Showing 27 results for Parsa
Parsa Yousefi Chaijan, Fatemeh Dorre, Zahra Moghaddasi, Maryam Mashayekhi,
Volume 13, Issue 3 (9-2010)
Abstract
Background : Urine tract infection(UTI) among children is the most prevalent bacterial infection and the second prevalent infection after Viral Flu.Regarding this cfact that urine culturing has very important role in diagnisis and perseverance of this disease and sampling method has significant effect on this disease remedy.
In this study the effect of genital area ablution on decreasing the contamination of urine culture is examined.
Methods and Materials: This study is in the form of case_controlled.In this study 620 little girls (3-12 years –old) referring to Amir Kabir children special clinic are examined.Population under investigation was cpatients who had not history of taking antibiotic during last seven days, sondage and genital anomaly and inflammation and genital discharge.
Patients were randomly entered in two different groups one with ablution and the other without ablution.After data collection, available inputs were statistically analyzed with SPSS and the effect of genital area ablution was determined on decreasing the contamination of urine culture.
Results: Among 310 patients in with_ablution group 11 patients were reported UTI(3/7%).3 patients were contaminated (1%),296 patients were normal (95/3%).Among 310 patients in the second group,14 patients were reported UTI(4/7%),6 patients were contaminated(2%),290 patients were normal(93/3%).Contamination rate in with_ablution group were 1% and in the other group was 2%Based on Pvalue :0/491 in both groups no significant statistically difference were found between these two groups and the analysis result distribution in both groups in a=0/05 level were statistically the same.
Conclusion: In both group no significant statistically difference were found between these two groups ,so we concluded that the genital area ablution doesn’t have such an effect on decreasing the contamination of urine culture and we don’t suggest ablution of genital area in children before providing urine sampling.
Nasser Parsa,
Volume 14, Issue 2 (5-2011)
Abstract
Alzheimer’s disease is one of the most common causes of loss of mental function broadly known as “Dementia”. Alzheimer’s disease affects approximately 2% (6.5 Million) of people in the developed countries and responsible for over 100,000 death per year in USA Alzheimer’s disease usually occurs between sixth to ninth decade and its progressive deterioration comprised of gradual destruction of memory, judgment, language, reasons in addition to behavioral alterations. Microscopic biopsy shows cortical atrophy along with ventricular enlargement of the brain. These clinical manifestations reflect the neurotic degeneration in cerebral cortex, especially, the temporo-parietal cortex and the hippocampus. Pathological abnormalities of Alzheimer’s disease include brain deposition of two fibrillary proteins. These two are known as Beta-amyloid proteins containing Apolipoprotein E and Tau proteins. Alzheimer’s disease affects primarily cholinergic neurons, therefore, treatment is followed by specific drugs that inhibit the degradation of acetylcholine within synapses. Current medications only treat the cognitive symptoms but not the underlying disorder. Several lines of ongoing research are showing promising scientific results. These include, uncovering the biological markers for early detection and developing new effective drugs. Also, new approaches have been employed to block the molecular processes that lead to this disease. Moreover, many clinicians are exploring alternative pathways for Alzheimer’s disease treatment, such as good diet along with mental and physical exercise as preventive methods.
Nasser Parsa, Amir Almasi-Hashiani,
Volume 14, Issue 7 (Brucellosis Supplement 2012)
Abstract
Human Brucellosis is an infectious disease caused by Brucella bacteria. An average of 150 cases of brucellosis among 330 million people is reported in the USA each year. This bacterium is small, gram-negative rods that grow in phagocytes. They primarily cause diseases among different animals and humans become infected when is in contact with animals or their products. Brucella can cause various symptoms in humans which is similar to human influenza. Brucellosis is diagnosed in a laboratory by finding Brucella organisms in samples of blood or bone marrow or to detect antibodies against the bacteria in two blood samples, collected 2 weeks apart. Depending on severity of illness, recovery may take as long as several months. There is no vaccine available for human except live vaccines and that should be consulted to a health care provider. DNA findings for Brucella species in the index patients focused our attention on revealed human cancers. Also, granalomatous inflammation of testes and medulloblastomas has been linked to chronic Brucellosis infection which could be similar to Helicobacter pylori that is associated with gastric tumor formation. More scientific investigation is needed to properly address the connection of Brucella with other human malignancies.
Nafiseh Gazerani, Fatemeh Nahidi, Parsa Yousefi, Alireza Abadi,
Volume 15, Issue 1 (April-May 2012)
Abstract
Background: Infantile colic is a behavioral syndrome characterized by severe crying without a specific cause in healthy under three-month-old infants. The aim of this study was to compare the effectiveness of infant massage and rocking on the duration and frequency of crying time in colicky infants.
Materials and Methods: This randomized clinical trial involved 100 infants 1-2 weeks of age with colic who referred to Amir Kabir Hospital, Arak, Iran, in 2010. The infants were randomly assigned to massage group (n=50) and rocking group (n=50). In the massage group, mothers were recommended to massage their child three times a day for 7 days. In the rocking group, mothers were recommended to rock their child during crying every day for 7 days. In both groups, mothers recorded infant crying durations during one week in a checklist. Data were analyzed by SPSS software.
Results: The mean difference of total crying times and durations were 8.34 and 4.12 during the first day and 4.26 time/day and 1.32 hour/day during the last day in the massage group, whereas in the rocking group, these values were 7.50 and 2.42 in the first day and 6.94 and 2.14 hour/day in the last day, respectively. The means of crying times and durations in the massage group were more than those of the rocking group (p<0.001).
Conclusion: Infant massage can reduce the duration of crying in colicky infants and it can enhance the relationship between mother and child and their relaxation
Ahmadreza Ghandi, Parsa Yousefi, Hosseinali Hadi, Ahmadreza Behrouzi, Aahdieh Sadat Ghafari,
Volume 15, Issue 7 (December 2012)
Abstract
Background: Transient hip tenosynovitis is one of the common causes of pain and limping in children and includes 0.4% to 0.9% of admissions in emergency wards. The aim of this study is to evaluate this disease in terms of clinical presentations, age and sex distribution, and six-month recurrence. Materials and Methods: In this cross-sectional study, 51 children with diagnosis of transient hip tenosynovitis were investigated. Inclusion criteria were physician's clinical suspicion of acute tenosynovitis according to clinical presentations, physical exam, and age range of 3 to 8 years. Results: Among the 51 children with tenosynovitis, 34 patients were male with age of 61.70±19.1 months and 17 patients were female with mean age of 48.35±20.49 months that presented a significant statistical difference (p=0.026). The most common complaint was hip pain and the most commonly involved joint was the hip. Also, most of the patients had the history of viral diseases. Conclusion: Transient hip tenosynovitis is more common in boys. The right hip is the most involved joint and the majority of patients have the history of recent viral diseases.
Mahnaz Edalat-Nejad, Rezvan Sadeqi, Parsa Yousefichaijan, Mahdie Qaffari,
Volume 15, Issue 9 (February 2013)
Abstract
Background: Adequately delivered hemodialysis dose has been shown to have a distinct impact upon the morbidity and mortality of patients on chronic dialysis therapy. Online conductivity monitoring (OCM) using sodium flux as a surrogate for urea allows for repeated measurement of hemodialysis adequacy in each treatment session. Materials and Methods: In this cross-sectional study, 156 treatment sessions in patients undergoing chronic hemodialysis were assessed by measurement of the conductivity performed by Diascan in AK 96 dialysis machines. Dialysis adequacy was measured by daugirdas logarithmic estimates of single-pool Kt/V. Values of calculated Kt/V and simultaneously obtained online Kt/V were compared. Statistical analysis was performed using paired sample t-test. Results: There was a statistically significant difference between calculated Kt/V and online Kt/V in this study. The mean calculated Kt/V was 1.1±0.18 and mean online Kt/V was 0.77±0.32 (p<0.001). There was a moderate correlation between calculated Sp Kt/V and on-line Kt/V (r =0.44, p=0.012). Conclusion: Despite the underestimation of hemodialysis adequacy by online conductivity monitoring in comparison with Sp Kt/V, it is a useful tool in clinical practice.
Fazad Zamani, Parsa Yousefi, Mohammad Rafeei, Neda Saleh Jafari,
Volume 16, Issue 7 (10-2013)
Abstract
Background: Adenoidal hypertrophy is a common condition of childhood, when abstructive sleep apnea ocurs adenoidectomy is indicated. In less sever cases, non surgical interventions maybe considered, however few medical altematives are currently available. Intranasal steroids used to reduce nasal airway obstruction. The aim of this study to assesthe effectiveness of intranasal corticosteroids for improving nasal airway obstruction and in children with adenoid hypertrophy.
Materials and methods: 77 children 1-12 years exhibiting adenoid hypertrophy symptom and confirmed with radiologic imaging and without tonsilar hypertropy that not inclined to surgery were included and divided two groups in one group were treatend with intranasal betanethason 3 times daily for 3 weeks and and second group treatend with intranasal NACL as placebo. The subjects were assessed for airway obstruction symptoms including, snoring mounth breathing and prulaunt rhinorea, via questionarre ear examination, first month and third month of treatment.
Results: Intranasal betanethasone improved airway obstruction symptoms especially night snoring but hadn’t effective on other symptoms and infection complications including rhinorea.
Conclusion: Intranasal betanethasone can be used as alterative treatment for adenoidal hypertroply because its effect on airway obstruction symptoms due to probably reduction adenoideal size.
Fatemeh Dorreh, Parsa Yousefi, Javad Javaheri, Babak Eshrati, Zahra Amiri,
Volume 16, Issue 8 (11-2013)
Abstract
background: Early detection and treatment are crucial to prevent mental retardation in congenital Hypothyroidism (CH). The aim of this study was to evaluating of screening program of CH in Markazi Province.
Materials and Methods: In cross sectional descriptive study we used recorded data in Markazi province health center. From 2006 to 2012,127112 newborns were screened by measurement of serum TSH level by heel prick. Neonates who had blood TSH&ge5MIU/L were recalled for more evaluation. Neonates with confirmed hypothyroidism underwent treatment.
Results: From127112 screened neonates, 414 were diagnosed as CH patients (both permanent and transient). The prevalence of CH was . Recall rate was 4.8%. In 94.4% of patients, treatment were begun before the 40th day of life. The coverage percent in the province was 100% from the second year of the program.
Conclusion: Recall rate and the incidence of CH were higher than those in other studies, both in Iran and other countries. The mean age of treatment initiation and coverage percent were in favorable range.
Somaye Ghaderi, Fatemeh Alaee Karahrudi , Parsa Yousefi Chaijan , Navideh Nasiri Oscui ,
Volume 16, Issue 10 (1-2014)
Abstract
Background: Hospitalization of a child in pediatric intensive care unit (PICU) is a very stressful experience for parents. High stress in father can product decline in psychological adaptation and associated problems. The present study aimed to determine effect of fathersʼ participation in the care of hospitalized child in PICU on fathersʼ stress and coping strategies.
Materials and Methods: This is a clinical trial with 60 fathers with children admitted to the PICU in intervention and control groups. Fathers in intervention group, participated in the care of the child in 5 times, during a 5-days course. Fathersʼ stress and coping strategies were surveyed in intervention group before and after participation course and in control group before and after a 5-days course.
Results: Fathersʼ stress in intervention group decreased significantly after participation (p˂0.001) but in control group difference was not significant after time course. Fathers in both groups applied similar coping strategies that majority were emotion focused.
Conclusion: Fathers having children in PICU would experience a lot of stress. Their participation in the care of the children would be very effective to decline their stress and reach most adaptation with disease, cure and cares in children.
Habib Soheili, Parsa Yousefi Chaijan, Anita Alaghmand, Bahman Sadeghi Saddeh, Amin Tavasoli, Mahdyieh Naziri,
Volume 17, Issue 1 (4-2014)
Abstract
Background: Allergic rhinitis affects 40% of general population and has an increasing prevalence. Sleep disturbance is an important problem in individuals with allergic rhinitis. Recent studies have shown that 68% of cases with perennial rhinitis and 48% with seasonal rhinitis have impaired sleep.
Materials and Methods: In this case-report study, 33 children with allergic rhinitis aging 6-18 years entered the study. Thirty five children without allergic rhinitis entered the study as control group. A questionnaire containing demographic data and types of sleep disorders filled for every child.
Results: Except respiratory disorder, there was no other significant difference between groups in any sleep disorder. Sixteen children (48.5%) in case group has respiratory disorder while none of control children were involved (P=0.0).
Conclusion: Nasal congestion is the main factor involved in sleep impairment in children with allergic rhinitis. Therefore, it seems that it is the first symptom to be treated.
Parsa Yousefichaijan, Mahdieh O Sadat Ghafari, Hasan Taher Ahmadi, Leila Farajzadeh, Azam Zamamiyan,
Volume 17, Issue 4 (7-2014)
Abstract
Background: Pediatricians frequently confront with elevated body temperature in children and subsequent anxious parents. They practice several approaches in management of fever. A recently addressed issue is administration of alternating doses of acetaminophen and Ibuprofen. This method is relatively common , despite lack of sufficient evidence in this field.
Materials and Methods: This study is a randomized clinical trial. A total of 240 children, aged 6 months to 12 years suffering from gastroenteritis was recruited in this research. Children were classified in 3 groups. First group received Acetaminophen, second group received Ibuprofen and third group were treated with acetaminophen – Ibuprofen every other day alternately.
Results: 240 child were taken apart in this research . 112 ones were female (46.66%) and 128 were male (53.33%). The mean time of lowering fever in the first group was 2.07 days. This figure in the second and third groups were 1.82 and 1.87 respectively. Average doses in the first, second and third groups were (in order) 9, 8.17 and 7.13 doses. Medication in the first group minimum effectiveness rather than two other groups.
Conclusion: The alternating regimen of Acetaminophen – Ibuprofen is more effective than monotherapy in reduction of fever in infants and children between 6 months to 12 years.
Parsa Yousefi Chaijan, Bahman Salehi, Ali Khosrobeigi, Melika Hajirahimi, Mohammad Rafiei, Hassan Taher Ahmadi,
Volume 17, Issue 8 (11-2014)
Abstract
Background: Some children have abrupt onset of severe urinary frequency, voiding as often as every 10-15 min during the day, without dysuria, UTI, daytime incontinence, or nocturia. The most common age for these symptoms to occur is 4-6 yr, after the child is toilet trained, and the vast majority are boys. This condition is termed the daytime frequency syndrome of childhood or Pollakiuria. The condition is functional no anatomic problem is detected. The symptoms occur often just before a child starts kindergarten or if the child is having emotional family stress-related problems. OCD is a chronically disabling illness characterized by repetitive, ritualistic behaviors over which the patient has little or no control. OCD has a lifetime prevalence of 1-3% worldwide, and as many as 80% of all cases have their onset in childhood and adolescence. The purpose of this study was to investigate the relationship between OCD and Pollakiuria.
Materials and Methods:In this case-control study, we evaluated (152) children aged 6-18 years old who were visited in the pediatric clinics of Amir-Kabir Hospital, Arak, Iran. The control group considered of (76) healthy children and the case group included (76) age and sex matched children with Pollakiuria. Then, the children’s behavioral status was evaluated using the children’s Yale-Brown Obsessive-Compulsive Scale (C-YBOCS). The C-YBOCS is helpful in identifying children with OCD. The data was analyzed using descriptive and analytical statistics in SPSS-16.
Results: OCD was detected in (5) case (6.6%) with Pollakiuria and (8) controls (10.5%). The difference in OCD was not significant (p-value 0.282) between the two groups.
Conclusion: OCD isn’t more common in Pollakiuria versus non-Pollakiuria children. It is recommended to conduct a study with higher sample volume in order to detect the relationship between OCD and Pollakiuria.
Mojtaba Hashemi, Javad Javaheri, Marjan Habibi, Parsa Yousefi Chaijan, Mahdyieh Naziri,
Volume 18, Issue 6 (9-2015)
Abstract
Background: The prevalence of constipation in childhood is 0.7% to 29.6%. Inorganic causes are considered as the most common cause of constipation in children. Polyethylene glycol (PEG) is the most effective and safest laxatives which is usable in children in the long-term. This study was conducted to evaluate and compare the effect of PEG treatment and probiotic bacilluscoagulans and bifidobacterium and probiotic to enhance the growth of probiotics.
Materials and Methods: In this double blind clinical trial study(interventional study), 120 children aged 2-16 years with chronic functional constipation enrolled the study based on ROME III criteria. The bowels became empty by using liquid paraffin. Then, children were randomly divided into three groups of polyethylene glycol+placebo and Probiotics+placebo and polyethylene glycol+probiotics recipients. After 6 weeks of treatment, treatment success rates between the three groups were compared before and after the study Data analyzed by SPSS 20 software.
Results: The results of the study conducted on the three groups for treatment of constipation showed that the effect of polyethylene glycol and probiotic on treatment was considerable before and after treatment but the levels of effect was similar in the comparison of groups. The simultaneous use of two drugs was more effective than a single drug.
Conclusion: Overall, the results of our study showed that concurrent use of polyethylene glycol and probiotics is much more effective in the treatment of constipation.
Sahar Parsaee, Homa Mohseni Kochesfehani, Gholamreza Kaka, Homayon Sadraee, Mojtaba Kahali,
Volume 18, Issue 6 (9-2015)
Abstract
Background: Stress is a mental or emotional disturbance that occurs in response to external stimuli and can also appear during pregnancy. The aim of this study is to investigate the effect of maternal stress during pregnancy on the cerebellar structure changes and seizure threshold of their offspring .
Materials and Methods: In this experimental study, 20 pregnant female rats were divided into two groups: 1) Non stress group, and 2) Stress group which were under immobilization stress one hour for 14 days . The seizure threshold test in offspring was performed by injecting Pantilen tetrazol drug (PTZ)(n=8) . To investigate the cerebellum development, the offspring were divided into three groups . Control group: mothers did not any stress and offspring did not receive PTZ (n=4). Sham group: mothers did not stress but the offspring had received PTZ(n=4). Experimental group: mothers did stress and offispring did receive PTZ(n=4). After the section of cerebellum, the thickness of cerebellum layers and the number of cells in each layer were evaluated.
Results: The mean of seizure threshold in the offspring whose mothers were under the stress of pregnancy significantly increased compared to children whose mothers no received stress (p<0.001). In the other side, mean number of purkinje cells in the experimental group significantly decreased compared with the other groups (p<0.001). No significant differences were found in the mean of granular and molecular layers thickness of cerebellum in the experimental group when compared with the other groups(p<0.05). However, mean cellular density in the granular layer of cerebellum in the experimental group significantly decreased compared to other groups (p<0.001).
Conclusion: Stress during pregnancy increased the seizure threshold in offspring and caused some developmental and structural disorders in the cerebellar rat offspring.
Parsa Zargar, Esmaeel Ghani, Farideh Jalali Mashayekhi, Ebrahim Eftekhar,
Volume 19, Issue 3 (6-2016)
Abstract
Background: A small percent of patients with colorectal cancer (CRC) respond to 5-Fluorouracil (5-FU), as a first line of chemotherapy. In this study in, in order to design a new chemotherapy protocol, the effect of 5-FU and acriflavine (ACF) cotreatment on mortality rate of CRC cell lines was investigated.
Materials and Methods: Cytotoxicity of 5-FU and ACF against CRC cell lines (LS174T, SW480 and HCT116) was detected using MTT assay. Cells were treated with different concentrations of 5-FU (0.5-64 µM) or ACF (0.07-5 µM) for 72 hours and then cell viability and drugs IC50 was calculated. To assess the effect of ACF on anticancer activity of 5-FU, cells were cotreated with different concentrations of 5-FU and IC30 concentration of ACF.
Results: ACF and 5-FU suppress the viability of CRC cell lines in dose-dependent manner. 5-FU and ACF have most cytotoxic effect on LS174T and the lowest cytotoxic effect on SW480 cells. Cotreatment of ACF with 5-FU could not significantly change the sensitivity of cells against 5-FU (p>0.05).
Conclusion: In this study, the fatal and cytotoxic effect of ACF on three CRC cell lines was shown. However, cotreatment of ACF with 5-FU could not improve the anticancer activity of 5-FU.
Roshanak Haji Mohammad Ali, Masoud Parsania, Gholamreza Amin,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: Herpes simplex virus type 1 (HSV-1) may lead to oral herpes, encephalitis and keratoconjunctivitis. Today, following the increasing of HSV-1 prevalence and drug resistance, there has been an interest in the use of natural substance. In this study, we assessed the effect of hexane and methanol extracts of Chelidonium majus L. against acyclovir-resistant HSV-1.
Materials and Methods: The toxicity threshold of Chelidonium majus L. hexane and methanol extracts on HeLa cell was determined with trypan blue and MTT methods. Their direct antiviral effects were evaluated against HSV-1. Different concentrations of extracts in different times of virus replication have been evaluated. In each stage, the viral titers were tested by TCID50 assay.
Findings: The methanol extract at the concentration of 200 µg/ml and hexane extract at the concentration of 600 µg/ml were determined as effective minimal cytotoxic concentration on HeLa cell line. These concentrations did not have significant virucidal effects on Herpes simplex virus. The maximum antiviral effects of methanol extract at the concentration of 200 µg/ml was exhibited 1 and 2 hours after virus adsorption and reduced virus titer 4 logTCID50 compared to the control. Hexane extract did not have antiviral effect.
Conclusion: methanol extract of chelidonium majus L. compared to hexane extract showed significant antiviral effect on acyclovir-resistant HSV-1. Further research is required to identify specific bioactive compounds of this plant in order to be used in anti-herpes drugs. |
Masoud Rezagholizamenjany, Parsa Yousefichaijan,
Volume 21, Issue 7 (2-2019)
Abstract
Nephrotic syndrome
Nephrotic syndrome is a manifestation of glomerular disease as a proteinuria in the nephrotic and triad of hypoalbuminemia, edema, hyperlipidemia, and high protein in the urine. Nephrotic proteinuria is defined as protein excretion of more than 40 mg/m2 of body surface per hour or protein to creatinine ratio of more than 2-3 at the first morning urine sample. Its annual incidence in most western countries is 2-3 cases per 100000 children per year, and in developing countries it is often higher due to malaria (1). New findings in this area are often about treatment, which are evaluated and reviewed in following.
Ameneh Omidi, Somayeh Shatizadeh Malekshahi, Parsa Veisi,
Volume 23, Issue 5 (December & January - Special Issue on COVID-19 2020)
Abstract
Background and Aim: Coronaviruses are a large family of viruses that are known to cause respiratory tract infections in humans. SARS-CoV-2 is a new type of this family initiated in late 2019 and its related disease is known as Coronavirus Disease 2019 (COVID-19). Common symptoms of COVID-19 include fever, dry cough, fatigue, myalgia, arthralgia and shortness of breath.
Methods & Materials: In This narrative review a literature search was conducted in scientific databases including Google Scholar and PubMed to find studies published from December 2019 to May 10 2020 on the role the extrapulmonary manifestations of COVID-19.
Ethical Considerations: Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors.
Results: In addition to respiratory symptoms, involvement of various organs such as gastrointestinal tract, nervous system, skin, olfactory system, cardiovascular system, liver, kidney, and eyes was also reported. Extrapulmonary manifestations of COVID-19 included anosmia, ageusia, skin rash, chickenpox-like blisters, acute cardiac failure with increased troponin levels, kidney inflammation and edema, common gastrointestinal symptoms (e.g. diarrhea, nausea and vomiting), elevated liver enzyme levels, neurological disorders (e.g. stroke), nonspecific symptoms (e.g. headache and dizziness), and decreased consciousness level.
Conclusion: The hypothetical mechanisms of various organ involvements during COVID-19 include immune-mediated inflammation such as cytokine storm, respiratory dysfunction, hypoxemia, cellular damage, or combination of these mechanisms. Further studies should be conducted on the causes of various COVID-19-induced damages to determine the exact relationship between the pathogenesis, prognosis and severity of the disease.
Taha Fereydouni, Saeed Hajihashemi, Parsa Yousefichaijan, Ali Rahbari,
Volume 23, Issue 6 (February & March 2020)
Abstract
Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress is among f the major causes of nephrotoxicity and its progression. Deferasirox, due to oxidative stress and increased cell apoptosis causes the dysfunction of renal tubules and renal toxicity. According to its antioxidant and anti-inflammatory properties, the present study explored the effect of vitamin C on deferasirox-induced kidney damage.
Methods & Materials: This study was performed on 30 Wistar rats in 3 groups of control, deferasirox, and deferasirox plus vitamin C. To induce the nephrotoxicity, the intra-peritoneum injection of deferasirox (75 mg/kg/day) was used. After taking plasma from the blood samples of the explored rats, we determined the values of Cr, Na+, K+, Mg+, osmolality, and BUN in the obtained plasma and urine samples. The creatinine clearance, as well as the relative and absolute excretion of sodium and potassium, were also calculated. After separating the two kidneys, they were used for the histologic study with Hematoxylin and Eosin (H&E) staining, as well as Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP) biochemical studies.
Ethical Considerations This study was approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1396.309).
Results: Cotreatment with deferasirox and vitamin C reduced renal tissue MDA and relative and absolute Na and K excretion and urine osmolarity; this method also increased creatinine clearance and renal tissue FRAP.
Conclusion: The co-administration of vitamin C presented a significant protective effect on the renal toxicity induced by deferasirox. The protective property of deferasirox is because of the antioxidant impacts of vitamin C in reducing oxidative stress and lipid peroxidation.
Dr Jamileh Amirzadeh-Iranagh, Sima Ghorbanzadeh, Phd Student Yeganeh Dadashzadeh-Sangary, Phd Student Parsa Javanmard,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: The growing increase in the elderly population requires more research to identify the health priorities of this group, especially in critical situations such as the COVID-19 pandemic. Therefore, the current study was conducted to determine the influential components of marital satisfaction and its relationship with lifestyle in Urmia City in 2021.
Methods: In this descriptive-analytical and cross-sectional correlational study, 220 married elderly living in Urmia were selected through cluster sampling. The Miler's life satisfaction and Haynes's marital satisfaction questionnaires were used in addition to the demographic questionnaire to collect data in this research. Data were analyzed using descriptive statistical tests (mean and standard deviation, frequency, and percentage) and analytical (Pearson correlation coefficients and multiple linear regression) at a significant level of P ≤ 0.05.
Results: A step-by-step multiple linear regression model also revealed that variables of lifestyle (ß = -0.364), age (ß = 0.425), number of children (ß = 0.143), occupation (ß = 0.425) and illness (ß = 3.608) - had the most considerable contribution in the sensitive prediction of marital satisfaction. The regression model excluded other demographic variables.
Conclusions: This study showed that lifestyle and demographic variables such as age, number of children, occupation, and illness have the greatest contribution in predicting marital satisfaction. Therefore, it seems necessary to design counseling services in comprehensive health centers for this group so that counselors can teach healthy lifestyles to older adults to improve marital relationships.
