Showing 22 results for zamani
Mehrangiz Zamani, Fatemeh Soltan Beigi,
Volume 4, Issue 3 (Autumn 2001)
Abstract
Introduction: Primary dysmenorrhea with prevalence of 90% is the one of the most gynecologic problems and it is one of the important ethiology of decrease of quality of live in women. The treatment is varity cocp, NSAIDS (common treatment) The use of acupuncture. Tens, Laparascopic surgery, vitamin B1 acid -3 omega, transdermal N.G. (nitroglycerin) in the studies were evaluated but the number of cases and the period of follow up is limited. In the study in India with Gokhale and et.al in 1996, the curative Rate of treatment with Vitamin B1 was proved. In this study we evaluated the treatment effect of Vitamin B1, and follow up the patients 3 months later and 6 months after the onset of treatment.
Material and Method: In this study 2 years between 1999-2001 a Randomized double blind placebo controlled study, one group (118-n) received Vitamin B1 (100 mg) and other group (124=n) received placebo daily in the onset of three month treatment and end of treatment and 6 months later of onset of treatment the patient is calculated with visual analgesic scale and cox-menstrual scale.
Results: The prevalence of primary dysmenorrhea in the population of this study was 51/9% mean age of menarche 13/3 year. The rate of NSAID using is 63/1%. 85/5% of patients had irregular menses. The prevalence of premenstrual sign. And the signs correlated with dysmenorrhea were evaluated between two groups of treatment evaluated 3 months after treatment period in the placebo control care rate was 21% and in Vitamin B1 was 86/4% (chi=103.59 p value=0.000).
Conclusion: The results in this study were similar with the results of Gokhale in India. This treatment did not have any side effect and this treatment tolerated easily.
Dr Ali Chehrei, Dr Manijeh Kahbazi, Dr Bahman Salehi, Dr Afsaneh Zarganj-Fard, Dr Fatemeh Darreh, Dr Parvin Soltani, Dr Ashraf Zamani, Dr Mohammad Khalili, Dr Afsaneh Noroozi,
Volume 9, Issue 2 (6-2006)
Abstract
Introduction: Performing correct research in different aspects of community as well as medical sciences can be a way to resolve many problems. In order to create a systematic knowledge of research method in academic members of Arak University of medical sciences and enabling them in providing proposals and performing researches, a clinical research center was developed. This study is done to investigate the effect of this center on improving clinical researches in the University. Materials and methods: This is a HSR, before and after, interventional study in which, clinical academic members of Arak University of medical science were evaluated. First the information of the pre intervention period was gathered (jan2002-jan2004). Then the intervention was done in the form of developing a research center in Vali-Asr hospital, performing serial research workshops, research conferences, research consultations and planning data bases during a 2 years period. Again data was gathered and then compared to those of pre intervention period. Results: The comparison of pre and post intervention periods showed that in pre intervention period from 38 proposals 30 and in post intervention period from 89 proposals 76 were approved by research committee of the University. In the two pre and post intervention periods 14(46.6%) and 50(65.8%) of accepted proposals were clinical respectively. Also from the view point of quality, 11 and 15 proposals were HSR, 2 and 22 clinical trials and 8 and 8 descriptive, respectively. The number of published articles in first period was 45 and in second 84. Presented articles in internal and external congresses were 33 and 59 in the two periods overally, which 25 and 51 articles were presented in the country and 8 and 8 in abroad congresses, respectively. Conclusion: Regarding the results it seems developing research center in this University and other similar Universities can have a significant effect on the process of clinical researches.
Soleyman Zand, Ashraf Zamani,
Volume 11, Issue 3 (9-2008)
Abstract
Background: Backache is a common problem in pregnancy period . Scientists believe that some simple exercise can help to prevent the occurrence of backache during their pregnancy period. Thus, this research carried out in order to investigate the effect of some simple exercises and correct daily activity in prevention of backache in pregnancy period. Methods and Materials: This is a clinical trial study that was carried out on 138 of pregnant women .The first group including 66 women which considered as control group and treatment group including 72 women. The research had four stages: 1) stage of taking history. 2) Arrange a teaching program. 3) stage of performance( In case group samples were done 60 minutes aerobic exercises for 3 days a week for the 30 weeks undersupervision a physiotherapist). 4) Assessment the results. Data were analyzed by SPSS for statistical analysis. Results: According to the result 18.2% of woman that were under treatment and 36.6% of control group, suffered from backache. Chi-square test showed significant differences between two groups. In addition Odd ratio of treatment population was 2(CI%95 = 4/04-1/91 & p<0/05). Conclusion: The result showed simple exercises during pregnancy period can not eliminate backache, but it can decrease delay backach.
Mahdi Mosayebi, Fereshteh Zamani Alavijeh, Mahmood Reza Khazaii,
Volume 14, Issue 3 (7-2011)
Abstract
Background: The purpose of this study was to identify the effect of health education according to health belief model (HBM) on the adoption of preventive behaviors of infection with giardia lamblia by primary school students in Arak.
Materials and Methods: In a randomized quasi-experimental case study, 1200 students were randomly divided into two equal groups of test (instruction) and control (non-instruction). The sample size for giardiosis identification tests included 300 students, who had been equally and randomly selected from the control and test groups. Health education was according to HBM and its impact on the students' lifestyle-related patterns of behavior was considered.
Results: Paring nails in the test group, significantly increased after education while it decreased significantly in the control group. The number of students who carried a glass for drinking slightly increased, but it remarkably decreased in the control group. The number of students who applied soap after using the restrooms remarkably increased in both the test and control groups. The relationship between not paring nails and infection with giardia lamblia was statistically significant. Additionally, after education, the ratio of reduction of infection with giardia lamblia in the test group to its increase in the control group was statistically significant.
Conclusion: Preventive behaviors significantly improved and appeared influential in the reduction of infection with giardia lamblia. Thus, using a HBM in prevention of parasitic infections along with instructing the parents are suggested for prevention of parasitic infections.
Davood Hekmatpou, Mohsen Shamsi, Majid Zamani,
Volume 16, Issue 3 (6-2013)
Abstract
Background: Nowadays, the elderly population is growing all over the world. Diseases and conditions resulting from this evolutionary process can severely affect the quality of life of the elderly. Therefore, the aim of this study was to determine the effect of educational programs of healthy lifestyle on the quality of life of the elderly in Arak city.
Materials and Methods: This quasi-experimental was carried out on 60 elderly subjects in Arak city. The subjects participated in classes on nutrition, exercise, sleep hygiene, and life skills for a month and they were followed for three months after intervention. Data were collected by the short form quality of life (SF-36) in elderly.
Results: The mean score of quality of life was 61.06±7.42. The highest mean was associated with social health (74.5±15) while the lowest mean was for physical health (46±17). In terms of quality of life indicators before educational intervention, four categories emerged: poor (13.3%), medium (30%), good (41.7%), and high (15%). After intervention, the majority of the samples fell in the good (38.3%) and high (45%) categories. There was a significant difference before and after the educational intervention (p<0.001).
Conclusion: Education to elderly about the healthy lifestyle practices can prevent a lot of problems and help them to improve their quality of life. Therefore, classroom education is fruitful for this group that is often neglected.
Babak Eshrati, Seyed Shahriar Hosseini, Mohsen Farahani, Mahin Sadat Azimi, Maryam Zamanian,
Volume 16, Issue 4 (7-2013)
Abstract
Background: Funnel plot is a graphical tool for investigating publication bias in meta-analysis studies. The aim of this study is to introduce another application of funnel plot that is monitoring one of the Iranian family performance indices and determining the position of each health center of Markazi province in terms of patient referral rates by general practitioners to specialists and to compare it with bar and caterpillar plots.
Materials and Methods: In order to draw the funnel plot, the average monthly percent of referrals for each district of Markazi province in 2011 was computed. In this study, Iranian Ministry of Health and Medical Education standard figure of 10% was considered as the limit of referral to the second level of Iranian health services. The 99% confidence interval of the control limit for each district was computed according to 3 standard deviations of the percent of referrals relative to the total patient visits.
Results: Based on funnel plot results, five out of ten districts were in the expected range of referral (Ashtian, Saveh, Tafresh, Khomein, and Komijan). However, in other five districts, the referral rate was greater than the expected rate (Arak, Shazand, Zarandiyeh, Delijan, and Mahallat). Mahallat district had the highest rate of referral.
Conclusion: The funnel plot was more informative than the other two plots Thus, it can be viewed as a useful tool in monitoring health programs throughout the country.
Fazad Zamani, Parsa Yousefi, Mohammad Rafeei, Neda Saleh Jafari,
Volume 16, Issue 7 (10-2013)
Abstract
Background: Adenoidal hypertrophy is a common condition of childhood, when abstructive sleep apnea ocurs adenoidectomy is indicated. In less sever cases, non surgical interventions maybe considered, however few medical altematives are currently available. Intranasal steroids used to reduce nasal airway obstruction. The aim of this study to assesthe effectiveness of intranasal corticosteroids for improving nasal airway obstruction and in children with adenoid hypertrophy.
Materials and methods: 77 children 1-12 years exhibiting adenoid hypertrophy symptom and confirmed with radiologic imaging and without tonsilar hypertropy that not inclined to surgery were included and divided two groups in one group were treatend with intranasal betanethason 3 times daily for 3 weeks and and second group treatend with intranasal NACL as placebo. The subjects were assessed for airway obstruction symptoms including, snoring mounth breathing and prulaunt rhinorea, via questionarre ear examination, first month and third month of treatment.
Results: Intranasal betanethasone improved airway obstruction symptoms especially night snoring but hadn’t effective on other symptoms and infection complications including rhinorea.
Conclusion: Intranasal betanethasone can be used as alterative treatment for adenoidal hypertroply because its effect on airway obstruction symptoms due to probably reduction adenoideal size.
Narges Zamani, Mehran Farhadi, Hamin Reza Jamilian, Mojtaba Habibi,
Volume 17, Issue 11 (2-2015)
Abstract
Background: Impulsivity is a core social pathology. Therefore, the purpose of this study was to Effectiveness of group dialectical behavior therapy based on core distress tolerance and emotion regulation components on Expulsive Anger and Impulsive Behaviors.
Materials and Methods: Research method is a semi experimental socio-statistic approach consisting of experimental group (dialectical behavior therapy) and control group. Participants were patients referred to Amir Kabir Hospital in Arak. and who were Expulsive Anger and Impulsive Behaviors. Based on stratified random sampling, 16 patients (women) were placed in each group. Research tools included the structured diagnosis interview according to DSM-IV-TR (2000), Barrat impulsivity scale (1994) Distress Tolerance Scale (2005) Difficulties of Emotion Regulation Scale (2004) and dialectical behavior therapy were done for two months, 8 groups Sessions.
Results: The results of this study showed that there was significant difference between control and experimental groups after implementation of dialectical behavior therapy relying on component tolerance and regulation of emotional distress variables impulsive behavior and explosion furies (p<0.01).
Conclusion: Distress tolerance and emotion regulation components effective on Expulsive Anger and Impulsive Behaviors.
Fazad Zamani, Habib Soheily, Hamid Reza Jamilian, Neda Salehjafari, Mohammad Rafiei, Amin Tamizi,
Volume 18, Issue 1 (4-2015)
Abstract
Background: Allergic rhinitis is a common disease which is present in 20% of general population. Major symptoms include sneezing, rhinorrhea, nasal congestion, and nasal pruritus. It seems that tricyclic antidepressants blocking histamine receptors may be used as an effective treatment in allergic rhinitis.
Materials and Methods: In this clinical trial study, 84 patients with allergic rhinitis entered the study and randomly divided into two groups. Patients of 1st group received cetirizine and 2nd group received doxepin for 2 weeks. After 2 weeks patients were evaluated about sneezing, rhinorrhea, nasal congestion, and nasal pruritus.
Results: The results of our study showed that clinical score of patients after 2 weeks was not different in both groups (p=0.261). The only symptom that was affected by the kind of treatment and was significantly different between groups was sneezing (p=0.005).
Conclusion: It seems that there is not much difference in using cetirizine and doxepin in treatment of seasonal allergic rhinitis sympotoms. It is recommended that future studies use TCAs with more potent blocking anti-histamine receptors feature and on more samples.
Narges Zamani, Mojtaba Habibi, Mohammad Darvishi,
Volume 18, Issue 1 (4-2015)
Abstract
Background: Depression is on the top list of mental disorders which account for about 25 percent of patients referred to health centers in your world. So, is presented in different ways to treat it. Therefore, the aim of this study is to compare the effectiveness of Dialectical Behavior Therapy and Cognitive Behavioral Group Therapy in reducing depression in mothers of children with disabilities.
Materials and Methods: This study is quasi-experimental and consists of experimental and control groups. This study population was mothers referred to mobility, occupational therapy and physiotherapy centers who had depressive symptoms. 8 patients in each group were selected by convenience sampling. The research instrument were the Structured Clinical Interview for DSM-IV Axis I disorders and the revised Beck Depression Inventory form (1996). Dialectical behavior therapy and cognitive behavior therapy groups were instructured for 2 months (8 sessions of 2 to 2.5 hours). But the control group did not receive intervention.
Results: The results showed that there were significant differences between the mean depression scores of dialectical behavior therapy and cognitive therapy group with control group (p<0.001). Also, there is a significant difference between the mean depression scores of dialectical behavior therapy with cognitive therapy (p<0.001).
Conclusion: In the area of treatment and working with depressed people and those who are in crisis mode, it seems that dialectical behavior therapy and cognitive therapy group in view of its nature is very efficient and promising.
Jamal Falahati, Farzad Zamani Barsari, Mohammad Taeid, Rahmatollah Jadidi,
Volume 18, Issue 3 (6-2015)
Abstract
Background: Nasolacrimal duct obstruction as a common problem causes bothersome social and physical symptoms such as euphoria, acute and chronic dacryocystitis attacks, pain, pruritus and erythm of eye. Although, there is no consensus about available therapeutic methods. So the aim of this study is to investigate and compare the effect and complications of endoscopic dacryocystorhinstomy and patients' preferences in two common surgical methods for settling nasolacrimal duct obstruction.
Materials and Methods: In this clinical trial study, 220 patients with nasolacrimal duct obstruction were randomly divided into two groups and underwent external and endoscopic dacryocystorhinostomy surgery. Finally, patients were compared with a view to echymosis and tearing after operation and the time of surgery and bleeding during operation. The patients data were analysed by Chi-square test and using SPSS-16 software.
Results: Our results show significant difference between two groups in post-operative echymosis, post-operative bleeding and the time of surgery (p=0.000). There was no significant difference in post-operative tearing between two groups (p=0.418).
Conclusion: According to the results of our study, the use of endoscopic dacryocystorhinostomy is remarkably better than external dacryocystorhinostomy Therefore, with regard to the most of patients' tendency to endoscopic surgery, surgeons should achieve more experience in this method.
Narges Zamani, Mehran Farhadi, Hamidreza Jamilian, Mojtaba Habibi,
Volume 18, Issue 8 (11-2015)
Abstract
Background: The purpose of this study was to determine the effectiveness of dialectical behavior therapy in reducinng expulsive anger.
Materials and Methods: This is a pre-test and post-test semi-experimental study with control group. The study population included 32 patients with expulsive anger that reffered to Amir kabir remedial education center based on psychiatrist diagnosis and were randomely divided into case (dialectical behavior therapy) and control group. The case group was educated the dialectical behavior therapy skills for 16 sessions from 2 until 2.5 hours at teamly. To collect data, the patients filled Eysenk expulsive questionnaire before and after intervention. Considering no necessary assumptions were fulfilled to conduct the multivariate analysis of covariance and variance, so, the univariate analysis of variance was used.
Results: The results of variance analysis proved that dialectical behavior therapy significantly reduced expulsive angers.
Conclusion: With due attention to the results, it can be said that dialectical behavior therapy leads to reducing expulsive angers in treated patients, thus, this method can be included in interventional programs for target groups in psychotherapy centers. Aslo, it helps to improve the life of patients by reducing expulsive angers.
Sonya Zamani, Farhad Mashayekhi, Zivar Salehi, Nasim Abbasi,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Diabetic retinopathy (DR) is the complication of diabetes mellitus (DM) and causes blindness among adults. Chronic extra cellular hyperglycemia in diabetes stimulates reaction oxygen species ROS production and increases oxidative stress. GPX-1 that was coded by GPX-1 gene is a key enzyme in protecting vessels against oxidative stress. The aim of this study was to evaluate the association of GPX-1 gene Pro 198 Leu polymorphism in patients with diabetic retinopathy.
Materials and Methods: In this case-control study, 160 blood samples of participants including 80 patients with diabetic retinopathy and 80 healthy individual were tested. Genotyping of GPX-1 gene was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) by ApaI enzyme. Data analysis was performed using MedCalc (12.1) program.
Results: The genotype frequencies of the GPX-1 in DR patients for Leu/Leu, Leu/Pro, Pro/Pro were 10%, 62.5% and 27.5%, respectively, while for the control groups were 10%, 70% and 20%, respectively.In ohter words, Ile/Pro heterozygote was the most frequent genotype in patients and controls. According to the results of this study, there was not significant difference between patients with diabetic retinopathy and controls(p=0.52).
Conclusion: It is concluded that GPX-1 gene Pro 198 Leu polymorphism is not associated with DR. Further research is required to clarify the role of GPX-1 gene in DR in Rasht population along higher sample size.
Seyyed Nematollah Seify, Ehsanollah Ghaznavi Rad, Ashraf Zamani, Mohammad Yosef Alikhani, Mohammad Rafiei, Soleyman Zand, Hamid Abtahi,
Volume 18, Issue 12 (3-2016)
Abstract
Background: Listeria monocytogenes is one of the most important causes of abortion and postpartum infection in newborns. Because of the importance of L . monocytogenes in the health of pregnant women and newborn babies, the aim of this study was to determine the prevalence of these bacteria in pregnant women and to compare the level of prevalence between women with a history of abortion and with no a history of abortion.
Materials and Methods: In this study, 540 samples of pregnant women were provided from Arak Taleghani hospital. The samples were cultured in enrichment media, then L .monocytogenesis was isolated in specific media.
Results: Of clinical samples, 14 cases had Listeria monocytogenes. Of these samples, 8 cases in women had a history of abortion, while women with no history of abortion were 6 Most cases of positive culture were related to the age of 25 to 34 years, including 7 cases, the lowest cases were 35 to 44 years old including 3 women and 4 women were between 17 and 24 years old.
Conclusion: The study showed that Listeria monocytogenes can cause infection in pregnant women. The use of Phenotypic methods and specific media can apparently isolate listeria monocytogenes from healthy pregnant women.
Neda Saleh Jafari , Farzad Zamanibarsari, Hamidreza Jamilian, Bahman Sadeghi Sede , Hamidreza Zafari,
Volume 19, Issue 7 (10-2016)
Abstract
Background: The definite treatment of indicated Hypertrophy of the tonsils is Tonsillectomy. The aim of this study was to compare the efficacy and necessity of diclofenac suppository and simultaneous prescription of acetaminophen alone in controlling and reducing pain and improving swallowing and satisfaction after surgery for tonsillectomy in children.
Materials and Methods: In this clinical trial, 180 children 7 to 14 years Tvnsykltvmy surgery were enrolled. Patients in an improbable way, easy and were divided into three groups of 60. Immediately after the surgery acetaminophen, diclofenac, or a combination of both was used. The cases of pain in the early hours, seventh, thirteenth and nineteenth after surgery were compared.
Results: There was a significant difference between the average pains of all groups in all hours (p<0.05). There was a significant difference between the groups from the point of view of side effects such as Nausea, Vomiting and Pyrexia (p<0.05), But there was no significant difference between the groups from the point of view of After Surgery Bleeding (p>0.05).
Conclusion: We can say that Rectal Diclofenac is a more effective medication for reducing pain after the Tonsillectomy surgery in contrast with Rectal Acetaminophen or a mixture of the two, which may cause the patients to use less Narcotics after the surgery.
Nastaran Zamani, Azade Eskandary,
Volume 20, Issue 11 (2-2018)
Abstract
Abstract
Background: Anxiety and depression are psychological and physiological states that are identified by physical, emotional and behavioral changes. According to studies conducted, there is evidence concerning the effect of docosahexaenoic acid (DHA) on the emotional, motor, and cognitive functions of humans and animals. In this study, the effect of DHA (2.5 mg/kg) on anxiety and depression behaviors in adult male mice was examined.
Materials and Methods: In this experimental study, 42 adult male mice were randomly divided into 6 groups of 7 mice. The studied animals were divided into control, vehicle (intraperitoneal injection of sesame oil for 14 days) and treated groups (intraperitoneal injection of DHA with 2.5 mg/kg for 1, 3, 5, and 14 days) and then were studied for anxiety and depression behaviors with elevated plus maze and forced swimming tests.
Results: The results of this study showed that treatment of docosahexaenoic acid did not have a significant effect on anxiety behaviors on days 1, 3, 5 (p >0.05), but 14-days treatment significantly reduced the duration of immobility time in the forced swimming test (p˂ 0.05).
Conclusion: According to the results, it can be said that docosahexaenoic acid in the dose of 2.5 mg/kg does not affect the anxiety behaviors of rodents but it leads to a decrease in depression behaviors.
Arman Zamani, Abolghasem Babaei, Nayyer Sadat Mostafavi,
Volume 22, Issue 1 (4-2019)
Abstract
Background and Aim: Diagnosis of leukemia is very difficult, therefore, it is necessary to use image processing techniques. The main objective of this study was to provide a system based on intelligent models that could improve the accuracy of the diagnostic system for acute leukemia.
Materials and Methods: The images produced in this study were extracted from the University Degli Studi Dimilan database and processed in the MATlab 2014a software. In this research, Fuzzy-Cmeans method was used in fragmentation and neural network and support vector machine in classification networks.
Ethical Considerations: In this study, all principles of research ethics were considered.
Findings: Feature data were extracted using the original image transfer to RGB, HSV, Lab and Enhanced RGB spaces. The data obtained from the previous step were entered into the SVM network, then the network separated normal data from abnormal data. The results of comparing the output of the proposed method with different educational methods showed the highest mean of accuracy equal to 95.7%.
Conclusion: The application of the proposed network in this study was that eliminate the weak points of all the networks in addition to presenting the advantages of these network. Combining the networks improved the accuracy of output up to 98% and considerably reduced the time required for calculations.
Farzad Zamani,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim Inferior turbinate hypertrophy is one of the most common causes of nasal obstruction after nasal septal deviation. Enlargement of the turbinate is the result of the position of turbinate bone or swelling of turbinate submucosal. This study aimed to evaluate the effectiveness of the SubMucosal Resection (SMR) method with electrocautery method in the treatment of inferior turbinate hypertrophy.
Methods and Materials A total of 140 patients with inferior turbinate hypertrophy complicated with nasal congestion and rhinorrhea and candidate of surgery were randomly divided into two groups. In the first group, after induction of anesthesia, we performed SMR of inferior turbinate hypertrophy. In the second group, after induction of anesthesia, we performed monopolar cauterization with 20-gauge angiocath in three anterior, middle, and posterior regions and crests of the inferior turbinate.
Ethical Considerations This study was approved by the Ethics Committee of Arak University of Medical Sciences (Code: 91.133.3).
Results In the electrocautery group, a significant improvement was observed in nasal congestion after 6 months (P=0.017). In the SMR group, a satisfactory headache improvement was reported (P=0.034), one month after the operation. Also, the electrocautery group reported less pain and burning in the site of surgery, sneezing, coughing, and itching (P=0.013).
Conclusion Electrocautery can be superior over SMR because of its less bleeding, shorter time of surgery, the availability of primary equipment, and relative improvement in decreasing the rhinorrhea. However, if the patient suffers from isolated inferior turbinate hypertrophy, SMR as a suitable method is recommended.
Nastaran Zamani, Ahmad Ali Moazedi,
Volume 22, Issue 6 (February & March 2020)
Abstract
Background and Aim: Alzheimer’s disease is the most common causes of dementia among the elderly people. The aim of this study was to evaluate the synergistic effects of memantine and vitamin D on spatial learning and memory impairment in adult male rat model of Alzheimer's disease.
Methods & Materials: In this experimental study, male Wistar rats were randomly divided into nine groups (n=7): 1= Control, 2= NBM lesion (received bilateral electric lesion of NBM), 3= Sham (the electrode was entered into the NBM with no electric lesion), 4= NBM lesion+ Vehicle Memantine (received saline), 5= NBM lesion+ Vehicle Vitamin D (received saline), 6= NBM lesion+ Vehicle Memantine+ Vehicle Vitamin D (received saline plus sesame oil), 7= NBM lesion+ Vitamin D; 8= NBM lesion+Memantine, and 9= NBM lesion+Vitamin D+Memantine. After one week, the rats were trained to perform the Y-maze task for five days. Twenty five days after training, a retention test was performed to evaluate their long-term memory.
Ethical Considerations: This study with research ethics code of “EE/ 97, 24, 3061243/scu.ac.ir” was approved by the Research Ethics Committee of Shahid Chamran University of Ahvaz In Iran.
Results: Bilateral NBM lesion reduced spatial learning in comparison with control and sham groups. No effect on spatial learning was observed in NBM lesion+ Vehicle Memantine and NBM lesion+ Vehicle Vitamin D groups compared to the NBM lesion group. Spatial learning and memory in NBM lesion +Vitamin D+Memantine group (P<0.001) was significantly improved compared to NBM lesion+Vitamin D (P<0.01) and NBM lesion+Memantine (P<0.05) groups. Moreover, no significant difference was observed between the results in the 5th day of training and the memory retention at the 30th day.
Conclusion: Co-administration of memantine and vitamin D is more effective than memantine or vitamin D alone in spatial learning and memory improvement in rat model of Alzheimer's disease.
Tahere Azimi, Malihe Bagheri, Mahdi Pariyan, Behzad Khansarinejad, Ashraf Zamani, Mahdieh Mondanizadeh,
Volume 23, Issue 3 (August & September 2020)
Abstract
Background and Aim: Cervical Cancer (CC) is the third most common malignancy in the women, the main cause of which is human papillomavirus (HPV). Both E6 and E7 oncogenes of the virus play an important role in its tumorigenesis. Today, methods available for screening CC are not capable of detecting the disease at an early stage. Therefore, it is important to identify new biomarkers for early detection of this cancer. For this purpose, in the present study, miRNAs targeting the two oncogenes E6 and E7 of human papillomavirus (types 16 and 18) were studied in CC by bioinformatics.
Methods & Materials: First, using the NCBI database, the E6 and E7 gene sequences were obtained for both human papillomavirus types 16 and 18. Then, using the miRBase and RNA22 bioinformatics databases, the most appropriate targeting miRNAs for these genes were selected.
Ethical Considerations: This study was approved by Ethics Committee of Arak University of Medical Sciences.
Results: Based on the P obtained from bioinformatics databases, miRNA including miR-92a-5p (P=7.51e-2), miR-195-3p (P=2.24e-1), miR-34a-5p (P=2.73e-1) and miR-155-5p (P=4.95e-2) were introduced for the two genes E6 and E7.
Conclusion: Results from bioinformatics studies revealed that of the four miRNAs identified, miR-155-5p and miR-92a-5p are probably the targeting miRNAs specific for the E6 and E7 genes, respectively. Therefore, it seems that these miRNAs can be a suitable candidate for in vitro studies in CC patients.
