Showing 37 results for Ebrahimi
Bakhtyar Tartibian, Bahman Ebrahimi Turkmani,
Volume 17, Issue 7 (10-2014)
Abstract
Background: The aim of this research was to determine the relationship between inflammatory markers (Fibrinogen, C-reactive protein (CRP) and Creatine kinase (CK)) and respiratory responses FEF25-75% (Forced expiratory flow in 25-75 percent) and FEV1 (Forced expiratory volume in one second) in 14-16 year’s Urmia city boys in response to an incremental physical activity.
Materials and Methods: The subjects were boys of 14-16 years among 24 healthy participants. These groups divided into two groups randomly, one group as trained one (n=12) and the othes as control group. Blood sample was taken in baseline and after Modified Balke Protocol in trained group, And the blood sampling was taken in baseline and 48 hours later in control group. respiratory responses were measured immediately after Modified Balke Protocol.
Results: CRP and Fibrinogen significantly increased in trained group (p<0.001) and this group had high level of these markers compared with control group (p<0.001). The association between CRP with FEF25-75% and fibrinogen with FEF %25-75 and CK with FEF 25-75% in trained group was significant (p&le0.05).
Conclusion: The results of this study show that incremental physical activity increased inflammatory factors in active children. Incremental exercise shows a strong relationship between some inflammatory markers and respiratory parameters in adolescents 14-16 years old.
Kaveh Sadeghi, Shahla Shahsavandi, Mohammad Majid Ebrahimi, Homayoon Mahravani, Hadi Fazel,
Volume 17, Issue 11 (2-2015)
Abstract
Background: The outbreaks of new antigenic variants of influenza viruses in human populations have increased necessity the improvement of controlling programs. Influenza vaccines are formulated with adjuvant to enhance and direct the host immune responses. Currently, much effort is devoted to designing molecular adjutants. Hemokinin-1 (HK-1) activates T and B cells for proliferation, survival, differentiation into plasma cells, and antibody production. In this study, the effect of HK-1 as a molecular adjuvant for inducing humoral immune response against influenza virus was investigated.
Materials and Methods: The HK-1 coding sequence was cloned into pcDNA3.1 vector and used as adjuvant. Groups of mice were immunized with an inactivated influenza vaccine formulated with HK-1. The sera of vaccinated mice were collected prior to priming and boosting injections and at defined weeks, and analyzed with serological assays.
Results: The results showed that HK-1 was able to increase antibody titer against virus vaccine. The mice immunized with the adjuvanted vaccine produced higher antibody titers against influenza comparing to vaccine alone immunized group. Number of boosting had no effect on the enhancing of antibody titer.
Conclusion: These data revealed that HK-1 as a molecular adjuvant induces stronger humoral and memory responses against influenza immunization.
Maryam Nafezi, Maryam Tajabadi Ebrahimi, Maryam Eidi,
Volume 18, Issue 8 (11-2015)
Abstract
Background: Aflatoxins are known as the most important toxins which their consumption could cause acute poisoning and create carcinogenic effects. Moreover, previous studies demonstrated the ability of lactic acid bacteria to connect to aflatoxin in food material. The aim of this study is to investigate the effect of the native probiotic Lactobacillus para casei strains TD3 against toxicity induced by aflatoxin B1 in vivo.
Materials and Methods: 24 wistar male rats (250±10 g) were divided into 3 groups including: one negative control group and two groups treated with aflatoxin (170 µg/kg) and Lactobacillus para casei strain TD3 isolated from Tarkhine with aflatoxin (109 cfu/day) for 4 weeks. At the end of the experiment, the blood and tissue samples were collected for histopathological and biochemical studies.
Results: The results indicated that treatment with Aflatoxin leads to a significant increase in the amount of liver enzymes such as AST, ALP and also liver damages. Furthermore, the group that received Lactobacillus para casei strain TD3, the level of these enzymes was reduced and liver damages due to aflatoxin were improved.
Conclusion: The present study showed that aflatoxin can lead to liver damages and native Lactobacillus para casei strain TD3 which isolated from Tarkhine, probably leads to protective effects by binding to aflatoxin. Thus, it is considered as a biologic agent to remove aflatoxin in vivo.
Nasrin Shahbazi, Hasan Khalaji, Mohsen Ebrahimi Monfared,
Volume 19, Issue 1 (4-2016)
Abstract
Background: studies in adults have shown that external focus of attention is better than internal focus in motor learning. So, the aim of this study is to evaluate the effects of focus of attention- self talk on balance of women with multiple sclerosis.
Materials and Methods: In this semi- experimental study, statistical population included women with MS referred to MS Society of Arak. Whereas balance disorder in patients was diagnosed by neurologyist, they were invited to the study. Patients were accidentally divided into 3 groups each of 15 concluding control, self tak-external focus of attention and self talk- internal focus of attention groups and were evaluated by Berg balance scale. 42 samples completed executive steps of study. ANOVA and Tukey tests were used to compare balance score between groups with significant level of less than 0.05. All patients practiced balance tasks for 9 days and then they were undergone post test.
Results: Balance was improved in all groups. Although the external- self talk group was better than the two other groups, there was no significant difference between external and internal- self talk groups.
Conclusion: The findings of this study showed the effect of practice on improvement of balance skill and superiority of the experimental groups in comparison with control group. Probably, focus of attention with self talk has effect on balance of women with MS.
Mohsen Ebrahimi Monfared, Keyvan Qasami, Ali Reza Rezaei Ashtiani, Elaheh Kazemeini,
Volume 19, Issue 2 (5-2016)
Abstract
Background: Migraine is one of the prevalent disabling disorders. Considering geographical differences in reported epidemiology and improving patients care, the aim of the present study was to evaluate epidemiologic, demographic and clinical characteristics in patients with migraine headache in Arak.
Materials and Methods: This cross sectional and descriptive study was conducted on patients with migraine headache referred to the neurology clinics of Vali-Asr and Imam Reza hospitals of Arak for 6 months. A questionnaire containing the demographic, epidemiologic and clinical data was filled by patients. Finally, data were analyzed using SPSS 18.
Results: Among 820 patients with headache, 92 (11.21%) subjects were confirmed to have migraine headaches. Of the 92 patients, 54.3% were women and 45.6% were men. The mean age was 36.9±9.2 years old and 50% were married. The most common migraine triggers were stress (78.2%), sleep disturbances (65.2%), and fatigue (63%). The mean frequency of headaches was 6.9±3.5 attacks per month with an average duration of 11.1±4.5 hours per attack.
Conclusion: According to our results, the prevalence of migraine in women is more than in men. Dizziness, visual disturbances, nausea, no aura, headache is one-sided and pulsating are significantly accompanied by migraine. The number of consumed sedative pills in the month, brain imaging and a monthly fee of headache were significant. In total, clinical characteristics of migraine headaches in our patients were nearly compatible with the International Headache Society (IHS) criteria.
Homa Dadgarnia, Zahra Hajebrahimi,
Volume 19, Issue 2 (5-2016)
Abstract
Background: Endothelial cells are very sensitive to mechanical force including microgravity and the morphological and functional changes in them are believed to be at the basis of weightlessness-induced cardiovascular deconditioning. It has been shown that the proliferation, migration, and morphological differentiation of endothelial cells play critical roles in angiogenesis. So far, the influence of microgravity on the ability of endothelial cells to foster angiogenesis remains to be explored in detail. The aim of this study was to investigate the effect of microgravity condition on VEGFR-2 and CD34 genes expression in human umbilical vein endothelial cells (HUVEC) in angiogenesis.
Materials and Methods: In this study, HUVEC cells were purchased from Pastor Institute. We used a clinostat to simulate microgravity condition for 2, 24 and 72 hours. Real time PCR technique was used for gene expression analysis after extraction of RNA from cells.
Results: Our results showed that microgravity for 72h leads to a significant increase (6 times compared with control group, p<0.001) in the VEGFR-2 gene expression. However, expression of CD34 did not change (p>0.05) with microgravity.
Conclusion: Based on the results, microgravity has positive effect on angiogenesis and can be used to generate vascules for cell therapy of ischemic diseases and atherosclerosis.
Bahman Salehi, Shirin Moradi, Somayeh Ebrahimi, Mohammad Rafiei,
Volume 19, Issue 4 (7-2016)
Abstract
Background: Boredom is a psychological phenomenon that was defined as an aversive state or incompatibility with every repetitive experience while the release of stability is not allowed. Boredom has several complications. So, the goal of this study is to compare the predictors of boredom in students of Arak University of medical sciences and Islamic Azad University.
Materials and Methods: The current descriptive-comparative study has been done on966 students (from Arak University of medical sciences and Islamic Azad University). The scale of current study was a checklist list of demographic information, predictors of boredom assess questionnaire, Farmer and Sundberg’boredom proneness scale. Data were analyzed by using chi-square, Pearson correlation, multivariate regression, and Fisher'sz.
Results: The greatest number of students from both universities have normal boredom without a statistically significant difference between male and female students (p=0.06). University factor had the highest average between students. Totally, boredom had a significant correlation with each of the home (p=0.000) and society (p=0.001) factors. All three factors including home (p=0.033), university (p=0.033) and society (p=0.031) can explain and predict boredom in male and female students.
Conclusion: The results showed that university factor was the most important factor for predicting boredom between college students. Thus, in order to avoid adverse effects of boredom on students educational activities, this phenomenon and its causes should be considered.
Azam Fakhri, Soyar Sari, Ahmad Ebrahimi,
Volume 19, Issue 5 (8-2016)
Abstract
Background: Endometriosis disease is considered as a common disease dependent on androgen hormones. Androgens have different effects on endometrial growth. Androgen receptor as a signal transduction pathway could have a key role in regulating the process. Over hundreds of mutations leading to resistance gene function in androgen receptor (AR) has been recorded. Among these, the seuaence of CAG repeat in exon 1 had the largest share of studies related to the disease. The aim of the present study was to investigate the relationship between the AR gene CAG repeat variations in Iranian women with endometriosis.
Materials and Methods: In this study, 100 women with endometriosis and 100 healthy women as controls were selected. Exon 1 was amplified using PCR. Products of PCR were studied to determine CAG repeat variation in acrylamide gels.
Results: The number of CAG repeats in each group was determined between 18-26 repeats (mean±standard, 18.35±3.3).
Conclusion: According to the results of this study, no significant differences were found between the two groups of healthy women and women with endometriosis. The number of CAG repeats in each group was determined between 18-26 repeats which indicates a lack of relationship between CAG repeat diversity and endometriosis. According to the information, this study was conducted on patients with endometriosis in iran for the first time, although studies with larger sample are needed.
Nasim Ebrahimi, Sadegh Vallian Borujeni,
Volume 19, Issue 6 (9-2016)
Abstract
Background: Niemann-Pick disease (NPD) refers to a group of lysosomal storage diseases that causes abnormal metabolism of lipids. One of the genes that play a role in the pathogenesis of this disease is SMPD1. To date, more than hundred disease- causing mutations have been identified in SMPD1 gene. Due to the large number of mutations in this gene, direct analysis of the mutations is costly and time-consuming. Therefore, indirect linkage analysis using polymorphic markers as an alternative method for molecular diagnosis of the mutations has been recommended. In the present study, allele frequency of rs1542705 genetic marker was analyzed in the Iranian population. The aim was to determine the polymorphic information content (PIC) and the possibility of its application in indirect diagnosing of NPD.
Materials and Methods: After bioinformatics analysis of the SMPD1 gene region, rs1542705 marker was selected for genotyping in Isfahan population. In order to calculate the allele and genotype frequency of the marker, molecular tests were done on 113 DNA samples of unrelated healthy individuals by using ARMS-PCR technique. Finally, the information related to the genotype of the individuals was statistically analyzed using Powermarker and Genepop software.
Results: The analyses showed that the studied population was in accordance with Hardy-Weinberg equilibrium. Allele frequency of rs1542705 marker for T and C alleles was 71.24% and 28.76%, respectively, and the heterozygosity of the marker was 43.36%. Also, polymorphic information content (PIC) was 0.325.
Conclusion: The results of this study showed that rs1542705 marker could be considered as an informative marker for molecular diagnosis of Niemann- Pick disease using linkage analysis in the studied population.
Mohsen Ebrahimi Monfared, Mehdi Sadegh, Zahra Gohari,
Volume 19, Issue 12 (3-2017)
Abstract
Abstract
Background: Melatonin regulates the sleep-wake cycle and is protected against oxidants. Vitamin E has antioxidant effect. The aim of this study was to investigate effect of melatonin and/or vitamin E on the EEG, sleep quality and quality of life of female nurses working in hospitals in Arak.
Materials and Methods: 60 female nurses were randomly selected from hospitals in the Arak city. Participants divided into three groups (melatonin3 mg/day, vitamin E 200 IU/day and melatonin and vitamin E groups) and a control group. Before and two months after the baseline, PSQTI and the quality of life of 26 questions questionnaire were completed and EEG was recorded. Finally, the findings for both groups before and after the intervention were compared with each other.
Results: The average of sleep quality showed an improvement in groups receiving melatonin and melatonin+vitamin E (p>0.05). While data of life quality did not show any significant change between groups. In EEG activity, α waves in the range of 8-10 Hz showed maximum increase in melatonin group and minimum increase in vitamin E group. Also, α wave in the range of 10-12 Hz revealed the most decrease in the melatonin group.
Conclusion: It seems simultaneous administration of melatonin and vitamin E is able to improve sleep quality. In addition, melatonin could improve alpha-waves of brain activity.
Paria Nikpey, Tahereh Nazari, Shadi Khalili, Ahmad Ebrahimi,
Volume 20, Issue 4 (7-2017)
Abstract
Abstract
Background: Uterine myomas are benign tumors of the uterus which are derived from smooth muscle cells of the myometrium. Genetic factors play a major role in the progression of the disease. One of the most important genes which have impression in the mechanism of formation of the myoma is epidermal growth factor receptor (EGFR) that plays a basic role in the process of cell growth, differentiation, proliferation and mitogenesis. The aim of this study is survey of EGFR gene common mutations in Iranian women with uterine myomas. In this test, the common mutations of the exon 21 and 19 in the EGFR gene were surveyed.
Materials and Methods: In this case-control study, 80 women with myoma and 80 healthy women were studied as control. For checking deletion mutation of the Exon 19 (rs121913438), the Tetra ARMS/PCR method has been used and also for checking point mutation of the exon 21(rs121434568), the ARMS/PCR method has been used and results of the experiments were analyzed via χ 2 test.
Results: The comparison of the genotypes frequency of exon 21 (TT, TG, GG) and exon 19 (WW, WD, DD) related to EGFR gene in two groups of patients and control with using statistical test respectively represents the significant difference (p=1.320e-16) and (p=3.053e-13) in the different genotypes frequency among the patients and control groups.
Conclusion: The results of research indicate a significant relationship between EGFR gene mutations in exon 19 and exon 21 and potential for myoma in the studied population.
Zahra Sadeghi, Ahmad Ebrahimi, Fatemeh Davari Tanha, Sayed Yousef Seyedena,
Volume 20, Issue 7 (10-2017)
Abstract
Abstract
Background: Ectopic pregnancy is a type of pregnancy in which implantation of zygote occurs out of the uterine cavity. One of the most important problems is bleeding. On the other hand, Plasminogen Activator Inhibitor-1(PAI-1) gene is one of the involved factors in unsuccessful pregnancies, and 4G/5G polymorphism is the most common changes of this gene. So, it is important to study the prevalence of these changes in this gene in women with ectopic pregnancy.
Materials and Methods: In this case-control study, 100 Iranian women with ectopic pregnancy and 101 Iranian women with the normal pregnancy were selected. After blood sampling, ARMS PCR method has been used for detection 4G/5G polymorphism and data were analyzed by statistical analysis.
Results: In this study, 4G allele with 70.79% prevalence and 5G allele with 63.5% prevalence are the most common alleles for the control and case group, respectively. 4G/4G and 4G/5G genotypes in the control group and 4G/5G and 5G/5G genotypes in the case group are prevalent. An Armitage test found p<0.05 for both alleles, showing 4G allele (p= 1.524e-10; OR= 0.262) has decreasing effect and 5G allele (p= 1.524e-10; OR= 3.822) has increasing effect in ectopic pregnancy.
Conclusion: According to the findings, 5G allele and 4G/5G and 5G/5G genotypes have increasing effect, 4G allele and 4G/4G genotype have decreasing effect in ectopic pregnancy. So, we could consider 5G allele as a risk factor of ectopic pregnancy in this study.
Shahla Shahsavandi, Mohammad Majid Ebrahimi, Mohammad Reza Samiee,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: The inactivated vaccines are formulated with adjuvant to direct the host immune responses and also increase stability of the antigen. In recent years, the development of biological adjuvants and the evaluation of their ability in elicitation of immune responses against influenza virus have been considered. Hemokinin-1 (HK-1) activates T and B cells for differentiation into plasma cells, and antibody production. In this study, the effect of HK-1 for inducing humoral immune response against influenza chitosan based-nano vaccine was investigated.
Materials and Methods: Chitosan nanoparticle containing inactivated influenza antigen and chitosan nanoparticle containing the inactivated antigen formulated with HK-1 were prepared. Immune response following influenza nanoparticles vaccinations with and without the adjuvant was assessed in SPF chickens after prime and boost immunizations. Specific antibody levels against influenza were evaluated in serum samples of treatment and control groups by serological tests.
Findings: The chickens immunized with the HK-1 adjuvanted nano vaccine produced higher specific antibody titers that were sustained until the end of experiment comparable either with inactivated antigen alone or the H9N2 nanoparticles without HK-1 adjuvant. Administration of boosting had no effect on the enhancing of antibody titer.
Conclusion: The data show that the chitosan nanoparticles provide better absorption conditions and more stability and release of the influenza antigen in the presence of HK-1 biological adjuvant.
Reyhaneh Khoshchehreh, Mehdi Totonchi, Hossein Baharvand, Marzieh Ebrahimi,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: There is increasing evidence that cancer cells in addition to multiple genetic mutations, also acquire epigenetic abnormalities during development, maintenance, and progression. By utilizing the reprogramming technology as a tool to introduce the ‘pressure’ to alter epigenetic regulations, we might be able to clarify the epigenetic behavior that is unique to cancer cells. So far, iPSCs have been generated from normal primary cells, but it is unclear whether human primary cancer cell can be reprogrammed. We investigated the production of the iPS cells from the pancreatic adenocarcinoma cells using defined transcription factors.
Materials and Methods: We sought to reprogram patient derived xenograft from human PDAC, by introducing lentiviral mediated induction of Yamanaka Factors (OSKM) and characterized of induced cells by Alkaline Phosphatase staining, Real-Time PCR and immunostaining.
Ethical Considerations: This study with research ethics code EC/93/1025 has been approved by research ethics committee at Royan Institute.
Findings: Alkaline Phosphatase staining, Real-Time PCR and immunostaining showed that induction with the OSKM results in generating iPS cell line from fibroblast cells but not from PDAC PDX cells .We showed that, PDAC cells could not fully reprogrammed by the expression of 4 transcription factors.
Conclusion: This study demonstrated that the PDAC-PDX cancer cells were distinct from PDAC induced cells with regard to their epigenetic modifier genes expression pattern, although the expression of pluripotency genes did not increased significantly in the induced PDAC cells.
Anahita Khodabakhshi-Koolaee, Mohammad Pourebrahimi,
Volume 23, Issue 3 (August & September 2020)
Abstract
Background and Aim: Myasthenia Gravis (MG) is a neuromuscular disorder and auto-immune disease that is associated with symptoms of fluctuating muscle fatigue and dysfunction of the neuromuscular junction system. This disease greatly affects various aspects of the patient's life and impacts the person's perception of the quality of life. The aim of this study was to explain and analyze life experiences with myasthenia gravis disease in a young girl.
Methods & Materials: This report is a qualitative case with interpretive phenomenological approach that examines the life experiences of a young girl with myasthenia gravis in 2019. Data were collected through semi-structured interviews and analyzed using Van Manen's phenomenological approach.
Ethical Considerations: This study was registered in the Research Ethics Committee of Khatam University (Code: 3299/100/P/98).
Results: Thematic analysis indicated that myasthenia gravis disease affects all aspects of person's life world. These four aspects include living and feelings with time, body, space, and others. Eventually, three interrelated themes emerged from the patient's perception of the world around her, including physical weakness, future ambiguity, and frustration.
Conclusion: The present study shows a clear image and understanding of the problems of living with MG in a young girl. The phenomenological world of mixed by physical weakness, ambiguity in the future, and frustration that indicating the suffering and distress that the patient experiences following the illness. The results of this study contribute to the awareness of health and rehabilitation specialists in the field of work and research in myasthenia gravis as a neurological disease.
Leila Dehghan, Hamid Dalvand, Sadegh Samadi, Mohsen Ebrahimi Monfared, Fatemeh Rafiei,
Volume 23, Issue 4 (October & November 2020)
Abstract
Background and Aim: Musculoskeletal disorders are mainly prevalent among college students who experience direct contact with patients. This study aimed to determine the prevalence of musculoskeletal pains among Rehabilitation, Dentistry, and Nursing students at Arak University of Medical Sciences in 2017-2018.
Methods & Materials: In this cross-sectional descriptive study, 538 students of Arak University of Medical Sciences were recruited using the convenience sampling approach. Variables included age, sex, body mass index, study field, hours of using smartphone per day, and nine symptom sites being neck, shoulders, upper back, elbows, low back, wrist/hands, hips/thighs, knees, and ankles/feet. The researchers assessed the musculoskeletal pain by using the Nordic questionnaire and demographic questionnaire. Statistical analysis was performed using SPSS V. 18.
Ethical Considerations: The Research Ethics Committee of Arak University of Medical Sciences approved this study (Code: IR.ARAKMU.REC.1397.253).
Results: In this study, 538 students (205 males and 333 females) were studied with Mean±SD age of 22.04±2.53 years old. The results showed that the prevalence of musculoskeletal pain in the spine (neck 29.4%, upper 24.3%, and lower back 37.2%) was higher than in upper and lower extremities. Musculoskeletal pain in the shoulder, upper, lower back, and thigh were significantly different based on sex. Also, musculoskeletal pain in the neck and ankle, and foot were significantly different based on age (P<0.05). There was a significant difference between musculoskeletal pain of back and ankle based on smartphone use hours per day.
Conclusion: This study suggested that rehabilitation, nursing, and dentistry students are at risk for musculoskeletal pain, especially in the lumbar, cervical, and upper back.
Farzaneh Hajizadeh, Fatemeh Ebrahimi, Seyed Zia Tabatabaei,
Volume 25, Issue 3 (August & September 2022)
Abstract
Background and Aim The early years of life are the most critical stage in the growth and development of children. While the optimal development of children depends on a complex set of factors, the pattern of breastfeeding and complementary feeding of infants is of undeniable importance. Therefore, the present study conducted to investigate the factors related to the feeding patterns of one-year-old children referred to healthcare centers in Rafsanjan city.
Methods & Materials his descriptive study was performed on 600 mothers with one-year-old children under the auspices of healthcare centers in Rafsanjan city in 2017. Volunteered mothers with active health records were selected randomly. The required information was collected through a questionnaire containing demographic characteristics and questions related to the feeding of children and was analyzed by SPSS software, version 18.
Ethical Considerations The Ethics Committee of Rafsanjan University of Medical Sciences (RUMS) approved the present study (Code: IR.RUMS.REC.1396.179).
Results About 95% of mothers participating in this study started breastfeeding their children up to one hour after delivery, but 56.7% of them completed breastfeeding by one year of age. The results show that most mothers had started supplemental feeding with two or three spoons in each meal, and about 90% of them followed the health worker's advice. Also, the most important reasons for feeding children with powdered milk are disorders in the child's development (34%), inadequate breast milk (17%), maternal disease (14%), do not take the mother's breast (11%) and children being twins (8%).
Conclusion Despite face-to-face training for mothers in health care centers for feeding their children, still there are some difficulties in commencing complementary feeding and its continuation. Therefore, need for more health and nutrition education regarding the best ways for feeding children to mothers by personnel of Rafsanjan health care centers.
Mr Fathollah Ghorbani, Mohammad Rezaei, Dr Ebrahim Ebrahimi, Mis Lila Ghorbani, Dr Elham Rezaei,
Volume 25, Issue 5 (December & January 2022)
Abstract
Introduction: Beyond the members of the charter board, the horizon of Amedwar Kanandah for the sake of Bimaran Niyazmand, the member of the board of the board. In parallel, there is a new medical science in New Mutrah, in the opinion of specialists who claim that it is a model and that they have a source for beyond the organs with children. Definitively The current issue is that of new topics and the question of programs in the possession of jurisprudence and rights, which must be carefully selected from the angles that are the subject of jurisprudence debate.
Methods: This is a book in the form of a textbook and a description - an analysis with the use of the books of science and jurisprudence of his room.
Results: This type of child is based on the basis of investigations, which are believed to be valid, according to the permissibility of the organs that are nozadan with severe cranial defects, i.e., in the womb of a mother, or from a cutaneous period, but from birth in the middle of my heart; A defensible issue.
Conclusions: The use of the nostril organs affected by the cornea with limitations of the cervical spine, but with a significant meaning in the development of Rastafarian, and the use of non-main organs based on multiple rational and legal evidences; Milabashed project. The parts of my life are afflicted with severe corneal ulcers, based on the inevitability and inevitability of the disease, and the reason for the fact that the situation is similar to the meaning of the disease. Develop a legitimate development in the most vigorous manner, and the issue of the necessity of preserving human dignity This is an issue that cannot be denied. But from the point of view of the role that is not a conditional legality, it is a present issue with conditional auspices in no severe form.
Dr Abbas Saremi, Dr Mohammad Parastesh, Dr Sahar Ebrahimi,
Volume 25, Issue 6 (February & March 2023)
Abstract
Introduction: Physical activity is one of the important lifestyle factors that can have positive or negative effects on the reproductive system, and more research is needed to reflect the effect of inactivity on fertility in order to provide safe lifestyle recommendations to help couples achieve pregnancy is required. Therefore, this study was conducted with the aim of describing and comparing the physical activity status of fertile and infertile men in Arak city in 2022.
Methods: The present study is a case-control study that was conducted on 220 fertile and infertile men (22 to 40 years old) referred to Arak University Jihad infertility centers that were selected through available sampling. Participants completed self-test questionnaires on socio-demographic characteristics, lifestyle, physical activity, and sedentary behaviors. Anthropometric characteristics and body composition were also measured. Multivariate logistic regression was used to analyze the association of infertility with physical activity level, sedentary behavior, and body composition.
Ethical Considerations: This study was approved by the Ethics Committee of the University of Arak University (Code: IR.ARAKMU.REC.1401.046).
Ethical Considerations: The present research has been registered with the code IR.ARAKU.REC.1401.015 in the Ethics Committee of Arak University.
Results: In this study, it was observed that the amount of physical activity (P=0.02) and body composition (P=0.001) in fertile men is more favorable than infertile men. In men with a low level of physical activity, the risk of infertility increases 2.97 times (odds ratio 2.97 and 95% CI: 1.03, 8.61, and P=0.04). On the other hand, in men with moderate level of physical activity, the risk of infertility decreases (odds ratio 0.27 and 95% CI: 0.08, 0.92, and P=0.03). Also, in men who sit for more than 6 hours a day, the chance of infertility increases by 3.02 times (odds ratio 3.02 and 95% CI: 1.28, 7.10, and P=0.01). An increase in body mass index increases the risk of infertility by 1.61 times in men (odds ratio 1.61 and 95% CI: 1.23 and 2.11 and P=0.001).
Conclusions: Since obesity, physical inactivity and infertility in Iranian men are increasing at the same time, so there should be more focus and seriousness on the issue of lifestyle modification and especially physical activity regarding reproductive health.
Dr. Maryam Arabloei Sani, Dr. Zahra Hajebrahimi, Dr. Parichehreh Yaghmaei, Dr. Nasim Hayati Roodbari,
Volume 26, Issue 5 (December & January 2023)
Abstract
Background and Aim: Diabetes is a type of metabolic disease and one of the most common endocrine diseases. Oxidative stress and inflammation play an important role in the development and progression of diabetes. mTOR signaling pathway play an important role in glucose homeostasis and proliferation of pancreatic beta cells. In the present study, the therapeutic effects of p-cymene on oxidative stress markers and expression of the mTOR gene in diabetic male Wistar rats were investigated.
Materials and Methods: Diabetes was induced by injecting 55 mg/kg body weight of streptozotocin. Biochemical analyses of pancreatic tissue and real-time PCR were done to investigate the effects of metformin (55 mg/kg body weight) and p-cymene (25, 50, and 100 mg/kg body weight) on the activities of catalase and glutathione peroxidase enzymes and mTOR gene expression.
Findings: Streptozotocin decreased catalase and glutathione peroxidase enzymes and decreased the expression of the mTOR gene in pancreatic tissue. Treatment with metformin or p-cymene improved the activities of catalase and glutathione peroxidase enzymes and the expression of the mTOR gene in a dose-independent manner.
Conclusion: Results indicate that p-cymene has antioxidant properties and can regulate the mTOR signaling pathway. Therefore, p-cymene may be effective for the treatment of diabetes alone or in combination with metformin.
