Showing 25 results for Plant
Maryam Yadegari, Mozafar Khazaei, Yazdan Hamzavi, Ali Reza Toloei,
Volume 14, Issue 2 (5-2011)
Abstract
Background: Falcaria vulgaris has different properties and it used as dietary and medicinal herb in the west of Iran. Previously, we showed that this plant has protective and repairing effect on gastric ulcer were demonstrated .The aim of present work was to investigate the effects of F. vulgaris extract on female rat's fertility.
Material and methods: In this Exprimental study Virgin female NMRI rats (160-190 gr) were used in three experiments. In each experiment, animal divided into two subgroups (n=8): control which received Distilled Water (DW) (2cc/kg) and case which received herb extract (150mg/kg) interaperitonealy. In first experiment, animals received single dose of extract or DW.
In second experiment، female rat received extract or DW in perimplantation period (day 1 to 5 of pregnancy) and in third experiment ( day 5 to 7 of pergnancy). In both experiments implantation sites and neonates were counted in three experiments. Data were analyzed by T-Test test and p<0.05 were considered significant.
Results: All three experiments showed significant differences between control and case groups in implantation sites and neonates number. This differences were more prominence in first and third experiment.
Ali Hashemi, Saeed Shams, Mohammad Barati, Azizeh Samedani,
Volume 14, Issue 4 (9-2011)
Abstract
Background: Pseudomonas aeruginosa is one of the most important causes of nosocomial infection which due to extended spectrum-beta lactamases (ESBLs) and metallo-beta lactamase (MBL) producing strains is resistant to a wide range of antibiotics. The aim of this study was to detect ESBL and MBL producing P.aeruginosa isolated from patients and investigate the effects of methanol extracts of Zataria multiflora, Myrtus communis, and Peganum harmala on them.
Materials and Methods: In this experimental study, samples were obtained from 245 patients, referring to Shafa Hospital, Kerman, Iran. ESBLs producing strains were detected by double disk synergy test and phenotypic confirmatory test. In addition, E-test strips were used for MBL detection. P.aeruginosa MIC was determined for cefotaxime, ceftazidime, azteronam, imipenem, and meropenem. Methanol extracts of Zataria multiflora, Peganum harmala, and Myrtus communis plants were prepared by Agar perculation method.
Results: Out of 245 patients referring to the burn unit, 120 P.aeruginosa isolates were detected from which 41 contained ESBL but they lacked MBL. 60% of isolates were resistant to cefotaxime, 66% to ceftazidime, 42% to azteronam, 3% to imipenem, and 5% to meropenem. Among the extracts, Zataria multiflora had the highest antibacterial effect on standard strains of P.aeruginosa in comparison with Peganum harmala and Myrtus communis.
Conclusion: The prevalence of ESBL producing P.aeruginosa strains is high. In addition, noticing their high antibiotic resistance, utilization of herbs, such as Zataria multiflora may be considered an appropriate alternative for treatment however, more investigations are needed.
Ahmad Ghadami, Robaba Memarian, Eisa Mohammadi,
Volume 15, Issue 4 (9-2012)
Abstract
Background: Prevalence and incidence of end stage renal diseases requiring renal replacement therapies such as dialysis and kidney transplantation is on the rise. However, no qualitative research studies have been done to explore the experiences of people living with dialysis and kidney transplant in depth. Therefore, this qualitative study was done to explore the experiences of patients living with dialysis and those with kidney transplant. Materials and Methods: This qualitative study was carried out through content analysis approach. Sampling was done from the beginning and continued until data saturation. Semi-structured interviews were tools of data collection. A total of 18 participants were interviewed. The interviews were analyzed through Graham and Landman content analysis method. Results: After analyzing the data, two main themes including, dialysis, a grueling event, and renal transplantation, a normal life with healthy kidney transplant, were reported. Conclusion: Compared with hemodialysis, receiving a kidney through transplantation provides a significantly more pleasant quality of life for patients. However, there are certain obstacles in transplantation and graft survival in the views of transplantation patients. Hence, it is suggested that health officials design programs to provide support and instruction to facilitate the process of kidney transplantation for eligible patients even before entering the dialysis stage.
Zeynab Golshani, Vida Davoodi,
Volume 16, Issue 8 (11-2013)
Abstract
Background: Today, with raised use of antibiotics and prevalence of resistant strains, there is need for antimicrobial drugs that have fewer side effects than antibiotics. Rosmarinus officinalis is a medicinal plant which had many uses in traditional medicine. In this study, methanol leave extract of this plant is tested on various pathogens.
Materials and Methods: In this in vitro study, Rosmarinus officinalis was used to evaluate its antimicrobial effects. Methanol leave extract of this plant with concentrations of 400, 200, 100, and 50 mg/ml were prepared, and antibacterial activities were evaluated by well diffusion method on strains of Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus. Minimum inhibitory concentration and minimum bactericidal concentration were determined by the microplate method.
Results: In this study, the most efficacy of thanol extract of rosemary leaves was at concentration of 400 mg/ml against Pseudomonas aeruginosa and Escherichia coli. Minimum inhibitory concentration of the extract on the growth of these bacteria showed changes from 6.25 mg/ml to 100 mg/ml. Also MBC of extract showed range from 12.5 to 200 mg/ml respectively.
Conclusion: It was found that rosemary methanol extract inhibited growth of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa but did not inhibit of Bacillus cereus growth.
Farid Firouzbakhsh, Seyed Mohammad Hosein Afsarian, Saeedeh Hooshangi , Hamid Badali,
Volume 17, Issue 5 (8-2014)
Abstract
Background: Saprolegniasis is an important aquatic fungal disease that causes severe damages at different growth stages of aquatic animals. Saprolegnia parasitica has been identified as an important pathogen in aquaculture. This study was investigated the activity of antifungal methanolic extracts of Foeniculum vulgare, Achillea millefolium, Satureja hortensis, Cinnamomum zeylanicum, as well as Artemisia annua essential oil against S. parasitica in comparison with formalin.
Materials and Methods: In this descriptive study, Saprolegnia parasitica originated from rainbow trout’s farm effluent. Phenotypic identification was performed and amplification of ITS rDNA region was adjusted by using of two general primers like ITS1 and ITS4, subsequently sequencing by use of internal primer were performed. The antifungal effects of the plants were investigated based on broth microdilution method and compared by formalin.
Results: The results of sequencing verified the obtained fungus is S. parasitica. In broth microdilution method, the essential herb Artemisia inhibited the growth of S. parasitica at a concentration of 128 &mug/ml (MIC = 128 &mug/ml). At the same concentration, however, it did not show any fungicidal activity (MFC &ge 2048 &mug/ml). Methanolic extracts of the plants fennel, yarrow, Savory, and cinnamon displayed no direct effects on S. parasitica.
Conclusion: Based on the results obtained in the present study, Artemisia can be classified as a powerful antifungal essential plant. The essence of Artemisia performed more effectively compared to formalin for the growth inhibition of S. parasitica.
Azam Afaghi, Shahrbanoo Oryan, Mohammad Abdollahi, Kobra Rahzani, Aliakbar Malekirad, Hossein Kakooie,
Volume 17, Issue 7 (10-2014)
Abstract
Background: The current paper set out to investigate the level of asbestos fiber and asbestos body in sputum and assayed of haematological factors, liver enzymes and pulmonary function test in asbestos exposed group.
Materials and Methods: An analytical cross-sectional study was conducted with a total number of 100 subjects. The case group included 50 male workers with the age range of 25-60 who had at least worked for five years in the asbestos-cement factory. Control subjects consisted of 50 people who had no history of occupational exposure to asbestos. Lung function tests were measured with a portable calibrated vitalograph-PFT spirometer. liver enzymes were assayed with Pars Azmoon kits. Counts of red blood cells and white blood cells were assayed with a cell counter. We used light polarizan microscope to study the level of asbestos fiber and asbestos body in sputum.
Results: Asbestos fiber observed in sputum sample of workers and type of asbestos fiber is chrysotile. Asbestos bodies were found in only 10% of the workers. Decrease (but not significant) in lung function factors (FVC, FEV1, FVC/FEV1) had been seen in the workers in compare with control group. WBC, Eosinophil, neutrophil, lymphocyte, monocyte and liver enzymes levels were significantly higher (but in normal range) in workers as compared with the control group.
Conclusion: Presence of asbestos fiber and asbestos body in workers sputum samples showed workers exposure to asbestos and reduced level (insignificant) of lung function factors and increased level of leukocyte may be indicated pulmonary inflammation. These results also suggested that occupational exposure to asbestos dust may perturb liver mal function parameters
Hosseinali Abdolrazaghi, Azade Riyahi,
Volume 19, Issue 4 (7-2016)
Abstract
Background: This essay reports a case about tissue defect of heel due to melanoma excision.
Patient history: The patient was a man 60 years old with a heel ulcer that had reported malignant melanoma in biopsy. Then the ulcer was done under wide local excision.
Materials and Methods: We should use flap for tissue defect coverage that tendon and heel bone are exposed from it. It seems using skin graft is not useful, because skin graft in persistent contact with shoes will get chronic ulcer. Among different flaps (sural flap or medial plantar flap), we decided to use medial plantar flap. The advantage of this flap is its sensority and low volume.
Conclusion: Conclusion with due attention the results, The meial planter flap, as an efficient method, is adviced to teconstruct heed specially after excision of melanoma.
Mokhtar Nosrati, Zahra Shakeran, Zainab Shakeran,
Volume 20, Issue 5 (8-2017)
Abstract
Abstract
Background: Hepatitis B virus infection (HBV) is a significant global health problem and is a major cause of morbidity and mortality worldwide. Therefore, currently, introducing novel anti Hepatitis B drugs is taken into consideration. This study was planned to in silico screening novel Hepatitis B virus DNA polymerase inhibitors from two medicinal plants Terminalis chebula and Caesalpinia sappan.
Materials and Methods: This is a descriptive-analytic study. In the study, three-dimensional structure of the Hepatitis B virus DNA polymerase was predicted using homology modeling method. A set of phytochemicals from mentioned plants were retrieved from Pubchem database in SDF format. In silico screening was carried out using molecular docking between mentioned phytochemicals and modeled polymerase by iGemdock 2.1 software.
Results: Results of the study confirmed that all evaluated ligands have appropriate interactions to the polymerase with least toxicity and without genotoxicity potential. Results also showed that most interactions occur in reverse transcriptase domain which located in 354-694 area in the amino acid sequence of tested polymerase. Analysis of energy and amino acids involved in ligand-polymerase interaction revealed that Terchebin, Chebulinic Acid and Terflavin A have more effective interaction with the polymerase in compared to other ligands.
Conclusion: Based on the results it can be concluded that evaluated compounds could be good candidates for in vitro and in vivo research in order to develop novel anti- Hepatitis B drugs.
Mohammad Matini, Samira Bakhtiarnejad, Dara Dastan, Amir Hossein Maghsood, Mohammad Fallah,
Volume 20, Issue 6 (9-2017)
Abstract
Abstract
Background: Trichomoniasis is one of the most common non viral sexually transmitted diseases worldwide. The aim of this study was to investigate the effect of Plantago lanceolata extracts on Trichomonas vaginalis.
Materials and Methods: In this study, after collection and drying of P. lanceolata, n-hexanic, ethyl acetate, methanol and hydroalcoholic extracts, they were prepared by maceration. Five clinical T. vaginalis isoleates subjected to extract suscebtibility testing, in comparison of metronidazole. Minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) tests were carried out in duplicate and repeated two times for each T. vaginalis isolate.
Results: The results showed that the extracts of P. lanceolata had potent antitrichomonal activity. The most antitrichomonal activity was related to ethyl acetate extract with the least MIC of 500 µg/ml and mean of 1525 µg/ml, after 48 hrs incubation. And also, the lowest antitrichomonal activity was related to hydroalcoholic and methanolic extract with the least and mean MIC of 2000 µg/ml. The results of MLC and MIC tests were identical and this finding confirmed the trichomonacidal activity of the extracts. The drug suscebtibility testing showed that the T. vaginalis isoleates were susceptibale to metronidazole ranging from 3.1 to 6.2 µg/ml with a mean and standard deviation of 4.2 ± 1.5 µg/ml.
Conclusion: This study showed that the extracts of P. lanceolata hav e a considerable activity on T. vaginalis parasite. Hence, further studies are needed to clear more details of antimicrobial properties of P. lanceolata compounds.
Mahsa Kazemi Roodsari, Farhad Mashayekhi,
Volume 20, Issue 9 (12-2017)
Abstract
Abstract
Background: Matrix metalloproteinases (MMPs) are vital for the degradation/remodeling of the extra-cellular matrix, and are involved in spiral artery formation and invasion of endometrium during implantation. Tissue inhibitor of metalloproteinase 1 (TIMP1), is expressed in the several tissues of organisms and inhibits MMP activity. The aim of this investigation was to study the association between single-nucleotide polymorphism (SNP) in the TIMP1 (rs4898) (372 T/C) with in vitro fertilization and embryo transfer (IVF-ET) outcome by AS-PCR.
Materials and Methods: A total number of 200 blood samples including 100 IVF negative and 100 IVF positive (control) were collected in this study. DNA was extracted for TIMP1 genotyping. The genotype and allele frequencies of 372T/C polymorphism were examined by Allele-Specific PCR.
Results: The genotype frequencies of CC, CT and TT in 372 T/C polymorphism of TIMP1 gene in IVF- samples were 1%, 98% and 1%, respectively, while for IVF+ group were 7%, 91% and 2%, respectively (p=0.07). The allele frequencies of C and T in the IVF- were 50%, 50%, respectively and in IVF+ were 47.5%, 52.5%, respectively. The genotype and allele frequencies of TIMP1 rs4898 (372 T/C) did not differ between the patients and the control group (p=0.07 and p=0.68, respectively).
Conclusion: The results of this study indicate that SNP 372T/C of TIMP1 may not be associated with IVF-ET outcome in this population. Further studies with larger numbers of patients and controls are needed to confirm our results.
Komeil Amini, Kamran Mansouri,
Volume 21, Issue 5 (10-2018)
Abstract
Background and Aim: Human papillomavirus (HPV) infection is a prevalent, life-threatening disease and cause of cancer among women. Therefore, in recent years, developing novel anti-HPV agents is highly regarded. The study was planned to bioinformatic screening for E1 and E2 potential inhibitors of HPV serotypes including 16,18,31,33 and 45 types from medicinal plants.
Materials and Methods: This is a descriptive-analytic study. In the first step, three-dimension structure of phytochemicals were retrieved from PubChem database and then the cell cytotoxicity and mutagenesis potential of them were evaluated. In the next step, the amino acid sequences of two key proteins of mentioned types of HPV including E1 and E2 were obtained from Uniprot database. Furthermore, the conserved and variable regions of the protein sequences were predicted using multiple sequence alignment method. Finally, the three-dimension structure of mentioned proteins was determined by homology modeling method and potential interactions of the phytochemicals with the proteins were investigated using molecular docking method through Autodock 4.2.6 software.
Findings: The results demonstrated that ursolic acid has no cytotoxicity and mutagenesis potential with appropriate physicochemical properties. Results also showed that mentioned compound had strong interaction with both E1 and E2 of all studied serotypes. Furthermore, the evaluation of ursolic acid and E1 and E2 interactions showed that amino acid is involved in conserved regions of mentioned serotypes.
Conclusion: Based on the obtained results of present study ursolic acid could be good candidate for more in vitro and in vivo studies of its anti HPV activity.
Ali Iranpoor, Mojtaba Bayani, Mohammad Arjomandzadegan, Afrooz Nakhostin,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim Periodontal diseases are among the most prevalent inflammatory diseases caused by oral bacteria. Expansion of oral biofilm causes various diseases such as gingival inflammation and periodontitis. The Satureja plant has various species, all of which are aromatic. This plant is traditionally used for the treatment of some diseases. The present study was conducted to evaluate the effect of Satureja essential oil on periodontal pathogens.
Methods and Materials In this study, we evaluated four pathogens; Enterococcus faecalis, Streptococcus sanguinis, Eikenella corrodens, and Actinomyces viscosus. We also used the disk diffusion test and broth microdilution method to evaluate the antimicrobial effect of Satureja essential oil. Finally, we determined the minimum inhibitory concentration and minimum bactericidal concentration.
Ethical Considerations The Ethics Committee of Arak University of Medical Sciences approved this study (Code: IR.ARAKMU.REC.1397.67).
Results In concentration of 0.1 g/mL of Satureja plant, Actinomyces viscosus, Streptococcus sanguinis, Enterococcus faecalis, and Eikenella corrodens were found to be sensible to resistance. The Satureja essential oil had the highest effect on Eikenella corrodens. Results obtained from the biofilm test showed no biofilm in a concentration of 12.5 mg/mL and higher of Satureja plant.
Conclusion The Satureja plant was found to have an antibacterial and inhibitory effect on biofilm growth and formation in the oral cavity.
Homa Yousefie, Anahita Khodabakhshi-Koolaee, Mohammad Reza Falsafinejad,
Volume 22, Issue 6 (1-2020)
Abstract
Background and Aim: Currently, the prevalence of chronic kidney disease has increased for a variety of reasons. Renal diseases, followed by dialysis and kidney transplantation, can greatly affect the People's physical and mental health. Since most of previous studies have examined the physical and often preoperative problems of kidney transplant patients and many of them have used quantitative methods, the present study aimed to investigate the psychological challenges of renal disease patients after Kidney transplantation.
Methods & Materials: The study population consisted of kidney transplant patients referred to the Nephrology Clinic of Labafinejad Hospitalin Tehran, Iran in 2019 aged 35-50 years and 1-5 years had passed since their transplantation. A semi-structured in-depth interview was done for collecting information. A purposive sampling and continued until data saturation and until no themes were available. In the end, 15 patients were interviewed. Data analysis was performed by Colaizzi’s method.
Ethical Considerations: This study with a code of IR.IAU.SRE.1398.022 was approved by the Research Ethics Committee at Islamic Azad University, Science and Research Branch in Tehran, Iran.
Results: The primary themes were divided in to 3 main themes including: Concerns and psychologically disturbing feelings, emotional and spiritual support of the family, and uncertainty of receiving specialized, financial and welfare support.
Conclusion: Patients with kidney disease after transplantation surgery have psychological challenges in addition to physical problems that are of great importance to mental health professionals. Studying these challenges can provide a deeper understanding of their psychological problems and adaptation after surgery.
Leila Naserpoor, Katayoun Berjis, Rahil Jannatifar,
Volume 23, Issue 6 (11-2020)
Abstract
Background and Aim: Applying Assisted Reproductive Technologies (ARTs) is increasing. A critical step in ART is the frozen embryo transfer, in which the endometrium thickness has great significance in the outcome. In this case, the frozen embryo will be transferred during the next cycle. There are several ways to prepare an endometrium for transmitting embryos; however, choosing the best method remains debated. The present study aimed to evaluate the pregnancy rate of frozen embryo transfer in the presence or absence of GnRH agonists.
Methods & Materials: A retrospective analysis was conducted on 146 consecutive patients attending Qom’s infertility treatment center from 2015 to 2017; these subjects were candidates for the transfer cycle of the frozen-thawed embryo and randomly assigned to receive either protocol with or without GnRH agonist. Clinical features, implantation rate, pregnancy rate (chemical & clinical), and abortion rate were assessed.
Ethical Considerations: This study was approved by the Research Ethics Committee of the Academic Center for Education, Culture, and Research of Mashhad University (Code: IR.ACECR.JDM.REC.1398.001).
Results: There was no significant difference in baseline and clinical characteristics, implantation rate, pregnancy rate (chemical & clinical), and abortion rate between the study groups of endometrial preparations with or without GnRH agonist (P<0.05).
Conclusion: In this study, pregnancy outcome was similar in both study groups; thus, this method is recommended as an endometrial preparation without GnRH agonist.
Sedigheh Safaeian Titkanlou, Toktam Maleki Shahmahmood, Zahra Ghayoumi-Anaraki, Fatemeh Haresabadi, Majid Haddadi Avval, Mohaddeseh Soltani, Mohsen Rajati Haghi,
Volume 23, Issue 6 (11-2020)
Abstract
Background and Aim: Phonological awareness skills, as part of phonological processing abilities, can predict the extent of success in acquiring written and reading skills. Phonological awareness skills are of concern in children with severe and profound hearing loss, which has been less studied in this population. Thus, this study aimed to evaluate these skills in Cochlear-Implanted (CI) children and compare them with their healthy counterparts.
Methods & Materials: The study population included 25 CI children and 25 healthy children, aged 4-6 years, who were monolingual Persian speakers. The selected CI and healthy children were selected from the Rehabilitation Center of Naqmeh and the Kindergartens in Mashhad, City, Iran, respectively. After selecting each participant, the test of phonological awareness was administered. To compare the mean scores of each subtest, the obtained data were analyzed in SPSS v. 21 using the Mann-Whitney U test.
Ethical Considerations: This study was approved by the Research Ethics Committee of Mashhad University of Medical Sciences (Code: IR.MUMS.REC.1396.263).
Results: The mean scores of CI children were significantly lower than that of their healthy peers in all phonological awareness subscales (P<0.05).
Conclusion: The obtained data suggested that healthy children presented better performance than the CI children in the phonological awareness test. Poor phonological awareness skills in CI children seem to be associated with hearing deprivation before cochlear implantation; thus, it requires to speed up surgery at an early age and the implementation of an effective rehabilitation program.
Seyyed Mehrzad Shaddel, Masoud Bayat, Mojtaba Bayani, Vahideh Nazari,
Volume 24, Issue 2 (5-2021)
Abstract
Background and Aim: Considering the increasing use of dental implants in replacing lost teeth, the odds of failure over time in this treatment are inevitable, as with other dental treatments; thus, it requires careful and regular follow-up. Accordingly, the present study aimed to evaluate the awareness and attitude of general dentists about the follow-up of the dental implants to create baseline information to schedule future workshops concerning dental implants.
Methods & Materials: In this analytic cross-sectional study, 98 general dentists of Arak City, Iran were evaluated. Questionnaires were designed in 3 sections, as follows: demographic, awareness, and attitude. After checking the validity and reliability of the questionnaires, they were distributed among the research participants. The obtained data were analyzed using descriptive analysis, Chi-squared test, and Independent Samples t-tests. The significance level was considered 0.05.
Ethical Considerations: This article was approved by the Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1397.283).
Results: The average score of awareness of the questionnaires was equal to 10.8 (based on the score of 0-19); the mean score of attitude was measured as 12.8 (based on the score of 7-21). Fifty-Three of the explored dentists had performed implant treatment, whose awareness and attitude toward implants follow-up were significantly higher than those of the dentists who did not perform such treatment (P=0.0001). Work experience presented no significant effect on the examined dentists’ awareness and attitude (P>0.05).
Conclusion: General dentists have low awareness and attitude about implant follow-up. Follow-up plays an important role in the long-term success of implant therapy; therefore, dental education/retraining programs should be reviewed in this field.
Doctor Monireh Nadeali, Doctor Mojtaba Bayani, Doctor Vahideh Nazari, Doctor Rahmatollah Moradzadeh,
Volume 24, Issue 6 (1-2022)
Abstract
Background and Aim: Different implant angulation, which is unavoidable in clinical situations, can affect the accuracy of impression. The aim of this study was to investigate the effect of fixture position on the accuracy of connecting impression coping to implants with internal hex.
Materials and Methods: A gypsum model with 4 implants with internal hex connection was prepared. The implants were installed in different mesiodistal angles of 0, 15, 25 and 35 degrees to the longitudinal axis in the gypsum model. To simulate the gums, a gingival mask was injected around the implants to a height of 2 mm. After a training session for senior dental students on how to close the impression coping, forty students were asked to close the impression copings on four implants. The correctness of the impression coping was evaluated by an expert prosthodontist. Data were statistically analyzed using Cochran Q test. Significance level was considered 0.05.
Ethical Considerations: this article is approved by ethics committee of Arak University of Medical Sciences.
Findings: The correct performance of students in connecting the impression coping to the implant at angles of 0, 15, 25 and 35 degrees was equal to 85%, 72%, 52%, 35%, respectively. With the exception of 0 and 15 degree groups, a statistically significant difference was observed between different study groups.
Conclusion: The fixture position has a significant effect on the accuracy of connecting impression coping to the implants with the internal hex and by increasing the implant angulation, the accurate connection the impression coping to the implant decreases.
Nooshin Dalili, Fatemeh Pour-Rezagholi, Maryam Mousavi, Morvarid Alinezhad, Sadra Ashrafi,
Volume 25, Issue 5 (12-2022)
Abstract
Introduction: Years after the first successful kidney transplant, there are still many questions about the best immunosuppression regimen for these patients. Various studies have shown that long-term use of calcineurin inhibitor drugs can be associated with chronic nephrotoxicity and lead to irreversible damage to the transplanted organ. Therefore, the goal is to use immunosuppressive drugs and reduce the dose of calcineurin inhibitors as much as possible without increasing the risk of transplant rejection. This study aims to compare renal function, the rate of viral infections, and the occurrence of rejection after kidney transplantation in patients on two different treatment regimens including everolimus plus a low dose of calcineurin inhibitor against the standard protocol of calcineurin inhibitor along with mycophenolic acid in 60 kidney transplanted patients.
Methods: This clinical trial was conducted at Labbafinejad Hospital in Tehran between 2018-2019 on 60 kidney transplant patients aged 18 to 65 years and for 12 months.
Results: In terms of kidney function status based on GFR, except for the first month (P=0.02), there was no significant difference between the two groups in any of the time periods (P>0.05). Also, there was no statistically significant difference between the two study groups in terms of hospitalization length after transplantation and re-hospitalization during the study (P>0.05).
Conclusions: The results of this study showed that the everolimus regimen and low dose of calcineurin inhibitor can be used de novo in transplant patients without increasing the risk of rejection in them and at the same time it may be able to reduce the incidence of viral infections after transplantation.
Mr Fathollah Ghorbani, Mohammad Rezaei, Dr Ebrahim Ebrahimi, Mis Lila Ghorbani, Dr Elham Rezaei,
Volume 25, Issue 5 (12-2022)
Abstract
Introduction: Beyond the members of the charter board, the horizon of Amedwar Kanandah for the sake of Bimaran Niyazmand, the member of the board of the board. In parallel, there is a new medical science in New Mutrah, in the opinion of specialists who claim that it is a model and that they have a source for beyond the organs with children. Definitively The current issue is that of new topics and the question of programs in the possession of jurisprudence and rights, which must be carefully selected from the angles that are the subject of jurisprudence debate.
Methods: This is a book in the form of a textbook and a description - an analysis with the use of the books of science and jurisprudence of his room.
Results: This type of child is based on the basis of investigations, which are believed to be valid, according to the permissibility of the organs that are nozadan with severe cranial defects, i.e., in the womb of a mother, or from a cutaneous period, but from birth in the middle of my heart; A defensible issue.
Conclusions: The use of the nostril organs affected by the cornea with limitations of the cervical spine, but with a significant meaning in the development of Rastafarian, and the use of non-main organs based on multiple rational and legal evidences; Milabashed project. The parts of my life are afflicted with severe corneal ulcers, based on the inevitability and inevitability of the disease, and the reason for the fact that the situation is similar to the meaning of the disease. Develop a legitimate development in the most vigorous manner, and the issue of the necessity of preserving human dignity This is an issue that cannot be denied. But from the point of view of the role that is not a conditional legality, it is a present issue with conditional auspices in no severe form.
Azam Mivefroshan, Roghaiyeh Afsargharehbagh,
Volume 27, Issue 4 (10-2024)
Abstract
Introduction: Hyperlipidemia, a chronic metabolic disorder marked by elevated blood lipid levels, significantly increases the risk of cardiovascular disease in individuals with diabetes, hypertension, and obesity. While pharmacological interventions exist, factors such as medication side effects, cost considerations, and a growing interest in complementary and alternative medicine have stimulated research into the therapeutic potential of medicinal plants in managing hyperlipidemia. This study aims to assess the efficacy and safety of these botanical agents in reducing blood lipid levels.
Methods: A comprehensive literature search was conducted across reputable databases, including PubMed, ScienceDirect, Google Scholar, and other relevant online platforms. Keywords such as "hyperlipidemia," "herbal medicine," "traditional medicine," "herbal extract," and "herbal therapy" were employed to identify studies published up to 2024. Inclusion criteria were established to select studies that reported the impact of medicinal plants on lipid profile modifications.
Results: Based on the results, the study revealed that various medicinal plants, including Thymus vulgaris, Apium graveolens, Cichorium intybus, Fumaria officinalis, Heracleum rawianum, Anthemis altissima, Gundelia tourneforttii, Cynodon dactylon, Anthriscus sylvestrianum, Solanum nigrum, Arum elongatum, Glycyrrhiza glabra, Berberis vulgaris, Rheum ribes, and Mentha spicata, are commonly used in traditional medicine to address hyperlipidemia.
Conclusions: The use of indigenous Iranian medicinal plants for managing hyperlipidemia is deeply rooted in the country’s ancient history and has been increasingly validated by contemporary scientific research. These natural compounds can help lower blood lipid levels by inhibiting fat absorption and boosting lipid metabolism. The growing interest in traditional medicine and medicinal plants can be attributed to their inherent advantages, such as a lower incidence of side effects compared to synthetic drugs. Ongoing scientific research in this field offers promising avenues for developing innovative and effective herbal-based therapies
