Background: Cotonary artery illneses are the common heart illness that there is treatment methods now, many patients need the coronary artery bypass graft. Anxiety is a common phenomenon after all surgical operation. Anxiety in coronary artery bypass graft causes to increase metabolic rate, decrease immunity of body, and increases activity of heart coronary and gastrointestinal. This study was perfound to assess the effects of metatarsus foot reflexology on state anxiety levels after coronary artery bypass graft in Imam Ali Hospital Kermanshah.

Methods and Materials: This clinical trial included 88 patients that they were divided in to the intervention and control group based on the randomly. The intervention group received a 10 minute right foot massage one day on third and fourth day after coronary artery bypass graft and control group received no intervention, only at the time mentioned, score anxiety was measured with standard questionnaire spielberger.

Results: Patients state anxiety significanty decreased in the intervention group in the third day comparison with the control group, but no difference were not observed in the control group.

Conclusion: The finding of the study showed foot reflexology to be effective and simple that complication and damages are low that is used in reducing patients anxiety in treatment-health centers.

Background: According to the toxoplasmic retinochoroiditis leading to loss of central vision, corneal opacity, tearing, photophobia, and is, therefore early treatment is very important. This study aimed to evaluate the efficacy of intravitreal injection of toxoplasmic retinochoroditis clindamycin in comparison with conventional therapy (oral drug) was performed.

Materials and Methods: In this clinical trial, target population was all patients with the toxoplasmic retinochoroiditis referred to clinics in ophthalmology Arak city, that stratified randomly into two groups, interventional group “A” was received treatment with intravitreal injection clindamaycin " and control group “B” was received standard oral treatment (Pyrimethamine and sulfadiazine and clindamaycin). Tool for data gathering was questionnaires and medical records of patients in which visual acuity based on the Senllene Chart and retinal thickness with use tomography layers of the retina (OCT). Results of measurement were recorded by specialist retina before and after intervention (weekly and monthly until complete resolution of lesions in retina) during one year. The data entered into the SPSS 16 software and after matching age &sex of patients, was final analysis the using descriptive and inferential tests such as t-test was performed.

Results: Of the 26 patients with toxoplasmic retinochoroditis, 16 (61.5%), urban and number 10 (38.5%) were rural. The average improvement in visual acuity between the two groups in mean time to lesion healing (A) and (B) was different. The visual acuity in before and after treatment (separation of treatment) was significant difference in both groups (p<0.05). Also central macular thickness (in patients with toxoplasmic retinochoroditis) between before and after treatment in each group was different (p= 0.001), but the changes mean central macular thickness (in cases of toxoplasmic retinochoroditis) There was no significant difference between treatments (p=0.452).

Conclusion: Although any two methods of treatment are effective, but intravitreal injection clindamaycin method due to shorter lesion healing time and increase higher visual acuity, is better than the alternative similar way .

Background: Toxoplasma gondii is an important pathogenic protozoan. This parasite can cause severe infection and may lead to abortion. Abnormal levels of cholesterol and other lipids in blood samples of infected persons have raised some questions on the role of these factors in the pathogenesis of Toxoplasma.This study aimed to measure and compare lipid and testosterone levels and the relationship between them among a selected group of men with and without Toxoplasma gondii IgG antibody.  

Materials and Methods: This case – control study was conducted on a group of 20 to 29 years old men referred to the pre-marital clinics in Arak city in 2012. After completing a questionnaire, a blood sample (5 ml) was taken from each subject. Then, required diagnostic tests for toxoplasmosis was conducted. According to diagnostic results, 100 men with Toxoplasma antibodies were defined as cases and another group with equal number but without antibodies was defined as controls. Then, levels of testosterone and lipids in serum of these two groups were measured and compared.

Results:  Findings showed that testosterone levels were in normal range in both cases and controls, but the hormone level was significantly lower among cases. There was no significant difference in terms of serum lipid levels.

Conclusion:  Examination of relationship between blood testosterone and lipids levels among cases and controls showed that there was a significant negative correlation between testosterone and triglyceride levels. Also, there was a significant positive correlation between testosterone and HDL levels.

Background: In recent years, studies have been conducted on the role of coenzyme Q10 in improvement of sport performance and also cardiovascular health. The present study investigate effect of coenzyme Q10 supplementation combined with swimming aerobic exercises on Heart Rate Deflection Point (HRDP) and VO2max in active women.

Materials and Methods: A number of 32 trained women with the average age of 21/25 ± 0.86 years and Body Mass Index (BMI) of 20/127± 1.06 kg/square meter were selected randomly and were divided into eight -member each groups: Control, Supplement, Supplement – Exercise and Exercise. The subjects participated in four-week consumption of coenzyme Q10 and swimming exercises (three sessions in a week).The consumption rate of coenzyme Q10 100 mg/kg/d was in the form of capsule that subjects took it during lunchtime. Before and after a four-week period, the subjects performed an incremental exhaustive test on treadmill, using respiratory gas analyzer to determine HRDP and VO2max. It should be noted that data analysis was conducted using One-Way Variance Analysis Test (ANOVA) in P<0.05 significant level.

Results: Based on paired T-Test results, despite HRDP had increased in each four groups but the significant increase was observed only among groups in VO2max (P=0.008) based on ANOVA Test (P<0.05).

Conclusion: Although positive changes were observed inside the group after passage of four weeks, coenzyme Q10 supplementation combined with swimming aerobic exercise had not any significant effect on HRDP only increased VO2max.

Background: The growing elderly population in Iran and the association of aging with the high prevalence of physical and mental disorders have increased the necessity of determining quality of life of this age group. The quality of life of elderly women is affected by several factors due to their vulnerability. Hence, this study was designed to investigate the quality of life of elderly women in Arak.

Materials and Methods: This cross-sectional study was carried out on 271 elderly women who lived in Arak in 2013 using classified sampling. Data were obtained via general QOL (SF-36) questionnaires and analyzed by SPSS software.

Results: The mean (±SD) age of the participants was 67.5±7.02 years. The mean (±SD) total scores of SF-36, mental health, and physical health dimensions were 50.22±18.39, 58.54±19.38, and 46.35±20.82, respectively. The mean (±SD) score of eight dimensions of QOL were: general health 45.52±10.79, social function 56.58±24.94, physical pain 47.60±28.27, physical function 51.46±27.05, physical limitation 38.10±42.67, emotional problems 46.22±42.11, vitality 50.16±19.09, and mental health 58.54±19.38. There were significant difference between QOL, marriage, and income (P<0.05).

Conclusion: The results showed that the quality of life in this study was average and some factors, such as education, income, marriage, and residential situation, have a direct influence on QOL.

Background: One of the most common problems in Menopausal women is reduce of sexual satisfaction, which can affect their quality of life. The aim of the present study was the effect of Afrodit on sexual satisfaction in postmenopausal women.

Materials and Methods: In the triple blind clinical trial with the placebo group participated 80 healthy females 50-60 years that were referred to health centers affiliated to Tehran University of Medical Sciences. Participants were randomly assigned to two groups, Afrodit groups and placebo capsules for a month. Used tool in this study was Sabatsbrg. Part of which was to assess sexual satisfaction.

Results: After a month intervention, there is significant difference in the mean score for sexual satisfaction between two groups (p=0.01), Sexual satisfaction compared with pre-menopausal in two groups were compared. T-test results showed no significant difference. (p=0.16).

Conclusion: The results show Afrodit improves the sexual satisfaction in menopausal women. So it is essential that health providers are familiar with this herb supplement.

Background: Pediatricians frequently confront with elevated body temperature in children and subsequent anxious parents. They practice several approaches in management of fever. A recently addressed issue is administration of alternating doses of acetaminophen and Ibuprofen. This method is relatively common , despite lack of sufficient evidence in this field.

Materials and Methods: This study is a randomized clinical trial. A total of 240 children, aged 6 months to 12 years suffering from gastroenteritis was recruited in this research. Children were classified in 3 groups. First group received Acetaminophen, second group received Ibuprofen and third group were treated with acetaminophen – Ibuprofen every other day alternately.

Results: 240 child were taken apart in this research . 112 ones were female (46.66%) and 128 were male (53.33%). The mean time of lowering fever in the first group was 2.07 days. This figure in the second and third groups were 1.82 and 1.87 respectively. Average doses in the first, second and third groups were (in order) 9, 8.17 and 7.13 doses. Medication in the first group minimum effectiveness rather than two other groups.

Conclusion: The alternating regimen of Acetaminophen – Ibuprofen is more effective than monotherapy in reduction of fever in infants and children between 6 months to 12 years.

Background: Derived hormones from Adipokines include leptin, adiponectin, resistin, apelin, omentin.The aim of present study was to investigate the effect of 12 weeks aerobic exercise on plasma levels of Apelin, Omentin and glucose in obese older women with diabetes type 2.

Materials and Methods: In this study, 30 obese older women were chosen. They were also divided in to two groups: control (n=15 Age: 53.3+5.88 BMI: 28.7+2.2) and experimental (n=15 Age: 52.6+ 7.12: BMI: 30.03+3.6) according to their fat percentage and BMI. The training program included aerobic exercises which were conducted increasingly, 3 times a week for 12 weeks. Blood samples were taken before starting the exercise training and also 24 hours after the last training session. U Mann-Whitney Test was used to evaluate the data and in order to compare each group's pretest and posttest, Wilcoxon test was used at the significance level of p&le 0.05.

Results: There were significant changes in apelin and glucose plasma levels in the training group (p=0.001 and p=0.006 respectively). Furthermore, no significant difference was observed between each group's omentin levels.

Conclusion: It was finally concluded that exercise training can facilitate the process of glucose entrance into a cell because of the continuous muscle contractions and also decrease the plasma glucose. Also each adipokine response might be depend on the intensity and duration of exercise training, separately.

Background: Treatment failure and relapse is a major problem in the treatment and control of brucellosis. The present study directed to determine risk factors for failure of treatment and relapse in patients treated for brucellosis.

Materials and Methods: This study was a descriptive - analytic and prospective study and were conducted in 72 patients with acute brucellosis.Patients were followed up during treatment and for six months after completion of therapy, and patients with treatment failure or relapse were analyzed. All data analyzed using SPSS software and P-value of less than 0.05 was considered significant.

Results: The mean value of age in patients was 40.2 ± 16.5 years. Treatment failures was 6.9% and the relapse at the end of the ninth month was 12.5% that recurrence of symptoms were associated with increased titers of serological tests and 80.6 percent had successful treatment. In this study gender of male (P = 0.026), occupational exposure (P = 0.005), delayed treatment in less than two weeks (P = 0.016), hepatosplenomegaly (P = 0.003), thrombocytopenia (P = 0.023), CRP &ge +2 (P = 0.017) and Wright &ge 1/320 and 2-ME &ge 1.160 at the end of the sixth week of treatment (P = 0.004 and P = 0.010) were risk factors of treatment failure and relapse in brucellosis.

Conclusion: The diagnosis and treatment of relapse and treatment failure in acute brucellosis is not clear, therefore, the prediction of relapse may be useful in preventing recurrence and treatment of patients.

Background: The aim of this research was to determine the relationship between inflammatory markers (Fibrinogen, C-reactive protein (CRP) and Creatine kinase (CK)) and respiratory responses FEF25-75% (Forced expiratory flow in 25-75 percent) and FEV1 (Forced expiratory volume in one second) in 14-16 year’s Urmia city boys in response to an incremental physical activity.

Materials and Methods: The subjects were boys of 14-16 years among 24 healthy participants. These groups divided into two groups randomly, one group as trained one (n=12) and the othes as control group. Blood sample was taken in baseline and after Modified Balke Protocol in trained group, And the blood sampling was taken in baseline and 48 hours later in control group. respiratory responses were measured immediately after Modified Balke Protocol.

Results: CRP and Fibrinogen significantly increased in trained group (p<0.001) and this group had high level of these markers compared with control group (p<0.001). The association between CRP with FEF25-75% and fibrinogen with FEF %25-75 and CK with FEF 25-75% in trained group was significant (p&le0.05).

Conclusion: The results of this study show that incremental physical activity increased inflammatory factors in active children. Incremental exercise shows a strong relationship between some inflammatory markers and respiratory parameters in adolescents 14-16 years old.

Background: Vesicoureteral Reflux (VUR) is the most common urologic anomaly in children. In spite of prescribing prophylactic antibiotics in children with VUR, in some cases breakthrough infection (BTI) occurs while receiving prophylactic antibiotics which may cause pyelonephritis that can ultimately lead in renal scarring.

Materials and Methods: In this discreptive-analytic study, 288 children with primary vesicoureteral reflux under Cotrimoxazole(2mg/kg) treatment have been under supervision for duration of at least one year. Based on the collected data, predictive effect of some factors like gender, mean age of VUR diagnosis, VUR grade, unilateral versus bilateral and presence of abnormal renal scar on the breakthrough infection under prophylactic treatment, were examined.

Results: Breakthrough infection while receiving prophylactic antibiotics was observed among 111(38.54%) patients consisting of 88 girls (79.28%) and 23 boys (20.72%). The moderate to high VUR grades (grade III-V), presence of renal scar and female gender were found to be the important risk factors for BTI. However, no statistically significant relationship between mean age of VUR diagnosis and unilateral versus bilateral VUR with BTI was found.

Conclusion: Results of the current study will help improving parents' and physicians' awareness of the risk factors associated with BTI which may potentially lead to renal damage.

Background: Regarding the importance of prevention of cardiovascular disease during menopause the purpose of present study was evaluating the influence of eight weeks progressive aquatic exercise on serum Apoproteins of A and B and lipoproteins in obese and normal weight menopause women.

Materials and Methods: This was a semi-experimental study in which 29 menopause women from Isfahan (age: 57.4 ±4.68 years) voluntarily participated in it. According to body mass index (BMI), participants were divided to obese (n=15, BMI= 30.21 ±3.90) or normal weight (n=14, BMI=22.44 ±2.25) groups. Subjects of both groups participated in 8 weeks aquatic exercise, three times a week, by progressive intensity of 50 to 70% of maximal heart rate and duration of 45 minutes.

Results: Findings of study indicated a significant influence of exercise on VLDL, Apo A and B and ApoB/ApoA in in obese group. In normal weight group, exercise caused significant changes in LDL, VLDL, Apo A and B and ApoB/ApoA, but there was no significaut difference between groups in none of study variables.

Conclusion: According to our findings, progressive aquatic aerobic exercise induces similar reduction of some cardiovascular risk factors especially ApoB and ApoB/ApoA and increasing ApoA in obese and normal weight menopause women.

Background: The average age of menarche varies from country to country due to regional variation and different factors, including genetic and environmental factors that affect the onset of menarch. This study performed to survey relationship between nutrition and physical activity with menarche age of girls in Ahvaz city.

Materials and Methods: This survey is a cross-sectional study that was conducted on 1249 female students 8-15 years in 2012- 2013 year. Participants were selected by random cluster sampling from 4areas and 16 elementry and middle and high schoolsin Ahvaz city. The data were collected based on interviews and questionnaire (food frequency and physical activity). After collecting the data, then they were encoded and analyzed by SPSS16 software  and descriptive and analytic statistics.

Results: The mean of age at menarche in girls in Ahvaz was 11.86±1.07 and age at menarche was not associated with nutrition and physical activity.

Conclusion: Based on these findings, significant association between nutrition and physical activity and age at menarche (p<0.001)was not observed.

Background: The distal radius’ fracture is one of the most prevalent fractures in menopause women. Because of no delisery of an exact dosage by inhalation calcitonin, the effect of a systemic form such as parenteral on healing up of this area was investigated.

Materials and Methods: This study was a prospective cohort on 44 women 60 years-old with distal radius’ fracture divided into 2 equal groups of control and treatment (parenteral calcitonin, just after operation, 100 I.U/day during 10 days consecutive of each month for 3 months). The rate of improvement, hand ability and stiffness of joints of hand fingers and wrist according with physical examination, time of cortex healing up, level of alkaline phosphatase, calcium and phosphor serum levels and rate of osteoporosis accord to radiography indexes.

Results: The rate of osteoporosis and pain was less tham that of control group. Prevention of osteoporosiss and the cortex healirg was significaltly more than that of control group. The hard activity (Mayo Wrist index) and ability of ceetching of objects was better in calcitonin group. There were not any significant effects of calcitonin on level of alkalire phosphatose, calcium and phosphor us serum levels.

Conclusion: Calcitonin especially with calcium supplements can accelerate the improvement of distal radius’ fracture. Then patients will tolerate fewer problems at convalescence period.

Background: Male fertility depends on the proper function of a complex system of organs which plays an important role in spermatogenesis. In this study the effects of sulpiride-administration were assessed by means of sperm parameters and in vitro fertilization potential.

Materials and Methods: In this experimental study thirty adult male mice were divided into 3 groups as test, control-sham and control. The test group were injected with 40 mg/kg sulpiride solution daily for 45 days IP. Sham mice were injected by solvent only. After 45 days, all mice were dispatched by cervical dislocation consequence of unconsciousness. Cauda epididymis were used to collect sperm cells and assess their motility, viability and DNA integrity. The rate of in vitro fertilization and embryonic development were also examined.

Results: In comparison with sham and control groups, sperm motility and viability rate showed a significant reduction in the sulpiride-administered animals. Rate of DNA damage increased which gives rise to a remarkable reduction of fertilization rate, zygote division, blastocysts number, and significant increase of arrested embryos in sulpiride treated mice (p<0.05).

Conclusion: Data suggest that following sulpiride-induced hyperprolactinemia, induction of spermatogenesis dysfunction, causes low sperm quality that accompanies a significant lower fertility potential and embryonic development in comparison with the sham and control groups.

Background: Menopause is a critical period in the women life which is associated with different neurophysiological and cognitive changes. This study aimed to determine the relationship between menopausal symptoms with metabolic syndrome in postmenopausal women.

Materials and Methods: This descriptive - analytical study was conducted on 165 postmenopausal women referred to health centers in Ahvaz. Data collection tools were standardized questionnaire menopausal rating symptoms (MRS), questionnaire to record demographic information and the results of experiments and measurements (blood pressure, Waist circumference). The data were analyzed by Pearson correlation coefficients, Mann-Whitny in by SPSS version 19.

Results: The results showed that the overall mean of MRS in this study was 11.85±5.4. The mean of metabolic syndrome was 36±4.8 percent and we found significant association between blood pressure (p=0.04), blood sugar (p=0.02),HDL-C(p=0.02) and urogenital symptoms. But there werent significant relationship between other metabolic syndrome components and other menopausal symptoms (somatic and psychological Dimensions).

Conclusion: The relationship was observed between metabolic syndrome and urogenital symptoms, therefore, as a preventative health strategy women with urogenital complaints should examin for metabolic syndrome.

Background: Catamenial recurrent pneumothorax is spontaneous pneumothorax in women of reproductive age, which includes 1-30% of spontaneous pneumothoraces in women and is associated with the menstrual cycle.

 Case: A 39-year-old woman with sudden onset dyspnea, respiratory distress and decreased right side respiratory sounds with a history of spontaneous pneumothorax and chest tube placement one month ago. The patient's symptoms improved after chest tube placement and within less than 24 hours after onset, she began menstruating. Treatment was performed with chemical pleurodesis with tetracycline and oral danazol.

Conclusion: Catamenial pneumothorax and thoracic endometriosis should be considered in all women of childbearing age with spontaneous recurrent pneumothorax. Early detection of this syndrome can result in reduction of morbidity and mortality with recurrence episodes.

Background: Allergic rhinitis is a common disease which is present in 20% of general population. Major symptoms include sneezing, rhinorrhea, nasal congestion, and nasal pruritus. It seems that tricyclic antidepressants blocking histamine receptors may be used as an effective treatment in allergic rhinitis.

Materials and Methods: In this clinical trial study, 84 patients with allergic rhinitis entered the study and randomly divided into two groups. Patients of 1st group received cetirizine and 2nd group received doxepin for 2 weeks. After 2 weeks patients were evaluated about sneezing, rhinorrhea, nasal congestion, and nasal pruritus.

Results: The results of our study showed that clinical score of patients after 2 weeks was not different in both groups (p=0.261). The only symptom that was affected by the kind of treatment and was significantly different between groups was sneezing (p=0.005).

Conclusion: It seems that there is not much difference in using cetirizine and doxepin in treatment of seasonal allergic rhinitis sympotoms. It is recommended that future studies use TCAs with more potent blocking anti-histamine receptors feature and on more samples.

Background: Cancer is one of the most common causes of deaths in the world. Cancer incidence and prevalence is increasing in the world. There is no clear trend is available on incidence of these cancers in Iran, therefore, this study aimed to determine the incidence of 10 common cancers among Iranian women from 2003 to 2009.

Materials and Methods: A cross-sectional study was conducted by analyzing existing data. Data from a national registry of cancer cases were received. Data included the records from the cancer registry system in Iranian women during 2003 to 2009. The incidence rates were then standardized using direct method. We used Cochrane Armitage Test for linear trend by Winpepi software to determine the variation in the incidence of cancers.

Results: The results show that the proportion of all cancers is rising in women as compared to all population. Breast, skin, colorectal, gastric, esophageal, thyroid, leukemia, ovary, brain and uterus were the most common cancer among Iranian women. During the years of the survey, these cancers are significantly increased.

Conclusion: The results of this study showed that the incidence of cancer in women is increased. screening programs can be useful in reducing the cancers.

Background: Premenstrual Syndrome (PMS) consists of repetitious physical and psychological symptoms that occurs in luteal phase of menstrual period and will be over when menstrual period starts. The goal of this study is to investigate the effect of calcium therapy plus vitamin D and cognitive behavioral therapy (CBT) on the parameters of PMS symptoms in women suffering from PMS.

Materials and Methods: This study has an experimental plan of pretest and post-test of the control group. The statistical society is 250 female staff of Tehran Universities in academic year 2013-2014. Premenstrual syndrome screening tool (PSST) questionnaire was used as an evaluation tool. The collected data were analyzed using the indexes of the descriptive statistics and covariance analysis (p<0.05).

Results: The minimum age of the statistical society was 24, 52.5 % of them held a master's degree and 60% were single. Cognitive behavioral therapy method, calcium and vitamin D therapy were significant in improving the parameters of symptoms at p<0.05 level of significance.

Conclusion: Combining cognitive behavioral therapy and calcium supplementation and vitamin D is significantly effective in improving components of PMS sympotoms and applying these methods is recommended by the consultants and gynecologists.