Showing 28 results for Infection
Parsa Yousefi Chaijan, Fatemeh Dorre, Zahra Moghaddasi, Maryam Mashayekhi,
Volume 13, Issue 3 (9-2010)
Abstract
Background : Urine tract infection(UTI) among children is the most prevalent bacterial infection and the second prevalent infection after Viral Flu.Regarding this cfact that urine culturing has very important role in diagnisis and perseverance of this disease and sampling method has significant effect on this disease remedy.
In this study the effect of genital area ablution on decreasing the contamination of urine culture is examined.
Methods and Materials: This study is in the form of case_controlled.In this study 620 little girls (3-12 years –old) referring to Amir Kabir children special clinic are examined.Population under investigation was cpatients who had not history of taking antibiotic during last seven days, sondage and genital anomaly and inflammation and genital discharge.
Patients were randomly entered in two different groups one with ablution and the other without ablution.After data collection, available inputs were statistically analyzed with SPSS and the effect of genital area ablution was determined on decreasing the contamination of urine culture.
Results: Among 310 patients in with_ablution group 11 patients were reported UTI(3/7%).3 patients were contaminated (1%),296 patients were normal (95/3%).Among 310 patients in the second group,14 patients were reported UTI(4/7%),6 patients were contaminated(2%),290 patients were normal(93/3%).Contamination rate in with_ablution group were 1% and in the other group was 2%Based on Pvalue :0/491 in both groups no significant statistically difference were found between these two groups and the analysis result distribution in both groups in a=0/05 level were statistically the same.
Conclusion: In both group no significant statistically difference were found between these two groups ,so we concluded that the genital area ablution doesn’t have such an effect on decreasing the contamination of urine culture and we don’t suggest ablution of genital area in children before providing urine sampling.
Nasser Parsa, Amir Almasi-Hashiani,
Volume 14, Issue 7 (2-2012)
Abstract
Human Brucellosis is an infectious disease caused by Brucella bacteria. An average of 150 cases of brucellosis among 330 million people is reported in the USA each year. This bacterium is small, gram-negative rods that grow in phagocytes. They primarily cause diseases among different animals and humans become infected when is in contact with animals or their products. Brucella can cause various symptoms in humans which is similar to human influenza. Brucellosis is diagnosed in a laboratory by finding Brucella organisms in samples of blood or bone marrow or to detect antibodies against the bacteria in two blood samples, collected 2 weeks apart. Depending on severity of illness, recovery may take as long as several months. There is no vaccine available for human except live vaccines and that should be consulted to a health care provider. DNA findings for Brucella species in the index patients focused our attention on revealed human cancers. Also, granalomatous inflammation of testes and medulloblastomas has been linked to chronic Brucellosis infection which could be similar to Helicobacter pylori that is associated with gastric tumor formation. More scientific investigation is needed to properly address the connection of Brucella with other human malignancies.
Ebrahim Alijani, Ali Akbar Pourfathollah, Soheila Ajdary, Batool Sharifi-Mood, Ahmad Zavaran-Hosseini, Vahid Khaze-Shahgoli,
Volume 16, Issue 2 (5-2013)
Abstract
Background: Considering the fact that more than one third of the world’s population is infected with Mycobacterium tuberculosis bacteria, identifying individuals with latent tuberculosis infection (LTBI) is vital for controlling TB. Tuberculin skin test (TST) and IFN-gamma release assays are practical methods used for screening people with LTBI. Due to the insufficiency of data on endemic tuberculosis region and the need for evaluation of these methods in a high-risk population, this study was performed in Zahedan.
Materials and Methods: This descriptive study was carried out on 75 individuals, including 21 health care workers (HCWs) as well as 54 family members of patients with active TB. IFN-&gamma release assay and TST were also carried out on the participants.
Results: Of the 75 participants, 26 had positive IFN-&gamma release assay results and 49 persons showed negative results. TST was also performed and 12 participants did not show up for taking the results. Among the remaining 63 participants, 60.31% had more than 10 mm indurations. The results in 32.25% of the participants were positive for both IFN-gamma release assay and skin test, whereas 34.92% of the participants presented negative tests results for both IFN-gamma release assay and skin test. The agreement between these two tests was 66.67 % (P=0.001, K=0.36, 95% Confidence Interval).
Conclusion: The results showed a weak agreement between the two tests.
Alireza Mohammadi, Mohsen Dalvandi, Hossein Sarmadian, Mohammad Khalili,
Volume 16, Issue 5 (8-2013)
Abstract
Background: Hydatid disease is a common infection caused by Echinococcus granulosus. Cerebral involvement is very rare and only occurs in 2% of all hydatidosis in endemic areas. We report a case of primary multiple cerebral hydatid cysts in a 23 years old patient. Case: A 23 years old female was admitted in our emergency ward with primary generalized tonic colonic seizure, left body and face hemiparesis and history of headache in last two months. Contrast enhanced CT and MRI showed a big well-defined, rounded, cystic lesion in the motor strip of right temporo-parietal region with mass effect causing midline shift which was diagnostic for brain hydatid cyst and several smaller cysts. There was no evidence of other organs involvement. The patient underwent the brain surgery. A big hydatid cyst (10cm in diameter) and some others adhering to brain parenchyma in different sizes were evacuated completely and without rupture using Dowling method. Patient received albendazole 400mg/two times a day for 2 months too. There was no cyst in patient’s MRI study in two years follow up.
Conclusion: Though low incidence, primary multiple cerebral hydatid cysts should be considered in endemic area using brain CT and MRI. Surgery is standard treatment of the disease.
Salman Ahmady Asbchin1, Moein Safari, Hosein Moradi, Vahid Sayadi,
Volume 16, Issue 6 (9-2013)
Abstract
Background: The most important pathogen in nosocomial infections are microorganisms in the patient's body. 90 percent of nosocomial infections caused by bacteria. Medlar is an medicinal plant that its therapeutic effects has historically been emphasized. The aim of this study was to evaluate the antibacterial effect of methanolic and ethanolic leaf extract of medlar against bacteria isolated from hospital environment.
Materials and Methods: In this experimental study, the Nosocomial bacteria were obtained from Shahid Mostafa Khomeini hospital, Ilam, Iran. Soxhlet extraction method was used for medlar leaf extract. Disk diffusion method was used to study the effect of antimicrobial and broth microdilution method were used to determine the minimum inhibitory concentration (MIC) and Minimum Bactericidal Concentration (MBC).
Results: Two strains of Pseudomonas aeruginosa, three strain of Staphylococcus aureus and five strains of Escherichia coli were isolated from hospital. The results showed that the methanolic extract of Medlar leaf inhibited the growth of all strains of pseudomonas aeruginosa and four strain of Staphylococcus aureus and also inhibits the growth of all strains of Escherichia coli strains except E4 strain. The maximum antimicrobial activity was against E2 strain that zone diameter around it was 19/67 Millimeters. Quantities of minimum inhibitory concentration for all three strains P1, P2 and P3 and E2, E3, E5, S1, S2 and S3 strains was equals with 125 mg/ml.
Conclusion: Medlar leaf methanolic extract possesses significant antibacterial activity against bacteria causing nosocomial infections and so this extract can be considered in the control of infectious diseases.
Mahbobe Khaton Ghanbari, Mohsen Shamsi, Ali Asghar Farazi, Mahbobe Khorsandii, Babak Eshrati,
Volume 16, Issue 7 (10-2013)
Abstract
Background: Survey and control of nosocomial infections in the world is a global priority that The objective is to minimize infections in addition to decreased length of hospitalization And also significantly reduce the cost of health care .The aim of this study was evaluating the knowledge, self-efficacy and Practice of nursing staff in Disciplines Standard Precautions in order to prevention of nosocomial infection.
Materials and Methods: This Cross-sectional and analytical study that was carried out on 130nursing staff selectedin in Arak university of medical sciense in 2013. Data collected with validity and reliebility questionnaire including of knowledge, self-efficacy and Practice of nursing staff in Disciplines Standard Precautions in order to prevention of nosocomial infection. Data was analyzed by using descriptive and analytical statistical methods and pearson correlation.
Results: The mean knowledge was 46.92±14.66 and Practice 49.46±6.96 and average self-efficacy was 52.2±10.81 about infection prevention. There was not significant relationship between knowledge and Practice. But there was a significant relationship between self-efficacy, knowledge and Practice and marriage. Moreover there was a significant relationship between knowledge and gender. (p<0.05).
Conclusion: Despite moderate self-efficacy majority of Nurses do not have appropriate knowledge about prevention of nosocomial infection based on the findings of this study. Considering the important role of nurses in nosocomial infection prevention, training is necessary to increase nurses prevention behaviors. Therefor paying more attention by authorities to apply the necessary actions for training of nurses.
Amitis Ramezani, Ali Eslamifar, Mohammad Banifazl, Hossien Keyvani, Effat Razeghi, Farrokh Lagha Ahmadi, Manouchehr Amini, Latif Gachkar, Anahita Bavand, Arezoo Aghakhani,
Volume 16, Issue 11 (2-2014)
Abstract
Background: Occult hepatitis C virus (HCV) infection is defined as the presence of HCV-RNA in liver or peripheral blood mononuclear cells (PBMCs) in the absence of detectable hepatitis C antibody (anti-HCV) or HCV-RNA in the serum. Although occult HCV infection is less aggressive than classic chronic HCV infection, nevertheless it is important in management of hemodialysis (HD) patients. Occult HCV infection has been described in two different clinical settings: in patients with normal liver enzymes or in patients with abnormal values of liver enzymes. The aim of this study was to detect the occult HCV infection in hemodialysis patients with elevated liver enzymes.
Materials and Methods: This cross sectional study was performed in hemodialysis patients referring to 3 dialysis units in Tehran. In 30 anti-HCV negative HD patients with elevated liver enzymes, presence of HCV-RNA in plasma samples was tested by Reverse Transcriptase-Nested Polymerase Chain Reaction (RT-nested PCR). In cases with negative anti-HCV and plasma HCV-RNA, HCV-RNA was checked in PBMC specimens by RT-nested PCR.
Results: A total of 30 HD patients with mean age 54.4± 14.1years and mean dialysis duration 81.2 ±64.4 months were enrolled in the study. All HD subjects were negative for HCV-RNA in plasma and occult HCV infection with RT-nested PCR method.
Conclusion: Occult HCV infection was rare in HD patients with elevated levels of liver enzymes.
Mohammad Reza Massoudinejad, Ashraf Mazaheri Tehrani, Farshid Ghanbari, Simindokht Mirshafian,
Volume 17, Issue 3 (6-2014)
Abstract
Background: The conventional methods of water disinfection are chemical process, ozonation, UV radiation, membrane processes and etc. In recent years, electrolysis method has been considered that is a green process with high efficiency and not by-products. The aim of study is evaluation of efficiency of the electrolysis process with continuous flow in the disinfection of water contaminated with fecal coliform.
Materials and Methods: This study is a Descriptive - analytical study. The samples are prepared in three groups by adding domestic wastewater, manure and E.Coli colonies to distilled water. The prepared samples were introduced to continuous electrochemical reactor. The removal efficiency of electrolysis process was investigated in different conditions which include electrode material (copper and graphite compressed), reaction time (40, 50, 60 and 70 minutes), voltage 48V, distance of electrode 5 cm and the initial pH 7.
Results: The results indicate that removal efficiency depends on source of pollutant, reaction time, and type of electrode. Also the optimal efficiency for E.Coli colonies achieved in electrolysis instrument was as follows: electrode material = copper electrode, distance of electrode=5cm, applied voltage= 48V and reaction time=70 minute. Under these conditions removal efficiency was obtained 99%. No significant changes in pH, TDS and EC in different times and coliform bacteria were not created by changing the source.
Conclusion: According to the results of this study, using the electrolysis process with continuous flow, as a convenient method with high performance and environmentally, suggest for the disin fecting the water contaminated with fecal Coliform.
Sayed Abolhasan Sayed Zadeh, Mehrdad Bakhtiari, Akram Soleimani,
Volume 17, Issue 8 (11-2014)
Abstract
Background: Vesicoureteral Reflux (VUR) is the most common urologic anomaly in children. In spite of prescribing prophylactic antibiotics in children with VUR, in some cases breakthrough infection (BTI) occurs while receiving prophylactic antibiotics which may cause pyelonephritis that can ultimately lead in renal scarring.
Materials and Methods: In this discreptive-analytic study, 288 children with primary vesicoureteral reflux under Cotrimoxazole(2mg/kg) treatment have been under supervision for duration of at least one year. Based on the collected data, predictive effect of some factors like gender, mean age of VUR diagnosis, VUR grade, unilateral versus bilateral and presence of abnormal renal scar on the breakthrough infection under prophylactic treatment, were examined.
Results: Breakthrough infection while receiving prophylactic antibiotics was observed among 111(38.54%) patients consisting of 88 girls (79.28%) and 23 boys (20.72%). The moderate to high VUR grades (grade III-V), presence of renal scar and female gender were found to be the important risk factors for BTI. However, no statistically significant relationship between mean age of VUR diagnosis and unilateral versus bilateral VUR with BTI was found.
Conclusion: Results of the current study will help improving parents' and physicians' awareness of the risk factors associated with BTI which may potentially lead to renal damage.
Seyed Reza Mohebbi, Hamed Naghoosi, Pedram Azimzadeh, Shaghayegh Derakhshani, Afsaneh Sharifian, Mohammad Reza Zali,
Volume 18, Issue 7 (10-2015)
Abstract
Background: In spite of designing and applying an effective vaccine against Hepatitis B virus (HBV), chronic infection with this virus is still one of the most important health problems worldwide. Host genetic background including single nucleotide polymorphisms play a significant role in chronicity or clearance of the infection. The final product of programmed cell death 1 gene (PDCD1) is expressed frequently on T-cells and in chronic viral infections, prevent the virus-specific T-cell response against the virus. In this study, the association of a single nucleotide polymorphism (+7146A/G) in intron 4 of PD1 gene with chronic hepatitis B infection in Iranian population has been assessed.
Materials and Methods: 212 chronic HBV patients and 208 healthy controls were analyzed in this case-control study. Genomic DNA of the studied individuals was extracted and after performing polymerase chain reaction (PCR), polymorphism of +7146 was determined via RFLP method.
Results: Frequencies of GG, GA and AA genotypes on position 7146 of the intron 4 of PD1 gene were 77.4%, 20.7% and 1.9% in patient group and 80.8%, 15.4% and 3.8% in control group, respectively. After statistical analysis, No significant difference was observed between patient and control groups (p=0.198).
Conclusion: Genotype frequencies in the studied population are in accordance with the results of previous studies. Results of the present study suggest that there is not any association between A/G single nucleotide polymorphism in intron 4 of PD1 gene and susceptibility to chronic hepatitis B in Iranian population.
Leila Akhtar Danesh, Zeinab Saiedi Nejad, Hossein Sarmadian, Alireza Amouzandeh-Nobaveh, Aliasghar Farazi, Ehsanollah Ghaznavi-Rad,
Volume 18, Issue 8 (11-2015)
Abstract
Background: Staphylococcus aureus is one of the important pathogens can cause infections in hospitals specially in intensive care units (ICU). It seems that nasal carriage is important risk factor for developing l infection at ICU units. This study was designed to investigate the frequency of S. aureus nasal carriage and its virulence in patients admitted to ICU units in Vali-Asr hospital at Arak university of medical sciences.
Materials and Methods: In this cross-sectional study, nasal swab samples were obtained from all the patients hospitalized in ICU unit of Vali-Asr hospital from July-December 2014 at admission. After identification, methicillin resistance and the frequency of pvl and acme genes determined by PCR. Demographic data were collected using questionnaire and were analysed using SPSS 20 software.
Results: Out of 390 patients, 81(20.8%) and 31(12.9) patients had been colonized with MSSA and MRSA, respectively. The result of culture was negative for 278 patients (71.3%). 77.4% of MRSA and 54.3% of MSSA isolates were positive for acme gene. Also, 11.11% of and 6.45% of MSSA MRSA isolates were positive for pvl gene.
Conclusion: The application of medical supportive devices like cv line, ventilator, history of surgery operation and antibiotic use significantly was associated with S. aureus nasal carriage. High prevalence of S.aureus shows that these bacteria settled in the hospital. Hence, infection control measures must be performed to reduce the risk of hospital infection.
Nader Zarinfar, Maryam Valikhani, Bahman Sadeghi, Masoumeh Soufian, Majid Akbari,
Volume 19, Issue 11 (2-2017)
Abstract
Abstract
Background: Probiotics are known as a factor for prevention of infectious diseases such as urinary tract infection(UTI). The present study aimed to investigate the positive effects of probiotics on urinery truct infection of cateterized intensive care unit patients.
Materials and Methods: In a triple blind clinical trial, 125 cateterized intensive care unit patients were randomly selected and divided into two groups, Treatment group (n = 63) was well matched with placebo group (n = 62) for age and sex and duration of admission .Case group received one lactocare capsule for 10 days and control group with a same method received placebo for 10 days. In both groups urine analysis and urine culture were measured with a same method at the first day and then twentieth day and finally data were analysed with t-test.
Results: The incidence of urinary tract infection between treatment and control group (respectively 17.4% and 22.5%) had no statistically significant difference (p=0.672). But, in terms of sex, incidence of urinary tract infections in women compared to men with the same condition was significantly different(p=0.002). In treatment group with long term cathetrization, urinary tract infections significantly were significantly different(p=0.041).
Conclusion: Administration of lactocare capsule has no statistically significant impact on the incidence of urinery truct infection of cateterized intensive care unit patients. In comparsion of cateterized men and women receiving probiotics, the reduction of urinary tract infection in women was more than in men. Probiotics had preventive effects on long term catheterization.
Mina Zolfaghari, Behzad Khansarinejad, Ali Ganji, Zeinab Hamzehloo, Hamid Abtahi,
Volume 19, Issue 11 (2-2017)
Abstract
Abstract
Background: Ureaplasma and M. genitalium species belong to a kind of bacteria that are sexually transmitted and are the possible cause of pelvic inflammatory disease and nongonococcal urethritis, and et al. The aim of this study was to determine the urea plasma and Mycoplasma genitalium species frequency in women with vaginal infection and various sexual partners who referred to women, s health promotion and treatment center in Arak.
Materials and Methods: Endocervical swab samples from 110 women with vaginal infections referred to women’s health promotion and treatment center in Arak, were prepared. Patients’ personal information and identities during reception process were registered. The samples were transferred to the laboratory in the transport environment and after DNA extraction, were evaluated according to Real-time PCR assay.
Results: Urea plasma and Mycoplasma genitalium bacteria existed in 96(87.27%) and 4(3.63%) of patients, respectively. Among them, 4 cases had both bacteria infections. The amount of isolation in young women between 30-39 years old was more than others.
Conclusion: The results show that the colonization of urea plasma species in adult women is 40-80% and in studied group is 87.27%. These results indicate that with due attention to the increasing number of sexual partners and the increase of sexual activity, the urea plasma colonization of women will increase. In view of the potential influence of mycoplasma species on side effects resulted from pregnancy infection of mothers and mortality, on-time diagnosis and treatment will be increasingly essential.
Hosna Rastegarpouyani, Seyed Masoud Hosseini, Seyed Reza Mohebbi, Pedram Azimzadeh, Shabnam Kazemian, Mahsa Saeedi Niasar, Afsaneh Sharifian, Mohammad Reza Zali,
Volume 20, Issue 2 (5-2017)
Abstract
Background: Parvovirus 4 (PARV4) was first discovered in 2005, in a hepatitis B virus–infected injecting drug user (IDU). To date, the best evidence about PARV4 transmission is parenteral roots and comes from IDU individuals. It seems that the prevalence of the virus in the normal population is very low. In this study, we investigated the prevalence of PARV4 virus among patients with chronic HCV infection compared with healthy controls and related risk factors among these groups.
Materials and Methods: A total of 206 patients, including 103 patients with chronic HCV infection and 103 healthy controls, were studied by use of nested-PCR and also real-time PCR techniques.
Results: AST enzyme levels with a mean of 40.45+34.84 and 18.58+5.9 in patients and healthy group respectively and the amount of enzyme ALT among patients with a mean of 40.45+35.75 and 21.50+11.35 in patients and healthy group respectively, were reported. Finally, after screening all DNA samples from patients and controls, we discovered that none of these people are infected with the PARV4 virus.
Conclusion: This study is the first to investigate the occurrence of PARV4 among HCV patients in Iran. The results show that, the virus is not important in Iranian population, even in patients with blood born infections such as HCV and further studies in other areas and various groups are required.
Asma Toraji, Mahnaz Hadizadeh, Fahimeh Nemati Mansoor,
Volume 21, Issue 1 (4-2018)
Abstract
Abstract
Background: Nanotechnology offers a great chance to treat drug-resistant microbial infections. The purpose of this study was to synthesize amoxicillin-encapsulated polymeric nanoparticles and compare the antibacterial activity of this nanoformulation with pure amoxicillin.
Materials and Methods: Amoxicillin-encapsulated polymeric nanoparticles were prepared using chitosan as a polymer and alginate as cross linking agent. The obtained nanoparticles were characterized by Fourier transform infrared, dynamic light scattering and scanning electron microscopy. The antibacterial effects of the nanoparticles were evaluated using broth microdilution and well diffusion methods against some common bacterial strains involved in hospital-acquired infections.
Results: The drug-encapsulated nanoparticles were found to be spherical in shape with average size of 96 nm. These nanoparticles had a significant antibacterial effect on all tested bacteria, except for Pseudomonas aeruginosa. They also displayed stronger antibacterial activity than the nanocarrier alone or free antibiotic. The highest mean zones of growth inhibition (23.7 mm) for methicillin-sensitive Staphylococcus aureus and the smallest zone (12.5 mm) for the resistant species of this bacterium were determined. MIC of the nanoformulation against these two strains was respectively determined at 1.5 and 48 µg/ml and for Escherichia coli and Pseudomonas aeruginosa at 6.6 and 256 µg/ml.
Conclusion: The results suggest that amoxicillin encapsulation in polymer nanoparticles has the potential to increase its antibacterial activity against bacteria causing nosocomial infections.
Ali Ganji, Ghasem Mosayebi, Mohsen Khaki, Ali Ghazavi,
Volume 23, Issue 1 (3-2020)
Abstract
Background and Aim: COVID-19, a viral respiratory illness. In this review, we discuss issues such as the genetic structure, pathogenic mechanism, clinical characteristics, diagnosis, treatment, and prevention of COVID-19 based on the latest findings.
Materials and Methods: The Medline was searched for terms such as “Coronavirus” ،“ COVID-19” and “Respiratory infection”.
Findings: In December 2019, the unprecedented outbreak of pneumonia with unknown etiology began in Wuhan, Hubei Province, China. The cause was a new coronavirus, named COVID-19 by the WHO. This virus has high transmissibility and affects the lower respiratory tract. Research into the mechanism and treatment of COVID-19 is under way, and new information is being provided every day, some of which are contradictory. COVID-19 is a serious and dangerous infectious disease and a significant threat to the health of the world's population, and should be prevented from spreading rapidly.
Conclusion: Because the exact mechanisms of the disease have not been fully elucidated and specific drug or vaccine have not yet been developed for it, control is mainly based on the interruption of the transmission cycle.
Erfan Rezaei, Mojtaba Didehdar, Seyed Hamed Mirhoseini,
Volume 24, Issue 3 (8-2021)
Abstract
Background and Aim: Fungal infections are among the most critical and common issues for hospitalized patients, especially in intensive care units. This study aimed to determine the fungal contamination of indoor air and surfaces in sensitive wards of the Arak University of Medical Sciences educational hospitals and determine the drug susceptibility pattern of isolated species.
Methods & Materials: In this descriptive cross-sectional study, 63 air samples were taken from sensitive hospital wards using the one-stage Anderson method, and 63 surfaces samples were taken using wet cotton swabs and cultured in saprodextrose agar medium containing chloramphenicol. Identification of the genus and, as far as possible, the species of fungi was performed using the culture method on the slide. Drug susceptibility testing was performed on isolated species by broth microdilution method (CLSI-M38A2 standard).
Ethical Considerations: This study was approved by the Research Ethics Committee at Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1395.315).
Results: From the total samples, 18 species of fungi were isolated. These included: Aspergillus niger (8), Aspergillus flavus (4), Aspergillus fumigatus (2), Rhizopus spp. (2), Mucor spp. (1) and Fusarium spp. (1). In the drug sensitivity assay, instances of resistance included: Partial sensitivity of Aspergillus fumigatus to Itraconazole (1), Partial sensitivity of Aspergillus niger to Ketoconazole (1), and Resistance of Aspergillus niger to Itraconazole (1).
Conclusion: The pattern of nosocomial fungal infection with pathogenic fungi and the drug susceptibility pattern of these organisms in other regions of Iran and the world is relatively consistent with the present study results. And drugs listed in global guidelines for treating these infections, such as voriconazole and caspofungin in the treatment of invasive aspergillosis and amphotericin B in the treatment of invasive mucormycosis and Fusarium wilt, are now effective drugs.
Mahboobeh Darzi Poor, Reza Tavakoli, Davood Shojae Zade, Zahra Rezagholizadeh Omran,
Volume 25, Issue 1 (3-2022)
Abstract
Background and Aim Nosocomial infection is a health problem in all countries. Considering the role of midwives in controlling nosocomial infection, the aim of this study was to determine the effect of an educational intervention based on model on preventive behaviors of nosocomial infection by Babol hospitals midwives was done.
Methods & Materials The present study was a quasi-experimental study with intervention and control group. The interventions were performed in three 40-minute sessions in the Shahid Yahya Nejad Hospital in April and May 2017. The data collection tool was a structure Health Belief Model based(Awareness, structure Health Belief Model and behavior) on a questionnaire completed Its validity and reliability were assessed two months before and one month after Midwives who met the inclusion criteria education. Data were collected and analyzed by SPSS software v. 24 by Anova , T-test and ANCO one-way Covariance tests.
Ethical Considerations This research paper has been approved by the ethics committee IR.IAU.TMU.REC.1398.068 and informed consent will be taken from the participants in the study the information will remain confidential.
Results Before the intervention, the two groups did not differ significantly in terms of, mean scores of different model structures. After intervention, there was a significant difference in the mean and standard deviation of the effect of education on knowledge score (1.0±0.3), perceived sensitivity (2.8±1.5), perceived severity (3.6±1.7) Perceived barriers (-6.4±1.3), perceived benefits (5.1±4), self-efficacy (4.6 ± 2.6) and behavior( 3.1±1.1) was seen in the intervention group (P>0.05).
Conclusion By increasing the scores obtained from the structures Especially self-efficacy and reduction of perceived barriers, designing and implementing an educational program based on model in midwives can increase their performance regarding the prevention of nosocomial infections.
Fatemeh Mohammadi, Maryam Nikrou, Kimia Sadeghi, Farid Askarifard, Mohammad Sayyadi,
Volume 25, Issue 2 (5-2022)
Abstract
Background and Aim Coronavirus disease 2019 (COVID-19) is a respiratory disorder that can affect many body systems, including the hemostatic system. In this study, we aim to investigate the role of hemostatic system and the blood coagulation in COVID-19.
Methods & Materials In this review study, the articles were searched using the keywords COVID-19, Respiratory infection, and Coagulopathy in Google Scholar, PubMed, Google Springer and Science Direct databases.
Ethical Considerations Ethical principles in writing this article were observed in accordance with the guidelines of the National Ethics Committee and the Committee on Publication Ethics (COPE).
Results Many changes in the coagulation profile of infected patients were reported, including changes in the platelet count, fibrinogen/fibrin degradation product, D-Dimer, fibrinogen, prothrombin time, and activated partial thromboplastin time. With the increase in the number of patients with COVID-19, several studies found out the occurrence of thrombosis and coagulopathy in patients.
Conclusion Due to the increase in the occurrence of coagulation disorders in patients with COVID-19, the administration of anticoagulants is needed for their treatment; it can play an effective role in improving the prognosis of patients.
Ali Moradpoor Shamami, Dr Masumeh Anvari, Seyedeh Tooba Shafighi, Hadi Sedigh Ebrahim-Saraie,
Volume 25, Issue 5 (12-2022)
Abstract
Introduction: Considering the importance of urinary tract infections caused by uropathogenic Escherichia coli (UPEC) in the medical field, this study aimed to investigate serogroups O25 and O16 and the pattern of antibiotic resistance among UPEC isolates obtained from hospitalized patients with urinary tract infections (UTIs) in Rasht hospitals.
Methods: A total of 110 urine samples were collected from patients with UTIs referred to selected hospitals in Rasht. The disk diffusion method, as recommended by the CLSI, was used to determine the pattern of antibiotic susceptibility. Serogroups O25 and O16 were detected using specific primers.
Results: Among the studied samples, 36.4% (40/110) were men and 63.6% (70/110) were women. Based on the antibiotic susceptibility pattern, a high level of antibiotic resistance was observed against nalidixic acid (81.8%) and co-trimoxazole (78.2%), while the most effective antibiotics were amikacin (85.5%) and nitrofurantoin (83.6%). In addition, multi-drug resistant phenotype was found in 72.7% (110/80) of UPEC isolates. According to PCR results, the frequency of serogroups O25 and O16 was 36.4% and 17.3%, respectively. Both serogroups had the highest resistance to nalidixic acid and co-trimoxazole, while the lowest resistance in serogroup O25 to nitrofurantoin (20%) and amikacin (14.3%) and in serogroup O16 to imipenem (5.3%) and nitrofurantoin (10.5%).
Conclusions: This study showed that the high prevalence of MDR strains among UPEC strains is very worrying and professionals should be very careful in prescribing antibiotics for patients. Like most studies, the frequency of serogroup O25 was high, and probably, this serogroup can play a role in causing urinary tract infections and antibiotic resistance of UPEC strains.
