Showing 32 results for Yousefi
Ahmadreza Ghandi, Parsa Yousefi, Hosseinali Hadi, Ahmadreza Behrouzi, Aahdieh Sadat Ghafari,
Volume 15, Issue 7 (December 2012)
Abstract
Background: Transient hip tenosynovitis is one of the common causes of pain and limping in children and includes 0.4% to 0.9% of admissions in emergency wards. The aim of this study is to evaluate this disease in terms of clinical presentations, age and sex distribution, and six-month recurrence. Materials and Methods: In this cross-sectional study, 51 children with diagnosis of transient hip tenosynovitis were investigated. Inclusion criteria were physician's clinical suspicion of acute tenosynovitis according to clinical presentations, physical exam, and age range of 3 to 8 years. Results: Among the 51 children with tenosynovitis, 34 patients were male with age of 61.70±19.1 months and 17 patients were female with mean age of 48.35±20.49 months that presented a significant statistical difference (p=0.026). The most common complaint was hip pain and the most commonly involved joint was the hip. Also, most of the patients had the history of viral diseases. Conclusion: Transient hip tenosynovitis is more common in boys. The right hip is the most involved joint and the majority of patients have the history of recent viral diseases.
Mahnaz Edalat-Nejad, Rezvan Sadeqi, Parsa Yousefichaijan, Mahdie Qaffari,
Volume 15, Issue 9 (February 2013)
Abstract
Background: Adequately delivered hemodialysis dose has been shown to have a distinct impact upon the morbidity and mortality of patients on chronic dialysis therapy. Online conductivity monitoring (OCM) using sodium flux as a surrogate for urea allows for repeated measurement of hemodialysis adequacy in each treatment session. Materials and Methods: In this cross-sectional study, 156 treatment sessions in patients undergoing chronic hemodialysis were assessed by measurement of the conductivity performed by Diascan in AK 96 dialysis machines. Dialysis adequacy was measured by daugirdas logarithmic estimates of single-pool Kt/V. Values of calculated Kt/V and simultaneously obtained online Kt/V were compared. Statistical analysis was performed using paired sample t-test. Results: There was a statistically significant difference between calculated Kt/V and online Kt/V in this study. The mean calculated Kt/V was 1.1±0.18 and mean online Kt/V was 0.77±0.32 (p<0.001). There was a moderate correlation between calculated Sp Kt/V and on-line Kt/V (r =0.44, p=0.012). Conclusion: Despite the underestimation of hemodialysis adequacy by online conductivity monitoring in comparison with Sp Kt/V, it is a useful tool in clinical practice.
Mohsen Rezazadeh, Rasoul Yousefi Mashouf, Hossein Sarmadyan, Ehsanollah Ghaznavi-Rad,
Volume 16, Issue 2 (5-2013)
Abstract
Background: Staphylococcus aureus is considered a common pathogenic factor in infections. Increase in infections caused by this bacterium in developing countries has led to many problems. The aim of this study is to identify the antibiotic patterns of methicillin-resistant Staphylococcus aureus isolated from patients in the central hospital of Arak.
Materials and Methods: In this descriptive cross-sectional study, a total of 100 samples were isolated from hospital patients during one year. The isolates sensitivity to cefoxitin and oxacilin disks were evaluated through disk diffusion. Using polymerase chain reaction (PCR), the isolates were tested for the presence of mecA gene. Finally, antibacterial resistance patterns of the isolates to 13 antibiotics were determined.
Results: In this study, 80 samples in a total of 100 isolates of Staphylococcus aureus were methicillin-resistant. Evaluation and assessment of antibiotic resistance showed the greatest resistance to penicillin (100%), tetracycline (88.50%), levofloxacin (85.70%), and ciprofloxacin (85.70%), respectively, while the lowest levels of resistance were observed to antibiotics chloramphenicol (5.70%), netilmicin (5.70%), and mupirocin (0%), respectively.
Conclusion: This study showed increased resistance to different antibiotics in Staphylococcus aureus that is a serious warning to the treatment of infections caused by this bacterium in the region. Therefore, in order to prevent increased resistance to other antibiotics, it is essential to withhold prescriptions and unessential use of available antibiotics.
Fazad Zamani, Parsa Yousefi, Mohammad Rafeei, Neda Saleh Jafari,
Volume 16, Issue 7 (10-2013)
Abstract
Background: Adenoidal hypertrophy is a common condition of childhood, when abstructive sleep apnea ocurs adenoidectomy is indicated. In less sever cases, non surgical interventions maybe considered, however few medical altematives are currently available. Intranasal steroids used to reduce nasal airway obstruction. The aim of this study to assesthe effectiveness of intranasal corticosteroids for improving nasal airway obstruction and in children with adenoid hypertrophy.
Materials and methods: 77 children 1-12 years exhibiting adenoid hypertrophy symptom and confirmed with radiologic imaging and without tonsilar hypertropy that not inclined to surgery were included and divided two groups in one group were treatend with intranasal betanethason 3 times daily for 3 weeks and and second group treatend with intranasal NACL as placebo. The subjects were assessed for airway obstruction symptoms including, snoring mounth breathing and prulaunt rhinorea, via questionarre ear examination, first month and third month of treatment.
Results: Intranasal betanethasone improved airway obstruction symptoms especially night snoring but hadn’t effective on other symptoms and infection complications including rhinorea.
Conclusion: Intranasal betanethasone can be used as alterative treatment for adenoidal hypertroply because its effect on airway obstruction symptoms due to probably reduction adenoideal size.
Fatemeh Dorreh, Parsa Yousefi, Javad Javaheri, Babak Eshrati, Zahra Amiri,
Volume 16, Issue 8 (11-2013)
Abstract
background: Early detection and treatment are crucial to prevent mental retardation in congenital Hypothyroidism (CH). The aim of this study was to evaluating of screening program of CH in Markazi Province.
Materials and Methods: In cross sectional descriptive study we used recorded data in Markazi province health center. From 2006 to 2012,127112 newborns were screened by measurement of serum TSH level by heel prick. Neonates who had blood TSH&ge5MIU/L were recalled for more evaluation. Neonates with confirmed hypothyroidism underwent treatment.
Results: From127112 screened neonates, 414 were diagnosed as CH patients (both permanent and transient). The prevalence of CH was . Recall rate was 4.8%. In 94.4% of patients, treatment were begun before the 40th day of life. The coverage percent in the province was 100% from the second year of the program.
Conclusion: Recall rate and the incidence of CH were higher than those in other studies, both in Iran and other countries. The mean age of treatment initiation and coverage percent were in favorable range.
Somaye Ghaderi, Fatemeh Alaee Karahrudi , Parsa Yousefi Chaijan , Navideh Nasiri Oscui ,
Volume 16, Issue 10 (1-2014)
Abstract
Background: Hospitalization of a child in pediatric intensive care unit (PICU) is a very stressful experience for parents. High stress in father can product decline in psychological adaptation and associated problems. The present study aimed to determine effect of fathersʼ participation in the care of hospitalized child in PICU on fathersʼ stress and coping strategies.
Materials and Methods: This is a clinical trial with 60 fathers with children admitted to the PICU in intervention and control groups. Fathers in intervention group, participated in the care of the child in 5 times, during a 5-days course. Fathersʼ stress and coping strategies were surveyed in intervention group before and after participation course and in control group before and after a 5-days course.
Results: Fathersʼ stress in intervention group decreased significantly after participation (p˂0.001) but in control group difference was not significant after time course. Fathers in both groups applied similar coping strategies that majority were emotion focused.
Conclusion: Fathers having children in PICU would experience a lot of stress. Their participation in the care of the children would be very effective to decline their stress and reach most adaptation with disease, cure and cares in children.
Habib Soheili, Parsa Yousefi Chaijan, Anita Alaghmand, Bahman Sadeghi Saddeh, Amin Tavasoli, Mahdyieh Naziri,
Volume 17, Issue 1 (4-2014)
Abstract
Background: Allergic rhinitis affects 40% of general population and has an increasing prevalence. Sleep disturbance is an important problem in individuals with allergic rhinitis. Recent studies have shown that 68% of cases with perennial rhinitis and 48% with seasonal rhinitis have impaired sleep.
Materials and Methods: In this case-report study, 33 children with allergic rhinitis aging 6-18 years entered the study. Thirty five children without allergic rhinitis entered the study as control group. A questionnaire containing demographic data and types of sleep disorders filled for every child.
Results: Except respiratory disorder, there was no other significant difference between groups in any sleep disorder. Sixteen children (48.5%) in case group has respiratory disorder while none of control children were involved (P=0.0).
Conclusion: Nasal congestion is the main factor involved in sleep impairment in children with allergic rhinitis. Therefore, it seems that it is the first symptom to be treated.
Parsa Yousefichaijan, Mahdieh O Sadat Ghafari, Hasan Taher Ahmadi, Leila Farajzadeh, Azam Zamamiyan,
Volume 17, Issue 4 (7-2014)
Abstract
Background: Pediatricians frequently confront with elevated body temperature in children and subsequent anxious parents. They practice several approaches in management of fever. A recently addressed issue is administration of alternating doses of acetaminophen and Ibuprofen. This method is relatively common , despite lack of sufficient evidence in this field.
Materials and Methods: This study is a randomized clinical trial. A total of 240 children, aged 6 months to 12 years suffering from gastroenteritis was recruited in this research. Children were classified in 3 groups. First group received Acetaminophen, second group received Ibuprofen and third group were treated with acetaminophen – Ibuprofen every other day alternately.
Results: 240 child were taken apart in this research . 112 ones were female (46.66%) and 128 were male (53.33%). The mean time of lowering fever in the first group was 2.07 days. This figure in the second and third groups were 1.82 and 1.87 respectively. Average doses in the first, second and third groups were (in order) 9, 8.17 and 7.13 doses. Medication in the first group minimum effectiveness rather than two other groups.
Conclusion: The alternating regimen of Acetaminophen – Ibuprofen is more effective than monotherapy in reduction of fever in infants and children between 6 months to 12 years.
Parsa Yousefi Chaijan, Bahman Salehi, Ali Khosrobeigi, Melika Hajirahimi, Mohammad Rafiei, Hassan Taher Ahmadi,
Volume 17, Issue 8 (11-2014)
Abstract
Background: Some children have abrupt onset of severe urinary frequency, voiding as often as every 10-15 min during the day, without dysuria, UTI, daytime incontinence, or nocturia. The most common age for these symptoms to occur is 4-6 yr, after the child is toilet trained, and the vast majority are boys. This condition is termed the daytime frequency syndrome of childhood or Pollakiuria. The condition is functional no anatomic problem is detected. The symptoms occur often just before a child starts kindergarten or if the child is having emotional family stress-related problems. OCD is a chronically disabling illness characterized by repetitive, ritualistic behaviors over which the patient has little or no control. OCD has a lifetime prevalence of 1-3% worldwide, and as many as 80% of all cases have their onset in childhood and adolescence. The purpose of this study was to investigate the relationship between OCD and Pollakiuria.
Materials and Methods:In this case-control study, we evaluated (152) children aged 6-18 years old who were visited in the pediatric clinics of Amir-Kabir Hospital, Arak, Iran. The control group considered of (76) healthy children and the case group included (76) age and sex matched children with Pollakiuria. Then, the children’s behavioral status was evaluated using the children’s Yale-Brown Obsessive-Compulsive Scale (C-YBOCS). The C-YBOCS is helpful in identifying children with OCD. The data was analyzed using descriptive and analytical statistics in SPSS-16.
Results: OCD was detected in (5) case (6.6%) with Pollakiuria and (8) controls (10.5%). The difference in OCD was not significant (p-value 0.282) between the two groups.
Conclusion: OCD isn’t more common in Pollakiuria versus non-Pollakiuria children. It is recommended to conduct a study with higher sample volume in order to detect the relationship between OCD and Pollakiuria.
Mohammad Reza Arabestani, Mojtaba Rajabpour, Rasoul Yousefi Mashouf, Mohammad Yusef Alikhani, Seyed Masoud Mousavi,
Volume 17, Issue 11 (2-2015)
Abstract
Background: Pseudomonas aeruginosa is one of the most common nosocomial pathogens with high mortality rates. OprD is the major resistance mechanism to carbapeneme antibiotics. The aim of this study was to determine the expression of the genes encoding these efflux pumps using qRT-PCR.
Materials and Methods: This study examined 100 strains of Pseudomonas aeruginosa isolated from patients admitted to various hospitals in the Hamedan. Conventional phenotypic tests were used for identifying the 100 collected samples, then 31 samples were selected based on type of collected specimen and antibiotic susceptibility test i.e. antibiotic disk diffusion method performed for aminoglycoside, quinolone and carbapenem antibiotics. Furthermore, MIC method was performed for imipenem. Finally, RNA was extracted and converted to cDNA for determining the efflux pump genes expression using qRT-PCR.
Results: Among 8 selected antibiotics, the greatest resistance was for levofloxacin (61.2%, n=19) and the lowest one for imipenem (9.6%, n=3). The results of MIC were to imipenem 12 samples (38.7%) resistant, 13 samples (41.93%) intermediate, and 6 samples (19.35%) sensitive. The OprD gene was present in all strains but different expression has been observed. The strains with over expression of OprD gene showed high sensitivity towards carbapenems family antibiotics especially imipenem.
Conclusion: Identifying of bacterial resistance mechanisms is very complicated and extensive due to different mechanisms involved for similar antibiotics. OprD is main cause of attachment to the carbapenems family antibiotics. The more expression of OprD shows the more antibiotic sensitivity.
Farnaz Tajbakhsh, Farhad Mashayekhi, Zivar Salehi, Hamid Saidi Saedi, Mostafa Yousefi,
Volume 18, Issue 2 (5-2015)
Abstract
Background: Breast cancer is the most common cancer and one of the main causes of cancer-related death all over the world that has become a major public health concern. Human apurinic/apyrimidinic endonuclease (ApE1) is a multifunctional protein that has an important role in the base excision repair (BER) pathway. Single- nucleotide polymorphism T>G found in exon 5 led to substitution of Asp>Glu at codon 148 (Asp148Glu). In this case-control study, we aimed to evaluate the association of this polymorphism on the risk of breast cancer in Guilan population.
Materials and Methods: To study gene polymorphism APE1 (Case- Control), blood samples were collected from 75 patients diagnosed with breast cancer and 75 control subjects, and genotyped by allele-specific PCR (AS-PCR). To estimate the association between genotype and allele frequencies in cases and controls, Chi-Square analysis was used.
Results: Analysis revealed no significant differences were found in genotype and allele distributions of ApE1 Asp148Glu polymorphism between breast cancer patients and controls (p=0.1, p=0.6 respectively) in this population.
Conclusion: Data from this study indicated no significant association between the Asp148Glu polymorphism and breast cancer risk (p=0.1). Further study is needed to clarify the impact of Asp148Glu polymorphism on the breast cancer.
Mojtaba Hashemi, Javad Javaheri, Marjan Habibi, Parsa Yousefi Chaijan, Mahdyieh Naziri,
Volume 18, Issue 6 (9-2015)
Abstract
Background: The prevalence of constipation in childhood is 0.7% to 29.6%. Inorganic causes are considered as the most common cause of constipation in children. Polyethylene glycol (PEG) is the most effective and safest laxatives which is usable in children in the long-term. This study was conducted to evaluate and compare the effect of PEG treatment and probiotic bacilluscoagulans and bifidobacterium and probiotic to enhance the growth of probiotics.
Materials and Methods: In this double blind clinical trial study(interventional study), 120 children aged 2-16 years with chronic functional constipation enrolled the study based on ROME III criteria. The bowels became empty by using liquid paraffin. Then, children were randomly divided into three groups of polyethylene glycol+placebo and Probiotics+placebo and polyethylene glycol+probiotics recipients. After 6 weeks of treatment, treatment success rates between the three groups were compared before and after the study Data analyzed by SPSS 20 software.
Results: The results of the study conducted on the three groups for treatment of constipation showed that the effect of polyethylene glycol and probiotic on treatment was considerable before and after treatment but the levels of effect was similar in the comparison of groups. The simultaneous use of two drugs was more effective than a single drug.
Conclusion: Overall, the results of our study showed that concurrent use of polyethylene glycol and probiotics is much more effective in the treatment of constipation.
Ahmad Hamta, Maryam Yousefi, Masood Fazeli Mosleh Abadi, Afsaneh Talaei, Abdorrahim Sadeghi,
Volume 18, Issue 9 (12-2015)
Abstract
Background: Thyroid nodules are common. 4-7% of adults have a palpable nodule and up to 50-70% of nodules are detected in high-resolution sonography. Thyroid nodules in women are 4 times greater than men and the rate of thyroid cancer in women is 3:1 compared to men, and is the sixth most common cancer in women. Epidemiological findings and experimental evidences show that sex hormones, especially estrogen, may have effect on this gland and its neoplasm. The aim of this study was to investigate the association between rs1256049 polymorphism in the estrogen receptor beta gene with thyroid nodular disease.
Materials and Methods: In this case-control study, 146 Patients with nodular thyroid and 151 health individuals were referred to Amiralmomenin hospital of Arak were recruited in study. Diagnosis is based on by ultrasonography and was confirmed by an endocrinologist. Genomic DNA was extracted from EDTA treated whole blood .The genotypes were determined using tetra-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) and analyzed by statistical methods.
Results: The frequency of CC, TC and TT genotypes in case group 136(93.2%), 10(6.8%) and 0(0%) and in the control group 139(92.1%), 12(7.9%) and 0(0%) were obtained respectively. No statistically significant association (p=0.72) was observed between nodular thyroid disease and rs1256049 polymorphism.
Conclusion: Our findings showed no significant association between rs1256049 polymorphism and nodular thyroid disease. For best deduction, it is recommended that this study be done in other populations.
Saeid Amini Rarani, Ahmad Ghadami, Ali Akbar Malekirad, Hojatollah Yousefi, Kourosh Mani,
Volume 19, Issue 10 (1-2017)
Abstract
Abstract
Background: Operating room personnel are subject to occupational hazards which could lead to an increase in free radicals and develop various diseases. The aim of the present study was to determine the effect of consuming green tea on the improvement of the blood oxidative biomarkers in operating room personnel who are exposed to anesthetic gases.
Materials and Methods: This study was a before-after clinical trial which was conducted on 24 operating room personnel. They were invited to consume 4 cups of a green tea beverage, prepared from 3 g of green tea leaves in 300 mL of boiled water (at 80˚ C), daily for 8 weeks. Then, Myeloperoxidase (MPO), DNA damage, Glutathione Peroxidase (GPx), and Superoxide Dismutase (SOD) in the plasma were measured in order to evaluate the level of oxidative stress biomarkers before and after consuming green tea.
Results: Green tea consumption by operating room personnel brought about a significant increase in glutathione peroxidase and superoxide dismutase and a considerable decrease in myeloperoxidase and DNA damage.
Conclusion: According to the results of this study, green tea consumption as an antioxidant supplement by operating room personnel, who are regularly exposed to anesthetic gases, can minimize oxidative stress and DNA damage considerably. Thus, it is advisable for operating room personnel to consume green tea as a natural antioxidant supplement.
Azam Zarneshan, Mohammadreza Zolfaghari, Mahdia Gholamnejad, Mehdi Yousefi,
Volume 20, Issue 8 (11-2017)
Abstract
Abstract
Background: IL-4 plays a key role in the pathogenesis of asthma and the increased serum level of that is positively correlated with asthma severity and obesity. IL-4 induces IgE secretion by B cells. Previous studies suggesting an anti-inflammatory effect of exercise training on asthmatic lungs. The aim of the present study was to investigate the effect of 12 weeks of aerobic exercise training on serum levels of IL-4 and IgE in overweight and obese asthmatic women.
Materials and Methods: 21 overweight and obese asthmatic women were selected and divided into two groups including experimental (n=12) and control (n=9) groups. The experimental group performed aerobic exercise training, three times a week, 60 minutes each session. Fasting blood samples were collected before and 2 days after completion of the course. The data were analyzed by using SPSS22 software
Results: A significant decrease in serum IL-4 (p = 0.015, t = - 2.68), BMI (p = 0.014, t = - 2.72) and weight (p = 0.001, t = -3.99) was shown following the 12 weeks of training in the experimental group compared to the control group. There were no significant correlations between the obesity changes and the Inflammatory Marker Changes (p>0.05).
Conclusion: The present study indicates that aerobic exercise training reduced the serum levels of IL-4 independent of obesity changes in overweight and obese asthmatic women.
Masoud Rezagholizamenjany, Parsa Yousefichaijan,
Volume 21, Issue 7 (2-2019)
Abstract
Nephrotic syndrome
Nephrotic syndrome is a manifestation of glomerular disease as a proteinuria in the nephrotic and triad of hypoalbuminemia, edema, hyperlipidemia, and high protein in the urine. Nephrotic proteinuria is defined as protein excretion of more than 40 mg/m2 of body surface per hour or protein to creatinine ratio of more than 2-3 at the first morning urine sample. Its annual incidence in most western countries is 2-3 cases per 100000 children per year, and in developing countries it is often higher due to malaria (1). New findings in this area are often about treatment, which are evaluated and reviewed in following.
Homa Yousefie, Anahita Khodabakhshi-Koolaee, Mohammad Reza Falsafinejad,
Volume 22, Issue 6 (February & March 2020)
Abstract
Background and Aim: Currently, the prevalence of chronic kidney disease has increased for a variety of reasons. Renal diseases, followed by dialysis and kidney transplantation, can greatly affect the People's physical and mental health. Since most of previous studies have examined the physical and often preoperative problems of kidney transplant patients and many of them have used quantitative methods, the present study aimed to investigate the psychological challenges of renal disease patients after Kidney transplantation.
Methods & Materials: The study population consisted of kidney transplant patients referred to the Nephrology Clinic of Labafinejad Hospitalin Tehran, Iran in 2019 aged 35-50 years and 1-5 years had passed since their transplantation. A semi-structured in-depth interview was done for collecting information. A purposive sampling and continued until data saturation and until no themes were available. In the end, 15 patients were interviewed. Data analysis was performed by Colaizzi’s method.
Ethical Considerations: This study with a code of IR.IAU.SRE.1398.022 was approved by the Research Ethics Committee at Islamic Azad University, Science and Research Branch in Tehran, Iran.
Results: The primary themes were divided in to 3 main themes including: Concerns and psychologically disturbing feelings, emotional and spiritual support of the family, and uncertainty of receiving specialized, financial and welfare support.
Conclusion: Patients with kidney disease after transplantation surgery have psychological challenges in addition to physical problems that are of great importance to mental health professionals. Studying these challenges can provide a deeper understanding of their psychological problems and adaptation after surgery.
Naser Safdarian, Shadi Yousefian Dezfoulinejad,
Volume 23, Issue 2 (June & July 2020)
Abstract
Background and Aim: Breast cancer is the abnormal cell growth in the breast. In both benign and malignant masses, there is rapid and high cell growth. Nowadays, due to the development of technologies, the diagnosis of diseases has become non-invasive and physicians attempts to diagnose the disease without surgery and based on internal organ images.
Methods & Materials: In this study, by using images prepared from the Digital Database for Screening Mammography (DDSM), a new method is proposed for detecting cancerous masses in the mammographic images using geometric features extraction and optimization of Support Vector Machine (SVM) parameters to classify breast cancer masses automatically. First, images were pre-processed and then boundaries were determined using threshold method. Next, morphological operators were used to improve these boundaries and the segmentation of images was carried out to classify cancerous masses. Finally, by using the SVM parameter optimization method, Grasshopper Optimization Algorithm (GOA), and 4-fold crossvalidation method, data were classified into two groups of benign and malignant (cancer) masses.
Ethical Considerations Images from DDSM database were used in this research, all images are open access in this database.
Results: The accuracy, sensitivity and specificity values for applying the Radial Basis Function (RBF) kernel in SVM classifier (before optimization process) were obtained 97%, 100% and 96, respectively. After optimization of SVM parameters by the GOA, it was reported 100% for all accuracy, sensitivity and specificity indices for applying linear kernel function, indicating the high accuracy of the proposed method. The average values of accuracy, sensitivity and specificity indices for applying all three SVM kernel functions after optimization were 95.83, 100 and 94.81%, respectively.
Conclusion: The extracted geometrical features from breast cancer masses are highly efficient for model training and the diagnosis of breast cancer. The GOA could improve the overall accuracy of the proposed method by optimizing the SVM parameters. The results showed the higher performance of the proposed method compared to other methods.
Taha Fereydouni, Saeed Hajihashemi, Parsa Yousefichaijan, Ali Rahbari,
Volume 23, Issue 6 (February & March 2020)
Abstract
Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress is among f the major causes of nephrotoxicity and its progression. Deferasirox, due to oxidative stress and increased cell apoptosis causes the dysfunction of renal tubules and renal toxicity. According to its antioxidant and anti-inflammatory properties, the present study explored the effect of vitamin C on deferasirox-induced kidney damage.
Methods & Materials: This study was performed on 30 Wistar rats in 3 groups of control, deferasirox, and deferasirox plus vitamin C. To induce the nephrotoxicity, the intra-peritoneum injection of deferasirox (75 mg/kg/day) was used. After taking plasma from the blood samples of the explored rats, we determined the values of Cr, Na+, K+, Mg+, osmolality, and BUN in the obtained plasma and urine samples. The creatinine clearance, as well as the relative and absolute excretion of sodium and potassium, were also calculated. After separating the two kidneys, they were used for the histologic study with Hematoxylin and Eosin (H&E) staining, as well as Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP) biochemical studies.
Ethical Considerations This study was approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1396.309).
Results: Cotreatment with deferasirox and vitamin C reduced renal tissue MDA and relative and absolute Na and K excretion and urine osmolarity; this method also increased creatinine clearance and renal tissue FRAP.
Conclusion: The co-administration of vitamin C presented a significant protective effect on the renal toxicity induced by deferasirox. The protective property of deferasirox is because of the antioxidant impacts of vitamin C in reducing oxidative stress and lipid peroxidation.
Farnaz Ghorbani, Mostafa Ghandi, Navid Yousefi, Maryam Shokri Mojdeh,
Volume 25, Issue 6 (February & March 2023)
Abstract
Introduction: Dentists are at high risk for COVID19 disease and spreading it to colleagues, families and patients. The aim of this study was to evaluate COVID 19 epidemic anxiety among students and dental assistants of Qazvin University of Medical Sciences.
Methods: In this descriptive-Analytic cross-sectional study, 142 dental students who were willing to participate the study were surveyed. Data collection tools was included a demographic and Corona Disease Anxiety Scale (CDAS) questionnaire. After collecting information, each participant's anxiety score was measured from zero to 54. These raw scores were converted to standard T scores for comparability with other studies, and according to the scope of standard T studies, participants in one of three groups of no anxiety or mild (T≤ 39), moderate (60 ≤ T ≤ 40), And severe anxiety (T≥61), and then the data were analyzed with SPSS23 statistical software. Ethical code of this study is IR.QUMS.REC.1399.224 in Qazvin University of Medical Sciences.
Results: According to the results, the level of anxiety was higher in older age groups, among men against women, and among married against single people, respectively. Also, the level of anxiety caused by Coronaviruses pandemic was higher in undergraduate against postgraduate students. However, difference was not statistically significant (P <0.05).
Conclusions: Based on the study, it can be stated that the level of coronaviruses anxiety in dental students is mild. In these situation, measures to maintain the psychological health of students should be a necessity of the planning of the directors and professors of the dental school.
