Showing 37 results for Trans
Mahdieh Mondanizadeh, Ghasem Mosayebi, Ehsan Arefian, Massoud Saidijam, Behzad Khansarinejad,
Volume 17, Issue 2 (5-2014)
Abstract
Background: Although miR-124 molecule has been known as an inducer of neurogenesis, few researches have been done on the targets of this molecule and its functional mechanisms in differentiation toward neurons and maintaining neuronal state. The microarray technique has been established as the reference method for studying the genes under the control of miRNAs. However, the high cost of this method has hampered its use in most research centers. On the other hand, the improvement of bioinformatical algorithms and computer modeling systems has led to the development of the bioinformatical softwares that can predict mRNA targets for miRNAs. Therefore, the aim of this theoretical study was to bioinformatically evaluate the effect of miR-124 on transcription factors that can be involved in neurogenesis and neuronal cell amplification, by using various specific softwares. Materials and Methods: Using different algorithms in TargetScan, DIANA and miRWalk databases, the potential transcription factors targets of miR-124 were identified. Then, a score table was prepared from the candidate genes, based on the affinity of the seed region of miR-124 and the number of targets in the 3`-UTR region of transcription factors. Finally, transcription factors with higher scores were chosen as candidates for practical analysis.
Results: The results of bioinformaical analysis showed that the LAMC1, ITGB1, PTBP1, SOX9, SP1, and EFNB1 molecules are the most potential factors that might be affected by miR-124 during neurogenesis.
Conclusion: It seems that transcription factor SP1 is under the control of the miR-124 and plays a crucial role in neurogenesis process. Therefore, this protein can be considered as a suitable new candidate for experimental evaluation.
Saeid Moosavipour, Mahboobeh Sadat Alhoseyni , Seyed Reza Mir Mahdi,
Volume 17, Issue 10 (1-2015)
Abstract
Background: According to the Erikson`s generativity vs staqnation theory this study examines the impact of old women transition experiences on depression, feel aging and physical changes in rehabilitation institute of charity in Arak.
Materials and Methods: In this quasi- experimental study, 30 elderly women living in nursing homes aged over 65 years and tested geriatric depression score of 9 and above earned were selected and randomly divided into two groups of 15 people .one group was selected as control and the other test group. Questionnaires included: geriatric depression questionnaire, feel Aging questionnaire and physical changes. program experience with that already was set to be repeated during ten sessions on group test. finally independent and paired t-test were used for statistical analysis.
Results: Although ten sessions to transfer the experience were able aging feeling and depressed elderly women reduce but the decrease was not significant between the test and control groups, as well as reduced physical changes between test and control groups were not significant.
Conclusion: The lack of suitable components severely needed to establish an effective interaction model for hinder the effectiveness of the meetings was to conduct experiments requiring more study.
Azita Mohsennejad, Mahboobeh Khorsandi, Nasrin Roozbahani, Babak Eshrati,
Volume 19, Issue 1 (4-2016)
Abstract
Background: Improvement of nutrition like fish and sea products is influential in preventing from non-contagious diseases. The transtheoretical model is one of the models for effective investigation on nutrition behaviors. This study was done with the aim of investigating fish consumption among women 30 to 50 years old based on the transtheoretical model.
Materials and Methods: This study was an analytical and cross sectional analysis which was conducted in 2014 on 360 women 30 to 50 years in Arak city. The data have been collected by using researcher-made questionnaires which its validity and reliability was assessed in accordance to the transtheoretical model were obtained by visiting houses. Then the collected data were analyzed by pearson correlation test.
Results: The average age of the respondents was 39.34±7.5. The average of fish consumption was 0.62 ±0.83 times a week. 64 % of people in consumption of at least two servings of fish a week were in the two first stages of change (pre-contemplation and contemplation).The average score of self-efficacy in fish consumption was a total of 10.58 ±3.12 out of 15 and the average score of cons of fish was 26.35 ±4.78 and the average score of pros of fish was 21.6 ±2.67 out of 25. Pearson correlation indicates that the amount of fish consumption with constructs of the self-efficacy, stages of change and pros of fish had respectively the most positive correlation (p≤0.05). Fish consumption had no significant difference with age, education, Body Mass Index, occupation, monthly income and marital status.
Conclusion: Fish consumption despite its high level of perceived benefits is really low and to eliminate these barriers, education and cultural-building especially in women who are influential people in family nutrition is necessary.
Bahloul Ghorbanian,
Volume 19, Issue 5 (8-2016)
Abstract
Background: The study on rats showed that some of cytokines and proteins which were produced by macrophages and other cells, plays a critical role in regulating of ABCA1 expression. But, in this area, the study in human subjects, especially subsequent physical activity has not performed. The purpose of this study was to investigate the relationship between lymphocytic ABCA1 protein with IL-10 and TNF-α cyrokines subsequent eight weeks interval combined exercise training (ICET) among overweight and obese boy adolescents.
Materials and Methods: In this semi-experimental study, 28 students (16.93±1.89 yr, 88.07±9.98 kg and 28.35±2.55 kg/m²) were randomly selected and assigned into training (n=13) and control (n=15) groups. Exercise protocol was ICET (8WK, 4 d/wk, 70 min/d).Cell hemolysis and sensitive Elisa method was used for evaluating ABAC1 protein T-student tests and Pearson correlation were used to analyze the data.
Results: The survey changes of post to pre-test of ABCA1, IL-10 and TNF-α showed that there was a positive significant correlation between lymphocytic ABCA1 protein with IL-10 (r=0.43, p=0.032) and a negative significant correlation with TNF-α (r=-0.53, p=0.012) (p<0.01) after eight weeks training. Also, after exercise, ABCA1 level was significantly increased but the levels of in creased IL10 and decreased TNF-α were not significant.
Conclusion: Due to the increased lymphocytic ABCA1 protein concentration and the correlation between variables following training, the results prove that TNF-α and IL-10 may have negative and positive regulatory effects on lymphocytic ABCA1 protein expression, respectively.
Nushin Rezaee Vandchali, Mojtaba Fathi, Ali Koolivand, Sheida Malekafzali, Farideh Jalali Mashayekhi,
Volume 19, Issue 10 (1-2017)
Abstract
Abstract
Background: Human exposure to air pollution is associated with an increased risk of diseases such as heart failure, asthma and cancer. It has been suggested that oxidative stress is involved in air pollution-induced disorders. Recently, γ-glutamyltransferase (GGT) is known as a marker of oxidative stress. This study was aimed to evaluate the effect of exposure to outdoor air pollution on enzyme activity of GGT and also usage of GGT serum level as a marker for studying of harmful effects of air pollution in the resident with high air pollution level.
Materials and Methods: In this analytical cross-sectional study, 110 healthy adult men, never-smoking, who worked in an area with high air pollution and 90 men who worked in an area with low air pollution, as control group, were enrolled. All subjects were in the age range of 25-45 years with minimum work history of three years. The GGT activity in the serum samples was determined using a spectrophotometric method.
Results: Our results showed that the serum levels of GGT in the subjects in the areas with high air pollution (33.92 ± 1.61 U/L) did not differ significantly with those of control region (33.62 ± 1.74 U/L).
Conclusion: Overall, this study did not support the hypothesis that GGT enzyme could be considered as an oxidative stress marker following exposure to outdoor air pollution. Further studies with a larger sample sizes and also trials in other areas are required to confirm these results.
Mojtaba Khansooz, Bahram Abedi, Mehdi Moradi, Abbas Mehranpour,
Volume 19, Issue 12 (3-2017)
Abstract
Abstract
Background: The aim of this study was to investigate the acute effect of supplementation Jadvar on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes after exhaustive incremental exercise in men's handball.
Materials and Methods: In this semi-experimental double blinded study 12 handball players with at least 2 years record in league (with average age=21.42, height=186cm, weight=83.25, and body mass index=24.09kg/m2) divided into 2 groups (n=6) accidentally. Both groups performed maximum Bruce protocol until exhausting level. Before (fasting) and after performing protocol ,blood samples were taken from middle forearm vein and transferred to lab then supplementation group consumed three 500 mg jadvar capsules and control group consumed three 500 mg maltodextrin for 7 days daily. 24 hours after eating last capsule ,they performed maximum Bruce protocol up to exhausting level and the samples were collected like primary protocol blood samples before (fasting)and after performing protocol and were transferred to the laboratory.
Results: The results of dependent and independent t-test showed that consuming jadvar supplements for 7days did not have significant effect on aspartate aminotransferase(AST) and alanine aminotransferase(ALT)(p≥0.05).But alanine aminotransferase in supplementation group (16.83 mg.dl-1) decreased in comparison to placebo group (20.5 mg.dl-1). Also, aspartate aminotransferase was increased from 28 mg.dl-1 to 35.17 mg.dl-1 , but neither decrease nor increase was not meaningful (p≥0.05).
Conclusion: It seems that acute consuming of jadvar supplement and one session incremental exercise does not have meaningful effect on AST and ALT in man handball players.
Homeyra Akbarzadeh, Abbas Alipour, Abolfazl Firuozian, Hadi Darvishi Khezri, Ghahraman Mahmoudi,
Volume 19, Issue 12 (3-2017)
Abstract
Abstract
Background: Ventilator-associated pneumonia (VAP) is one of the most important causes of mortality in intubated traumatic patients admitted in ICU. The aim of current study was to determine correlation between blood products transfusion with incidence of VAP in traumatic patients under mechanical ventilation in ICU.
Materials and Methods: This study was a prospective descriptive-analytical study. Current study was carried out on traumatic patients under mechanical ventilation admitted to Imam Khomeini hospital ICU wards of Sari city, from September 2015 to September 2016. In addition to demographic data, patients' clinical information were daily recorded.
Results: Of total of 2304 patients admitted to ICU, 186 traumatic patients under mechanical ventilation longer than 48 hours were reviewed and analyzed. Among patients infected with VAP, 36 persons(87.8%) had transfusion of blood products before VAP incidence. Blood products transfusion (before and / or after 48 hours) had the highest adjusted risk ratio in the incidence of VAP (Odds ratio; OR=3.58). Also, amount of injected Packed Red Blood Cells and platelet were significantly higher in patients infected with VAP (p<0.005).
Conclusion: Considering remarkable increase in incidence of VAP following blood products transfusion and its correlation with injected PRBC and platelet, considering these modifiable risk factors for controlling and preventing the incidence of VAP in traumatic patients under mechanical ventilation in ICU is necessary and reasonable.
Mahbobe Ebadi, Fatemeh Hoseini, Fateme Pahlevan, Mohammad Esmaeilzade Akhoundi, Vahid Farhadi, Roqaye Asqari,
Volume 20, Issue 5 (8-2017)
Abstract
Abstract
Background: The aim of this study was to evaluate the effectiveness of of transcranial direct current stimulation (tDCS) on working memory in patients with major depression.
Materials and Methods: The research method was quasi-experimental with pretest and post-test and follow-up with control group. The research population comprised female outpatient referrals to private psychiatric centers and psychological counseling centers in Tehran in the first half of 2016, They had received a diagnosis of depression by a psychiatrist at least once. Of these, 30 females were selected as a sample group with convenience sampling method and based on the criteria of inclusion and exclusion and were divided randomly into two groups , experimental (n = 15) and control (n = 15) group. The experimental group received transcranial direct current stimulation (tDCS) in 10 sessions, While this intervention was not provided to the control group. The data were collected by N-BACK. Analysis of variance with repeated measurments was used to test the research hypothesis.
Results: The results showed that transcranial direct current stimulation (tDCS) had a significant effect on increasing working memory and the impact will continue to follow up.
Conclusion: Therefore, this approach can be used to improve working memory in people with major depression.
Majid Amiri Motlagh, Mohammad Ali Atlasi, Zeinab Vahidinia, Sayyed Alireza Talaei, Zeinab Rezazadeh Lavaf, Abolfazl Azami Tameh,
Volume 20, Issue 5 (8-2017)
Abstract
Abstract
Background: Glutamate is the most widespread excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays major role in the pathogenesis of ischemia brain injury.Glutamate transporters have a major role in glutamate removal and maintain its concentration below excitotoxic levels. Although estrogen’s and progesterone’s neuroprotective effects were well-described, the exact molecular mechanism has yet to be determined. This study has investigated estrogen and progesterone effect on glutamate transporters expression in the ischemic penumbra/peri-infarct region in rat.
Materials and Methods: Adult male Wistar rats were subjected to transient middle cerebral artery occlusion (tMCAO) for 1 h. Estrogen and progesterone combination was immediately injected after tMCAO subcutaneously. Sensorimotor functional tests for evaluating behavioral deficits and TTC staining for measurement of infarct volume were performed 24 h after MCAO. Real-time PCR technique was used for gene expression analysis of glutamate transporters EAAT2 and EAAT3.
Results: The combination of estrogen and progesterone could significantly reduce lesion volume. Also, hormone therapy could improve ischemic neurological disorders. After hormone therapy, gene expression of glutamate transporters EAAT2 and EAAT3 did not show significant changes.
Conclusion: Combined estrogen–progesterone treatment significantly reduces neurological deficits and infarct volume; these effects are independent of the glutamate transporters signaling pathways.
Fatemeh Ghatreh Samani, Ali Nourian, Laya Farzadi,
Volume 20, Issue 10 (1-2018)
Abstract
Abstract
Background: Ultrasonography (US) is the most important imaging modality in detecting both intrauterine and ectopic pregnancies. This study aimed to compare serum β-hCG level with Transvaginal Ultrasound in symptomatic patients with ectopic pregnancy.
Materials and Methods: A total of 210 patients with definite diagnosis of ectopic pregnancy were enrolled prospectively. All patients underwent transvaginal US by an experienced radiologist who was blind to the final status of the patient. Serum levels of β-hCG and the time gap between US examination and last menstrual period (LMP) were compared between patients with positive and negative US findings.
Results: US were positive in 194 patients (92.4%) and negative in the remaining 16 patients (7.6%). The two groups were similar in terms of age (median, 31 years vs. 30.5 years, respectively; p=0.57). Both the median time gap between US and LMP (median, 43 days vs. 34 days, p=0.03) and serum level of β-hCG (median, 1027 mIU/ml vs. 172.5 mIU/ml, p<0.001) were significantly higher in patients with positive US findings. Both differences were independent of each other in multivariate analysis. The best discriminative zone was set at a serum β-hCG level of 326 mIU/ml with a sensitivity and specificity of 86.6% and 87.5%, respectively.
Conclusion: According to our findings, both the median serum level of β-hCG and time gap between US and LMP in patients with missed diagnosis of ectopic pregnancy were significantly lower in comparison with correct diagnosis and proposed discriminative zone for serum level of β-hCG in our study is different from the previous studies though further studies are recommended especially in symptomatic patients with suspected ectopic pregnancy.
Atefe Azimi, Abdollah Omidi, Elham Shafiei, Arash Nademi,
Volume 20, Issue 10 (1-2018)
Abstract
- Abstract
- Background: Students face a lot of emotional problems and psychological stress that affect their individual and social adaptation as well as their quality of life. Therefore, examining treatment models for these problems is very important. One of these models, the Fractal Diagnostic Treatment Model, is based on emotional regulation skills for a wide range of emotional disorders that can be used properly. The purpose of this study was to investigate the effectiveness of integrated diagnostic therapy on individual and social adaptations and emotional adjustment.
- Materials and Methods: A total of 70 female students were selected and assigned into two diagnostic groups (35 patients) and control (35 people). The experimental group received 12 sessions of diagnostic diagnosis weekly. Data were gathered in this study by Social Compliance Scale and Graz's Regulatory Emotion Questionnaire. Data were analyzed using descriptive statistics and multivariate covariance analysis (MANCOVA).
- Results: The results showed that transdiagnostic treatment focused on the dimensions of emotional regulation, including: refusal of emotional responses (F = 120.69, p < 0.01), impulse control problems (F = 14.57, p < 0.01), lack of emotional awareness (F =104.82, p< 0.01), lack of emotional resolution (F=42.64, p< 0.01), participation problems (F = 41.00, p<0.01), and limitations in achieving emotional regulation (F = 85.33, p<0. 01) is effective. Also, the results showed that exacerbation-based fetal diagnostic therapy was effective on individual adaptations (F = 146.76, p < 0.01) and social (F = 85.02, p<0.01).
- Conclusion: Regarding the effect of Fract-Intervention therapy based on emotional adjustment on personal and social adaptation and student's emotional adjustment dimensions, these results are applicable to clinical practitioners, counselors and practitioners in academic counseling centers.
Mis Mahnaz Najafi, Mohammad Reza Asad, Mostafa Rahimi, Rahman Souri, Ali Ahvar,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: The aim of study was to investigate the effect of 8 weeks of moderate-intensity continuous training (MICT) and high intensity interval training (HIIT) on the GLUT4 gene expression in skeletal muscle of obese male rats.
Materials and Methods: Twenty-eight male Wistar rats with 150 ± 25 grams body weight were divided into base control (n = 6), obese control (n = 6), MICT (n = 8), and (n = 8) HIIT groups as study sample. At the beginning of the study, base control group rats were sacrificed. In other groups, rats underwent high fat regime diet for 8 weeks. After one week of familiarization, rats in training groups run on treadmill for 8 weeks and 5 days per week. Forty-eight hours after the last session, the rats were scarified and gastrocnemius muscle tissue sample were removed. GLUT4 gene expression was measured by Real-Time PCR methods.
Findings: Results indicated that high fat diet for 8 weeks significantly increased rats body weight (p= 0.001), whereas both of MICT and HIIT training significantly decreased body weight (p= 0.001). Moreover, the MICT and HIIT had significant increase in GLUT4 gene expression in gastrocnemius muscle of obese rats (p = 0.001). Although, there were no differences between two experimental groups (p = 0.99).
Conclusion: According to the results, the MICT and HIIT increase gene expression of GLUT4 in mixed muscle fibers in obese rats. |
Shahrzad Hadi Chegni1, Mohammad Taghizadeh, Bahram Goliaei,
Volume 22, Issue 6 (1-2020)
Abstract
Background and Aim: Human Serum Albumin (HSA) is one of the most abundant proteins in the blood vascular system which regulates the transportation of many chemical compounds and molecules. The purpose of this study is to review the studies about the effects of three groups of pesticides (Insecticides, herbicides and fungicides) on the molecular structure of HSA protein.
Methods & Materials: This systematic review covers 35 studies of biophysical studies of the effect of pesticides on HSA protein. These papers were searched in PubMed, Science Direct, Web of Science databases and using Google Scholar search engine among those published from 1980 to 2019.
Ethical Considerations: In this study, all ethical principles were considered.
Results: Given the close relationship between biological activities of HSA and its secondary structure, the most of the reviewed articles analyzed the secondary structures of the HSA using various biophysical methods such as Fourier Transform Infrared (FTIR), Circular Dichroism (CD) and computational analysis. In general, HSA-pesticides interactions can cause a reduction in α-helix structure and an increase in other secondary structures including β-sheet, β-anti, and random coils. In the most reports, it has been proven that the pesticides interact with HSA through hydrophobic and electrostatic interactions and hydrogen bonding. These interactions take place in the IIA subdomain (Site 1) of HSA. The binding constants of these interactions were in the range of 10 3 to 10 6 M-1.
Conclusion : The changes around the single important tryptophan residue of HSA (Trp-214) induce conformational deformity in the IIA subdomain of this protein which causes the loss of its native structure and leads to a decrease in free HSA concentrations which subsequently interrupts the transport of the essential compounds like drugs and hormones in the blood vascular system.
Homa Yousefie, Anahita Khodabakhshi-Koolaee, Mohammad Reza Falsafinejad,
Volume 22, Issue 6 (1-2020)
Abstract
Background and Aim: Currently, the prevalence of chronic kidney disease has increased for a variety of reasons. Renal diseases, followed by dialysis and kidney transplantation, can greatly affect the People's physical and mental health. Since most of previous studies have examined the physical and often preoperative problems of kidney transplant patients and many of them have used quantitative methods, the present study aimed to investigate the psychological challenges of renal disease patients after Kidney transplantation.
Methods & Materials: The study population consisted of kidney transplant patients referred to the Nephrology Clinic of Labafinejad Hospitalin Tehran, Iran in 2019 aged 35-50 years and 1-5 years had passed since their transplantation. A semi-structured in-depth interview was done for collecting information. A purposive sampling and continued until data saturation and until no themes were available. In the end, 15 patients were interviewed. Data analysis was performed by Colaizzi’s method.
Ethical Considerations: This study with a code of IR.IAU.SRE.1398.022 was approved by the Research Ethics Committee at Islamic Azad University, Science and Research Branch in Tehran, Iran.
Results: The primary themes were divided in to 3 main themes including: Concerns and psychologically disturbing feelings, emotional and spiritual support of the family, and uncertainty of receiving specialized, financial and welfare support.
Conclusion: Patients with kidney disease after transplantation surgery have psychological challenges in addition to physical problems that are of great importance to mental health professionals. Studying these challenges can provide a deeper understanding of their psychological problems and adaptation after surgery.
Atieh Sadat Danesh, Fatemeh Nojavan,
Volume 23, Issue 1 (3-2020)
Abstract
Background and Aim: From the viewpoint of Iranian Traditional Medicine (ITM), hemorrhoidal bleeding is not only an organic disease; it also indicates the quality and quantity of blood and temperaments in the body. According to this view, bleeding from different areas has several causes, two important causes of which are: a. vascular hyperemia and consequent blooding in bleeding-prone areas, and b. changes in blood quality that cause the arteries to open and bleed. This study, by reporting a case of hemorrhoidal bleeding, is an evidence of some therapeutic principles in ITM.
Case Report: Patient was a 39-year-old married woman with four children and warm-wet temperament complaining of heavy menstrual bleeding for one year. After three months of herbal drug administration, menstrual bleeding became normal. One month later, she had hemorrhoidal bleeding. Her bleeding was treated based on ITM method by removing the black bile (Soda) from the body, phlebotomy and leech therapy around the anus.
Ethical Considerations: This study has been approved by the Research Ethics Committee of Arak University of Medical Sciences with code: IR.MUQ.REC.1396.110.
Conclusion: Based on ITM, it seems that the cause of hemorrhoidal bleeding in this case is vascular hyperemia and poor blood quality following symptomatic treatment of heavy menstrual bleeding.
Mehrdad Nasrollahzadeh Sabet, Mohammad Foad Heidari, Mohammad Khanalipour, Saadat Allah Ghaffari, Milad Jafari Ashiani, Sajjad Biglari, Emran Esmaeilzadeh,
Volume 23, Issue 5 (11-2020)
Abstract
Background and Aim: Since late 2019, with the emergence of a new type of coronavirus that causes a new respiratory disease called COVID-19, there have been many concerns about the spread of this disease and how to deal with it. Due to the ability of the virus to be transmitted rapidly, diagnosing the infected individuals in the early stages for isolating them is critical. This study aims to evaluate the reliability of Computed Tomography (CT) scan in diagnosing COVID-19.
Methods & Materials: Participants were 212 patients admitted to hospital with confirmed diagnosis of COVID-19. Demographic information, medical history, symptoms, and the chest CT scan results were collected and analyzed. Finally, the power of CT scans in the diagnosis of this disease was compared with the Real-Time Polymerase Chain Reaction (RT-PCR) molecular test.
Ethical Considerations: This study received ethical approval from the ethics committee of AJA University of Medical Sciences (Code: IR.AJAUMS.REC.1399.091).
Results: The sensitivity of CT scan in the diagnosis of COVID-19 was relatively high, but its false-positive results were also high.
Conclusion: CT scan is a relatively sensitive method for diagnosing COVID-19, but caution should be made due to its high false-positive results which can lead to increased financial burden on the health system.
Dr Rahmatolah Khosravanpoor, Dr Mahnoush Mahmoodi, Mr Marzieh Khosravanpoor, Dr Mahnoush Reisi,
Volume 25, Issue 4 (9-2022)
Abstract
Introduction: The use of digital games is highly prevalent among adolescents and can adversely affect their physical and mental health. The aim of this study was to determine the predictors of the stages of change in problematic digital games in high school students using a transtheoretical model.
Methods: This descriptive-analytical cross-sectional study was performed on 703 high school students in Bushehr 2020. A valid and reliable researcher-made questionnaire was performed for data gathering and analyzed using SPSS ver. 22 by descriptive indices, one-way ANOVA, chi-square, and rank ordered logistic regression. The present research was approved at Research Ethical Committee of Bushehr University of Medical Sciences (Code: IR.BPUMS.REC.1398.101).
Results: According to the results, self-efficacy, dramatic relief and social freedom were the predictors of the change stages of reducing and quitting digital games. This means that girls and students with higher self-efficacy (P = 0.037, OR = 1.054), have a better chance of being in higher stages of change and by increasing a unit of dramatic relief score (P = 0.025, OR = 1) and social freedom (OR = 1.135, P <0.001), the chances of individuals to be in the upper stages of change increased.
Conclusions: It seems that the design of educational interventions based on self-efficacy variables and taking into account the change processes of dramatic relief and social freedom, which increase the chances of people to be placed in higher stages of change, in reducing the behavior of digital games of students, especially for boys will be effective.
Nooshin Dalili, Fatemeh Pour-Rezagholi, Maryam Mousavi, Morvarid Alinezhad, Sadra Ashrafi,
Volume 25, Issue 5 (12-2022)
Abstract
Introduction: Years after the first successful kidney transplant, there are still many questions about the best immunosuppression regimen for these patients. Various studies have shown that long-term use of calcineurin inhibitor drugs can be associated with chronic nephrotoxicity and lead to irreversible damage to the transplanted organ. Therefore, the goal is to use immunosuppressive drugs and reduce the dose of calcineurin inhibitors as much as possible without increasing the risk of transplant rejection. This study aims to compare renal function, the rate of viral infections, and the occurrence of rejection after kidney transplantation in patients on two different treatment regimens including everolimus plus a low dose of calcineurin inhibitor against the standard protocol of calcineurin inhibitor along with mycophenolic acid in 60 kidney transplanted patients.
Methods: This clinical trial was conducted at Labbafinejad Hospital in Tehran between 2018-2019 on 60 kidney transplant patients aged 18 to 65 years and for 12 months.
Results: In terms of kidney function status based on GFR, except for the first month (P=0.02), there was no significant difference between the two groups in any of the time periods (P>0.05). Also, there was no statistically significant difference between the two study groups in terms of hospitalization length after transplantation and re-hospitalization during the study (P>0.05).
Conclusions: The results of this study showed that the everolimus regimen and low dose of calcineurin inhibitor can be used de novo in transplant patients without increasing the risk of rejection in them and at the same time it may be able to reduce the incidence of viral infections after transplantation.
Mr Fathollah Ghorbani, Mohammad Rezaei, Dr Ebrahim Ebrahimi, Mis Lila Ghorbani, Dr Elham Rezaei,
Volume 25, Issue 5 (12-2022)
Abstract
Introduction: Beyond the members of the charter board, the horizon of Amedwar Kanandah for the sake of Bimaran Niyazmand, the member of the board of the board. In parallel, there is a new medical science in New Mutrah, in the opinion of specialists who claim that it is a model and that they have a source for beyond the organs with children. Definitively The current issue is that of new topics and the question of programs in the possession of jurisprudence and rights, which must be carefully selected from the angles that are the subject of jurisprudence debate.
Methods: This is a book in the form of a textbook and a description - an analysis with the use of the books of science and jurisprudence of his room.
Results: This type of child is based on the basis of investigations, which are believed to be valid, according to the permissibility of the organs that are nozadan with severe cranial defects, i.e., in the womb of a mother, or from a cutaneous period, but from birth in the middle of my heart; A defensible issue.
Conclusions: The use of the nostril organs affected by the cornea with limitations of the cervical spine, but with a significant meaning in the development of Rastafarian, and the use of non-main organs based on multiple rational and legal evidences; Milabashed project. The parts of my life are afflicted with severe corneal ulcers, based on the inevitability and inevitability of the disease, and the reason for the fact that the situation is similar to the meaning of the disease. Develop a legitimate development in the most vigorous manner, and the issue of the necessity of preserving human dignity This is an issue that cannot be denied. But from the point of view of the role that is not a conditional legality, it is a present issue with conditional auspices in no severe form.
Akram Jokar, Homa Sheikhani Shahin, Mehrzad Moqaddasi, Alireza Jowhari,
Volume 26, Issue 5 (12-2023)
Abstract
On average, patients suffering from non-alcoholic steatohepatitis after about seven years, their disease turns into fibrosis and reversibility at this stage becomes very difficult because this disease is an irreversible stage of the disease. Fatty liver is non-alcoholic (2). Researches have come to the conclusion that liver inflammation and insulin resistance decrease and insulin sensitivity increases with sports activity (3). TNF-α has a high inflammatory effect; So that different agents and species of this family and their receptors play a role in NASH disease and liver fibrosis (5). However, exercise increases prostaglandins and cAMP. The mentioned hormones inhibit the function of TNF-α (6). On the other hand, anti-inflammatory cytokines increase due to exercise and inhibit the increase of TNF-α. With the increase in production and secretion of TNF-α, other inflammatory factors such as TGF-β1 signaling are activated and fibrosis signaling will start in liver cells (5). TGF-β1 (Transforming growth factor beta 1) is one of the members of the large family of transforming growth factors beta (TGF-β) and a key cytokine in obesity and insulin resistance (7). In a research, during 48 weeks of applying a high-fat diet to rats, they found that steatosis occurs in the liver of rats from the eighth week onwards, and the amount of TGF-β1 in them increased significantly. In the end, they came to the conclusion that this factor can be one of the main characteristics of determining the degree of liver fibrosis in patients with NASH (10). High-intensity interval training (HIIT) is one of the new training models whose positive effects have been identified in a variety of metabolic diseases (13). On the other hand, there are very few researches about the effect of aquatic environment and swimming on the improvement of metabolism and inflammation in NASH patients. Based on the results of a systematic review in 2018, it was shown that endurance exercise in water improved systemic inflammation and weight control (18). Despite the conflicting results in this field and the beneficial effects of exercise in water and also human's innate interest in water, the effect of high-intensity interval exercise in water in patients with non-alcoholic steatohepatitis has not been observed by the researchers of this study. Therefore, the effect of eight weeks of high-intensity interval training in water on inflammatory factors in patients with non-alcoholic steatohepatitis was investigated.
Materials and methods
In this study, eight-week-old rats were divided into two groups: healthy (n=20) and high-fat diet (HFD) (n=20). After eight weeks and proof of disease induction, the HFD group was randomly divided into two groups: control-disease (n=9) and exercise-disease (n=9); Also, the healthy group was divided into two groups: control-healthy (n=9) and exercise-healthy (n=9). The rats in the training group performed HIIT swimming training, including 20 times of 30 seconds of swimming with 30 seconds of rest between each time, for eight weeks (three days a week). One-way ANOVA and Bonferroni's post hoc test (P<0.05) were used to determine the difference between groups.
Ethical Considerations
The proposal of this study has been approved by the Ethics Committee of Shiraz University of Medical Sciences (IR.SUMS.REHAB.REC.1400.008).
Findings:
As shown in diagram 1; Based on the results of the one-way analysis of variance test, it can be said that there was a significant difference between the mean TNF-α blood serum (P=0.001). According to the results of Bonferroni's post hoc test, these differences in blood serum TNF-α variable between the control-healthy and control-disease groups (P=0.001), exercise-disease (P=0.001) and exercise-healthy (P=0.002), control-disease with exercise-disease (P=0.012) and exercise-healthy (P=0.001), exercise-healthy with exercise-disease (P=0.002) was.
According to graph 2, it can be seen that there is no significant difference in TGFβ1 variable in all four groups (p=0.068). However, by comparing the averages, it is found that the amount of TGFβ1 protein has decreased by 49.1968% in the patient-exercise group after high-intensity intermittent swimming exercise compared to the control-patient group. Meanwhile, this protein in the exercise-healthy group was reduced by 45.2741% compared to the control-patient. Figure 1 shows the protein bands related to TGFβ1 protein.
Discussion and conclusion: The results of the present research showed that high-intensity intermittent swimming exercises reduce inflammatory and fibrotic factors, and in general, it can be concluded that eight weeks of high-intensity intermittent swimming exercises improve the inflammatory and fibrotic factors associated with non-alcoholic steatohepatitis. . However, to obtain a definitive result, this type of exercise should be studied in human studies in this patient community.
Appreciation and thanks: This article is taken from the master's thesis in sports physiology (first author) of Zand Institute of Higher Education, Shiraz, with ethics code IR.SUMS.REHAB.REC.1400.008. In the end, we sincerely thank all friends and colleagues who helped us during the stages of this research.
Conflict of interest:The authors of this article have no mutual benefit from its publication.
Authors' share (participation rate): All four authors participated in the preparation of this article.
Key words: high-intensity swimming interval training, non-alcoholic steatohepatitis, tumor necrosis factor alpha, transforming growth factor beta
