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Pariyan Azad Derakht, Mohammad Fathi, Dr Raziyeh Rezaei, Raziyeh Rezaei,
Volume 27, Issue 5 (12-2024)
Abstract

Introduction: Physical activity positively influences various physiological factors, laying the groundwork for beneficial changes. Myostatin and follistatin are among these factors, whose levels are influenced by gender and physical activity. The present study was conducted with the aim of investigating the effect of traditional resistance training (RT) and high functional training (HIFT) on the serum levels of myostatin and follistatin in young women.
Methods: In this semi-experimental study, 30 young women were selected and divided into three groups: intense functional training, traditional resistance training, and control. Blood was drawn 24 hours before and 48 hours after the end of the interventions to measure the serum levels of myostatin and follistatin. The exercise protocols were performed for eight weeks, 3 days a week and 60 minutes a day. Ultimately, the collected data were analyzed using the ANOVA statistical method, with a significance level set at P < 0.05.
Results: The results showed that follistatin level was significantly higher in the RT and HIFT groups than in the control group (P = 0.001). Also, the amount of follistatin in the HIFT group was considerably higher than the RT group (P = 0.01). The results showed that the level of myostatin in the RT and HIFT groups was significantly lower than the control group (P = 0.001). Also, the amount of this factor in the HIFT group was substantially lower than in the RT group (P = 0.01).
Conclusions: In general, the findings of the present study show that performing intense resistance and functional exercises causes a favorable change in the expression of physiological factors related to muscle growth in women. It seems that the effect of intense functional exercises is greater than resistance exercises.
Hamid Moghavemi, Sadegh Abbasian, Mohammad Ali Sardar,
Volume 27, Issue 5 (12-2024)
Abstract

Introduction: Reducing physical activity as well as consuming more calories than the body needs increases obesity and its related disorders, such as metabolic syndrome. Therefore, this study aimed to determine the effect of eight weeks of high-intensity interval training (HIIT) and resistance training (RT) on brain tissue gene expression of AKT2 and insulin resistance in obese Wistar rats.
Methods: 30 male rats weighing 160 to 185 grams were fed a high-fat diet for 12 weeks. After the approval of the obesity protocol of increasing the weight of the rats, which to be more than 300 grams, the rats were divided into three groups, including the control group (n = 10), HIIT group (n = 10), as well as RT group (n = 10). Until the end, the rats continued to eat a high-fat diet. HIIT was performed for eight weeks and five sessions per week, with an intensity of 80 to 95% of maximum oxygen consumption on a treadmill. Moreover, RT was performed with an intensity of 40-60% of a maximum repetition on the ladder. After eight weeks of training interventions, the expression level of the AKT2 gene in brain tissue was measured by the real-time PCR method.
Results: The results of the present study demonstrated a significant increase in AKT2 gene expression of HIIT and RT groups compared to the control group (P < 0.05). Furthermore, the results illustrated that the insulin resistance of rats in both training groups was significantly reduced (P < 0.05).
Conclusions: According to the findings of the present research, it could be concluded that HIIT, as well as RT interventions, probably causes an increase in AKT2 gene expression and could be effective in reducing insulin resistance and improving glucose profile.
Maryam Keshvari, Ali Heidarianpour, Farzaneh Chehelcheraghi,
Volume 27, Issue 5 (12-2024)
Abstract

Introduction: The thickness of the molecular and pyramidal layers in the hippocampus represents a pivotal aspect of Alzheimer's research. This study was conducted to investigate the effect of swimming endurance, resistance, and combined exercises on the molecular and pyramidal layers of the hippocampus tissue thickness of Alzheimer's rats.
Methods: In this experimental study, 40 large white Wistar laboratory rats (6 weeks old; Weight 180-200 g) were randomly and equally divided into five groups: healthy control, Alzheimer's control, endurance, resistance, and combined. Alzheimer's disease was induced by intraperitoneal injection of trimethyltin chloride (8 mg/kg). Two weeks after the injection and confirmation of Alzheimer's induction, the training protocols of endurance (5-sessions/week, the first to the fourth week incrementally from 5-15-min to 45-min of swimming, the fifth to the twelfth week 60-min of swimming), resistance (5-sessions/week, The first week of familiarization with the exercise, week 2; 30%, week3-5; 70-90%, week6-8; 100-110%, week9-10; 120-130%, and week11-12; 140-150% of body weight), combined (2 resistance sessions/week and three endurance sessions/week) was performed for 12 weeks. Forty-eight hours post-intervention, animals were dissected, and hippocampus tissue was harvested. Finally, the data were analyzed at the significance level of P < 0.05.
Results: The thickness of the molecular and pyramidal layers of the hippocampal tissue of Alzheimer's animals decreased compared to healthy animals, and all three endurance, resistance, and combined exercise protocols increased layers (P < 0.001). However, the increase in the molecular and pyramidal layers thickness of the hippocampal tissue of combined group rats compared to the endurance and resistance group had a greater increase (P < 0.01).
Conclusions: These findings highlight the changes in the thickness of the hippocampal tissue layers concerning Alzheimer's pathology and the effect of combined exercises on this parameter. While exercise may have positively affected hippocampal volume and synaptic plasticity, more research is needed to fully understand the impact of exercise on hippocampal layer thickness in Alzheimer's.
Reavan Afshar, Masoud Rahmati, Rahim Mirnasouri,
Volume 28, Issue 1 (3-2025)
Abstract

Introduction: Considering the synthesis and secretion of irisin and BDNF from muscle tissue during exercise and the possible relationship of these factors with improving muscle strength and performance, the present study aimed to investigate the effect of 12 weeks of strength training on muscle strength, body fat percentage, irisin, and BDNF in inactive middle-aged women.
Methods: In a semi-experimental study, 20 inactive middle-aged women (mean age 37.70 ± 5.91 years, weight 79.80 ± 5.82 kg) were selected and randomly assigned to two strength training groups (n = 10) and control groups (n = 10). The training group performed 12 weeks of strength training, three sessions per week at an intensity of 65 to 80% of maximum strength. Then, blood samples were taken using ELISA to measure irisin and BDNF. Independent t-test and Pearson correlation test were used to analyze the data. The significance level (P ≤ 0.05) was considered.
Results: Strength training significantly increased serum irisin concentration (P = 0.035) and serum BDNF concentration (P = 0.058) and also considerably decreased body fat percentage (P = 0.058) in middle-aged women. There was also a positive and significant relationship between lower body strength and serum irisin levels (P = 0.040). The Results from the Pearson correlation test indicate a significant positive relationship between BDNF and upper body strength (P = 0.038).
Conclusions: Based on the results of the present study, it seems that increased secretion of serum irisin and BDNF hormones is related to increased muscle strength following strength training in middle-aged individuals.
Mohammad Ali Gharaat, Sajjad Karami,
Volume 28, Issue 1 (3-2025)
Abstract

Introduction: Different training methods increase performance capabilities in addition to metabolic changes in body organs. The present study aimed to compare the effect of endurance and strength training on anthropometric indicators, glucose changes, fat metabolism, and irisin levels of young male students.
Methods: Thirty-six obese students (age: 21.19 ± 2.43 years; weight: 88.59 ± 6.20 kg; height: 175.41 ± 12.96 cm; body mass index: 30.45; fat percentage: 25.73%) were randomly placed in one of control, endurance, and strength training groups (n= 12). The strength training group trained for 8 week/3 session/4 sets/10 repetitions/ from 50 to 70% of the one repetition maximum (incremental manner, every 2 weeks), and the endurance training group trained for 30 minutes of aerobic jogging with 60 to 80% heart rate maximum. Plasma irisin, glucose, insulin, insulin resistance, fat percentage, body mass index, weight, waist circumference, and hip circumference were measured. The data were analyzed by one-way analysis of variance and Tukey's test at 0.05.
Results: Body weight (P = 0.03), fat percentage (P = 0.04), and body mass index (P = 0.04) significantly decreased in the post-test of endurance training group. Irisin level in the post-test in the control group had a significant difference with endurance and strength training (P = 0.01 and P = 0.02, respectively). Insulin in the post-test of the control group was significantly different from the endurance and strength group (P = 0.00 and P = 0.00, respectively). The level of insulin resistance in the post-test of the endurance and strength group had a significant difference compared to the control (P = 0.00 and P = 0.00, respectively).
Conclusions: Eight weeks of aerobic treadmill training and strength training with free weights can improve body composition, increase irisin levels, and reduce insulin resistance in obese male adolescents.
Fateme Tahsinin, Ali Heidarianpour, Elnaz Shokri,
Volume 28, Issue 1 (3-2025)
Abstract

Introduction: Being overweight is associated with increased cortisol secretion, along with heightened anxiety and depression. This study aimed to compare the effect of six weeks of concurrent moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) with HIIT training alone on body composition, plasma cortisol levels, and anxiety and depression levels in overweight male students.
Methods: In this semi-experimental research, 27 overweight students were selected and randomly divided into three groups 9: MICT+HIIT concurrent training, HIIT training, and a control group. The MICT )15 minutes of exercise per day at 60-65% of maximum heart rate with an additional 5 minutes every two weeks). The HIIT (3 minutes of running at 70-75% of maximum heart rate, followed by 3 minutes of active rest at 50% of maximum heart rate, with three repetitions in the first two weeks, four repetitions in the second two weeks, and five repetitions in the final two weeks).
Results: Both types of training protocols resulted in reductions in weight, body mass index, cholesterol, low-density lipoprotein, cortisol levels, anxiety, depression, and an increase in high-density lipoprotein (P < 0.05). There was no significant difference between the two types of exercise in terms of effectiveness on these variables; however, only peak oxygen consumption and triglycerides were associated with better changes in the MICT+HIIT group.
Conclusions: For overweight male adolescents aiming for weight loss and improved mental health, HIIT alone is sufficient, and adding MICT does not provide additional clinical benefits.

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