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Showing 27 results for Parsa
The Effect of Prenatal Stress on Seizure Threshold and Histomorphometrical Changes on Cerebellar Cortex in NMRI Mice
Sahar Parsaee, Homa Mohseni Kochesfehani, Gholamreza Kaka, Homayon Sadraee, Mojtaba Kahali,
Volume 18, Issue 6 (9-2015)
Abstract

  Background: Stress is a mental or emotional disturbance that occurs in response to external stimuli and can also appear during pregnancy. The aim of this study is to investigate the effect of maternal stress during pregnancy on the cerebellar structure changes and seizure threshold of their offspring .

  Materials and Methods: In this experimental study, 20 pregnant female rats were divided into two groups: 1) Non stress group, and 2) Stress group which were under immobilization stress one hour for 14 days . The seizure threshold test in offspring was performed by injecting Pantilen tetrazol drug (PTZ)(n=8) . To investigate the cerebellum development, the offspring were divided into three groups . Control group: mothers did not any stress and offspring did not receive PTZ (n=4). Sham group: mothers did not stress but the offspring had received PTZ(n=4). Experimental group: mothers did stress and offispring did receive PTZ(n=4). After the section of cerebellum, the thickness of cerebellum layers and the number of cells in each layer were evaluated.

  Results: The mean of seizure threshold in the offspring whose mothers were under the stress of pregnancy significantly increased compared to children whose mothers no received stress (p<0.001). In the other side, mean number of purkinje cells in the experimental group significantly decreased compared with the other groups (p<0.001). No significant differences were found in the mean of granular and molecular layers thickness of cerebellum in the experimental group when compared with the other groups(p<0.05). However, mean cellular density in the granular layer of cerebellum in the experimental group significantly decreased compared to other groups (p<0.001).

Conclusion: Stress during pregnancy increased the seizure threshold in offspring and caused some developmental and structural disorders in the cerebellar rat offspring.


Combined Effect of 5-Fluorouracil and Acriflavine on Mortality Rate of Colorectal Cancer Cell Lines
Parsa Zargar, Esmaeel Ghani, Farideh Jalali Mashayekhi, Ebrahim Eftekhar,
Volume 19, Issue 3 (6-2016)
Abstract

Background: A small percent of patients with colorectal cancer (CRC) respond to 5-Fluorouracil (5-FU), as a first line of chemotherapy. In this study in, in order to design a new chemotherapy protocol, the effect of 5-FU and acriflavine (ACF) cotreatment on mortality rate of CRC cell lines was investigated.

Materials and Methods: Cytotoxicity of 5-FU and ACF against CRC cell lines (LS174T, SW480 and HCT116) was detected using MTT assay. Cells were treated with different concentrations of 5-FU (0.5-64 µM) or ACF (0.07-5 µM) for 72 hours and then cell viability and drugs IC50 was calculated. To assess the effect of ACF on anticancer activity of 5-FU, cells were cotreated with different concentrations of 5-FU and IC30 concentration of ACF.

Results: ACF and 5-FU suppress the viability of CRC cell lines in dose-dependent manner. 5-FU and ACF have most cytotoxic effect on LS174T and the lowest cytotoxic effect on SW480 cells. Cotreatment of ACF with 5-FU could not significantly change the sensitivity of cells against 5-FU (p>0.05).

Conclusion: In this study, the fatal and cytotoxic effect of ACF on three CRC cell lines was shown. However, cotreatment of ACF with 5-FU could not improve the anticancer activity of 5-FU.


Comparison of Antiviral Effects of Methanol and Hexane Extracts of Chelidonium Majus L. Against Acyclovir Resistant Herpes Simplex Type 1
Roshanak Haji Mohammad Ali, Masoud Parsania, Gholamreza Amin,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: Herpes simplex virus type 1 (HSV-1) may lead to oral herpes, encephalitis and keratoconjunctivitis. Today, following the increasing of HSV-1 prevalence and drug resistance, there has been an interest in the use of natural substance. In this study, we assessed the effect of hexane and methanol extracts of Chelidonium majus L. against acyclovir-resistant HSV-1.
Materials and Methods: The toxicity threshold of Chelidonium majus L. hexane and methanol extracts on HeLa cell was determined with trypan blue and MTT methods. Their direct antiviral effects were evaluated against HSV-1. Different concentrations of extracts in different times of virus replication have been evaluated. In each stage, the viral titers were tested by TCID50 assay.
Findings: The methanol extract at the concentration of 200 µg/ml and hexane extract at the concentration of 600 µg/ml were determined as effective minimal cytotoxic concentration on HeLa cell line. These concentrations did not have significant virucidal effects on Herpes simplex virus. The maximum antiviral effects of methanol extract at the concentration of 200 µg/ml was exhibited 1 and 2 hours after virus adsorption and reduced virus titer 4 logTCID50 compared to the control. Hexane extract did not have antiviral effect.
Conclusion: methanol extract of chelidonium majus L. compared to hexane extract showed significant antiviral effect on acyclovir-resistant HSV-1. Further research is required to identify specific bioactive compounds of this plant in order to be used in anti-herpes drugs.

Nephrotic Syndrome in Children with This Condition
Masoud Rezagholizamenjany, Parsa Yousefichaijan,
Volume 21, Issue 7 (2-2019)
Abstract
Nephrotic syndrome
Nephrotic syndrome is a manifestation of glomerular disease as a proteinuria in the nephrotic and triad of hypoalbuminemia, edema, hyperlipidemia, and high protein in the urine. Nephrotic proteinuria is defined as protein excretion of more than 40 mg/m2 of body surface per hour or protein to creatinine ratio of more than 2-3 at the first morning urine sample. Its annual incidence in most western countries is 2-3 cases per 100000 children per year, and in developing countries it is often higher due to malaria (1). New findings in this area are often about treatment, which are evaluated and reviewed in following.

Extrapulmonary Manifestations of Coronavirus Disease 2019: A Narrative Review
Ameneh Omidi, Somayeh Shatizadeh Malekshahi, Parsa Veisi,
Volume 23, Issue 5 (December & January - Special Issue on COVID-19 2020)
Abstract
Background and Aim: Coronaviruses are a large family of viruses that are known to cause respiratory tract infections in humans. SARS-CoV-2 is a new type of this family initiated in late 2019 and its related disease is known as Coronavirus Disease 2019 (COVID-19). Common symptoms of COVID-19 include fever, dry cough, fatigue, myalgia, arthralgia and shortness of breath.
Methods & Materials: In This narrative review a literature search was conducted in scientific databases including Google Scholar and PubMed to find studies published from December 2019 to May 10 2020 on the role the extrapulmonary manifestations of COVID-19. 
Ethical Considerations: Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors.
Results: In addition to respiratory symptoms, involvement of various organs such as gastrointestinal tract, nervous system, skin, olfactory system, cardiovascular system, liver, kidney, and eyes was also reported. Extrapulmonary manifestations of COVID-19 included anosmia, ageusia, skin rash, chickenpox-like blisters, acute cardiac failure with increased troponin levels, kidney inflammation and edema, common gastrointestinal symptoms (e.g. diarrhea, nausea and vomiting), elevated liver enzyme levels, neurological disorders (e.g. stroke), nonspecific symptoms (e.g. headache and dizziness), and decreased consciousness level.
Conclusion: The hypothetical mechanisms of various organ involvements during COVID-19 include immune-mediated inflammation such as cytokine storm, respiratory dysfunction, hypoxemia, cellular damage, or combination of these mechanisms. Further studies should be conducted on the causes of various COVID-19-induced damages to determine the exact relationship between the pathogenesis, prognosis and severity of the disease. 

Protective Effects of Vitamin C Concomitant Treatment on Deferasirox-induced Renal Toxicity in Rats
Taha Fereydouni, Saeed Hajihashemi, Parsa Yousefichaijan, Ali Rahbari,
Volume 23, Issue 6 (February & March 2020)
Abstract
Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress is among f the major causes of nephrotoxicity and its progression. Deferasirox, due to oxidative stress and increased cell apoptosis causes the dysfunction of renal tubules and renal toxicity. According to its antioxidant and anti-inflammatory properties, the present study explored the effect of vitamin C on deferasirox-induced kidney damage.
Methods & Materials: This study was performed on 30 Wistar rats in 3 groups of control, deferasirox, and deferasirox plus vitamin C. To induce the nephrotoxicity, the intra-peritoneum injection of deferasirox (75 mg/kg/day) was used. After taking plasma from the blood samples of the explored rats, we determined the values of Cr, Na+, K+, Mg+, osmolality, and BUN in the obtained plasma and urine samples. The creatinine clearance, as well as the relative and absolute excretion of sodium and potassium, were also calculated. After separating the two kidneys, they were used for the histologic study with Hematoxylin and Eosin (H&E) staining, as well as Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP)  biochemical studies.
Ethical Considerations This study was approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1396.309).
Results: Cotreatment with deferasirox and vitamin C reduced renal tissue MDA and relative and absolute Na and K excretion and urine osmolarity; this method also increased creatinine clearance and renal tissue FRAP.
Conclusion: The co-administration of vitamin C presented a significant protective effect on the renal toxicity induced by deferasirox. The protective property of deferasirox is because of the antioxidant impacts of vitamin C in reducing oxidative stress and lipid peroxidation. 

Relative Contribution to Predicting Components of Marital Satisfaction of Older Adults in Urmia City and Its Correlation with Lifestyle in the COVID-19 Pandemic: A Cross-Sectional Study
Dr Jamileh Amirzadeh-Iranagh, Sima Ghorbanzadeh, Phd Student Yeganeh Dadashzadeh-Sangary, Phd Student Parsa Javanmard,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: The growing increase in the elderly population requires more research to identify the health priorities of this group, especially in critical situations such as the COVID-19 pandemic. Therefore, the current study was conducted to determine the influential components of marital satisfaction and its relationship with lifestyle in Urmia City in 2021.
Methods: In this descriptive-analytical and cross-sectional correlational study, 220 married elderly living in Urmia were selected through cluster sampling. The Miler's life satisfaction and Haynes's marital satisfaction questionnaires were used in addition to the demographic questionnaire to collect data in this research. Data were analyzed using descriptive statistical tests (mean and standard deviation, frequency, and percentage) and analytical (Pearson correlation coefficients and multiple linear regression) at a significant level of P ≤ 0.05.
Results: A step-by-step multiple linear regression model also revealed that variables of lifestyle (ß = -0.364), age (ß = 0.425), number of children (ß = 0.143), occupation (ß = 0.425) and illness (ß = 3.608) - had the most considerable contribution in the sensitive prediction of marital satisfaction. The regression model excluded other demographic variables.
Conclusions: This study showed that lifestyle and demographic variables such as age, number of children, occupation, and illness have the greatest contribution in predicting marital satisfaction. Therefore, it seems necessary to design counseling services in comprehensive health centers for this group so that counselors can teach healthy lifestyles to older adults to improve marital relationships.
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