite of undefined mechanism of its effect, the effect of pentoxifylline on skin biomechanical indices in acute phase of skin wound healing in rat is evaluated.
Materials and Methods: In this experimental study 14 adult Wistar rat were divided in two groups of experimental (n=7) receiving 100mg/kg twice a day and control (n=7) receiving distilled water intraperitoneal. Incisional wounds, 20mm length in identical pattern were created on back skin of rats. On day 15 skin strips containing incision were excised and used to evaluate biomechanical indices, work up to maximum force-Nm and Tensile strength= Rm-N/mm2. Results were analyzed by Spss soft ware and K-S, Levens and student T-Test.
Results: According to biomechanical test findings, pentoxifylline administration causes improvement in biomechanical indices of skin after 15 days of drug administration. Discrepancy between skin biomechanical indices of experimental and control subgroups was significant (p<0.05).
Conclusion: Pentoxifylline caused improvement in skin biomechanical indices and accelerated skin wound healing in experimentals.
Maryam Baazm, Mohammad Reza Darabi, Saeed Babaie, Reza Talebi,
Volume 16, Issue 10 (1-2014)
Abstract
Background: One of the side effects of chemotherapy agents is gonadal suppression leading to infertility. The present study examined the feasibility of using a gonadotropin releasing hormone agonist (GnRH-A) in the prevention of busulfan induced azoospermia in prepubertal mice.
Materials and Methods: In this case and control research, Leuprolide (3.8 mg/kg) was given to prepubertal male mice 2 weeks after or prior to busulfan (40 mg/kg) administration. The animals received one or two doses of leuprolide after busulfan administration with 4 weeks apart. Six weeks after the last leuprolide treatment, the sperm parameters were analyzed icluded sperm count and motility according to the World Health Organization criteria.
Results: At the time of scarifies, testicular weight were increased in animals receiving leuprolide. In animals receiving leuprolide pretreatment, the percentage of progressive and immotile sperm was significantly (p&le0.05) increased and decreased respectively. But the percentage of non progressive sperm did not change. The sperm motility in busulfan treated animals with post treatment didn't change. The sperm count also increased in pretreatment animals but it was not significant (p&ge0.05).
Conclusion: The present study demonstrates that leuprolide pretreatment resulted in improvement in sperm motility in prepubertal male mice.
Zahra Naseri, Mohammad Yousef Alikhani, Seyyed Hamid Hashemi, Mohammad Reza Arabestani,
Volume 17, Issue 5 (8-2014)
Abstract
Background: Brucellosis is a major cause of zoonosis disease and is endemic in hamadan Province in Iran. The purpose of this study was to isolate Brucella species from brucellosis patients and identify different species of this bacterium in order to determine the prevalence of the species.
Materials and Methods: This study was descriptive- cross sectional and fifty blood samples were obtained from brucellosis patients with clinical symptoms. The samples were cultured in BACTEC system and incubated for 14 days. Then, the samples were cultured on Brucella agar and biochemical tests were done for identification of bacteria. Finally, Polymerase Chain Reaction (PCR) applied for confirmation and isolated identification with specific primers.
Results: Seven Brucella strains were isolated from 50 blood samples of the patients with brucellosis by blood culture and PCR. The PCR results on blood specimens showed 4 positive in spite of the negative results of blood culture. PCR and biochemical methods revealed that all the 11 isolated bacteria were Brucella Melitensis.
Conclusion: This study was designed to evaluate PCR technique as a diagnostic tool for brucella spp in comparison to conventional techniques. This study showed a high prevalence of brucellosis due to Brucella Melitensis in Hamadan Province and efforts in this region should be aimed at the eradication of this bacterium.
Saeid Babaei, Mohammad Reza Darabi, Mohammad Bayat, Mahmood Reza Nakhaei, Parvindokht Bayat, Maryam Ba Azm, Mina Ghadamian, Soheila Bana Sadegh,
Volume 17, Issue 7 (10-2014)
Abstract
Background: It is expected that affected people with diabetes will increase to 439 million in 2030, 15% of them are affected with chronic leg ulcer disease. Increasing number of researches implicate the positive influence of pentoxifylline (PTX) on the skin wound healing. Pentoxifylline is a xantin derivative that modifies or inhibits inflammatory factors, reduces blood viscosity, improves peripheral blood currency and increases oxygenation of tissues the In this study the effect of Pentoxifylline (PTX) on skin biomechanical indices in acute phase of skin wound healing in diabetic rat is in considerable interest.
Materials and Methods: It is an experimental- interventional study in which fourteen adult male wistar rats were divided into experimental group (n=7), receiving pentoxifyllineintraperitoneally and control group (n=7) receiving distilled water (DW). Diabeteswas induced by intraperitoneal administration of streptozotocin in both groups then full thickness incisional wound (20mm length) in identical pattern was made on the dorsum of rats. After 15 days a band of skin (4×60mm) containing wound was extracted and used to evaluate skin biomechanical indexes (work up to maximum force-Nm and Tensile strength= Rm-N/mm2). Results were analysed by SPSS software version 19 and K-S, Levens Test and Student SampleT-Test were used.
Results: Pentoxifylline administration improved skin biomechanical indices after 15 days after skin incisional wound. Differences between experimental and control’s indices were significant (p<0.05).
Conclusion: Pentoxifylline accelerated wound healing and improved tensile strength of skin in diabetic rats of experimental group.
Mohammad Reza Arabestani, Mojtaba Rajabpour, Rasoul Yousefi Mashouf, Mohammad Yusef Alikhani, Seyed Masoud Mousavi,
Volume 17, Issue 11 (2-2015)
Abstract
Background: Pseudomonas aeruginosa is one of the most common nosocomial pathogens with high mortality rates. OprD is the major resistance mechanism to carbapeneme antibiotics. The aim of this study was to determine the expression of the genes encoding these efflux pumps using qRT-PCR.
Materials and Methods: This study examined 100 strains of Pseudomonas aeruginosa isolated from patients admitted to various hospitals in the Hamedan. Conventional phenotypic tests were used for identifying the 100 collected samples, then 31 samples were selected based on type of collected specimen and antibiotic susceptibility test i.e. antibiotic disk diffusion method performed for aminoglycoside, quinolone and carbapenem antibiotics. Furthermore, MIC method was performed for imipenem. Finally, RNA was extracted and converted to cDNA for determining the efflux pump genes expression using qRT-PCR.
Results: Among 8 selected antibiotics, the greatest resistance was for levofloxacin (61.2%, n=19) and the lowest one for imipenem (9.6%, n=3). The results of MIC were to imipenem 12 samples (38.7%) resistant, 13 samples (41.93%) intermediate, and 6 samples (19.35%) sensitive. The OprD gene was present in all strains but different expression has been observed. The strains with over expression of OprD gene showed high sensitivity towards carbapenems family antibiotics especially imipenem.
Conclusion: Identifying of bacterial resistance mechanisms is very complicated and extensive due to different mechanisms involved for similar antibiotics. OprD is main cause of attachment to the carbapenems family antibiotics. The more expression of OprD shows the more antibiotic sensitivity.
Bahram Pourghassem Gargari, Fereshteh Aliasghari, Sousan Kolahi, Mohammad Asghari Jafarabadi, Elham Mirtaheri,
Volume 17, Issue 12 (3-2015)
Abstract
Background: Rheumatoid arthritis is an inflammatory disease. Hypertension could occur as a result of chronic inflammation in RA patients. Some evidence demonstrates anti-inflammatory effects of alpha-lipoic acid in inflammatory diseases. However, a limited number of studies have evaluated the effects of alpha-lipoic acid in rheumatoid arthritis. Therefore, the current study was designed to investigate the effects of alpha-lipoic acid supplementation on blood pressure and some inflammatory factors.
Materials and Methods: The present study was a randomized, double-blinded, placebo-controlled clinical trial in which 70 female patients aged 20–50 years were randomized to two groups to receive either alpha-lipoic acid (1200 mg/day) or placebo. The intervention duration was 8 weeks. Systolic and diastolic blood pressures were measured before and after the supplementation period. Also, C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Statistical analysis was done using SPSS13 software.
Results: 65 RA patients completed the trial. Systolic and diastolic blood pressure in alpha-lipoic acid group was significantly decreased in comparison with placebo group (p<0.05). But, CRP and IL-6 serum levels did not indicate any significant within- and between group changes.
Conclusion: In the present study, alpha-lipoic acid supplementation resulted in significant blood pressure reduction in rheumatoid arthritis participants.
Mohammad Reza Arabestani, Mohammad Abdoli Kahrizi,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Agr systems, is responsible for control and coordination in production of virulence factors, exotoxins secretory and hemolysins in Staphylococcus aureus. The aim of this study was to determine and identify the frequency of agr genes in susceptible and methicillin-resistant Staphylococcus aureus strains in clinical samples and carriers employed in remedial centers.
Materials and Methods: This descriptive study was done among a total of 200 strains of Staphylococcus aureus isolated from clinical samples and healthy carriers in Hamadan. Antibiotic susceptibility pattern of all isolates was determined by disk diffusion methods. After DNA extraction, the presence of mecA and agr genes was investigated using PCR. SPSS software package version 20 was used to perform statistical tests.
Results: All 200 Staphylococcus aureus strains were susceprible to vancomycin. The prevalence of mecA was 50%. The PCR results showed that agrA was the most perevalent gene followed by the agrC in all isotated Staphylococcus aureus strains. None of the isolates harbored the agrB and agrD gene.
Conclusion: Pathogenesis of Staphylococcus is dependent on some proteins other superficial or excreted which under controlling of agr system. In the present study, the feequency of agrA gene in the methicillin-resistant strains, methicillin-sensitive strains isolated from clinical samples and carriers employed in remedial centers was higher than the other agr types. Therefore, presumably, agrA gene plays an important role Staphylococcal infections.
Esmaeel Soleimani, Mojtaba Habibi Asgarabad, Sajjad Basharpour, Ali Shikheslami, Roghayeh Nooripour Liavali,
Volume 19, Issue 3 (6-2016)
Abstract
Background: Migraine is a chronic neurological disorder that leads patients to avoid any kind of activities. Since different factors are involved in migraine incidence and its triggers, so drugs are used to prevent or treat it are so variable. Also, combined medications are used to relieve migraine. This study examined the effectiveness of self-control training on quality of life in patients with migraine.
Materials and Methods: Statistic population of this study included all migraine patients in Ardabil in 2014(Estimation: N=1150) that 40 patients were selected by convenience sampling. Demographic and disease information questionnaire and quality of life questionnaire (SF-36) were used to collect data in clinical centers. Multivariate analysis of variance (MANCOVA) was used to analyze data, because present research was a experimental and clinical trial with pre-test and post-test with control group.
Results: The results showed that there is a significant difference between mean in quality of life in migraine patients and control subjects. It means that physical health and mental health of quality of life was different between control and experimental groups after self- control training.
Conclusion: Self-control training can be used to enhance quality of life in migraine patients. These results have important and effective applications in the treatment of migraine patients. Generally, specialists of clinical centers can use this method alongside other treatment interventions.
Hamidreza Shokrani, Reza Nabavi, Zahra Alizade Sarabi,
Volume 19, Issue 3 (6-2016)
Abstract
Background: Demodex mites can infect the sebaceous glands and hair follicles from almost every area of human skin especially on the face. Demodicosis is considered to be a factor in the pathogenesis of some skin disorders. The aim of this study was to determine the prevalence of Demodex mites and to identify the association between risk factors and Demodex infection.
Materials and Methods: This cross-sectional study was conducted with 100 university students in Khorramabad, Iran. Samples were collected from three different regions of the face (nose, cheeks and forehead) using two different methods, including cellophane tape method (CTP) and skin pressurization. A questionnaire was filled for each individual and data were subjected to statistical analyses using chi-square test.
Results: The overall prevalence of Demodex mites was 55%. The detection rate of infection by cellophane tape method was much higher than that of the skin pressurization (p<0.01). The incidence of Demodex was found to occur more frequently in males and in people with oily skin (p<0.05). Furthermore, the infection rate among students with acne vulgaris was significantly higher than that of students without acne (p<0.05). We found a significant difference between acne vulgaris and density of Demodex mites (p<0.01).
Conclusion: The cellophane tape method (CTP) is an easy and suitable method for epidemiologic investigations. Skin types and gender were identified as risk factors. Our study suggests that Demodex infection could be associated with acne vulgaris.
Somayeh Bagheri, Hossein Maghsoudi, Fatemeh Motevalli, Farahnaz Khoshdel Nezamiha, Seyed Mehdi Hasanzadeh, Reza Arabi Mianroodi,
Volume 19, Issue 3 (6-2016)
Abstract
Background: Streptokinase is one of the most common and cost effective fibrinolytic drugs for treatment of heart attacks and vein thrombosis. Unlike many advantages over other thrombolytic drugs, administration of streptokinase can produce some complications such as immunologic reactions, hemorrhage and incomplete treatment due to relative short half life. Pegylation is one of the most common methods for improving of these shortcomings.
Materials and Methods: In this study, designing a proper candidate for specific pegylation with cysteine was done by means of SPDBviewer software. After a meaning ful mutation by SOEing PCR method, mutated (sk45cys) and intact SK (ski) genes were cloned in pET26-b vector and the structures were transformed in E.coli. Clones, Afrer growing, were expressed by IpTG and exptression of proteins was confirmed by SDS-PAGE and western blotting. The proteins were purified by affinity chromatography with NiNTA columns and amidolytic activity of purified proteins was assayed using chromogenic method and different concentrations of S2251 substrate.
Results: Results of activity assays showed that amidolytic activity of SK45cys had about 10% increase in comparison to Ski, after 30 minutes of complex formation with plasminogen.
Conclusion: Generally, it was concluded that, considering cys45 as a superficial aminoacid and also relative increase of activity, SK45cys can be considered a suitable protein for specific pegylation.
Hamid Motamedi, Shahnaz Dehbashi, Hamed Tahmasebi, Mohammad Reza Arabestani,
Volume 21, Issue 5 (10-2018)
Abstract
Background and Aim: Staphylococcus aureus(S.aureus) has many pathogens. Antibiotic resistance may increase the invasion of this bacterium. The aim of this study was to determine the role and effect of some antibiotic resistance in the spread of pathogenic strains of S.aureus in different clinical specimens.
Materials and Methods: 95 clinical isolates of S.aureus were collected from different clinical specimens. Antibiotic resistance pattern was determined by Disc diffusion method (Kirby-Bauer) for 6 different classes. Identification of adhesion agent genes in isolated isolates was performed using Multiplex-PCR and specific primers. For analysis of the results, GraphPad Prism version 6 and ꭕ2 statistical sampling was used. p≤0.05 was considered significant.
Findings: Of 95 isolates of S.aureus, 29 isolates (30.52%) were resistant to methicillin, 12 isolates (12.63%), resistant to clindamycin, 48 isolates (50.52%), resistant to gatyfloxacin, 88 (92.63%) isolates resistant to gentamicin, 57 (60%) isolates resistant to erythromycin and 79 isolates (83.15%) were resistant to tetracycline. fnbA genes were isolated in 14 isolates (14.73%), fnbB in 29 isolates (30.52%), fib in 21 isolates (22.10%), clfA in 17 isolates (17.89%) and clfB in 19 isolates (20%). There was a significant correlation between resistance to macular antibiotics, tetracycline, beta-lactam, lacosamide, aminoglycoside and pathogens.
Conclusion: The adhesion factors in S.aureus possibly cause some structural changes and cause resistance to various antibiotic classes.
Hamed Tahmasebi, Sanaz Dehbashi, Mohammad Reza Arabestani,
Volume 21, Issue 7 (2-2019)
Abstract
Background and Aim: Gene mutation in Staphylococcus aureus is one of the most important causes of antibiotic-resistant strains. The High Resolution Melting Curve (HRM) analysis of DNA method can detect these mutations very high quality. The purpose of this study was to evaluate the role of clinical sample type in the occurrence of nucleotide mutations in the mecA gene of S. aureus by HRM method.
Materials and Methods: In this experimental study, 43 clinical isolates of S. aureus were used. To detect possible mutations, isolates with mecA gene were replicated and sequenced. Then, analysis was performed using StepOne Software v2.3 and HRM v3.0.1 software. Sequencing results were used as gold-standard.
Ethical Considerations: This study with research ethics code IR.UMSHA.REC.1396.637 has been approved by research ethics committee at Hamadan University of Medical Sciences.
Findings: Of 43 clinical isolates of S. aureus, 11 isolates (25.58%) had mecA gene and 32 isolates (47.41%) lacked the mecA gene. According to different clinical samples, 3 isolates (27.27%) were resistant to methicillin from blood samples, 2 isolates (18.18%) from urine specimens, 2 isolates (18.18%) from wound samples, 2 isolates (18.18%) of the catheter samples, 1 isolate (9.09%) of the abscess and 1 isolate (9.09%) were separated from the nose swab. In the meanwhile, isolates from the wound and urine had the highest mutation in the adenine amino acid as A → T, A → G, A → C, and
A → X. Isolates taken from blood have mutations in Guanine amino acid as
G → A.
Conclusion: There was a significant relationship between type of mutation and type of clinical specimen in methicillin-resistant Staphylococcus aureus isolates.
Zohreh Karimi Taheri, Mohammad Hosein Aarabi, Ali Nazari Alam, Majid Nejati, Mohammad Shayestehpour, Hamid Reza Gilasi, Afshin Salehi, Mohammad Esmaeil Shahaboddin,
Volume 24, Issue 1 (April & May 2021)
Abstract
Background and Aim: Despite the anti-cancer and antimicrobial properties of licorice extract and lavender essential oil, some factors, such as low bioavailability and biodegradable, limit their therapeutic use. Using nanoparticles is a method to overcome these restrictions. This study aimed to investigate the anti-proliferative effects of nanoemulsion containing licorice extract and lavender essential oil on cancer cells; we also evaluated its antimicrobial properties in vitro.
Methods & Materials: In this experimental study, nanoemulsions, containing licorice extract and lavender essential oil were developed by the spontaneous emulsion method. The anti-proliferative effect of nanoemulsion was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) colorimetric method on two cell lines HepG2 and SK-MEL-3. To measure the antimicrobial effect of 4 standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Minimum Inhibitory Concentration (MIC) method was used.
Ethical Considerations: This study was approved by the Ethics Committee of Kashan University of Medical Sciences (Code: IR.KAUMS.MEDNT.REC.1396.106).
Results: The results of MTT test on HepG2 cells indicated that the concentrations of 630, 1250, and 2500 μg/mL nanoemulsions caused toxicity to the cell and led to the death of >50% of the cells (IC50=401μg/mL; P<0.05). Evaluating SK-MEL3 cells revealed that except for 75 μg of nanoemulsion, other concentrations induced death in >50% of the cells (IC50 = 82 μg/mL; P<0.05). In addition, nanoemulsions, with antimicrobial properties, were studied in 4 strains of bacteria; the highest antimicrobial properties were observed in Staphylococcus epidermidis.
Conclusion: Nanoemulsion containing licorice extract and lavender essential oil presents antimicrobial and antiproliferative effects on the two cell lines studied. The current study results indicated that the nano emulsification of lavender essential oil and licorice extract can enhance their biological impact; thus, they can be used as a drug formulation.
Mohamadreza Arab, Abdolreza Yavari, Marzieh Babaee, Farhad Fatehi,
Volume 24, Issue 6 (February & March 2022)
Abstract
Background and Aim: Swallowing disorder is a common and constant problem in people with Down Syndrome. In experimental method electromyography can be used to evaluate Mastication . The aim of this study was to evaluate the electromyography of the masseter and temporal muscles during Mastication in 2 to 12 years old children with Down syndrome in Arak.
Material and methods: This is a descriptive-analytical and case-control study, that conducted with the purpose of electromyographic study of masseter and temporal muscles during Mastication on 15 children from available 2 to 12 years old Down Syndrome and 15 children that were matched according the method of person-to-person matching in terms of age and gender with samples with Down syndrome
Ethical considerations: In this study, conscious consent was obtained from all parents and no physical harm was inflicted on individuals.
Findings: About the comparison of the mean of amplitude (intensity) of electrical signal of muscle between two groups except right temporal muscle during Mastication and about the mean of the mean frequency when Mastication except for left temporal muscle, in other cases the difference was significant. In the case of comparing the median frequency of the electrical signal of the muscle in most muscles the difference was not significant.
Conclusion: Mean amplitude (intensity) and frequency of the mean electrical signal of the muscle when chewing in most muscles was different between the two groups with Down syndrome and normal, but the differences in mean median frequency in most muscles were insignificant.
Mohsen Kamalinia, Dr Kianoush Zahrakar, Mehdi Arab Zadeh,
Volume 26, Issue 3 (August & September 2023)
Abstract
Introduction: Resilience is known as a component that plays an important role in tolerating the hardships of the occupational and marital environment. Therefore, it is identified as the main construct of personality, so identifying variables that can predict resilience is important.
Methods: The present study is based on the basic purpose and in terms of the method of collecting descriptive data is correlational with structural equation model. The statistical population of the study included married female nurses in public health centers and hospitals of Alborzand province that 400 of them were selected by multistage cluster sampling method. To collect data, Conor and Davidson Resilience Questionnaire, Denis and Vanderwal Cognitive Flexibility Scale, Cognitive Emotion Regulation Questionnaire Granevsky et al., Short Form Skorn and Smith Self Differentiation Questionnaire, and Locke-Wallace Marital Adjustment Scale were used. To analyze the data, structural equation modeling test and SPSS 26 and Amos24 software were used.
Results: The critical ratio between cognitive flexibility (r=76.7), cognitive emotion regulation (r = 72.9.), self-differentiation (r = 71.2), marital adjustment (r = 79.6) and resiliency was found at the significance level of 0/01. The results showed that the data fit with the conceptual model of the research. Also, the mediating role of marital adjustment, between cognitive flexibility, self-differentiation and the cognitive emotion regulation questionnaire on resilience was confirmed. According to the results, to increase the resilience of married female nurses, it is recommended to pay special attention to cognitive, emotional and emotional variables of this class.
Conclusion: According to the results of this study, it is suggested to the officials of the treatment staff to pay special attention to cognitive, emotional and emotional variables of this group to increase the resilience of married female nurses.
Dr. Maryam Arabloei Sani, Dr. Zahra Hajebrahimi, Dr. Parichehreh Yaghmaei, Dr. Nasim Hayati Roodbari,
Volume 26, Issue 5 (December & January 2023)
Abstract
Background and Aim: Diabetes is a type of metabolic disease and one of the most common endocrine diseases. Oxidative stress and inflammation play an important role in the development and progression of diabetes. mTOR signaling pathway play an important role in glucose homeostasis and proliferation of pancreatic beta cells. In the present study, the therapeutic effects of p-cymene on oxidative stress markers and expression of the mTOR gene in diabetic male Wistar rats were investigated.
Materials and Methods: Diabetes was induced by injecting 55 mg/kg body weight of streptozotocin. Biochemical analyses of pancreatic tissue and real-time PCR were done to investigate the effects of metformin (55 mg/kg body weight) and p-cymene (25, 50, and 100 mg/kg body weight) on the activities of catalase and glutathione peroxidase enzymes and mTOR gene expression.
Findings: Streptozotocin decreased catalase and glutathione peroxidase enzymes and decreased the expression of the mTOR gene in pancreatic tissue. Treatment with metformin or p-cymene improved the activities of catalase and glutathione peroxidase enzymes and the expression of the mTOR gene in a dose-independent manner.
Conclusion: Results indicate that p-cymene has antioxidant properties and can regulate the mTOR signaling pathway. Therefore, p-cymene may be effective for the treatment of diabetes alone or in combination with metformin.
Zohreh Mohammadi Kamalabadi, Allahyar Arabmomeni,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: Exercise and physical activity have always been recommended as a core treatment for knee osteoarthritis. However, it is unclear which types of exercises have the most splendid effect on this condition. This study aimed to evaluate the impact of two methods of water exercise (Traband exercise and NASM exercise) on pain and motor function in women with knee osteoarthritis.
Methods: In this semi-experimental study, with a design pre and post-test and a control group, 45 women with knee osteoarthritis with an average age = 56.5 years and a BMI = 29.04 kg/m2 were purposefully selected and divided into three groups (n = 15); Water Exercise with Theraband, Water Exercise with the NASM Approach and Control randomly. An exercise protocol with Theraband and NASM approach (approved by the Medical College of Georgia for patients with knee osteoarthritis) was performed for eight weeks, three sessions per week, and each session lasted about 60 minutes in the water. Visual Analog Scale (VAS) and physical performance tests of the Osteoarthritis Research Society International (OARSI) were used to estimate the study variables. MANCOVA and post hoc Bonferroni tests were conducted to analyze the data at a significant level (P ≤ 0.05).
Results: The results showed that, similarly, in both experimental groups, the amount of pain and the time of tests TUG, 40MW, and SCT decreased significantly (P≥ 0.05). In addition, in both experimental groups, there was a significant increase in the scores of the 30-S-CS and 6MWT tests (P≥ 0.05).
Conclusions: These results showed the beneficial effects of training in water with the traband and training in water with the NASM approach on pain and motor performance indicators. Therefore, the use of these training methods is recommended as a suitable prevention and treatment method for knee osteoarthritis.
Mohsen Kamalinia, Kianoush Zahrakar, Mehdi Arabzadeh,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: Resilience is an influential component of various psychological, emotional, and emotional variables and is substantial in occupational, individual, and family issues research.
Methods: The present study is fundamental in its purpose and descriptive in collecting data; it is a correlational type with a structural equation model. The statistical population of the study also includes all married female nurses in government medical centers and hospitals in Alborz province who were working in 2022, from which 400 people were selected as a sample using a multi-stage cluster sampling method. Connor and Davidson's (2003) resilience questionnaire, the revised short form of the Skorn-Smith Self-Differentiation Questionnaire (2003), and Bagarozzi's (2001) Marital Intimacy Questionnaire were used to collect data.
Results: There is a positive and significant relationship between self-differentiation (r = 0.732,
P > 0.01) and marital intimacy (r = 0.856, P > 0.01) with resilience. Also, the standard deviation, skewness, and kurtosis of the self-differentiation variable were 20.686, 0.212, and -0.941; the marital intimacy variable was 89.597, 887, and -0.019; and the resilience variable was 30.055, 0.202, and -1.131.
Conclusions: The results showed that the data fit the research's conceptual model and also confirmed the mediating role of marital intimacy in the relationship between self-differentiation and resilience. Therefore, it is recommended that healthcare professionals pay special attention to the cognitive, emotional, and affective variables of this group to increase the strength of married female nurses.
Mojgan Mohammadifar, Fereshteh Bahmani, Alireza Abed, Gholamali Hamidi, Mohammad Hossein Aarabi, Sayyed Alireza Talaei,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: The analgesic effects of rosemary and peppermint essential oils have been shown in many studies. Low solubility of essential oils in water and low bioavailability limit their consumption, and nanoparticles can help solve these limitations. This study aimed to investigate the analgesic effect of a nanoemulsion containing rosemary and peppermint essential oils in a rat model of neuropathic pain.
Methods: Forty male rats were assigned to four groups: control (CON), neuropathic pain received normal saline (NPS), nanoemulsion (NPN), or gabapentin (NPG). Neuropathic pain was induced using the CCI model. Animals received a nanoemulsion containing 10% rosemary extract and peppermint essential oil via gavage for 21 days. Behavioral tests (Thermal Hyperalgesia, Thermal Allodynia, and Mechanical Allodynia) were done on days 1, 4, 7, 14, and 21 of the study. Biochemical tests were also done on the sciatic nerve of animals at the end of the study.
Results: The NPS rats had a significantly increased pain threshold compared to the control group (P < 0.001). Furthermore, the analgesic potential of nanoemulsion containing rosemary and peppermint essential oils was seen in allodynia and hyperalgesia tests. Biochemical analyses showed that CCI reduced total antioxidant capacity, superoxide dismutase, and glutathione peroxidase activity, and also increased MDA levels in the rats' sciatic nerve (P < 0.001 for all comparisons). Administering nanoemulsion containing rosemary and peppermint essential oils reversed all the above-mentioned changes in the biochemical parameters (P < 0.001).
Conclusions: Our findings revealed that treating rats with a nanoemulsion containing rosemary and peppermint essential oils can reduce neuropathic pain symptoms by balancing their sciatic nerve's oxidant and antioxidant systems.
