Showing 49 results for Mosayebi
Kevan Ghasami, Ali Ghazavi, Yahya Jand, Mohamdali Payani, Mahmodreza Khazaei, Ghasem Mosayebi,
Volume 13, Issue 2 (6-2010)
Abstract
Background: Multiple sclerosis (MS) is a chronic, autoimmune disease of the central nervous system (CNS) of unknown etiology. Vitamin D3 (1,25(OH)2D3) has strong immune modulating potential. Nitric Oxide (NO) has been identified as one of the most destructive products of the immune system and is an important factor in demyelination. The effect of short-term vitamin D3 supplementation on NO level was assessed in MS patients. Materials and Methods: The study included 60 MS patients (male and female). Patients were randomized independently, in a double blind design, into one of two treatment groups. Controls (n=30) received current treatment. Vitamin D treated (n=30) individuals received current treatment plus 300000 IU vitamin D3. Vitamin D3 injection was repeated monthly for 6 months. Nitric oxide (NO) production was estimated by Griess reaction. Results: NO levels decreased following vitamin D3 treatment but the differences did not reach significance (12.411.1 μmol/L to 9.88.9 μmol/L). Control group was also associated with an increase in NO levels but not statistically significant (18.417.07 μmol/L to 22.0716.8 μmol/L). Conclusion: Vitamin D3 has not significant effect on the level of nitric oxide. However, further studies should be done to evaluate the potential of vitamin D as an immune modulator in management of MS.
Mahmood Amini, Seid Alireza Hosseini, Yahya Jand, Tooraj Zandbaf, Babak Eshrati, Shabanali Alizadeh, Ghasem Mosayebi, Ali Ghazavi, Ali Cyrus,
Volume 13, Issue 4 (1-2011)
Abstract
Background: Nowadays, the use of inflammatory biomarkers in the diagnosis of appendicitis is on the rise. On the other hand, the role of oxygen free radicals in various inflammatory states has been verified. Noticing the high prevalence of negative appendectomy (9.3-22.2%), the aim of this study was to investigate the level of blood total antioxidant capacity (TAC) as a biomarker for early diagnosis of acute appendicitis. Materials and Methods: In this prospective analytical trial, over a one-year period, 407 patients, with preoperative diagnosis of acute appendicitis who had undergone operation, were studied. After measuring the TAC level, data were analyzed through the analytic ROC curve and parametric mean comparison tests. Results: Of all the patients, 298 were identified with appendicitis. TAC levels in adult female and male groups were respectively 663.9±164.75 and 752.58±167.37 µm/L which revealed a significant difference (p<0.0001). Also, in children, the mean of TAC level in perforated appendicitis sub-group was significantly greater than those in gangrenous and suppurative groups. Conclusion: TAC level can be used as a predictive factor for the diagnosis of perforated appendicitis in children however, it cannot be used as a biomarker for the diagnosis of appendicitis. Because of the significant difference existing between the level of TAC in male and female patients, further studies are suggested to investigate the level of inflammatory biomarkers with respect to menstrual cycle in women.
Mahmoud Kamani, Hamid Abtahi, Ghasem Mosayebi, Razieh Nazari, Masode Karimi,
Volume 14, Issue 1 (3-2011)
Abstract
Background: In pyoderma infections, the density of pus is related to desoxiribo-nucleoproteins. The use of streptodornase (DNase) in combination with streptokinase can help dissolve purulent secretions of infections which results in healing the wound through the discharge of pus from the necrotic tissue. The aim of this study was to produce recombinant streptodornase from group A strain of Streptococcus pyogenes which is highly efficient in terms of active streptodornase production using expression vector. Materials and Methods: In this applied-fundamental study, genomic DNA of streptodornase gene (sd) was extracted by phenol-chloroform. Then by using specific primers of streptodornase gene, it was amplified through PCR. The resulting streptodornase gene was cloned in pGEX4T1-sd transformer for expression and the pGEX4T1-sd plasmid was transferred to the sd. E.coli BL21. Protein production was done by induction via IPTG and optimization of the conditions. The recombinant protein was purified using the glutathione sepharose 4B kit. Results: The nucleotide sequence of PCR and group A streptodornase Streptococcus was totally the same. The production of the streptodornase recombinant protein was done by inducing pGEX4T1-sd plasmid via Isopropyl β-D-1-thiogalactopyranoside. Protein purification was done through affinity-chromatography by using glutathione sepharose 4B. The recombinant protein was reacted with anti-streptodornase mouse serum through Western-Blot method. Conclusion: Recombinant streptodornase can be produced by pGEX4T1 in E. coli. The recombinant protein maintains its antigenic property desirably. Noticing the domestic need in Iran, low rate of production, and pathogenesis of streptococci, production of this recombinant product is feasible.
Mahdi Mosayebi, Fereshteh Zamani Alavijeh, Mahmood Reza Khazaii,
Volume 14, Issue 3 (7-2011)
Abstract
Background: The purpose of this study was to identify the effect of health education according to health belief model (HBM) on the adoption of preventive behaviors of infection with giardia lamblia by primary school students in Arak.
Materials and Methods: In a randomized quasi-experimental case study, 1200 students were randomly divided into two equal groups of test (instruction) and control (non-instruction). The sample size for giardiosis identification tests included 300 students, who had been equally and randomly selected from the control and test groups. Health education was according to HBM and its impact on the students' lifestyle-related patterns of behavior was considered.
Results: Paring nails in the test group, significantly increased after education while it decreased significantly in the control group. The number of students who carried a glass for drinking slightly increased, but it remarkably decreased in the control group. The number of students who applied soap after using the restrooms remarkably increased in both the test and control groups. The relationship between not paring nails and infection with giardia lamblia was statistically significant. Additionally, after education, the ratio of reduction of infection with giardia lamblia in the test group to its increase in the control group was statistically significant.
Conclusion: Preventive behaviors significantly improved and appeared influential in the reduction of infection with giardia lamblia. Thus, using a HBM in prevention of parasitic infections along with instructing the parents are suggested for prevention of parasitic infections.
Shahin Fateh, Mohamd Reza Mamaghani, Ghasem Mosayebi,
Volume 15, Issue 1 (April-May 2012)
Abstract
Background: Because of high mortality and morbidity of severe acute pancreatitis (AP) and its increasing incidence in recent years, early detection of severity of AP is very important. Since interleukin (IL) rapidly responds to body temperature changes, this study was done to examine the relationship between blood levels of interleukin 15 and 17 and severity of acute pancreatitis.
Materials and Methods: In this cross-sectional study, 52 patients with AP were studied. For all patients, paraclinical information, Ranson criteria, and APACHE-II were completed. Serum interleukin 15 and 17 levels were measured by ELISA method. Then the relationship between them and AP severity was determined based on Ranson criteria and APACHE-II.
Results: In this study, 36.5% of the patients were male and 63.5% were female and the mean age was 61.06 years. The serum level of IL-17 was negatively correlated with the severity of AP based on Ranson criteria (p=0.021, r= -0.319). ROC curve showed significant values for blood level of IL-15 and CRP in AP diagnosis. Sensitivities were 92.3% and 78.8% and specificities were 40% and 48%, respectively.
Conclusion: Based on Ranson criteria, the role of serum level of IL-17 as an unknown factor was seen significant in determining the severity of AP. However, the diagnostic value of serum IL-15 should also be verified with further studies.
Mahmood Amini, Ali Ahmadabadi, Yahya Jand, Ghasem Mosayebi, Ali Ghazavi ,
Volume 15, Issue 2 (June-July 2012)
Abstract
Background: Acute pancreatitis is a common cause of abdominal pain, without any characteristic signs, symptoms, or a gold standard diagnostic modality. The purpose of this study was to evaluate the diagnostic value of urine trypsinogen-2 strip test in acute pancreatitis. Materials and Methods: In this cross-sectional study, 76 patients with abdominal pain suspected to acute pancreatitis who were admitted to the Emergency ward of Valiasr Hospital, Arak, were evaluated. In 46 patients, acute pancreatitis was confirmed (pancreatitis group), whereas in 28 patients, acute pancreatitis was ruled out (control group). In both groups serum levels of amylase, lipase, CRP, and urine trypsinogen-2 were measured by quantitative and qualitative methods. Sensitivity and specificity of the tests were determined and data were analyzed using SPSS software. Results: Urine trypsinogen-2 dipstick was positive in 36 of the 45 patients in the pancreatitis group (sensitivity: 80%) and in 2 of the 28 patients in the control group (specificity: 92.8%). Urine trypsinogen-2 ELISA test was positive in 41 of the 45 patients in the pancreatitis group (sensitivity: 91.1%) and in 4 of the 28 patients in the control group (specificity: 89%). Amylase sensitivity and specificity were equal to 82.6% and 75%, respectively. Lipase sensitivity and specificity were 76% and 85.7%, respectively. Conclusion: Urine trypsinogen-2 dipstick can be used to differentiate acute pancreatitis from other causes of abdominal pain. This rapid, easy-to-use, and accurate test can be used in emergency wards and primary health care units with limited diagnostic facilities.
Shaban Ali Alizadeh, Abolfazl Fatehi, Yahya Jand, Ghasem Mosayebi, Mohammad Rafiei,
Volume 15, Issue 2 (June-July 2012)
Abstract
Background: Several studies have demonstrated that the levels of inflammatory markers in healthy women are under the influence of menstrual cycle changes. The aim of this study was to compare blood levels of inflammatory markers in women with appendicitis in different phases of menstrual cycle. Materials and Methods: In this case-control study, 70 female and 12 male patients with appendicitis, and 61 healthy women were enrolled based on inclusion and exclusion criteria. Inflammatory markers, such as leukocyte count, CRP, ESR, and TNF-α were measured and compared using student t-test and one-way ANOVA based on different phases of menstrual cycle. Results: There were no significant changes in the ESR, CRP, and TNF-α concentrations and the number of peripheral blood leukocytes in different phases of the menstrual cycle in women with appendicitis. The mean number of leukocytes and CRP concentrations were significantly higher in patients with appendicitis compared with the control group. Conclusion: The findings show that there are not significant differences in the inflammatory markers in women with appendicitis during the different phases of menstrual cycles. It seems that day to day variation of sexual hormones in the menstrual cycle have led to very different conclusions about the change of inflammatory markers in different phases of menstrual cycle. Therefore, studies investigating inflammatory markers in women with acute appendicitis based on day of menstrual cycle, time of sampling in the day, and severity of appendicitis are suggested.
Mana Shojapuor, Ghasem Mosayebi, Keyvan Ghasami, Ali Ghazavi, Abdolrahim Sadeghi,
Volume 15, Issue 4 (September 2012)
Abstract
Background: Multiple sclerosis (MS) is an autoimmune disease which demyelinates the central nervous system. Vitamin D, is a potential environmental factor which influences this disease. The majority of the biological activities of the polymorphism forms of vitamin D are done through its receptor gene (VDRG). The aim of this study was to examine the relationship between BsmI polymorphisms in VDRG and the incidence of MS. Materials and Methods: In this case-control study, the BsmI polymorphism in the VDRG was studied in 80 Iranian MS patients and 50 healthy controls of the same genetic background and age through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method Results: There was a significant difference in the frequency of BsmI VDRG polymorphism genotypes between MS patients and controls (P=0.023). Conclusion: This study indicated that the VDRG BsmI polymorphism is associated with MS in this population.
Somayeh Kiaie, Hamid Abtahi, Mohammad Alikhani, Ghassem Mosayebi,
Volume 15, Issue 7 (December 2012)
Abstract
Background: Vibrio cholerae is a gram-negative bacterial pathogen that causes diarrheal disease cholera. One of the most pathogenic factors of Vibrio cholera is pili. Pili plays an important role in colonization and persistence of bacteria in small intestine. Materials and Methods: In this study, pili A (tcpA) gene was amplified by Polymerase chain reaction (PCR) method and sub-cloned into expression vectors such as pGEX4T-1. Escherichia coli competent cells were transformed by recombinant plasmids and the expression of protein with IPTG. The recombinant proteins were purified by affinity chromatography (GST) and immunoblot analysis was used for evaluation of new recombinant proteins antigenicity. The concentration of recombinant proteins was measured according to Bradford assay. Results: The results of this study indicated that recombinant proteins were expressed successfully in competent cell of E. coli, such as E. coli BL21 (DH3). The recombinant protein was purified by affinity chromatography (GST). The immunoreactivity pattern of anti-Tcp antibody with recombinant proteins of TcPA showed that the recombinant proteins had antigenic properties. Conclusion: Because these recombinant proteins are antigenic, these proteins may be considered as tentative candidates for designing cholera vaccine.
Mojtaba Sharafkhah, Ghasem Mosayebi,
Volume 16, Issue 2 (5-2013)
Abstract
Background: Epidemiologic studies show the high prevalence of some infections and cancers in individual blood groups. Perhaps, level of immunity factors differs in people with individual blood group. The aim of this study is to compare the level of antibodies and complement factors in ABO blood groups.
Materials and Methods: In this descriptive study, peripheral blood samples from 40 male healthy individuals with different ABO blood groups (n=10 in each group) with similar age (18-25 years) and genetic background were collected. The serum levels of total IgG, IgM, IgA, C3, and C4 were analyzed by nephelometry method. All data were analyzed by SPSS software version 11.5.
Results: The levels of IgA, IgG, and C4 protein in individuals with O blood group were significantly higher than those of other groups (p=0.02, p=0.01, and p=0.004, respectively). Also, the mean concentration of IgM in individuals with AB blood group was significantly higher than that in other groups (p=0.02). There was a significant difference between the level of C3 in O blood group and those of other blood groups (p=0.01). The mean concentrations of all parameters (except IgG) in B blood group were lower than those in other blood group.
Conclusion: Generally, natural antibodies in O blood group were higher than those in other groups. This high level of total antibodies in O blood group may reduce susceptibility to some infections.
Ahmad Reza Behruzi, Mohammad Hossein Hadi, Ahmad Reza Ghandi, Ghasem Mosayebi,
Volume 16, Issue 11 (2-2014)
Abstract
Background: Osteoporosis is characterized by low bone density and loss of structural integrity which can increase the risk of bone fracture and its side effects. In the recent studies, new evidences of the relationship between immune system such as TNF-&alpha and IL-17A and bone destruction have been accumulated. The aim of present study was to investigate serum level of TNF-&alpha and IL-17A in women with post-menopausal osteoporosis.
Materials and Methods: In this analytical study 40 women with post-menopausal osteoporosis and 10 healthy women were enrolled to the study based on inclusion and exclusion criteria. The serum level of TNF-&alpha and IL-17A were calculated by using ELISA method and compared between groups.
Results: The mean level of TNF-&alpha in case and control group was 957.7±479.01 and 418.09±176.7 respectively which in case group was significantly more than control group (p=0.001). The mean level of IL-17A in case and control group was 95.23±36.7 and 125.7±30.6 respectively which in case group was significantly less than control group (p=0.019).
Conclusion: The level of TNF-&alpha in women with post-menopausal osteoporosis was more than healthy women which can mention the roll of TNF-&alpha in pathogenesis of osteoporosis and potential therapeutic roll of anti TNF-&alpha agents but because of unclear roll of IL-17A in pathogenesis of osteoporosis we could not explain its mechanism in pathogenesis of osteoporosis. It seems more studies with regard to IL-17A roll in bone metabolism is required.
Mahdieh Mondanizadeh, Ghasem Mosayebi, Ehsan Arefian, Massoud Saidijam, Behzad Khansarinejad,
Volume 17, Issue 2 (5-2014)
Abstract
Background: Although miR-124 molecule has been known as an inducer of neurogenesis, few researches have been done on the targets of this molecule and its functional mechanisms in differentiation toward neurons and maintaining neuronal state. The microarray technique has been established as the reference method for studying the genes under the control of miRNAs. However, the high cost of this method has hampered its use in most research centers. On the other hand, the improvement of bioinformatical algorithms and computer modeling systems has led to the development of the bioinformatical softwares that can predict mRNA targets for miRNAs. Therefore, the aim of this theoretical study was to bioinformatically evaluate the effect of miR-124 on transcription factors that can be involved in neurogenesis and neuronal cell amplification, by using various specific softwares. Materials and Methods: Using different algorithms in TargetScan, DIANA and miRWalk databases, the potential transcription factors targets of miR-124 were identified. Then, a score table was prepared from the candidate genes, based on the affinity of the seed region of miR-124 and the number of targets in the 3`-UTR region of transcription factors. Finally, transcription factors with higher scores were chosen as candidates for practical analysis.
Results: The results of bioinformaical analysis showed that the LAMC1, ITGB1, PTBP1, SOX9, SP1, and EFNB1 molecules are the most potential factors that might be affected by miR-124 during neurogenesis.
Conclusion: It seems that transcription factor SP1 is under the control of the miR-124 and plays a crucial role in neurogenesis process. Therefore, this protein can be considered as a suitable new candidate for experimental evaluation.
Mana Shojapour, Ghasem Mosayebi, Fardin Faraji, Keyvan Faraji, Ali Ghazavi,
Volume 17, Issue 3 (6-2014)
Abstract
Background: Multiple sclerosis (MS) is an autoimmune disorder with unknown etiology. Genetic and environmental factors associated with MS susceptibility. Genetic studies show an important role for human leukocyte antigens (HLA) and susceptibility to autoimmune diseases such as MS. There is controversy between the association of HLA alleles with MS susceptibility in various studies. However, with consider the high incidence of MS in Iranian population and limit information about association of HLA and MS, we analyzed HLA alleles in MS patients.
Materials and Methods: In this case-control study, 60 MS patients and 40 normal individuals with the same ethic background and geographic area were analyzed for HLA-DRB and DQB alleles by single specific primer-polymerase chain reaction (SSP-PCR) method.
Results: HLA-DRB1*03 and DQB1*02 alleles frequencies in MS patients were greater than healthy controls. There was no significant difference in frequency of other HLA-DR alleles between the MS patients and normal individuals.
Conclusion: DRB1*03 and DQB1*02 alleles confer increased susceptibility to MS in this population. However, to determine the role of HLA in Iranian MS patients, more studies are needed.
Khadijeh Khosravi, Nader Zarinfar, Ehsanollah Ghaznavi Rad, Ghasem Mosayebi,
Volume 18, Issue 4 (7-2015)
Abstract
Background: Brucellosis is a highly contagious zoonotic disease between humans and animals known for high frequency of relapsing and ability to cause chronic infection. The function of immune system plays an important role in induction of chronic diseases. However, the role of immune system response is not completely studied. Therefore, this study designed to investigate the cytokine profile of the patients suffering from chronic and acute brucellosis.
Materials and Methods: This descriptive- analytical study was performed on 22 patients with acute brucellosis (mean age 38±17), 21 patients with chronic brucellosis (mean age 43±10) and 21 healthy people (mean age 26±4) with the same age and sex as patients. The serum IFN-&gamma, IL-17, IL-5 and TGF- &beta levels were measured using ELISA method.
Results: The mean IFN-&gamma serum level in acute and chronic brucellosis patients group was significantly higher than control group (p=0.045). The mean IL-17 serum level in acute brucellosis patients was significant decreased once compared with control group and in chronic patients was significantly decreased when compared with control group (p=0.024). In addition, the mean IL-5 and TGF-&beta serum levels of acute brucellosis patients group were significantly decreased as compared to chronic patients (p=0.001).
Conclusion: The results of current study indicate that cytokine profile of chronic brucellosis patients is more related to Th2 immune response. Hence, Th2 immune response inhibition would be an appropriate way to treat and prevent disease to become chronic.
Masoud Motalleby, Ashraf Mazaheri, Mohadeseh Mosayebi, Sayyed Mehdi Takhtfiroozeh,
Volume 18, Issue 5 (8-2015)
Abstract
Background: The air pollutants such as CO, SO2, NO2, O3, and particulate matters have harmful effects on public health. Determination of the actual concentration of the pollutants and description of air quantity and quality contents in comparison of standard conditions and timely informing people to regulate control programs is essential. Kashan is exposed to the winds contain-ing the suspended particulate matters due to the proximity of the desert. Moreover, the growth of population, factories and industries in the city are artifical resources of the air pollution. Hence, assessment and monitoring of air pollution standard condition in kashan is crucial.
Materials and Methods: In this cross-sectional and descriptive study, the concentration of CO, SO2, NO2, O3, and suspended particulate matters less than 10 microns (PM10) measured according to WHO standards in Panzdah-e-Khordad station of Kashan in 2011. The annual mean and maximum rates, the mean and maximum rate of summer and winter, and annual percentile 98%, determined for each pollutant and used in AirQ software. Then, the number of death and disease attributed to each pollutant was calculated.
Results: The results demonstrate that the cumulative number of deaths attributed to PM10, NO2, SO2, and O3 was 100, 22, 82, and 54, respectively.
Conclusion: In total, the suspended particulate matters have the most effects on death and disease resulted from the air pollution. Hence, managing the resources of particulate matters and SO2 pollutants has many effects on reducing the adverse health effects of air pollution in Kashan.
Somaye Pormosayebi, Mohsen Shamsi, Mahbobeh Khorsandi, Ali Kolivand, Mehdi Ranjbaran,
Volume 18, Issue 8 (11-2015)
Abstract
Background: Today, environmental pollutants are one of the most important human problems. The purpose of this study was to assess the health belief model structures for promotion of preventive behaviors in pregnant women exposed to air pollution in Arak city in 2014.
Materials and Methods: In this cross-sectional study, 208 pregnant women referred to healthcare centers in Arak city were selected by multistage sampling and were studied. Data were collected by using a valid and reliable self- report questionnaire. The questionnaire included the demographic characteristics of the mother, the aspects of the HBM model, and the maternal practice checklist. Finally, the data were analyzed.
Results: The mean age of subjects was 26.48 ±4.77 and the mean gestational age was 14.88 ±5.59 weeks. The highest level of education for pregnant women (47.1%) was a diploma. The mean practice score was 72.9 and among the structures, the highest and the lowest score was obtained for perceived susceptibility(83.25) and barriers(59.16), respectively. To predict the hehavior by using the HBM structures, regression analysis showed that of the studied variables, the external practice guides, perceived susceptibililty, and barriers are as behavior predictive predictive agents that totally, predicted 26% (R2=0.265) of behavior changes.
Conclusion: According to the results of the study, the design of educational interventions should be based on the external practice guides, perceived susceptibility and barriers structures as the most important predictors of maternal behavior.
Davarkhah Rabbani, Mohammad Reza Rezaeimofrad, Ashraf Mazaheri, Mohadeseh Mosayebi,
Volume 18, Issue 9 (12-2015)
Abstract
Background: The growth of population, improvement of quality of life and the development of industries have led to increase in the rate of urban and industrial waste. As the leachate of the waste has a lot of pollution, influences harmfully human health and the environment. Researches have shown that the advanced oxidation processes (AOPs) such as Fenton and Fenton-related processes can reduce chemical oxygen demand (COD) of the leachate effectively.
Materials and Methods: In this paper, the rate of decrease in the total suspended solids (TSS) of leachate from a composting facility in Isfahan was studied using electrochemical, Fenton and electro-Fenton processes. These processes were conducted at reaction times 0, 20, 40, and 60 minutes, with the currents of 0.5, 1 and 1.5A and hydrogen peroxide dosages 1000, 2000, and 3000 mg/L.
Results: In the three mentioned processes, the most TSS removal was observed at the first 40 minute of the reactions. Among the studied processes, the electro-Fenton removed up to 92.4% of the TSS and was recognized as the most effective method. Furthermore, electrochemical and Fenton removed 41.7% and 60.3% of the TSS, respectively.
Conclusion: Therefore, decreasing the TSS of leachate could change its qualities and reduce the leachate pollution and the adverse environmental effects.
Khadijeh Khosravi, Nader Zarinfar, Ehsanollah Ghaznavi-Rad, Ghasem Mosayebi,
Volume 19, Issue 2 (5-2016)
Abstract
Background: Brucella is an intracellular bacterium that causes chronic infection in humans and domestic animals. The underlying mechanisms that cause prolonged illness are complex and not fully understood. Immune responses may have an important role in the chronicity of infection. Here, we evaluated the lymphocyte proliferation responses in patients with chronic and acute brucellosis.
Materials and Methods: This descriptive - analytical study was performed on 22 patients with acute brucellosis, 21 patients with chronic brucellosis and 21 healthy people with the similar age, sex and genetic background as control group. Peripheral lymphocytes were isolated using Ficoll and the cellular proliferation was quantified in presence of antigen and phytohemaglutinin-A by MTT method.
Results: The brucella antigen-specific stimulation index in patients with chronic brucellosis was significantly lower than the acute brucellosis patients (p=0.001). Also, stimulating the lymphocytes with phytohemaglutinin-A has shown that proliferative response in patients with chronic brucellosis was lower than the other groups (p=0.04).
Conclusion: The results indicated that chronic brucellosis inhibits lymphocyte proliferation. This inhibition of lymphocyte proliferation may be due to the induction of anergy.
Parisa Nourbakhsh, Rezvan Merzaei, Fatemeh Yeganeh-Fard, Ghasem Mosayebi,
Volume 19, Issue 5 (8-2016)
Abstract
Background: Breast cancer is one of the major causes of cancer-related death and the most common solid malignancy in women worldwide. Chemerin as a new adipokine has an inflammatory activity that initiates inflammation via chemotaxis of immature DCs and macrophages. This study aimed to evaluate the level of chemerin in patients with breast cancer.
Materials and Methods: In this cross-sectional study that was performed as a case-control study, we enrolled 45 patients with breast cancer in Vali-asr hospital from June to December 2015 (age range, 18-60 years) and 40 healthy volunteers as a control group (age range, 22-56 years). The patients with invasive breast were selected before mastectomy. The level of serum chemerin was measured by ELISA kit.
Results: The results showed that the mean serum chemerin level in the breast cancer patients (1536 ±608 ng/L) was significantly lower than the normal individuals (1919±544 ng/L),(p=0.04). There is no correlation between the level of chemerin with body weight, stage of disease, duration of disease and the number of white and red blood cells.
Conclusion: With due attention to the inflammatory role of chemerin, decreasing the serum chemerin level in patients with breast cancer may be related to the consumption of chemerin in the inflammatory responses or immunosuppression by tumor. The low level of chemrerin may be suitable for tumor growth and progression.
Ali Ghazavi, Ali Ganji, Mohsen Khaki, Ghasem Mosayebi,
Volume 21, Issue 5 (10-2018)
Abstract
Background and Aim: There are two philosophies about the origin of the immune system, defense and homeostasis. In this article, the existential philosophy of the immune system was reviewed, in which the defense role is only part of its homeostasis functions.
Materials and Methods: The Medline was searched for terms such as “Homeostasis”، “Immunculus”، “Natural autoantibody” “Evaluation” and “Immune system”.
Findings: Hemostasis is the most important part of immune regulation and the existential philosophy of this system, so that its defensive role is only part of homeostasis functions. Natural antibodies play this role as immune reflection by showing qualitative and quantitative changes in the antigenic composition of the body. Therefore, the level of natural antibodies can also serve as a prognostic marker.
Conclusion: Although many improvements have been made in explaining the hemostatic role of the immune system, many studies have to be conducted to identify its particular aspects.