Showing 35 results for Corona
Niloofar Agharezaee, Flora Forouzesh,
Volume 23, Issue 5 (11-2020)
Abstract
Background and Aim: Coronaviruses are a large family of viruses that cause disease in humans and animals. Coronavirus Disease 2019 (COVID-19) is an acute respiratory infectious disease caused by a new coronavirus. The World Health Organization has declared this infectious disease as a global pandemic.
Objective: This study aims to review the latest research advances in genetics, pathogenicity, and clinical features of COVID-19, as well as current therapies to combat this disease.
Methods & Materials: This is a systematic review study on articles published from 2010 to 2020 by searching in reputable databases such as PubMed, Scopus, Google Scholar, Web of Science, and ScienceDirect.
Ethical Considerations: Ethical principles have been observed in accordance with the guidelines of the National Ethics Committee and the COPE regulations.
Results: Examining the genome and genetic studies of the virus, it can be said that there are many similarities between different coronavirus types, but there are differences in their genomic and phenotypic structures that can affect their pathogenesis. Re-use of existing therapeutic drugs, previously designed for other infections and viral pathologies is currently the only practical approach to fight COVID-19. The tests for SARS-CoV-2 genome-specific vaccines and the therapeutic antibodies are currently being tested, but they require a long-term process and complete safety testing.
Conclusion: Rapid diagnosis of SARS-CoV-2 infection is the basis of disease control. There is currently no specific antiviral drug approved for SARS-CoV-2 infection. Therefore, preventive measures are necessary to stop and control the spread of COVID-19, according to genetic studies and the obtaining knowledge of the molecular mechanism of this virus.
Amir Hossein Ahmadi Hekmatikar, Mahdieh Molanouri Shamsi,
Volume 23, Issue 5 (11-2020)
Abstract
Background and Aim: Coronavirus Disease 2019 (COVID-19), as a viral disease, has increasingly highlighted the need for lifelong exercise due to its immunological and physiological effects is necessary on health. In this review study, while examining the effects of moderate-intensity exercise on the physiological and immunological responses associated with COVID-19, appropriate exercise patterns during the COVID-19 pandemic are presented.
Methods & Materials: In this study, the search was conducted in Web of Science, Scopus, ISC, PubMed, Google Scholar, MagIran, and Noor databases on related articles using the following keywords: coronavirus, COVID-19, exercise and coronavirus, exercise and immune system, high-intensity exercise and immune system.
Ethical Considerations: All ethical principles in writing this article have been observed according to the instructions of the National Ethics Committee and the COPE regulations.
Results: Moderate-intensity exercise can help boost the function of the immune system. On the other hand, high-intensity exercise can have negative effects on the immune system, which can be a bad strategy increasing the risk of infectious diseases.
Results Moderate-intensity exercise can help boost the function of the immune system. On the other hand, high-intensity exercise can have negative effects on the immune system, which can be a bad strategy increasing the risk of infectious diseases.
Conclusion: Due to the onset of the second wave of COVID-19 in the world, it is recommended to continue to exercise at home observing the hygiene rules (maintaining humidity and disinfecting environmental surfaces) and using appropriate intensity and duration.
Mohammad Rahmanian, Ali Reza Kamali, Hadi Mosalanezhad, Mahdi Foroughian, Navid Kalani, Naser Hatami, Mohammad Heidarnezhad, Esmaeal Rayatdoost, Samaneh Abiri,
Volume 23, Issue 5 (11-2020)
Abstract
Background and Aim: The recent Coronavirus Disease 2019 (COVID-19) outbreak has caused a lot of stress and anxiety in the world. Given that health care workers are at the forefront of fighting against COVID-19, they are the first to be exposed to this disease.
Methods & Materials: This is a descriptive cross-sectional study conducted on 402 medical and administrative staff working in hospitals and health centers affiliated to Jahrom University of Medical Sciences in 2020. Data collection tools were a demographic form and the Corona Disease Anxiety Scale (CDAS).
Ethical Considerations: This study was approved by the Vice-Chancellor for Research of Jahrom University of Medical Sciences (Code: IR.JUMS.REC.1399.046).
Results: The mean score of psychological symptoms of anxiety in the medical staff (46.91) was higher than in the administrative staff (42.63). Its physical symptoms were also higher in the clinical staff (12.80) compared to the administrative staff (10.94). There was a significant difference between the clinical and administrative staff in terms of anxiety (P=0.030).
Conclusion: Medical staff has higher psychological and physical symptoms of anxiety compared to the non-medical staff during the COVID-19 outbreak. Therefore, in order to reduce the anxiety of medical staff, health policymakers should take the necessary measures to take care of this group.
Mehrdad Nasrollahzadeh Sabet, Mohammad Khanalipour, Milad Gholami, Abdolazim Sarli, Arefeh Rahimi Khorrami, Emran Esmaeilzadeh,
Volume 23, Issue 5 (11-2020)
Abstract
Background and Aim: The new Coronavirus Disease 2019 (COVID-19) outbreak initiated from China in late December 2019, has posed a great global health threat. Since patients with high blood pressure, diabetes, and cardiovascular diseases are at high risk of COVID-19, this study aims to investigate the prevalence, severity, clinical manifestations, and mortality rate in COVID-19 patients with underlying diseases compared to those without underlying diseases.
Methods & Materials: This study was performed on 1408 patients with COVID-19 admitted to Golestan, Hajar, Khanevadeh and Besat hospitals in Tehran, Iran. Required data including disease prevalence, severity, clinical manifestations and mortality rate in patients with and without underlying diseases were collected and then analyzed using statistical tests in SPSS software, considering a significance level of P<0.05.
Ethical Considerations: This study was approved by the AJA University of Medical Sciences (Code: IR.AJAUMS.REC.1399.091). Ethical principles have been observed in accordance with the guidelines of the National Ethics Committee and the COPE regulations.
Results: Patients were 912 men (64.8%) and 496 women (35.2%) aged 18-98 years (Mean age= 57.8 years). Results reported that 27% of patients were intubated and 21.9% were died. Blood oxygen level in 53.7% of patients was less than 93 mg/dL; 36.1% had a history of hypertension, 24.1% had a history of diabetes, and 21.7% had a history of cardiovascular disease.
Conclusion: The severity, clinical manifestations, and mortality rate of COVID-19 patients with cardiovascular disease, diabetes and hypertension are significantly different compared to those without underlying diseases.
Saeed Pirmoradi, Hedieh Jafari,
Volume 24, Issue 4 (9-2021)
Abstract
Background and Aim: The human coronavirus is a member of the Coronaviridae family and causes upper respiratory tract infections. Despite repeated severe epidemics and the lack of appropriate antiviral drugs, not much progress has been made on the epitope-based vaccine designed for HCoV.
Methods & Materials: The method of this study was to select the spike corona virus protein sequence from NCBI, retrieve the protein sequence and determine the T, B epitopes required to produce the chimer vaccine, evaluate the antigenicity and allergenicity and toxicity of the selected epitopes, respectively. Different servers were designed to configure the primary chimer composition of the epitope vaccine. Then, the chimer vaccine was evaluated in terms of structure and connectivity to B cells and MHCI and II compounds, and the two-dimensional structure and position of amino acids and bonds in the immunogenic model were studied, as well as the physicochemical and stability of the model vaccine by some other servers. Finally, it was tested for binding against HLA molecules using silico docking techniques to investigate the interaction with the epitope.
Ethical Considerations: All ethical principles are considered in this article. Participants were informed about the research objective and its implementation stages. They also made sure their information was confidential. The principles of the Helsinki Convention were also observed.
Results: The results showed that the immunogenic construct created in terms of two-dimensional and three-dimensional structure and the position of amino acids and bonds in the model of immunogenic structure, toxicity and allergenicity and antigenicity were in good condition. And had stability (instability index 33.93) and favorable half-life and suitable physicochemical conditions.
Conclusion: In general, the immunogenic structure that was prepared in this research process could have a favorable interaction with some components of the immune system (HLA) in the docking process, which indicates the optimal identification of this structure by the humoral and cellular immune system and stimulation in In order to produce immunity in the body of the host, of course, more reliable proof of it requires clinical phase processes.
Seyedeh Sara Azadeh, Hoda Keshmiri Neghab,
Volume 24, Issue 5 (11-2021)
Abstract
In December 2019, a new type of coronavirus called COVID-19 was identified as an unknown cause of pneumonia in Wuhan, China. The pandemic virus was transmitted to humans from a type of seafood that could spread significantly among humans in a short time. Clinical signs of coronaviruses include fever, severe sweating, cough, pneumonia, and a weakened immune system, with acute cases leading to death. One of the most important coronavirus receptors in the host cell is the angiotensin 2 converting enzyme. It is noteworthy that the patient’s recovery process increases during the inhibition of angiotensin 2 converter enzyme. Therefore, the administration of drugs that inhibit this enzyme can be effective in recovering a patient with coronavirus. Flavonoids are one the inhibitors of the angiotensin-converting enzyme, which is abundant in fruits and vegetables. Fistula, a type of flavonoid known in nature as an antioxidant and anti-inflammatory agent in the treatment of many, can be effective in the treatment of coronavirus by inhibiting the enzyme converter angiotensin 2.
Mahbobeh Karbalaei, Jahangir Karami, Parvaneh Karimi,
Volume 24, Issue 5 (11-2021)
Abstract
Background and Aim: The type of circadian rhythms is essential in maintaining physical and mental health and recovery from the disease. This study aimed to investigate the role of circadian rhythms on sleep quality and corona anxiety in men and women.
Methods & Materials: The present study is a descriptive comparative causal description. The statistical population included all 18-50 who participated in the survey online. People who completed the questionnaire online were selected for sampling. The research instruments included the circadian inventory rhythms Horne and Ostberg (1976), Petersburg Quality of Sleep Questionnaire (1989), and Alipour et al.’s (2020) Corona-related Anxiety Scale in the Iranian sample. Multivariate analysis of variance (MANOVA) and the Scheffe test were used to analyze the data.
Ethical Considerations: This study was registered with the Ethics Committee Razi University Technology Units Development Center at Institute for Psychoanalytic Studies (No.: 99133).
Results: The results showed that the mean of mental and corona physical anxiety in women and men with evening type is higher than in other classes. Men and women in the evening type have a lower sleep quality than in the morning and middle types. The results also showed significant differences between the types regarding corona anxiety, sleep quality, and sex. The difference between the mean of the morning type and evening types’ mean was more than other differences between the means.
Conclusion: Individual differences in morning-evening types seem to play an essential role in the quality of sleep and the experience of corona anxiety
Ebrahim Rahbar Karbasdehi, Fatemeh Rahbar Karbasdehi,
Volume 24, Issue 5 (11-2021)
Abstract
Dear Editor
Since December 2019, the coronavirus has affected all aspects of our lives worldwide. This deadly crisis, for which no health care system was fully prepared, has created enormous pressures on health care delivery and has directly and indirectly affected the treatment of many common diseases. Cancer patients are a vulnerable group in the current epidemic due to their immunodeficiency status due to cancer and various anti-cancer therapies [1]. Research shows that cancer patients are at greater risk for more severe infections and subsequent complications, especially if surgery or chemotherapy is given in the month before the coronavirus infection [2]. These conditions have led to a significant increase in coronavirus mortality in cancer patients [3].
Fatemeh Mohammadi, Maryam Nikrou, Kimia Sadeghi, Farid Askarifard, Mohammad Sayyadi,
Volume 25, Issue 2 (5-2022)
Abstract
Background and Aim Coronavirus disease 2019 (COVID-19) is a respiratory disorder that can affect many body systems, including the hemostatic system. In this study, we aim to investigate the role of hemostatic system and the blood coagulation in COVID-19.
Methods & Materials In this review study, the articles were searched using the keywords COVID-19, Respiratory infection, and Coagulopathy in Google Scholar, PubMed, Google Springer and Science Direct databases.
Ethical Considerations Ethical principles in writing this article were observed in accordance with the guidelines of the National Ethics Committee and the Committee on Publication Ethics (COPE).
Results Many changes in the coagulation profile of infected patients were reported, including changes in the platelet count, fibrinogen/fibrin degradation product, D-Dimer, fibrinogen, prothrombin time, and activated partial thromboplastin time. With the increase in the number of patients with COVID-19, several studies found out the occurrence of thrombosis and coagulopathy in patients.
Conclusion Due to the increase in the occurrence of coagulation disorders in patients with COVID-19, the administration of anticoagulants is needed for their treatment; it can play an effective role in improving the prognosis of patients.
Miss Homa Rastegari, Dr Davood Hekmatpou, Dr Ramiz Kamrani, Dr Moloud Farmahini Farahani,
Volume 26, Issue 1 (4-2023)
Abstract
Introduction: One of the common problems of patients with covid-19 is the occurrence of respiratory problems that may accompany the person for a long time. Also, based on clinical and research evidence, different degrees of anxiety and stress have been observed in those who have recovered from this disease. This study was conducted with the aim of determining the effect of diaphragmatic breathing on dyspnea and state anxiety in patients with covid-19.
Methods: This study was a randomized clinical trial conducted in 2021-2022. The study population consisted of 78 patients with covid-19 hospitalized in Amir al-Momenin Hospital in Arak city, who were selected by available sampling and divided into two groups of 40. In this study, the Spielberger anxiety inventory, Borg scale, MRC breathlessness scale and measurement of blood oxygen saturation were used. The test group received diaphragmatic breathing training on the day of discharge and performed the exercise for ten minutes, and after discharge, they performed diaphragmatic breathing twice a day (ten minutes each time) at home for a week. Questionnaires were completed by the patients before the intervention, immediately after and one week later. The data was analyzed with SPSS software version 23 at the level (P < 0.05).
Results: The findings showed that the mean anxiety score of the patients immediately and one week after the intervention in the test group was significantly lower than the control group (P < 0.001). The mean oxygen saturation in the test group after the intervention was significantly higher than the control group (P < 0.001). Also, a significant difference was observed between the mean dyspnea scores using the MRC and Borg dyspnea scales after the intervention in the two groups (P < 0.001).
Conclusions: The results showed diaphragmatic breathing reduced anxiety and shortness of breath in patients with covid-19 after discharge. Therefore, teaching this simple and effective method is recommended for these patients during discharge from the hospital.
Dr Majid Gholami-Ahangaran, Dr Maryam Karimi-Dehkordi,
Volume 26, Issue 1 (4-2023)
Abstract
Introduction: Coronaviruses are mainly the cause of respiratory disease in humans, and among the known species, the coronaviruses that cause SARS, MERS, and Covid 19 cause severe respiratory disease. So far, no specific treatment has been found for these diseases. Considering the beneficial effects of medicinal plants as antioxidant and anti-inflammatory compounds, the use of herbal compounds can be effective in mild infection of coronaviruses.
Methods: PubMed database was used to search for articles containing the terms coronavirus, SARS, MERS, as well as human and herbal medicine. The inclusion criteria were all full articles with the mentioned keywords and the exclusion criteria were summary articles and articles presented in conferences. A total of 36 articles on human coronaviruses were found. Most of the studies were about SARS (SARS-CoV) with 26 articles (72.22%). Two articles (5.55%) were found about Covid-19 (SARS-CoV-2) and only one article (2.77%) about MERS (MERS-CoV). It should be noted that one study included SARS-CoV and MERS-CoV and six studies (16.66%) also investigated SARS, MERS and Covid-19 at the same time. Ethical principles have been respected in writing the article, according to the instructions of the National Ethics Committee and COPE regulations.
Results: Some medicinal plants have been identified with effective antiviral activity against SARS, MERS, and Covid-19 coronaviruses, including green tea, cinnamon, licorice, cure, sage, chives, rhubarb, nettle, and blackberry. Considering that these medicinal plants have already been used with different therapeutic effects in the human medicinal pharmacopoeia, it is recommended to conduct clinical trials on humans in order to achieve an effective dose against common human coronaviruses.
Conclusions: Although some medicinal plants have been recommended for use in the treatment of coronavirus respiratory syndrome in humans, the effects of these plants on other biological factors have not been studied, until now. It is necessary to evaluate their side effects simoultaneous with clinical trials and confirming the effectiveness of these compounds.
Mrs Fatemeh Jahanshahi, Dr. Morteza Ghasemi, Mr. Pooyan Falahi, Mrs Neda Ghasemi,
Volume 26, Issue 1 (4-2023)
Abstract
Introduction: The current research was conducted with the aim of "investigating the role of medical staff in health policies during the corona virus pandemic".
Methods: This research is practical in terms of purpose and exploratory research in terms of method.
Results: The statistical population of this research is all the medical staff of Arak city Since access to all these people is not possible; Therefore, the sampling method is used. The data collection tool in this research was a questionnaire. This research was done using the factor analysis model.
Conclusions: The data and information extracted from the factor analysis test showed that: establishing proper communication with patients, interacting with citizens and the government, paying attention to the laws and encouraging others to comply with them, learning specialized training to contain the corona virus, explaining the situation to worried people, Adhering to health protocols and informing others, perception of organizational justice, alignment between individual and organizational goals, transfer of sense of responsibility to the work environment, existence of an efficient evaluation system and encouragement to inject vaccines are the most important role of the medical staff in health policies. They were during the corona disease pandemic.
Dr Roghayeh Kiyani, Ms Haleh Behroti,
Volume 26, Issue 2 (7-2023)
Abstract
Introduction: Adverse effects of Coronavirus on somatic and mental health is undeniable .nurses staff are exposed to risk of somatic and psychological effects because of continuous working time. The aim of this study was to investigate the effectiveness of training coping strategies with stress on distress tolerance and psychological empowerment of corona nurses in Khoy hospitals.
Methods: This research was applied in terms of purpose and quasi-experimental in terms of research method with pre-test – post-test design with control group And from the statistical population that included all nurses in the corona ward of Khoy hospitals in 2021 , 30 people were selected as the available sample. The subjects were randomly assigned into two groups (15 individuals in experimental group and 15 individuals in control group).In order to collect data, the Distress Tolerance Questionnaire and the Psychological Empowerment Questionnaire were used. The experimental group subjects participated in eight 90-minute sessions of training coping strategies with stress. Multivariate analysis of covariance was used to test the hypotheses. This study was approved by the Ethics Committee of Islamic Azad University of Tabriz (Code: REC.1400.135).
Results: The results showed that training coping strategies has increased distress tolerance and psychological empowerment in the post-test phase (P < 0.01).
Conclusions: According to the findings of the present study, it can be concluded that teaching coping strategies can be used as an effective method to improve stress tolerance and psychological empowerment of coronary nurses.
Fateme Halalkhor, Ameneh Poorrahim, Marefat Siahkouhian,
Volume 26, Issue 5 (12-2023)
Abstract
Introduction: Anti-cytokine considerations in COVID-19 patients can play a significant role in preventing death, therefore, physical activity by reducing risk factors, as well as saffron with anti-inflammatory and antioxidant properties, are considered as anti-cytokine solutions. Therefore, the purpose of this research is to investigate the effect of saffron supplementation and endurance training on the concentration of interleukin-6, interleukin-10 and L-cysteine in outpatients with coronavirus.
Methods: The statistical population of this research is outpatients with coronavirus, 36 of whom were randomly selected. Cytokines and L-cysteine were measured using a special kit and ELISA method. The research hypotheses were checked at a significance level of P < 0.05 using ANOVA test with repeated measurements with between-group factor.
Results: The results showed that endurance activity and saffron supplementation caused a significant decrease in IL-6 levels and the ratio of interleukin 6 to interleukin 10 (P ≥ 0.05). Also, endurance activity along with saffron supplementation caused a significant increase in serum L-cysteine concentration (P = 0.035). The results showed that there is no interaction effect between the measurement stages and the group, as well as intra-group and inter-group differences in interleukin-10 variables (P = 0.511).
Conclusions: The levels of IL-6 and IL-10 decrease due to saffron supplementation and endurance training, and the amount of L-cysteine increases, which helps the recovery of COVID-19 patients.
Bahare Bayat, Kobra Rahzani, Davood Hekmatpou,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: The coronavirus crisis is a multidimensional phenomenon that affects even the family. The impact of the situation on the family has been less discussed. Therefore, a qualitative study was conducted to explain families' experiences with patients suffering from COVID-19.
Methods: A qualitative study was conducted with a content analysis approach in 2021. Sampling started with purposive sampling and continued theoretically until information saturation was reached. The primary data collection tool was a semi-structured, in-depth interview in which
10 participants were interviewed. The participants were people from the family of a patient with COVID-19 who, while willing to participate in the study, were either involved in caring for the patient or were worried about the patient's infection. In addition, their patient recovered from Corona and was alive. The interview location was chosen according to the participants' opinion, whether it was at their home or a place that was convenient for them. The interviews were analyzed using the Granheim and Lundman method.
Results: After analyzing the data, initially, 391 codes, 16 subcategories, and finally, five themes were extracted. The five themes that emerged are the experienced symptoms of the disease with two subcategories (symptoms of the onset of the disease and the course of the symptoms), mental and emotional disturbances with seven subcategories (contagion anxiety, death anxiety, fear of the vague nature of the disease, torment of conscience, obsession, emotional suffering, and financial worries), sacrifice in care with two subcategories (suffering care and multiplicity of roles), resilience in the path of care with three subcategories (supportive aspects, reduction of caregiving stress and obtaining information about the disease), Change and evolution in the course of life with two subcategories (individual growth and getting the meaning of life).
Conclusions: According to the present study, after one of the family members gets infected with Corona, the other members have a crisis. The individual, psychological, social, and economic dimensions of the family foundation are facing challenges. It needs the comprehensive support of the family as the first and most important institution of society. Although facing this crisis and accompanying challenges leads to the experience of special suffering, it lays the foundation for personal growth and a better understanding of the meaning of life. Therefore, it can be said that the experience of this crisis is not only from the social aspect but also from the individual aspect, along with tremendous positive and negative developments.
