Showing 1408 results for Type of Study: Original Atricle
Ali Ghasemi Kahrizsangi, Mehrdad Najafi,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: Today, diabetes is one of the main problems in the world. Type-2 diabetes is more common in obese and overweight people, and obesity is a serious health problem. In addition to the importance of exercise in diabetes, some supplements can be effective on inflammatory factors. Therefore, the aim of the present study was to determine the effect of 8 weeks of endurance training along with purslane seed supplement consumption on the pro-inflammatory factors IL-6 and CRP in middle-aged type-2 diabetic men on the threshold of obesity.
Methods: In this semi-experimental study, 40 male patients with type 2 diabetes with an average age of 40-55 and fasting blood sugar above 120 were selected, then randomly divided into four groups of 10 including: control group, exercise group, exercise+supplement group. And the complementary group was divided. The subjects had no history of regular sports activity (for the previous 6 months) and consumption of purslane and were on the threshold of obesity (BMI between 28 and 30). The subjects walked 3 sessions a week and each session was for one hour without rest. The duration of the training session started from 30 minutes in the first week and reached 45 minutes of training in the eighth week with an intensity equal to 50-70% of the maximum reserve heart rate. The supplement group consumed 7.5 grams of purslane seeds per day for 8 weeks. The control group was not subjected to any training or supplements during 8 weeks. Paired t-test was used to compare the results before and after check the significant difference between the four groups, the analysis of covariance test was used, and if a significant difference was observed, the Bonferroni post hoc test was used to determine the location of the difference between the groups using SPSS 25 and EXCEL2010 statistical software at the significance level (P<0.05).
Results: The results of covariance analysis showed a significant difference in CRP (P=0.000). The results of Bonferroni's post hoc test indicated a difference between the two groups of exercise-supplement and placebo exercise compared to the control group (P<0.05). No difference was observed in IL-6 values.
Conclusions: It seems that the consumption of purslane seeds along with exercise improves the inflammatory index and CRP predicts heart problems. As a result, the use of purslane seed supplement if combined with exercise can be an effective method for middle-aged men with type 2 diabetes on the verge of obesity, but the effect of endurance training is more effective than purslane seed supplement.
Mehtab Farahani, Fatemeh Mehrabi, Mohammad Ali Mardom, Abdollah Abolfathi, Zahra Borzabadi Farahani, Fatemeh Rafiei,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: The purpose of this study was to investigate the effect of education based on the self-efficacy model on coping strategies and hope in breast cancer patients undergoing chemotherapy.
Methods: This study was conducted on 62 breast cancer patients undergoing chemotherapy. The intervention group received four training sessions on chemotherapy side effects and management strategies based on the self-efficacy model, while the control group received routine care without additional training. Demographic questionnaires, the Billings and Moss Coping Skills Questionnaire, and the Schneider Hope Scale were completed by both groups immediately before and after the intervention. Data were analyzed using appropriate statistical tests.
Results: The average hope in the intervention and control groups was low before and after the intervention. It remained low in the control group but showed a significant increase in the intervention group (P < 0.05). Statistical tests showed that there is a significant relationship between the average total life expectancy and their age, economy and education (P<0.05). Before the intervention, both groups demonstrated low use of coping strategies. After the educational intervention, the control group maintained low usage while, the intervention group showed substantially increased use of coping strategies.
Conclusions: Self-efficacy training intervention increased life expectancy and coping strategies in breast cancer patients undergoing chemotherapy.
Jamal Rezaei Orimi, Bita Ghazizadeh, Azam Khosravi, Seyyed Amir Hosein Latifi, Mehdi Salehi, Mohammad Hosein Asadi, Seyed Abdollah Mahmoodi,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: Studies examining scientific output provide valuable insights into the development and growth of research activities. The primary objective of this article is to evaluate graduate theses in the field of the history of medicine in Iran from 2001 to 2021, with a particular focus on research trends, the contributions of universities and academic institutions, and patterns of scholarly activity.
Methods: This research is of an applied type and was conducted using the quantitative content analysis method. The statistical population of the research consisted of 558 theses published in universities and scientific centers of the country. Data were collected using a structured content analysis checklist and subsequently analyzed employing descriptive statistical methods.
Results: The research findings indicate that Tehran University produced the highest number of theses with 66, followed by Shahid Beheshti University of Medical Sciences with 49, and Payame Noor University with 36. The highest number of theses were written in 2017 (9.67%), and the lowest number was in 2003. Moreover, the history, professional doctorate, and Persian language and literature departments published the highest number of theses, with 160, 78, and 46, respectively.
Conclusions: The results of this research show that the history of medicine in Iran has experienced significant growth in the past two decades. This growth is evident in the increasing number of theses and the increased participation of universities and scientific centers.
Roya Fatemi Nejad, Mohammad Reza Dayer, Mehran Dorostghoal, Mohammad Reza Parishani,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: Botulinum neurotoxin protein (Botox) is widely used for cosmetic purposes to reduce facial wrinkles without regard to its side effects. The present study was conducted to investigate the effects of Botox on blood biochemical factors and the kidney tissue structure of female rats.
Methods: In this study, 28 adult female Wistar rats were selected and randomly divided into four groups (n = 7). The first three groups received intraperitoneal injections of Botox (in the lower third of the abdomen, one centimeter below and to the left of the navel) at doses of 4, 6, and 8 units, respectively, while the fourth group (the control group) received a saline injection. Then the animals were kept in the animal house for three months with full access to food and water at a temperature of 22°C and a 12-hour light-dark cycle. Following a 24-hour fasting period at the end of the study, blood samples were collected via cardiac puncture under ether anaesthesia. Then, the animals were euthanized without pain, and their kidney tissue samples were extracted for histological examination.
Results: Biochemical results indicated a significant increase in serum creatinine levels following injection with 6 and 8 units of Botox, indicating renal impairment. Although the increase in the amount of serum uric acid levels compared to the control group did not reach statistical significance at the 95% confidence level (P < 0.05), it showed significance at the 94% level (p < 0.06), suggesting primary renal damage. Histopathological examination demonstrated that intraperitoneal injection of 8 units of Botox induced scattered and limited structural alterations in renal tissue, including vacuolar degeneration of tubular epithelial cells.
Conclusions: The results of this research show that the long-term and repeated use of Botox may cause significant renal damage in addition to local lesions and threaten a person's life.
Hasan Rahmani, Faezeh Asgari , Abed Asgari, Habiballah Rahimi, Leila Ghanbari-Afra,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: Maintaining general health and preventing occupational burnout are two fundamental components of individuals' lives, and each can influence the other. Therefore, the present study aims to investigate the relationship between occupational burnout and general health among emergency medical technicians (EMTs).
Methods: This descriptive-analytical study was conducted on 150 EMTs from Qom University of Medical Sciences in 2020, who were selected by a simple random sampling method. Data were collected using the Maslach Burnout Inventory and the Goldberg General Health Questionnaire. Data analysis was performed using descriptive statistics and Pearson correlation coefficient.
Results: Based on the findings of the present study, the average age of participants was 35.14 ± 8.09 years. The average scores for occupational burnout and general health were 57.98 ± 19.28 and 48.26 ± 10.97, respectively. Pearson correlation analysis revealed a significant relationship between occupational burnout and general health (r = 0.613, P < 0.001)
Conclusions: Based on the findings of the present study, occupational burnout and general health among the EMTs were at a moderate level. Higher burnout scores were associated with worsened general health disorders among EMTs. It seems that selecting students interested in prehospital emergency professions can enhance the situation of this feeling in individuals working in this field. Additionally, it is essential for prehospital managers to pay attention to the occupational burnout and general health in order to improve the quality of services provided by the EMTs.
Mohamad Reza Bayatiani, Fatemeh Seif, Mohamad Arjomandzadegan, Mona Moghadasi, Arash Parvin,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: In today’s world, with the expansion of electronic technologies and equipment generating electromagnetic fields, humans and other living organisms are continuously exposed to these fields. This exposure can have significant biological effects on the growth and function of living organisms. This study aimed to evaluate the effects of alternating magnetic fields with different intensities and frequencies on the growth of Escherichia coli (E. coli), a Gram-negative bacterium, and Staphylococcus aureus (S. aureus), a Gram-positive bacterium.
Methods: This study investigated the effects of alternating magnetic fields with intensities of 1 and 2 millitesla and frequencies of 50, 75, 100, and 150 Hz on the growth of Escherichia coli and Staphylococcus aureus. The standard plate counting technique was used for this purpose. Samples were incubated at 37°C for 24 hours, and the number of colonies was counted as colony-forming units per milliliter (CFU/ml).
Results: The results showed that the number of Escherichia coli colonies significantly increased under the influence of magnetic fields compared to the control group (P < 0.05). In contrast, the number of Staphylococcus aureus colonies significantly decreased after exposure to the magnetic field (P < 0.05).
Conclusions: The results of this study indicate that alternating magnetic fields can have different effects on the growth of various bacteria. According to these findings, a decrease in the number of colonies was observed in Staphylococcus aureus due to the magnetic field, while an increase in the number of colonies was observed in Escherichia coli. These findings could be used in the development of new methods for controlling bacterial growth and in biotechnological applications.
Elham Mohammadi, Nazanin Amini, Safoora Omidvar, Azam Moslemi, Maede Sadat Alhoseini, Faeze Vabak,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: Cataract is one of the common causes of disability in the elderly. Candidates for cataract surgery, like any other type of surgery, experience a lot of anxiety, and this anxiety has an adverse effect on their psychological, physiological and post-operative recovery. This study was conducted with the aim of investigating the effect of pre-operative education on the level of anxiety of cataract surgery candidates.
Methods: In this educational experiment, 80 patients who were candidates for cataract surgery were divided into two experimental and control groups using available sampling method. The patients in the test group received the educational intervention and the patients in the control group received the usual ward care. The anxiety levels of the two groups were determined using the Spielberger questionnaire during hospitalization, after surgery, and upon entering the ward. These levels were then compared between the two groups. The data were analyzed using descriptive statistics, Fisher's exact test, Levene's test, Chi-square test, and T-test.
Results: The results did not show a statistically significant difference between the test and control groups before the educational intervention in terms of overt anxiety (p = 0.54) and anxiety (p = 0.20), but after the implementation of the educational intervention, the results showed a statistically significant difference between the two test and control groups in terms of the mean of overt anxiety (p = 0.00) and hidden anxiety (p = 0.002).
Conclusions: The implementation of pre-operative educational intervention leads to the reduction of post-operative patients' anxiety, hence it is suggested that training be performed as a low-cost and effective method in pre-operative care.
Mojgan Mohammadifar, Fereshteh Bahmani, Alireza Abed, Gholamali Hamidi, Mohammad Hossein Aarabi, Sayyed Alireza Talaei,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: The analgesic effects of rosemary and peppermint essential oils have been shown in many studies. Low solubility of essential oils in water and low bioavailability limit their consumption, and nanoparticles can help solve these limitations. This study aimed to investigate the analgesic effect of a nanoemulsion containing rosemary and peppermint essential oils in a rat model of neuropathic pain.
Methods: Forty male rats were assigned to four groups: control (CON), neuropathic pain received normal saline (NPS), nanoemulsion (NPN), or gabapentin (NPG). Neuropathic pain was induced using the CCI model. Animals received a nanoemulsion containing 10% rosemary extract and peppermint essential oil via gavage for 21 days. Behavioral tests (Thermal Hyperalgesia, Thermal Allodynia, and Mechanical Allodynia) were done on days 1, 4, 7, 14, and 21 of the study. Biochemical tests were also done on the sciatic nerve of animals at the end of the study.
Results: The NPS rats had a significantly increased pain threshold compared to the control group (P < 0.001). Furthermore, the analgesic potential of nanoemulsion containing rosemary and peppermint essential oils was seen in allodynia and hyperalgesia tests. Biochemical analyses showed that CCI reduced total antioxidant capacity, superoxide dismutase, and glutathione peroxidase activity, and also increased MDA levels in the rats' sciatic nerve (P < 0.001 for all comparisons). Administering nanoemulsion containing rosemary and peppermint essential oils reversed all the above-mentioned changes in the biochemical parameters (P < 0.001).
Conclusions: Our findings revealed that treating rats with a nanoemulsion containing rosemary and peppermint essential oils can reduce neuropathic pain symptoms by balancing their sciatic nerve's oxidant and antioxidant systems.
