---

Background and Aim: Tamoxifen is a group of drugs of selective estrogen receptor modulators, and is one of the drugs effective in the prevention and treatment of some cancers (such as breast cancer). In this study, the interaction of tamoxifen with DNA is investigated experimentally. Also, the electronic structure (at atomic scale) of the molecular system of tamoxifen was theoretically investigated, using atom in molecule (AIM) theory.
Methods & Materials: First, in the experimental section of this study, the interaction of Tamoxifen with DNA were investigated by UV-ViS technique and hydrodynamic method (Viscometry). In addition, the analysis of the experimental results shows the obvious effect of concentration on the mechanism of how the tamoxifen molecule binds to DNA. Then, in the theoretical part of this research, using computational biophysical chemistry methods, some properties of tamoxifen molecular system, such as electronic Density of States (DOS), boundary orbital’s energy (HOMO/LUMO), Electrostatic Potential Energy (EPS) and electronic contour maps of the electron density and its Laplacian, will be calculated.
Ethical Considerations: This article is a meta-analysis with animal sample.
Results: Result of the UV-ViS spectroscopy technique and viscometry indicated hyperchromism and hypochromism effect. In addition, the result were depend on the concentration of the drug and affected the kind of binding of Tamoxifen to DNA. the analysis of computational studies on the drug tamoxifen suggests that the mechanism of the local charge/energy distribution in the molecular system of tamoxifen plays an important role in how this drug binds to DNA.
Conclusion: Based on the experimental results of UV-ViS technique and viscometry, as well as the electronic/vibrational properties of the tamoxifen molecular system, it was defined that the Tamoxifen interacts significantly with all the binding sites of DNA.

---

Background and Aim: Acquisition skill in sentence producing is one of the criteria for speech development. By developing and increasing the age, we are witnessing the emergence of compound sentences in speech. Clinical treatments for language disorders in Iran are mostly based on the experiences of Speech Language Therapists or in accordance with English language norms. We need to examine how the length of utterance and compound sentences develop in Persian. The study aimed to report the development of compound sentences and Mean Length of Utterance (MLU) for a Persian-speaking child from 15 to 34 months.
Methods & Materials: In this longitudinal case report, based on Developmental-Descriptive model, MLU and emergence of simple compound sentences of a Persian speaking girl sampled and described from 15 to 34 months by daily scripting. R software version 4.0.2 was used for data analysis. Correlation of age with linguistic variables through Pearson correlation coefficient was evaluated. 
Ethical Considerations: In this paper, the principles of publication ethics were considered.
Results: At the age of 21 months and 13 days, the child uttered her first simple two-word sentence, and at the age of 26 months and 29 days, she used a four-word compound sentence. With the emergence of compound sentences, the increase in the MLU has gained considerable speed. In a few days, we see the addition of a unit to the length of the sentence (word). There was a significant relationship between the MLU and age (r=‌0.925, P=‌0.001), Mean length of sentence and number of words in Persian speaking child (r‌=‌0.910, P=‌0.002) and total number of words and age (r‌=‌0.928, P<0.001). 
Conclusion: Although several longitudinal studies have been conducted on the development of MLU and number of words in other languages, similar studies are rare in Persian. It is important to conduct studies of this type in order to make cross-linguistic comparisons and to study the linguistic universality and language specificity. By increasing age, we see an increase in the number of words in a child's vocabulary, the emergence of compound sentences, and an increase MLU. At 27 to 28 months, there is a dramatic change in the development expressive language as the compound sentences appear. It seems that emergence of compound sentences in the language output, also plays a significant role in increasing the MLU and can be considered in clinical language assessments.

---

Background and Aim: Research has shown that social power affects information processing in many ways and can induce powerful movements or gestures. This study aimed to investigate the effect of pretending power gestures on changing the pain threshold of a group of female students.
Methods & Materials: The method of the present study was quasi-experimental with a pre-test post-test design with a control group. The statistical population of this study included all female students of Arak University in the academic year 2016-2017, from which 60 people selected by convenience sampling method, and randomly divided into three groups: high power posing (sitting on a chair and putting your feet on the table, placing your hands behind your head and holding your head up), low power posing (sitting on a chair with your legs together, arms between your legs and bending your head to bottom) and control. Rosenberg self-esteem scale and tourniquet technique with cuff pressure gauge (to measure pain threshold) used to collect data. After the pre-test measurements and two minutes of gestures, the post-test was performed immediately. Data were analyzed using the analysis of covariance.
Ethical Considerations: This study was approved by the ethics committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1399.276).
Results: The results showed that pretending high/low power gesture significantly affects pain threshold; pretending to have a high-power gesture increases the pain threshold, and pretending to have a low-power gesture lowers the pain threshold.
Conclusion: Based on the results, using power gestures as a simple tool in pain situations is recommended for pain management or as a supplement to analgesics.

---

Background and Aim: The aim of this study was to investigate the prevalence and associated factors of musculoskeletal pain in undergraduate students of Engineering and Humanities Faculties of Arak University in 1397-98.
Methods & Materials: This cross-sectional study of 464 students (humanities, 169 and engineering, 295 people) with mean age (20.56+1.51 years), Body Mass Index (22.29±3.35 kg/m2)). Was done at the undergraduate level of Arak University in the 2018-2019 years. Nordic questionnaire to assess musculoskeletal pain during the last 7 days, 12 months as well as functional disorders during the last 12 months in the neck, shoulders, wrists and hands, back, lower back, pelvis, thighs, legs and ankles were examined.
Ethical Considerations: This study was approved by the Ethics Committee of Research Projects of Hamadan University (Code: IR.BASU.REC.1398.013).
Results: The highest prevalence of musculoskeletal pain was in the spine (63.4%) which is in the back (27.6%), neck (23.5%) and then shoulders (21.8%), respectively. In software and chemical engineering, neck, shoulder, wrist, and hand pain were most common due to computer work and study time per day. Back and lower back pain were very common in psychology and Quranic sciences due to inactivity and increasing Waist-Hip ratio.
Conclusion: Musculoskeletal pain is one of the most serious problems in some fields of study in colleges, which can be found to reduce the complications by finding the causative factors and educating students.

---

Background and Aim: Resistance training with blood flow restriction can have the same effects as traditional resistance training. The current study aimed to determine the effect of six weeks of selected resistance training with active and passive rest, with and without blood flow restriction, on young men’s C Reactive Protein (CRP), Lactate Dehydrogenase (LDH), and muscle endurance.
Methods & Materials: From the available and voluntary samples, 24 healthy young soldiers of the Islamic Republic of Iran Air Force were divided into 3 groups of 8 subjects: traditional resistance training, resistance training with blood flow restriction, and passive rest and resistance training with blood flow restriction and active rest. Exercise programs were performed for 6 weeks, 3 sessions per week with an intensity of 70-80% One-repetition maximum (1RM) for the traditional resistance group (3 sets of 10), 20-30% 1RM for the passive rest group (30-15-15-15), and 20 -30% 1RM was administered for the active rest group (30-7-15-7-15). Before and after six weeks, physiological and anthropometric characteristics, muscle endurance, and hormonal levels were measured, and ELISA measured blood samples. Data were analyzed using covariance and Bonferroni post hoc tests and paired t-test for comparison within groups.
Ethical Considerations: All experimental procedures were approved by the Ethics committee of the Sport Sciences Research Institute of Iran (Code: I.R.SSRC.REC.1398.129), Clinical Trial (Code: ID IRCT20191207045644N1) from the Iran Clinical Trial Registration Center and were conducted under the Declaration of Helsinki.
Results: Results showed that 6 weeks of exercise had a significant effect on Muscle endurance (P=0.001) but on the levels of C-reactive protein (P=0.43) and Lactate dehydrogenase (P=0.44) had no significant difference. 
Conclusion: According to the results of this study, it seems that a combination of resistance training with restriction of blood flow and Interval training (active rest) can be a good alternative to traditional training and, in some cases, replace resistance training with occlusion and passive rest.

---

Background and Aim: Patellofemoral Pain Syndrome is one of the most common musculoskeletal problems in the elderly that Can affect their daily activity. This study aims to compare the effectiveness of a period strengthening core stabilization exercise with the Knee strengthening exercises on improving pain in female athletes with Patellofemoral Pain Syndrome.
Methods & Materials: In this study, 20 female athletes with Patellofemoral Pain Syndrome participated. They were accidentally divided into two groups: strengthening core stabilization exercise (10 people( and strengthening knee exercise (10 people). A visual analog scale measured patients’ pain before and after eight weeks of practice interventions. Paired t-test and independent t-test were used at the significant level of (P<0.05) to analyze the results.
Ethical Considerations: This study was approved by the Research Ethics Committee of Bu Ali Sina University Hamedan (Code: IR.BASU.REC.1398.032).
Results: The results showed that the pain level in both groups decreased significantly after strengthening core stabilization exercises (P=0.006) and the Knee strengthening exercises (P=0.000). Although intergroup comparison did not show a significant difference in the results (P̀=0.064), the calculation of the effect showed a more significant effect of strengthening knee exercise [ES=1.8) on the improvement of pain compared to the strengthening core stabilization group (ES=0.7).
Conclusion: The results showed that knee strengthening and core stabilization exercises reduced the pain. But due to the higher effectiveness of knee strengthening exercises in improving pain, it is recommended to use this protocol to reduce the pain of these patients.

---

Background and Aim: Evaluating variability can help to investigate the process underlying motor coordination problems. The current study aimed to measure motor coordination and its variability in children with Developmental Coordination Disorder (DCD). Moreover, the symmetry of motor coordination variability in these children and the relation between motor skills and variability were explored.
Materials and Methods: After evaluating motor skills in children, aged 7-10 years using Movement Assessment Battery for Children-2 (MABC-2), 15 children with DCD and 20 non-DCD children performed a bilateral coordination task. Using motion capture system, motor coordination and variability were recorded and calculated by computing continuous relative phase and its standard deviation, respectively.
Ethical Considerations: The study with an ethical code of IR.UT.SPORT.REC.1396030 was approved by Ethics Committee of Faculty of Physical Education and Sport Sciences of University of Tehran.
Findings: Children with DCD showed significantly higher variability, while there was no significant difference between the groups in performing the coordination task. Moreover, the variability of motor coordination was found asymmetrical in children with DCD. Finally, more variability was shown to be accompanied with lower score in motor skills of the participants.
Conclusion: The current study shows the necessity of employing assessments related to underlying process of movement coordination such as variability, which can help to provide more comprehensive understanding of motor patterns of children with DCD and the strategies that they adopt to execute and produce movement.
 

---

Background and Aim: Swallowing disorder is a common and constant problem in people with Down Syndrome. In experimental method electromyography can be used to evaluate Mastication . The aim of this study was to evaluate the electromyography of the masseter and temporal muscles during Mastication in 2 to 12 years old children with Down syndrome in Arak.
Material and methods: This is a descriptive-analytical and case-control study, that conducted with the purpose of electromyographic study of masseter and temporal muscles during Mastication  on 15 children from available 2 to 12 years old Down Syndrome and 15 children that were matched according the method of person-to-person matching in terms of age and gender with samples with Down syndrome
Ethical considerations: In this study, conscious consent was obtained from all parents and no physical harm was inflicted on individuals.
Findings: About the comparison of the mean of amplitude (intensity) of electrical signal of muscle between two groups except right temporal muscle during Mastication  and about the mean of the mean frequency when Mastication  except for left temporal muscle, in other cases the difference was significant. In the case of comparing the median frequency of the electrical signal of the muscle in most muscles the difference was not significant.
Conclusion: Mean amplitude (intensity) and frequency of the mean electrical signal of the muscle when chewing in most muscles was different between the two groups with Down syndrome and normal, but the differences in mean median frequency in most muscles were insignificant.

---

---

---

Background and Aim The occupational environment, the type of work overload or underload, physical risks, how individuals adapt to the workplace, and face the family - work constitute the sources of stress or occupational distress. Job stress emerges as the duties and tasks assigned to people are more than their abilities. This study aimed to investigate the relationship between stress management training and work ethics of employees.
Methods & Materials This research was an applied study in terms of purpose, a mixed exploratory (qualitative and quantitative) study in terms of data, a content analysis (qualitative stage) and  cross-sectional survey (quantitative stage) in term of conduct. The study population in the qualitative section comprised experts (Experts in Psychology, Educational Management, and Social Medicine) according to the inclusion and exclusion criteria. In the qualitative section, the study population included experts and managers who had received stress management training. Sample size and sampling method in qualitative part was based on the principle of theoretical saturation, resulting in 12 people using purposive sampling method. In the quantitative part, the sampling was based on the Cochran’s formula, resulting in 220 people who were selected using cluster sampling method. 
Ethical Considerations This barcode research was presented to the Ethics Committee and registered in the system (IR.IAU.TNB.REC.1400.121). 
Results The results showed that to deal with stressful situations, three basic strategies of event-focused coping, anxiety-focused coping, and avoidance-focused coping strategies can be used for stress management training models. Overall, the components presented for coping with stressful conditions have the necessary and appropriate validities. All three main coping strategies (event-focused, anxiety-focused, and refusal-focused) are suitable for explaining and fitting. So, they all are reliable and confirmed in the current research questionnaire of coping with stress.
 Conclusion Strategies for coping with stressful situations have a different effect on people’s professional work ethics so that the event-focused coping strategy has a significant positive relationship with professional ethics. On the other hand, the anxiety-focused and avoidance-focused coping strategies have negative and decreasing relationship with professional ethics. The more emphasis on the event-focused coping strategy, the more would be the professional ethics of individuals and the more emphasis on the anxiety-focused and avoidance-focused coping strategies, the less would be the professional ethics of individuals..

---

Background and Aim Sciatica is one of the most common diseases of the peripheral nervous system and may be caused by pressure on the sciatic nerve. Due to the fact that piriformis muscle located near the sciatic nerve, piriformis muscle spasm may put pressure on the nerve and cause sciatica and consequently piriformis syndrome. The present study aims to investigate the effect of core stability exercises on pain and inflammation of patients with piriformis syndrome.
Methods & Materials This is a randomized clinical trial. The study population consists of all patients with piriformis syndrome referred to medical centers in Arak, Iran from. Of these, 20 were purposefully selected and randomly divided into two groups of control (n=10) and exercise (n=10). The exercise group performed core stability exercises for 6 weeks, while the control group continued their normal life during this period. To examine the differences between the study groups, t-test, Chi-Square test, and McNemar’s test were used. The significance level was set at 0.05.
Ethical Considerations This study was approved by the Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1400.157) and was registered by Iranian Registry of Clinical Trials (ID: IRCT20211003052662N1). Informed consent was obtained from all participants.
Results The Mean pain score in the control group decreased from 95.2 to 90.7 after the exercise, which was not statistically significant (P=0.562). In the exercise group, the mean pain score decreased from 91.7 to 33.4, and this decrease was statistically significant (P=0.0); Therefore, at 95% confidence interval, we can say that core stability exercises had a significant effect on the pain of patients with piriformis syndrome (P<0.05). The number of patients with inflamed nerve in the control group decreased from 10 in the pre-test phase to 8 in the post-test phase, but this decrease was not statistically significant (P=0.5). In the exercise group, it was reduced from 10 to 2, and this decrease was statistically significant (P=0.008); Therefore, we can say that core stability exercises had a significant effect on the inflammation of patients with piriformis syndrome (P<0.05).
Conclusion Core stability exercises can reduce pain and inflammation in patients with piriformis syndrome. These exercises can be used in the treatment of these patients.

---

---

---

---

---

---

---

---