Showing 4 results for yadegari
Mehrdad Roghani, Tourandokht Balouchnejad, Samira Yadegari, Rouholah Miri,
Volume 9, Issue 3 (9-2006)
Abstract
Introduction: Considering the increasing incidence of atherosclerosis and cardiovascular disorders in diabetes mellitus, this study was conducted to evaluate the beneficial effect of two-month administration of Plantago Psyllium (PP) seed on the contractile reactivity of isolated aorta in diabetic rats. Materials and Methods: In this experimental study, 32 male Wistar rats were randomly divided into four control, PP-treated control, diabetic and PP-treated diabetic groups. To induce diabetes, Streptozotcin (STZ) was intraperitoneally administered (60mg/Kg). PP-treated groups received PP mixed with standard pelleted food at a weight ratio of 6.25%. After 2 months, contractile reactivity of thoracic aortic rings to KCl and Noreadrenaline were determined using isolated tissue setup. Data was analyzed using ANOVA and Tukey tests. Results: Serum glucose level showed a significant increase in diabetic group after one and two months (p<0.001), but it,s decrease in PP-treated diabetic group was not significant in comparison to diabetic group. Also PP-treated diabetic group showed a lower contraction to KCl (p<0.05) and noreadrenaline (p<0.01) as compared to diabetic group. Meanwhile, there was no significant difference between control and PP-treated control groups regarding contractile reactivity. Conclusion: It can be concluded that oral administration of PP for 2 months can decrease the contractile responsiveness of vascular system and this may prevent the development of hypertension in diabetic rats.
Maryam Yadegari, Mozafar Khazaei, Yazdan Hamzavi, Ali Reza Toloei,
Volume 14, Issue 2 (5-2011)
Abstract
Background: Falcaria vulgaris has different properties and it used as dietary and medicinal herb in the west of Iran. Previously, we showed that this plant has protective and repairing effect on gastric ulcer were demonstrated .The aim of present work was to investigate the effects of F. vulgaris extract on female rat's fertility.
Material and methods: In this Exprimental study Virgin female NMRI rats (160-190 gr) were used in three experiments. In each experiment, animal divided into two subgroups (n=8): control which received Distilled Water (DW) (2cc/kg) and case which received herb extract (150mg/kg) interaperitonealy. In first experiment, animals received single dose of extract or DW.
In second experiment، female rat received extract or DW in perimplantation period (day 1 to 5 of pregnancy) and in third experiment ( day 5 to 7 of pergnancy). In both experiments implantation sites and neonates were counted in three experiments. Data were analyzed by T-Test test and p<0.05 were considered significant.
Results: All three experiments showed significant differences between control and case groups in implantation sites and neonates number. This differences were more prominence in first and third experiment.
Mahsa Rostamian Delavar, Masoud Baghi, Elahe Yadegari, Kamran Ghaedi ,
Volume 20, Issue 8 (11-2017)
Abstract
Abstract
Background: Oxidative Stress and mitochondrial dysfunction leading to apoptotic death of neurons play key role in the pathogenesis of the Parkinson's disease. On the other hand، misregulation of microRNAs can cause several neurodegenerative diseases. Sirt1 and Bcl2 as two key genes, regulate pathogenic processes in neurodegenerative diseases such as mitochondrial dyfunction, oxidative stress and apoptosis.
Materials and Methods: To investigate the role of microRNAs in model of Parkinson's disease, miRWalk 2.0 and TargetScan (v7) databases were served to predict microRNA-target interactions.
Results: Possible targeting effects of different microRNAs on Bcl2 and Sirt1 genes in Rat organism were analyzed. Merging data from databases has shown that rno-miR-449a, rno-miR-182, rno-miR-211, rno-miR-34b, rno-miR-34c, rno-miR-448, rno-miR-466b and rno-miR-96 with strong possibility can inhibit expression of Bcl2 gene. Also, rno-miR-181, rno-miR-211, rno-miR-27a, rno-miR-449a, rno-miR-34c, rno-miR-30, rno-miR-200a and rno-miR-448can inhibit Sirt1 gene with high possibility.
Conclusion: According to the findings, it can be predicted that regarding to high interaction scores of rno-miR-211, rno-miR-34c and rno-miR-448 and 449awith Bcl2 and Sirt1 genes in above-mentioned databases, these microRNAs probably can have critical role in disease process. Thus, these microRNAs can be introduced as appropriate candidates for investigations in in vitro model of Parkinson's disease.
Behrooz Ghanbari, Mojtaba Hedayat Taghavi, Behamin Astani, Mahmoud Bakhtiari, Mohsen Yadegari, Yazdan Shafikhani,
Volume 26, Issue 0 (8-2023)
Abstract
Abstract:
Background
CAP ( community acquired pneumonia ) is one of the most common infectious diseases that leads to hospitalization of patients. Also, the effects of vitamin D deficiency on the functioning of the immune system and its association with infectious diseases such as CAP have received much attention in recent years. Therefore, we decided to investigate the relationship between serum vitamin D levels and the incidence and severity of CAP pneumonia in this study.
Methods
In this case-control study, 75 patients with CAP and 75 healthy individuals were evaluated and serum levels of vitamin D in these two groups were measured and compared.
Results
The present study shows that for each unit increase in serum vitamin D level, the need for hospitalization in the ICU according to the IDSA criterion is reduced by seven percent and according to the CURB65 criterion, the need for hospitalization in the ward and ICU is reduced by fifteen percent. Vitamin D deficiency also increases the chance of developing community-acquired pneumonia by 3.08 times. And for every unit increase in vitamin D, the chance of developing community-acquired pneumonia decreases by 4 percent. And in people with vitamin D deficiency, the chance of being admitted to the ICU according to IDSA is 2.05 times and according to CURB65 is 2.84 times.
Conclusions
Overall, based on the results of this study, it is concluded that vitamin D deficiency is associated with an increased incidence as well as a greater severity of community acquired pneumonia.
