Background and Aim: Increasing metabolism and production of free radicals in the body are among the factors causing increased oxidative stress, weakened the antioxidant system, and some diseases, including cancer. The purpose of this study was to investigate the antioxidant activity and toxic effect of the Schiff base manganese II compound N, Nʹ di pirodexil 1, 4 butadiamin.
Materials and Methods: The antioxidant capacity of the Schiff base manganese II complex N, Nʹ di pirodexil 1, 4 butadiamin at the concentrations of 62.5, 125, 250, and 500 µg/ml was Investigated using the 1.1-diphenyl-2-picricyl-hydrazyl (DPPH) technique. We also evaluated the toxic effect of the mentioned Schiff bases complex at concentrations of 0, 62.5, 125, 250 and 500 µg/ml by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) at 24, 48 and 72 hours on a breast cancer cell line (MCF7 [Michigan Cancer Foundation-7]).
Ethical Considerations: In this study, research ethical principles were considered.
Findings: The antioxidant capacity of Schiff bases manganese II complex N, N di pirodexil 1, 4 butadiamin at the concentration of 500 µg/ml was 38.83%. Further, considering the toxic effect of the Schiff bases on the MCF7 cell line, the results showed that IC50 at 24, 48 and 72 hours was about 124, 245 and 470 µg/ml, respectively.
Conclusion: The results obtained from the review of the antioxidant capacity of the Schiff base manganese II complex N, Nʹ di pirodexil 1, 4 butadiamin compared to (BHA) butylated hydroxyanisole suggest that the compound can be effective in free radical inhibition.

Background and Aim Psychological factors play a significant role in the exacerbation of cardiovascular diseases. This study aimed to investigate the effectiveness of teaching emotion regulation skill (based on dialectical behavioral therapy) on cognitive emotion regulation and Quality of Life (QoL) of patients with cardiovascular diseases.
Methods and Materials The present study has a quasi-experimental design with pretest-posttest and the control group. The statistical population of the study included all patients with cardiovascular diseases in Kermanshah City, Iran in 2018. Among them, 30 participants were selected by simple random sampling method. Then, they were randomly assigned to the two groups of experimental and control (each group 15 patients). We performed the intervention of excited ordering education based on dialectical behavioral therapy for the experimental group in eight 90-minute sessions, while the control group did not receive any intervention during this period. To collect study information, we used a short form of the emotional cognitive regulation questionnaire and MacNew Quality of Life Questionnaire. To analyze the data, we used the multivariate analysis of covariance in SPSS V. 20.
Ethical Considerations The Research Ethics Committee of Kermanshah University of Medical Sciences approved this study (Code: IR.KUMS.REC.1397.39).
Results The results showed that the scores of Positive Cognitive-Emotional Strategies and quality of life of cardiovascular patients after training of emotional regulation skills based on dialectical behavioral therapy in experimental group significantly increased in comparison with control group, and also Negative Strategies Scores were decreased (P<0.01). 
Conclusion Based on our positive study results, we recommend the therapists to use psychological treatments as complementary therapies for these patients.

Background and Aim Among nano-pharmaceutical materials, nanoemulsions are an important tool in the field of nanotechnology. They have been designed for clinical and therapeutic applications. Since the therapeutic efficacy of cancer is measured by the ability of the drug to reduce and eliminate tumors without damaging healthy tissues, nanoemulsions can be useful as a targeted drug carrier. Therefore, we are going to study the antioxidant and anticancer effects of nanoemulsions prepared using dill essential oil.
Methods and Materials Evaluate the antioxidant properties, we used DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid]) tests. We also applied MTT assay for the evaluation of induced cytotoxicity in liver hepatocellular carcinoma cells and normal human umbilical vein endothelial cells.
Ethical Considerations The Research Ethics Committee of Islamic Azad University (Mashhad Branch) approved this study (Code: IR.IAU.MSHD.REC.1398.027).
Results Nanoemulsions prepared using dill essential oil has a good potential for inhibiting DPPH (IC50=500 μg/mL) and ABTS (IC50=420 μg/mL) radicals. Nanoemulsions also caused a little toxicity to both cell lines. Nanoemulsions reduced cell viability in a dose-dependent manner and the cytotoxicity induced to cancer cells was higher than normal cells. 
Conclusion The present study indicates that nanoemulsions prepared by dill essential oil will have the potential to become a therapeutic strategy for diseases caused by oxidative stress.

Background and Aim: From the viewpoint of Iranian Traditional Medicine (ITM), hemorrhoidal bleeding is not only an organic disease; it also indicates the quality and quantity of blood and temperaments in the body. According to this view, bleeding from different areas has several causes, two important causes of which are: a. vascular hyperemia and consequent blooding in bleeding-prone areas, and b. changes in blood quality that cause the arteries to open and bleed. This study, by reporting a case of hemorrhoidal bleeding, is an evidence of some therapeutic principles in ITM.
Case Report: Patient was a 39-year-old married woman with four children and warm-wet temperament complaining of heavy menstrual bleeding for one year. After three months of herbal drug administration, menstrual bleeding became normal. One month later, she had hemorrhoidal bleeding. Her bleeding was treated based on ITM method by removing the black bile (Soda) from the body, phlebotomy and leech therapy around the anus.
Ethical Considerations: This study has been approved by the Research Ethics Committee of Arak University of Medical Sciences with code: IR.MUQ.REC.1396.110.
Conclusion: Based on ITM, it seems that the cause of hemorrhoidal bleeding in this case is vascular hyperemia and poor blood quality following symptomatic treatment of heavy menstrual bleeding.

Introduction: Salmonella infection (salmonellosis) is a common bacterial disease that affects the intestinal tract. Several methods like Multiplex or real-time PCR, ELISA, and Agglutination are used to identify these bacteria. However, normally rapid, cost effective and easy diagnostic methods such as agglutination test is recommended. In Iran, positive control antiserums used in diagnostic kits work based on polyvalent agglutination and are against O and H antigens. The purpose of this research was to produce specific anti-sera against O and H antigens for using in agglutination and ELISA kits.
Methods: New Zealand white rabbits were immunized by intravenous injections of inactivated bacterial O and H antigens adjusted to a cell density equivalent to a turbidity of a McFarland number 3 standard. Serum collection was performed 7 days after the last injection. Collected Antisera were tested with positive human specimens as well as cross-reaction antibodies. Absorption method was used to obtain specific anti-sera against O and H antigens. Produced Anti-O and Anti-H antibodies were mixed with bacterial H and O antigens respectively and incubated for 1 hours in 37˚c. The Mixture was centrifuged and the supernatant was collected. Furthermore, in order to use these antisera in specific kits such as ELISA, Immunofluorescence etc., purification methods like Ammonium sulphate precipitation, tangential Flow Filtration and Chromatography were performed. This study was approved by the ethics committee of Pasteur Institute of Iran (Code: IR.PII.REC.1399.006).
Results: Results of agglutination test before and after adsorption showed cross-reaction before adsorption and no cross-reaction with H and O antigens with monospecific antisera against O and H after adsorption, respectively. Moreover, high quality and quantity of mono-specific antibody was obtained after purification.
Conclusions: Serum-based assays are recommended for the timely diagnosis of the disease since these assays are specific, sensitive, inexpensive, and rapid. Therefore, the produced antiserum in the present research can be used in primary screening of salmonella infections based on agglutination tests which are cost effective and simple. In addition, purified anti-sera can be used in the development of ELISA and Immunofluorescence assays.

Introduction: Since a more appropriate psychological treatment has not yet been found in the treatment of autism to be a definite solution in autism, in this research, two more common psychological methods have been compared. Objectives The aims of this study were to compare the effectiveness of ABA and Fluortime play therapy on sensory processing in children with autism spectrum disorder in Qom in 1401.
Methods: The method of this quasi-experimental study was pre-test-post-test and follow-up with a control group. The statistical population of the research included all the children with autism in land Qom at Golhay Behesht Autism Center. The statistical sample of this research was 45 people who were selected by available sampling, and randomly divided into three experimental groups using the ABA method (15 people Fluortime method (15 people) and the control group (15 people) were placed. The first experimental group was treated with the method of ABA in the designated sessions. 23 20-minute sessions were presented to the subject group. During experimental group Fluortime was treated with the method of 23 sessions of 20 minutes, it was presented to the subject group, then it was analyzed using analysis of variance with repeated measurements. Ethical Considerations: This article is approved by the ethics committee of Islamic Azad University Ahvaz branch IR.IAU.AHVAZ.REC.1401.032.
Results: The results of the analysis showed that the Flortime play therapy training in sensory processing was significantly at the level of the effect of the implementation of independent variables on the registration components down (P = 0.02) Sensory seeking (P = 0.001) Sensory sensitivity (P = 0.019) Sensory avoidance (P = 0.004) is significant. On the other hand, the average difference of sensory processing components in the applied behavior analysis and game group is significant. Fluortime treatment is significant with the control group. So that the mean of the components of sensory processing in both experimental groups has a significant0.05 ≥ P decrease compared to the control group.
Conclusions: This finding, in line with the change trend of the mean of the components of sensory processing, shows that functional ABA and Fluortime play therapy during the implementation period. And three months after the completion of the implementation period, it has led to a significant decrease in the average scores of sensory processing components. Sensory processing in children with autism spectrum disorder. It should be mentioned that in comparison, the scores of sensory seeking, sensory sensitivity and sensory avoidance in the Fluortime were higher than in the ABA method, and low registration was higher in the ABA method, but the results of the Ben Feroni test show that although each method was significant separately in sensory processing, the difference in effect Functional behavior analysis and Fluortime play therapy on sensory processing components of p>0/05 is not significant.