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Background and Aim: Breast cancer is the most common cancer type and the leading cause of cancer-induced deaths in women, worldwide. The Fibroblast Growth Factor Receptor 2 (FGFR2) is a tyrosine kinase receptor that plays an essential role in the growth, invasion, movement, and angiogenesis of tumor cells. Several single nucleotide polymorphisms have been found in the intron 2 of the FGFR2 gene, i.e., associated with a high risk of breast cancer. Genetic variation in this receptor is a new risk factor for breast cancer. The current study aimed to evaluate the association of single-nucleotide polymorphism rs2981582C/T in women with breast cancer.
Methods & Materials:  In total, 80 women with breast cancer and 80 healthy women (controls) were selected from Markazi Province, Iran to participate in this research. Polymorphism rs2981582 was analyzed to investigate its association with breast cancer. DNA extraction from blood samples was performed using a kit. The presence of these single-nucleotide polymorphisms was determined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR - RFLP). Statistical analyses were performed by SPSS using Chi-squared test at P≤0.05.
Ethical Considerations: This study was approved by the Ethics Committee of the Arak University (Code: IR.ARAKMU.REC.1395.28).
Results: Significant differences were observed in the frequency of rs2981582 polymorphism in the FGFR2 gene between the control and patient groups (P=0.000). In the patient group, the TT genotype was significantly associated with the risk of breast cancer (P=0.001; OR=3.566). On the other hand, allele C indicated a protective role against the disease (P=0.000).
Conclusion: The obtained data revealed a significant relationship between rs2981582 C/T polymorphism and the risk of breast cancer; thus, this single-nucleotide polymorphism could be used as a biomarker to predict breast cancer.

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Background and Aim: The development of any society depends on the educational system of that society. The educational system can be efficient and successful when considering the academic performance of learners in different courses. This study aimed to investigate the effects of mental self-care education on students’ mental health and academic motivation.
Methods & Materials: This was a quasi-experimental study with unequal control and experimental groups. The statistical population of this study was students referring to school counseling centers; 40 of them (n=20/group) were selected by random sampling method. The Depression, Anxiety, and Stress Scale - 21 Items (DASS-21), and Academic Performance Rating Scale were used to collect the necessary data. Psychological self-care training was presented to the experimental group in ten 2-hour sessions. Then, a posttest was conducted on the study groups. Data analysis was performed using Multivariate Analysis of Covariance (MANCOVA).
Ethical Considerations: This article was approved by the Ethics Committee of the Islamic Azad University, Khomeini Branch (Code: IR.IAU.ARAK.REC.1399.001).
Results: The obtained findings indicated that mental self-care education was effective on students’ mental health (P<0.05). Furthermore, psychological self-care education was ineffective on students’ academic motivation.
Conclusion: Mental self-care education was used to improve mental health; however, this training did not affect academic motivation in the examined subjects.

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Background and Aim: Major Depressive Disorder (MDD) is the most common mental health condition, with a severe decline in performance, disability, and a 15% risk of suicide. Allopurinol increases the level of tryptophan in the body by inhibiting xanthine oxidase, and by elevating the level of tryptophan, i.e., a precursor to serotonin. Accordingly, it can improve the symptoms of depression. This study aimed to investigate the impact of allopurinol on MDD.
Methods & Materials: In this double-blind clinical trial, 70 patients with MDD, diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders- Fourth Edition-Third Edition (DSM IV-TR) were randomly (paired & individual patient records) divided into two equal groups. Both research groups received 40 mg of citalopram daily for 6 weeks. In addition to citalopram, the intervention group received 300 mg allopurinol daily and the control group received a placebo. At the end of the third and sixth weeks, the examined patients were tested for Hamilton Depression Rating Scale (HDRS).
Ethical Considerations: This study was approved by the Ethics Committee of the Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1394.68). Also, it was approved by the Iranian Registry of Clinical Trials (Code: IRCT201508277373n6).
Results:  The Mean±SD HDRS’s score, after 3 weeks of treatment, in the control and allopurinol groups was measured as 28.42±3.1 and 23.02±3.4, respectively. After 6 weeks after treatment, the Mean±SD depression score in the control and allopurinol groups was equal to 23.28±4.1 and 20.4±1.2, in sequence. A significant difference was observed between the research groups; thus, the intervention group obtained a lower mean score in the HDRS than the controls.
Conclusion: Allopurinol can improve the symptoms of depression and can also be used as an adjunct in the treatment of depression.

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Background and Aim: Acquisition skill in sentence producing is one of the criteria for speech development. By developing and increasing the age, we are witnessing the emergence of compound sentences in speech. Clinical treatments for language disorders in Iran are mostly based on the experiences of Speech Language Therapists or in accordance with English language norms. We need to examine how the length of utterance and compound sentences develop in Persian. The study aimed to report the development of compound sentences and Mean Length of Utterance (MLU) for a Persian-speaking child from 15 to 34 months.
Methods & Materials: In this longitudinal case report, based on Developmental-Descriptive model, MLU and emergence of simple compound sentences of a Persian speaking girl sampled and described from 15 to 34 months by daily scripting. R software version 4.0.2 was used for data analysis. Correlation of age with linguistic variables through Pearson correlation coefficient was evaluated. 
Ethical Considerations: In this paper, the principles of publication ethics were considered.
Results: At the age of 21 months and 13 days, the child uttered her first simple two-word sentence, and at the age of 26 months and 29 days, she used a four-word compound sentence. With the emergence of compound sentences, the increase in the MLU has gained considerable speed. In a few days, we see the addition of a unit to the length of the sentence (word). There was a significant relationship between the MLU and age (r=‌0.925, P=‌0.001), Mean length of sentence and number of words in Persian speaking child (r‌=‌0.910, P=‌0.002) and total number of words and age (r‌=‌0.928, P<0.001). 
Conclusion: Although several longitudinal studies have been conducted on the development of MLU and number of words in other languages, similar studies are rare in Persian. It is important to conduct studies of this type in order to make cross-linguistic comparisons and to study the linguistic universality and language specificity. By increasing age, we see an increase in the number of words in a child's vocabulary, the emergence of compound sentences, and an increase MLU. At 27 to 28 months, there is a dramatic change in the development expressive language as the compound sentences appear. It seems that emergence of compound sentences in the language output, also plays a significant role in increasing the MLU and can be considered in clinical language assessments.

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Background and Aim: Women are the central pillar of social development and the main axis of family health. Success, survival, and promotion of society depend on the health of women in society. Since Health Promotion lifestyle and psychological well-being are important determinants of health, this study was conducted to determine the Health Promotion lifestyle and psychological well-being in women attending the health centers of Arak City in 2019.
Methods & Materials: In this cross-sectional study, among women who attended health centers in Arak City, 221 women who met the inclusion criteria were included in the study by continuous sampling and the form of demographic information, health promoting lifestyle profile-Ii (HPLP-II), and Ryff Psychological well-being Questionnaire was completed. Data were described using descriptive statistics of frequency, frequency percentage, mean, standard deviation, and data analysis by analysis of variance, independent t-test, and regression using SPSS software v. 19.
Ethical Considerations: This study was approved by the Ethics Committee of Research Deputy of Iran University of Medical Sciences (Code: IR.IUMS.REC.1398.609).
Results: The mean health-promoting lifestyle in the study units was 135.96; the mean physical activity components were 16.31; The mean nutrition was 26.41, with the lowest and highest scores, respectively. The mean psychological well-being in the study units was 72.29. The mean components of purpose in life were 10.76, and the mean personal growth was 13.19, with the lowest and highest scores, respectively. Age, chronic diseases, employment, number of children, and alcohol consumption had a significant negative relationship with a health-promoting lifestyle, and a woman’s and her husband’s education had a significant positive relationship with a health-promoting lifestyle (P<0.05). Overall demographic variables predict as much as 13% of health-promoting lifestyles. Age, number of children, and chronic physical and psychological diseases had a significant negative relationship with psychological well-being and economic status. A woman’s and her husband’s education had a significant positive relationship with psychological well-being. Overall, demographic variables predict as much as 10% of psychological well-being. 
Conclusion: Considering that health-promoting lifestyle and psychological well-being are two critical determinants of health, studying these two indicators and the factors affecting them can help Intervention planning to promote women’s physical and mental health.

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Background and Aim: A lack of healthy nutrition first causes prediabetes and then overt diabetes, and every year about 5% to 10% of people with glucose intolerance develop type 2 diabetes. This study aimed to assess the factors affecting the consumption of healthy foods (CHF) based on the food pyramid among prediabetic women based on the Theory of Planned Behavior (TPB).
Methods & Materials: This cross-sectional study was conducted in 2019 on 99 prediabetic women selected from comprehensive healthcare centers in Arak, Iran. A demographic questionnaire, a TPB-based questionnaire, and a food consumption Questionnaire were used for data collection. Data were analyzed through Spearman’s correlation and linear regression analyses.
Ethical Considerations: This study was approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1398.07).
Results: The Mean±SD score of diet behavior was 1.34±0.28 (in the possible range of 0-2). Around 41% of participants consumed sugary foods such as sweets and chocolate at least once a week and 35% at least once a month. Regression analysis shows that by increasing a standard deviation in the behavioral intention score, the behavior score of a healthy diet will increase by 0.22 standard deviation (P<0.05).
Conclusion: To achieve a healthy lifestyle in the individual at risk for a diabetics education program to increase perceived behavior and motivation for decision making for adherence to healthy food can be attention for policymakers in a health system.

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Background and Aim: Evaluating variability can help to investigate the process underlying motor coordination problems. The current study aimed to measure motor coordination and its variability in children with Developmental Coordination Disorder (DCD). Moreover, the symmetry of motor coordination variability in these children and the relation between motor skills and variability were explored.
Materials and Methods: After evaluating motor skills in children, aged 7-10 years using Movement Assessment Battery for Children-2 (MABC-2), 15 children with DCD and 20 non-DCD children performed a bilateral coordination task. Using motion capture system, motor coordination and variability were recorded and calculated by computing continuous relative phase and its standard deviation, respectively.
Ethical Considerations: The study with an ethical code of IR.UT.SPORT.REC.1396030 was approved by Ethics Committee of Faculty of Physical Education and Sport Sciences of University of Tehran.
Findings: Children with DCD showed significantly higher variability, while there was no significant difference between the groups in performing the coordination task. Moreover, the variability of motor coordination was found asymmetrical in children with DCD. Finally, more variability was shown to be accompanied with lower score in motor skills of the participants.
Conclusion: The current study shows the necessity of employing assessments related to underlying process of movement coordination such as variability, which can help to provide more comprehensive understanding of motor patterns of children with DCD and the strategies that they adopt to execute and produce movement.
 

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Background and Aim: Different implant angulation, which is unavoidable in clinical situations, can affect the accuracy of impression. The aim of this study was to investigate the effect of fixture position on the accuracy of connecting impression coping to implants with internal hex.
Materials and Methods: A gypsum model with 4 implants with internal hex connection was prepared. The implants were installed in different mesiodistal angles of 0, 15, 25 and 35 degrees to the longitudinal axis in the gypsum model. To simulate the gums, a gingival mask was injected around the implants to a height of 2 mm. After a training session for senior dental students on how to close the impression coping, forty students were asked to close the impression copings on four implants. The correctness of the impression coping was evaluated by an expert prosthodontist. Data were statistically analyzed using Cochran Q test. Significance level was considered 0.05.
Ethical Considerations: this article is approved by ethics committee of Arak University of Medical Sciences.
Findings: The correct performance of students in connecting the impression coping to the implant at angles of 0, 15, 25 and 35 degrees was equal to 85%, 72%, 52%, 35%, respectively. With the exception of 0 and 15 degree groups, a statistically significant difference was observed between different study groups.
Conclusion: The fixture position has a significant effect on the accuracy of connecting impression coping to the implants with the internal hex and by increasing the implant angulation, the accurate connection the impression coping to the implant decreases. 

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Background and Aim Physical activity has multiple health benefits, but its association with fertility in women is still unknown. Considering the critical effects of lifestyle on reproductive health, this study aims to compare the physical activity and body composition of fertile and infertile women.
Methods & Materials This is a case-control study that was performed on 100 fertile and 100 infertile women aged 20-40 years referred to the infertility treatment centers in Arak, Iran. they completed self-reported questionnaires surveying sociodemographic characteristics and lifestyle, and the International Physical Activity Questionnaire (IPAQ) assessing physical activity and sedentary behavior. Anthropometric characteristics and body composition were also measured. Multiple logistic regression analysis was used to analyze the association of fertility with physical activity level, sedentary behavior, and body composition.
Ethical Considerations This study was approved by the Ethics Committee of the University of Arak University of Medical Sciences  (Code: IR.ARAKMU.REC.1400.050).
Results The level of physical activity (P=0.001) was lower and the body mass index (P=0.03) was higher in infertile women than in fertile women. In women with moderate level of physical activity, the risk of infertility was lower (OR=4.42, 95% CI: 1.60-12.99, P=0.004). Women who spent the time sitting for more than 300 minutes a day were 2.07 times more likely to have fertility than women who were physically active (OR=2.07, 95% CI: 1.36-3.14, P=0.001).
Conclusion Low physical activity, sedentary lifestyle and obesity are independent risk factors of infertility. To prevent infertility, more attention should be paid to the lifestyle of women.

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