Showing 54 results for saleh
Fahimeh Kazemi, Saleh Zahedi Asl,
Volume 18, Issue 6 (9-2015)
Abstract
Background: The physiological role of apelin, an adipokine secreted by adipose tissue , in insulin resistance and type 2 diabetes has been identified . The aim of this study was to determine t he correlation of plasma level s of apelin-13 with insulin resistance index (HOMA-IR) and plasma leptin of diabetic male rats after 8-week aerobic exercise .
Materials and Methods: Peresent study was an experimental study with animal model. Twenty eight diabetic male Wistar rats were divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide and streptozotocin. The trained diabetic rat ran 8-week on treadmill progressively. After the training period, plasma levels of glucose, insulin, leptin and apelin-13 were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson’s correlation were used for analyzing data. p<0.05 was considered to be statistically significant.
Results: A significant decrease in plasma levels of glucose, insulin and leptin and HOMA-IR in trained diabetic vs control diabetic rats, a significant increase in plasma levels of apelin in trained diabetic vs non-diabetic and control diabetic rats and a significant negative correlation of plasma levels of apelin with HOMA-IR and plasma leptin in trained diabetic rats was observed.
Conclusion: In present study, 8-week aerobic training by improvement of insulin sensitivity (decrease of HOMA-IR and plasma leptin) increased plasma levels of apelin-13 in diabetic male rats.
Samira Marzband, Farhad Mashayekhi, Zivar Salehi, Mohammad Hadi Bahadori,
Volume 18, Issue 7 (10-2015)
Abstract
Background: Approximately, 50% of male infertility causes have remained unknown. It seems that genetic disorders may lead to many cases of idiopathic infertility. XRCC1 ( X-ray Repair Cross Complementing group 1) acts as a scaffolding protein in the base excision repair (BER) and single strand break repair (SSBR). Single nucleotide polymorphisms (SNP) of XRCC1 may influence DNA repair capacity. Thus, they had been considered as a risk factor for infertility. XRCC1 Arg399Gln polymorphism was located on p rotected domain , BRCT1 . The aim of this study was to explore the p ossibility of association between XRCC1 Arg399Gln polymorphism and susceptibility to idiopathic male infertility.
Materials and Methods: In this case-control study, the genotype and allele frequencies of Arg399Gln polymorphism were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) on a Guilanian population consisting of 144 men with idiopathic infertility and 166 healthy men. Statistical analysis was performed using the MedCalc 12 software.
Results: According to our results, compared with Arg/Arg genotype, the Arg/Gln , Gln/Gln and Arg/Gln + Gln/Gln genotypes showed a significant association with an increased risk of idiopathic male infertility ( OR=4.19 95%CI 2.37-7.41, p<0.0001 ), (OR=3.42 95%CI 1.50-7.81, p<0.0034), (OR=4.06 95%CI 2.32-7.09, P<0.0001) , respectively. In addition, the Gln allele frequency in patients was significantly higher than that in controls(p=0.0004).
Conclusion: In total, Arg399Gln polymorphism of XRCC1 gene can be associated with male infertility and Gln allele might be a risk factor of idiopathic male infertility in in this sample population. Larger population and different ethnicities should be studied to achieve a definitive conclusion.
Sonya Zamani, Farhad Mashayekhi, Zivar Salehi, Nasim Abbasi,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Diabetic retinopathy (DR) is the complication of diabetes mellitus (DM) and causes blindness among adults. Chronic extra cellular hyperglycemia in diabetes stimulates reaction oxygen species ROS production and increases oxidative stress. GPX-1 that was coded by GPX-1 gene is a key enzyme in protecting vessels against oxidative stress. The aim of this study was to evaluate the association of GPX-1 gene Pro 198 Leu polymorphism in patients with diabetic retinopathy.
Materials and Methods: In this case-control study, 160 blood samples of participants including 80 patients with diabetic retinopathy and 80 healthy individual were tested. Genotyping of GPX-1 gene was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) by ApaI enzyme. Data analysis was performed using MedCalc (12.1) program.
Results: The genotype frequencies of the GPX-1 in DR patients for Leu/Leu, Leu/Pro, Pro/Pro were 10%, 62.5% and 27.5%, respectively, while for the control groups were 10%, 70% and 20%, respectively.In ohter words, Ile/Pro heterozygote was the most frequent genotype in patients and controls. According to the results of this study, there was not significant difference between patients with diabetic retinopathy and controls(p=0.52).
Conclusion: It is concluded that GPX-1 gene Pro 198 Leu polymorphism is not associated with DR. Further research is required to clarify the role of GPX-1 gene in DR in Rasht population along higher sample size.
Mojtaba Salehi, Seyed Reza Mohebbi, Mehrdad Ravanshad, Maryam Karkhane, Pedram Azimzadeh, Behta Keshavarz Pakseresht,
Volume 18, Issue 12 (3-2016)
Abstract
Background: Hepatitis B virus (HBV) is a member of hepadenaviridae family, which is infectious for humans and a few animal species. Successful clearance and elimination of infection from the body or development of HBV infection to chronic disease depend on the host genetic background in immune system genes. Interleukin-12 (IL12) and also Interleukin-12 Receptor B1 (IL 12 RB1) are the key factors in the spontaneous clearance of viral infections, especially HBV. The aim of the present research is to investigate the association between Interleukin-12 receptor B1 gene polymorphism (rs11575934 A/G) and susceptibility to chronic Hepatitis B virus infection.
Materials and Methods: In this case-control study, genomic DNA of 150 chronic HBV infected patients and 150 healthy controls were extracted from peripheral blood cells. Single nucleotide polymorphism (rs11575934 A/G) was genotyped using polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP).
Results: The frequency of GG, AG, AA genotypes was 6.7%, 40.7%, and 52.7% in chronic patients and 12.7%, 41.3%, and 46% in control group, respectively. No statistically significant difference between case and control groups has been observed (p=0.176).
Conclusion: In the present study, no significant correlation between rs11575934 A/G single nucleotide polymorphism of the IL12RB1 gene and susceptibility to chronic hepatitis B virus infection has been observed. According to the study, this polymorphism does not affect the susceptibility to chronic HBV infection.
Bahman Salehi, Shirin Moradi, Somayeh Ebrahimi, Mohammad Rafiei,
Volume 19, Issue 4 (7-2016)
Abstract
Background: Boredom is a psychological phenomenon that was defined as an aversive state or incompatibility with every repetitive experience while the release of stability is not allowed. Boredom has several complications. So, the goal of this study is to compare the predictors of boredom in students of Arak University of medical sciences and Islamic Azad University.
Materials and Methods: The current descriptive-comparative study has been done on966 students (from Arak University of medical sciences and Islamic Azad University). The scale of current study was a checklist list of demographic information, predictors of boredom assess questionnaire, Farmer and Sundberg’boredom proneness scale. Data were analyzed by using chi-square, Pearson correlation, multivariate regression, and Fisher'sz.
Results: The greatest number of students from both universities have normal boredom without a statistically significant difference between male and female students (p=0.06). University factor had the highest average between students. Totally, boredom had a significant correlation with each of the home (p=0.000) and society (p=0.001) factors. All three factors including home (p=0.033), university (p=0.033) and society (p=0.031) can explain and predict boredom in male and female students.
Conclusion: The results showed that university factor was the most important factor for predicting boredom between college students. Thus, in order to avoid adverse effects of boredom on students educational activities, this phenomenon and its causes should be considered.
Neda Saleh Jafari , Farzad Zamanibarsari, Hamidreza Jamilian, Bahman Sadeghi Sede , Hamidreza Zafari,
Volume 19, Issue 7 (10-2016)
Abstract
Background: The definite treatment of indicated Hypertrophy of the tonsils is Tonsillectomy. The aim of this study was to compare the efficacy and necessity of diclofenac suppository and simultaneous prescription of acetaminophen alone in controlling and reducing pain and improving swallowing and satisfaction after surgery for tonsillectomy in children.
Materials and Methods: In this clinical trial, 180 children 7 to 14 years Tvnsykltvmy surgery were enrolled. Patients in an improbable way, easy and were divided into three groups of 60. Immediately after the surgery acetaminophen, diclofenac, or a combination of both was used. The cases of pain in the early hours, seventh, thirteenth and nineteenth after surgery were compared.
Results: There was a significant difference between the average pains of all groups in all hours (p<0.05). There was a significant difference between the groups from the point of view of side effects such as Nausea, Vomiting and Pyrexia (p<0.05), But there was no significant difference between the groups from the point of view of After Surgery Bleeding (p>0.05).
Conclusion: We can say that Rectal Diclofenac is a more effective medication for reducing pain after the Tonsillectomy surgery in contrast with Rectal Acetaminophen or a mixture of the two, which may cause the patients to use less Narcotics after the surgery.
Zeynab Hosseinpour, Zivar Salehi, Soheila Talesh Sasani, Keyvan Aminian,
Volume 20, Issue 1 (4-2017)
Abstract
Abstract
Background: Ulcerative colitis (UC) is a chronic disease that specifically affects the mucosa of the rectum and colon. The pathogenesis of UC is not well defined, but it is proposed that genetic and environmental factors result in an aberrant immune response to a subset of commensal enteric bacteria.The aim of this study was to investigate whether miR-34b/c rs4938723 T/C polymorphism is associated with UC risk.
Materials and Methods: Blood samples were collected from 50 patients diagnosed with UC and 100 healthy control subjects. Genomic DNA was extracted from peripheral blood. Genetic variation of miR34b/c was determined by tetra-primers ARMS-PCR (amplification refractory mutation system-polymerase chain reaction). All statistical analyses were conducted using the MedCalc version 12.1.
Results: There was a significant difference in genotype and allele distributions between cases and controls. It was observed that the CT heterozygotes had a 2.29-fold increase in risk of UC (OR=2.29, 95%CI=1.08-4.82, p=0.02).
Conclusion: It is suggested that the miR34b/c (rs4938723 T>C) polymorphism may be associated with the risk of UC. However, larger studies with more patients and controls are needed to confirm this result.
Morteza Salimi Avansar, Abdolsaleh Zar,
Volume 20, Issue 2 (5-2017)
Abstract
Abstract
Background: The prevalence of obesity among children is alarmingly rising. Obesity in a chronical inflammatory condition accompanies with inflammatory markers such as Chemerin and CRP; therefore, the aim of this following study is to compare the affection of Endurance & High Intensity Interval Trainings on levels of Chemerin & Protein of C-reactive plasma in obese children.
Materials and Methods: This experimentation included 21 obese children (average weight 61.46±2.5 kg and BMI 7.1±4.31) aging 9-12 years old who were randomly divided into three groups of endurance, HIIT and control (n=7). The training groups performed regular exercises for 8 weeks long (3 sessions in every week). The differences between groups were evaluated using covariance analysis. (p<0.05).
Results: In both training groups, there was a more significant decrease in weight, BMI and body fat percentage than there was before workouts. In HIIT group, we witnessed a significant reduction in level of Chemerin (p=0.016) than before. CRP level was also decreased in both groups, but the changes were not significant.
Conclusion: In summary, 8 weeks of HIIT exercises compared to endurance trainings have greater effect on Chemerin and CRP levels in obese children.
Mostafa Jani, Bahman Salehi, Seyed Ali Aleyasin, Hossein Davoudi,
Volume 20, Issue 3 (6-2017)
Abstract
Abstract
Background: The aim of this study was to determine the effectiveness of cognitive-behavioral group therapy on quality of life of patients with cardiovascalar diseases.
Materials and Methods: This semi-experimental study was done based on a pretest -posttest design with control group. Statistical population included all of the patients with cardiovascular diseases referred to Amir-Kabir educational and medical center of Arak, and sample included 30 persons who selected by screening and simple random sampling and assigned into two control and experimental groups. Research instrument included Mcnew quality of life scales which participants answered it during two pre-test and post-test steps; also, experimental group participated in 9 cognitive-behavioral therapy meetings.
Results: There was a significant difference between mean quality of life and its components in both experimental and control groups.
Conclusion: Results analysis showed that group-based cognition- behavior theray has an influence on life quality (emotional, physical and social domains)(p>0.05).
Sara Alidadiani, Zivar Salehi,
Volume 20, Issue 6 (9-2017)
Abstract
Abstract
Background: Implantation of an embryo involves a complex sequence of signaling events, consisting of a large number of molecular mediators such as ovarian hormones, cytokines, adhesion molecules and growth factors. Vascular endothelial growth factor (VEGF) is an important angiogenic factor. VEGF is believed to play an important role in the process of implantation. The aim of this study was to evaluate the association of VEGF +405C/G polymorphism and the clinical outcomes of women who underwent IVF-ET procedures.
Materials and Methods: One hundred women with previous IVF-ET failures and 100 pregnant women as controls were genotyped for VEGF +405 C/G by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Statistical analysis was performed using the MedCalc software.
Results: Our results indicated a higher prevalence of the VEGF +405 GG genotype and G allele in patients with history of IVF-ET failure (OR=6.90; 95%CI=2.75-17.29; p<0.0001, OR=2.5; 95%CI=1.66-3.76, p<0.0001).
Conclusion: The present study revealed that the VEGF +405 GG genotype was associated with an increased risk of IVF-ET failure. However, further studies in larger populations including other genetic factors are required to achieve a definitive conclusion.
Bahareh Babaei Houlari, Zivar Salehi,
Volume 20, Issue 10 (1-2018)
Abstract
Abstract
Background: Successful pregnancy depends on the ability of the embryo to achieve appropriate extent of trophoblastic proliferation and invasion into maternal endometrium as well as, once implanted, to induce its own blood supply. Beta Human chorionic gonadotropin (β-hCG), enhances blastocyst implantation, uterine vascularization, and angiogenesis, as well as regulates maintenance of uterine quiescence and immunological adaptation during pregnancy. The β-subunit of hCG is encoded by CGB3, CGB6, CGB5, CGB7 and CGB8 genes. The aim of this study was to evaluate the association of CGB5-G/C polymorphism and the clinical outcomes in women who underwent IVF-ET procedures.
Materials and Methods: A total of 200 patients undergoing IVF-ET (100 patients with positive and 100 patients with negative IVF-ET outcome) were included in this study. Genotyping of CGB5 at -155G/C polymorphic site was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Statistical analysis was performed using the MedCalc software.
Results: Our findings show that the CC genotype of the CGB5 -155G/C polymorphism is associated with decreased risk of IVF-ET failure (OR=0.29; 95%CI=0.1-0.85; p=0.02). However, the allelic distribution of the CGB5 -155G/C is not significantly different between two groups (χ2=1.46; p=0.22).
Conclusion: The results of this study suggested that CGB5 (-155G/C) CC genotype has a protective effect on IVF-ET outcome. More studies with larger sample sizes on different populations are necessary to elucidate the underlying mechanisms which can explain the associations found between the GGB5 gene polymorphisms and IVF-ET outcome.
Ehsan Salehi, Ebrahim Hagizadeh, Mohammad Alidoosti,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: Advances in the field of medicine over the past few decades enabled the identification of risk factors that may contribute toward the development of coronary artery disease (CHD). However, this knowledge has not yet helped in the significant reduction of CHD incidence. The purpose of this study is to assess the risk factors of coronary artery heart events, after receiving stent, by competing risks with composite events tree. We can reduce CHD incidence with control of this risk factors.
Materials and Methods: This sectional study includes the Coronary Artery Disease (CAD) patients that received Percutaneous Coronary Intervention (PCI) cure with at least planting one stent from May 21, 2007 to May 22, 2009 in Tehran heart center. We followed patients for three years. Revascularization, nonfatal myocardial infarction, and cardiac death are considered as major acute cardiovascular events (outcome). We used decision tree with competing risks with composite events model for classification of patients. The data were analyzed by IBM SPSS Statistics 24 and R 3.3.3 softwares.
Findings: Four factors including fasting blood sugar, diabetes mellitus, body mass index and age established six homogeneous subgroups of patients for nonfatal myocardial infarction and revascularization. Maximum Revascularization incidence after 50 months was 17.8% and Maximum Nonfatal myocardial infarction was 9.7%.
Conclusion: CAD patients can reduce serious cardiac events by controling their weight and diabetes status, after receiving stent.
Zohreh Karimi Taheri, Mohammad Hosein Aarabi, Ali Nazari Alam, Majid Nejati, Mohammad Shayestehpour, Hamid Reza Gilasi, Afshin Salehi, Mohammad Esmaeil Shahaboddin,
Volume 24, Issue 1 (April & May 2021)
Abstract
Background and Aim: Despite the anti-cancer and antimicrobial properties of licorice extract and lavender essential oil, some factors, such as low bioavailability and biodegradable, limit their therapeutic use. Using nanoparticles is a method to overcome these restrictions. This study aimed to investigate the anti-proliferative effects of nanoemulsion containing licorice extract and lavender essential oil on cancer cells; we also evaluated its antimicrobial properties in vitro.
Methods & Materials: In this experimental study, nanoemulsions, containing licorice extract and lavender essential oil were developed by the spontaneous emulsion method. The anti-proliferative effect of nanoemulsion was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) colorimetric method on two cell lines HepG2 and SK-MEL-3. To measure the antimicrobial effect of 4 standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Minimum Inhibitory Concentration (MIC) method was used.
Ethical Considerations: This study was approved by the Ethics Committee of Kashan University of Medical Sciences (Code: IR.KAUMS.MEDNT.REC.1396.106).
Results: The results of MTT test on HepG2 cells indicated that the concentrations of 630, 1250, and 2500 μg/mL nanoemulsions caused toxicity to the cell and led to the death of >50% of the cells (IC50=401μg/mL; P<0.05). Evaluating SK-MEL3 cells revealed that except for 75 μg of nanoemulsion, other concentrations induced death in >50% of the cells (IC50 = 82 μg/mL; P<0.05). In addition, nanoemulsions, with antimicrobial properties, were studied in 4 strains of bacteria; the highest antimicrobial properties were observed in Staphylococcus epidermidis.
Conclusion: Nanoemulsion containing licorice extract and lavender essential oil presents antimicrobial and antiproliferative effects on the two cell lines studied. The current study results indicated that the nano emulsification of lavender essential oil and licorice extract can enhance their biological impact; thus, they can be used as a drug formulation.
Sousan Salehi, Maryam Tarameshkou, Saeed Mirahmadi, Saghar Hashemnia, Milad Hassansheikhi,
Volume 25, Issue 3 (August & September 2022)
Abstract
Background and aim: It is suggested that hearing impaired children with hearing aids and cochlear implant, showed poor pragmatic abilities. Pragmatic is the most related language component to social interaction. Further, it has effect on personality development and self-esteem. The main aim of the present study is investigating the relationship between pragmatic abilities and self-esteem in hearing impaired children.
Materials and methods: Sixty hearing impaired children with hearing aids or cochlear implant were included into this study according to inclusion and exclusion criteria. Then parents or other caregivers were asked to fulfill Children’s Communication Checklist (CCC) and self-esteem questionnaire. The participants were divided into three groups based on hearing impairment severity, including: severe, moderate and mild. The relationship between pragmatic ability and self-esteem was examined in three groups and without considering categorization, by Pearson correlation coefficient, significant level was 0.05.
Ethical considerations: This project is approved in Arak university of medical sciences with ethical registration code IR.ARAKMU.REC.1399.150. All parents gave written informed consent form.
Findings: the results illustrated that there is significant relationship between pragmatic abilities and self-esteem in all hearing impairment children without considering categorization (p<0.05). By considering categorization, significant relationship was showed in self-esteem and pragmatic abilities in moderate and mild groups (p<0.05).
Conclusion: according to our analysis, pragmatic abilities and self-esteem are related. This relationship is more obvious in low severity impairment.
