Showing 22 results for jamshid
Jamshid Najafian, Behrooz Moghadasi,
Volume 1, Issue 2 (Spring 1997)
Abstract
Malaria is a protozoan disease transmitted by the bite of Anopheles mosquitoes. It is the most important of the parasitic disease of human. Most endemic areas are in the tropics. The infection characterized by paroxysms of chills, fever, sweating, anemia, spienimegaly and a chronic relapsing course. In this report there was an afebrile malaria in nin endemic area. A 60 years old man complaints from abdominal pain, is presented. In exam, the only finding was huge splenomegaly. Evaluations appear malarian parasites in peripheral blood smear. After drug therapy, splenectomy was performed. He followed for 6 months , didn’t have any problems.
Alireza Jamshidi Fard, J. Bagust ,
Volume 1, Issue 3 (Summer 1997)
Abstract
Wall and Shortland (1991) have shown that afferent fibres entering the cord in thoracic and lumbar roots of adult rats have branches that may penetrate up to 11 segments caudally from the root entry zone. We have investigated the extent of branching and conduction velocities of ascending and descending branches of lumbar and thoracic primary afferent in isolated spinal cords of adults hamsters (60-100g) and juvenile rats (30-46 g). Hemisected spinal cords were maintained at cold artificial cerebrospinal fluid (25-27 C) in which the Ca2+ had been replaced by Mn2+ (2mm) to block synaptic activity. Hamsters, antidromic conducted responses were obtained up to 10 segments caudal to dorsal roots T6-T7 and 17 segments rostral to L3. The mean conduction velocity was 3.7 m/s (s.e.m.& 0.4) for descending primary afferents(n=21) and 9.9 a 1.2 m/s for ascending afferents (n=26). In the rat , antidromic responses were measured over 4 segments caudal and 17 segments rostral to the L3 dorsal root. Conclusion velocities were 4.4 & 0.5 m/s and 7.7 & 0.7 m/s for descending and ascending branches respectively (n=4). The result were similar to those reported by Wall & Shortland , although the temperature. Difference between the in vitro and in vivo preparations would have resulted in approximately halving of the velocity in isolated cord preparation. The conduction velocity of descending fibres was about half fibres which may be related to size differences within the branches.
Jamal Fellahati, Hamidreza Nikbin, Jamshid Motamed,
Volume 3, Issue 4 (Winter 2000)
Abstract
Refractive error is a disturbance that a picture from one object is not on retina, in this reason picture is not clear. A clear picture is very important for development of visual nervous system to 10 years- old in children. This study was performed in 7 boys school in Arak. Today 753 boys student in the range of 6-11 years-old by the screening test was examined for visual acuity. Prevalence for refractive error was 9.5%. The most prevalence refractive error was pure myopia (56.9%). Family History in 65.3% was positive.
Jamshid Ayatolahi,
Volume 4, Issue 3 (Autumn 2001)
Abstract
Introduction: Amebiasis, Caused by Entamoeba histolytica. Is one of the three most common prevalent parasites that causes mortality.
Material and Method: This clinical trial was carried out among 45 patients suffering from acute enteric amebiasis. Each patient receives 750 mg metronidazole and 630 mg iodoquinol every eight hours for one week, the following results were obtained.
Results: All of the patients were completely treated at the end of two weeks and did not have any sign of the diseases. Also two weeks after cessation of therapy, stool test for entamobea histolytica (cyst and trophozoite) was negative in all of patients.
Conclusion: It seems by further research, we can decrease does of medications and duration treatment in these patients.
Ali Reza Jamshidifard, Simin Najafgholian, Hamid Gerami,
Volume 4, Issue 3 (Autumn 2001)
Abstract
Introduction: Intracomparemental pressure were measured by the wick catheter technique in 32 compartments of 32 post traumatic patients who were clinically suspected of having acute compartment syndromes. A pressure of zero millimeters of mercury was used as an indication for normal compartment enough for being excluded in any subject.
Material and Method: Signs and symptoms were examined in subjects based on clinical definitions before measuring intracompartmental pressures. Paresthesia, tensness, pain in passive extension, pain in active extension, paralysis, pulselessness, capillary filling and pallor of each subject were marked to be used for comparison with the value of intraucompartmental pressure.
Results: Pain were present in all subjects as the most earliest sign while the skin pallor appeared to be the latest one.The lowest values of pressure were seen together with pain and paresthesia even below the 10 mmHg among the subjects.
In our cases when ever the pressure values of the affected compartment increased. The number of present signs and symptoms also increased.
Conclusion: Positive regression of the mentioned correlation (r=0.69) implies that the value of intracompartmental pressure could be indicative of the more complications associated with more sign and symptoms.
Since different signs and symptoms were present in our subjects even with the same value of pressure. The diagnosis and apporching to compartment syndromes may looks confusing so measuring intraucompartmental pressure by a wick cartheter seems to be the cheep. Available technique in diagnosis and management of the cases.
Shima Chehreie, Ali Reza Jamshidi-Fard, Ali Haeri Rouhani,
Volume 6, Issue 1 (Spring 2003)
Abstract
Introduction: Sympathetic skin response (SSR) is a central, polysynaptic process which is attributed to sympathetic sudomotor activity. The descinding pathway presents spinal sympathetic system to sweat glands of hands and feets skin. The glands which are affected in reflex sympathetic dystrophy (RSD).
Materials and Methods: In present study, SSRs were recorded from left hands of 62 adult healthy subjects and 12 affected hands of RSD patients in relaxed, supine position at room temperature. Recording were performed by a pair of silver cup electrodes (1cm2) after stimulation of contralateral median nerve at volar aspect of wrist, all connected to a polygraph (physiograph, Narco, USA) to record at least five stimulation recording prosedure in each subject.
Results: Comparison of mean latency, amplitude, duraion and shape of responses in RSD 'patients with normal control group showed significant differences between duration and amplitudes (P=0.0007 and P=0.0001) while the latencies were not different and the shape of responses were mostly biphasic in both RSD and normal group.
Conclusion: Hyperactivities of SSRs in RSD patients are due to sudomotor changes of skin resistance, the SSR may also play a role in the quantitive evaluation of patients with suspected RSD.
Saeed Babaei, Saeed Changizi Ashtiani, Hamid Gerami, Ali Reza Jamshidifard , Mohammad Rafiee,
Volume 6, Issue 3 (Autumn 2003)
Abstract
Introduction: At present, bone graft is unavoidable. In fact although among the all probable bone grafts, the autograft is the best choice, but because of some situations like two coincidence surgery upon one individual, size limitation of autografts (its impossible to get a big piece of graft from patient) increasing the bloodshed contingency, infection etc, made specialist to think about the possible substitution the allograft.
Materials and Methods: Seventeen Newzealandian rabbits were divided into four groups. The graft generator group consisted of one rabbit which was genetically different from other groups. The sham group composed of three rabbits which round autografts about 4 mm in diameter from their tibia were exchanged between rights and left tibias. These grafts were not deantigenized and a 4 mm vacant hole was created to see if it will repair spontaneously within three months. The control group consisted of three rabbits received a round 4 mm tibial autografts which double deantigenization process were done over them. The test group composed of 10 rabbits, received corticocancellous (intramembranous) allografts in left tibia and corticocancellous (endocondral). Allograft in right tibia all grafts were bearing the double deantigenization process.
Results: The rate of prosperity for CCl grafts was 80% and for CCE grafts was 60%.In sham group, healing process was extremely fast (in eight weeks).
In control group, healing process was done slower until six weeks but after 12 weeks it was compensated. The vacant holes were not repaired even after three months. Statistically, there was a meaningless difference between the rates of prosperity in both groups of grafts.
Conclusion: According to statistical assays, although the prosperous numbers of CCl were more than CCE grafts but this difference was meaningless. In the basis of histological assessments if the velocity of healing process is important, the CCI grafts are recommended
Nasrin Roozbahani, Fereshteh Narenji, Sharareh Khosravi , Mahtab Attarha, Masoumeh Hashemi, Jamshid Momeni Esfahani,
Volume 7, Issue 4 (Winter 2004)
Abstract
Introduction: Sex ratio is referred to male, female ration which is usually 1.06. This ratio is decreased during the last few years. One of its reasons seems to be poisons and environmental pollutions such as cigarette smoke. In this investigation we studied the relationship between fathers cigarette smoking and sex ratio in children.
Materials and Methods: This is a historical cohort study. Study population were neonates born in Arak hospitals during summer and autumn 1383. Sample size was determined 710 neonates, based on α=5%, β=10%. Sampling method was census in which all newborns with inclusion criteria were selected and questionnaires were filled. Samples were divided into three groups. 1-newborns with nonsmoker fathers 2- newborns with smoker fathers (less than 20 cigarette a day) 3- newborns with smoker fathers (20 or more cigarettes a day) (fathers cigarette smoking at least 3 months before conception in second and third group). Newborns sex ratio was determined in each group and caparisoned. Data analysis was done by frequency, ratio, mean and standard deviation indexes and k-s, leven, t, mann-whitney, chi square tests and relative risk, using SPSS software. At all stages study Helsinki declaration was regarded.
Results: Overall sex ratio was 1.04. This ratio was 1.272 for neonates with nonsmoker fathers and 0.77 for neonates with smoker fathers. Also sex ratio in newborns with smoker fathers using less than 20 cigarettes a day was 0.846 and for those with fathers using 20 or more was 0.60. Based on chi square there was a meaningful relationship between the three groups (p<0.00001). Relative risk in low cigarette group was 1.23 and in high cigarette group 1.42.
Conclusion: Based on findings it seems that fathers cigarette smoking near conception results in decreasing sex ratio and the increased use of cigarettes the decreased born of male neonates.
Mahdi Sharif, Masoud Keyghobadi, Hajar Ziaei, Jamshid Izadi, Shirzad Gholami, Alireza Khaliliyan,
Volume 8, Issue 2 (7-2005)
Abstract
Introduction: Different strains of Echinococcus Granulosus have been found in endemic areas of Iran. This variation has a significant aspect in the field of medical parasitology and veterinary and also in epidemiology, pathology, control and prevention of Hydatid cyst infection. Morphology, epidemiology and biochemical studies can be carried out to determine Hydatid cyst strains in human and animal origins as host. This study was done to measure different biochemical compositions of liver Hydatid cyst fluids in human, sheep, goat, cattle and camel in 2004.
Materials and Methods: In a cross sectional-analytical study, 112 samples of Hydatid fluids were collected from the liver cysts of different hosts: 16 sheeps, 64 cattles, 12 goats and 10 camels in slaughter houses of Sari and Ghaemshahr and 10 human in Imam hospital. All cyst fluids were centrifuged at 4500 rpm at 4˚C for 45 minutes and the supernatants were analyzed for various biochemical parameters.
Results: Quantitative differences were observed in the levels of Sodium, Glucose, Urea, Alanin Aminotransferase (AST) in liver cystic fluids obtained from different hosts, although these differences were not statistically insignificant. However, differences in the levels of Potassium, Calcium, Triglycerides, Cholesterol, Uric acid, Creatinin, Albumin, Gamma Glutamyl Transferase, Aspartat Aminotransferase (AST) and Creatinine Phosphokinase (CPK) in different Hydatid cyst fluids were statistically significant (P<0.05).
Conclusion: Differences in biochemical composition of different Hydatid cyst fluids suggest the possible existence of more than one strain of Echinococcus Granulosus in human and other intermediate domestic animal hosts in Mazandaran.
Dr Mohammad Ali Zargar Shooshtari, Dr Abolfazl Golmohammadi, Dr Meysam Jamshidi, Dr Hormoz Salimi,
Volume 9, Issue 1 (3-2006)
Abstract
Introduction: Renal cell carcinoma can be presented with extension of thrombosis to renal vein and inferior vena cava. Management of these patients consists of radical nephrectomy and thrombectomy. In this study we reviewed approach to these patients. Materials & Methods: This is a case series report. During 1379 to 1384, 148 patients diagnosed with renal cell carcinoma (RCC) limited to Gerota’s fascia (stage T3 or less) were admitted to Hasheminejad hospital. Fourteen patients had inferior vena cava (IVC) involvement. Radical nephrectomy as well as thrombectomy was performed in 8 patients. This investigation is done on these 8 patients. Results: Patients' average age was 51.4 years. Six patients were male (75%) and 2 female (25%). The most common symptoms were flank pain (75%), gross hematuria (62.5%) and structural symptoms (50%). All patients had tumors limited to Gerota’s fascia without any distant metastasis. Infrahepatic involvement of IVC was seen in 6 patients and in 2 patients thrombosis extended above the hepatic vein (infrahepatic). No perioperative mortality was seen. Postoperative complications were atelectasia in 2 patients and deep vein thrombosis in one which was treated with conservative management. Conclusion:By skillful surgical approach in patients with RCC and IVC involvement, thrombosis can be completely excised without increasing the rate of complications and longterm survival could be expected.
Ahmad Ameri, Jamshid Ansari, Majid Mokhtari, Ali Chehrei,
Volume 9, Issue 4 (12-2006)
Abstract
Introduction: Radiotherapy after breast cancer surgery will increase local control of the disease and also increase overall survival. Radiation have some side effects on lung function. In different radiotherapy techniques, these side effects are different. Pulmonary function tests and oxygen saturation are methods for evaluation of these complications. In this study we decide to campare pulmonary complications in two radiotherapy methods. Materials and Methods: In this clinical trial study fifty one patients with breast cancer in stage II and III according to TNM staging system, which were under modified radical mastectomy in Imam Hosein hospital and refered for adjuvant radiotherapy, randomly divided in two groups. In one group patients were treated with three field technique and in others with four field technique. All patients received total dose of 48-50 Gy. For patients, pulmonary function test and pulse oxymetery were done once before initiation of radiotherapy and then one and three months after radiotherapy. Results: Measurement of FEV1 , FVC and show that no significant statistical difference was present between the two groups one month and three months after radiotherapy, also in each of the two groups the amount of FEV1 , FVC and one month after radiotherapy had no significant statistical difference in comparison to baseline tests but FEV1 and FVC after three months was decreased and had significant statistical difference respectively (p<0.001, p<0.006). SO2 had no significant defference between the two groups and also in each group after one and three month of radiotherapy. Conclusion: Locoregional radiotherapy of breast and lymph nodes areas causes a decrease in some parameter of pulmonary function tests but no difference was present between three field and four field techniques.
Ahmad Sarvarian, Jamal Falahati, Jamshid Momeni, Ameneh Alaeen, Zahra Mohammadi,
Volume 11, Issue 2 (6-2008)
Abstract
Introduction: Cataract is a type of tarnish observable opacity in different layers constituting the lens and will cause light occlusion or scattering. Necessity for treatment of Cataract via surgery and its close relation with corneal astigmatism, when we applied a new method in cutting and type of cataract surgery, led us to measure the post-operation corneal astigmatism changes in frown incision Phacosection. Materials and Methods: This interventional study has been done on 73 eyes(58 patients). These patients were gone under Cataract surgery via no stitch frown incision scleral tunnel phacosection method. In this study we have 7mm external scleral incision with no suture. They were Keratometerized in four separate periods including pre-operation, one week, one month and three months post- operation. Data was analyzed using independent and paired t-tests. Results: Age, sex and left or right eye had no influence on astigmatism. Mean pre- operation astigmatism was 0.84 ± 0.87D, mean astigmatism 1 week post- operation was 0.27 ± 0.88 D, 1 month post- operation 0.06 ± 0.82 D, and three months post-operation was -0.03 ± 0.85 D (P= 0.0001). Before operation, 80% of the patients did have an astigmatism rate less than 1D that increased to 94.5% in three months period after operation and in 89% of the cases, the ultimate change in astigmatism has been found lower than 1D. The obtained information revealed that there is a meaningful difference between pre-operation astigmatism and the same after one week, one month and three months post-operation(P= 0.0001). Independent sample t and paired t-test were used to analyse data. Conclusion: Our study indicated that the no stitch frown incision scleral tunnel phacosection surgery can reduce pre-op corneal astigmatism, and because of induction of the slight controlled astigmatism we can apply this technique for all cataractic patients
Jamshid Ansari,
Volume 11, Issue 2 (6-2008)
Abstract
Introduction: Typhlitis is a complication in GI tract specially in ileum and cecum due to sever prolonged neutropenia. The syndrome usually occurs in patients with leukaemia who take aggressive chemotherapy or in solid tumor treated with taxane base regimen. The syndrome is accompanied with neutropenia, fever, generalized abdominal pain specially in right lower quadrant and probably a mass in this area. Case: The patient is a 44 year old man which was presented with enlargement of right testes since two months ago. In sonographic evaluation of testes a mass was defined and surgery was done for him, which pathologic result was seminoma. Staging workup was done and in CT Scan a lymph node with size of 35 mm was detected in paracaval area . According to this result the patient received chemotherapy with Cisplatin and Etoposide. One day after completion of chemotherapy he developed abdominal pain , fever and bloody diarrhea and referred to hospital and admitted with diagnosis of typhlitis. Conclusion: Typhlitis is not restricted to a complication of leukaemia treatment or taxane base chemotherapy and other cytotoxic drugs can induce this problem. On the other hand, neutropenia and typhlitis can occur immediately after chemotherapy in sensitive patient and so the time of nadir value of white blood cell is too short.
Bijan Yazdi, Jamshid Momeni, Alireza Akbari,
Volume 11, Issue 3 (9-2008)
Abstract
Background: Pain following propofol injection was reported between 28- 90 %. Ketamine have lesser cardiovascular depression effect and also local anesthetic effect. In this study effect of ketamin were analyzed when it given before propofol injection. Methods and Materials: In a randomized double blind clinical trial selected 120 ASA I, II Ptients with 15-65 years old. They were candidated for elective surgery, in half of the patients 100 µg/kg ketamine in 2 ml volume and in another half, 2 ml distilled water were given before propofol injection. Severity of injection pain was evaluated according to 4 scale criteria (none, mild, moderate, or severe) fifteen seconds after injection of 25% of the calculated dose of propofol. Heart rate (HR) and noninvasive blood pressure were recorded before and after propofol injection, immediately and 3 minutes after intubation. The data were analysed by Mann Whitney U, Pooled t-Test and the Chi-squared test. Results: Pain was not sensed in 51.56% and 75% of control and case groups respectively. In cases group showed little decrease in systolic and diastolic pressures after anesthetic induction (p=0.012 and p=0.005). There were upper diastolic pressures after intubation (p=0.00) and 3 minutes after intubation (p=0.000). During intervention heart rate changes had not significant difference between two groups. Conclusion: Ketamine pre-treatment was an effective method in reducing pain and providing hemodynamic stability after propofol induction.
Majid Najafi Kalyani, Shahnaz Karimi, Nahidi Jamshidi,
Volume 12, Issue 4 (Research in Education Supplement 2010)
Abstract
Abstract Background: The important reality is that all of human developments and successes are due to learning. Knowing students learning styles will help to produce an educational plan in order to optimal and effective learning. The aim of this study was the comparison of learning styles and preferred teaching methods of different students of medical sciences. Materials and Methods: This study is a cross-sectional research. That was done on all students at Fasa Medical Sciences University in 2009. For data gathering, questionnaires of demographic variables and Kolb Learning Style Inventory (KLSI) was used and analyzed. Results: Majority of students learning style was convergent learning (38.3%) and then assimilator learning style (29.9%). More frequent preferred teaching method was group discussion. There was a significant difference between learning styles and course of students (P=0.011). Conclusion: Since, the majority of students had convergent and assimilator learning styles is recommended, considering the diversity of learning styles, educational methods related ro learning styles were using.
Alireza Jamshidi Fard, Haleh Rafipour, Fardin Faraji,
Volume 16, Issue 5 (8-2013)
Abstract
Background: Several clinical studies suggest that melatonin is a neuroprotective molecule in neurodegenerative disorders and it showed to be reduced in Multiple Sclerosis (MS) patients. MS also results in blurred vision, papillitis and diplopia. The main objective of the study was to asses the influence of Melatonin supplimentation on visual characteristics in patients with MS.
Materials and Methods: In a Quasi Experimental plan, approved by AUMS ethical Committee, 34 (9 males and 25 females) patients with stable MS were asked to voluntearly participate in the study. All subjects (Mean EDSS 3.14) were taking their routine medications. Visual funtions were evaluated by Visual Functioning Questionnaire (VFO-25) and standard Pattern Reversal Visual Evoked Potentials (PR-VEP) records. Serum Melatonin levels were also measured using an ELISA assay. Recordings were performed after a single dose and after taking 1 tablet every night for 14 days, at the day 16th.
Results: In all subjects, Serum Melatonin levels were significantly enhanced. VFQ scores also showed significat improvement. Except the change in N75 latencies of left eyes, VEP latencies of P100, N145 of both eyes and N75 of right eyes were significantly (p<0.05) reduced.
Conclusion: Our findings suggest significat improvements of visual symptoms of MS after daily intake of 3 mg Melatonin. The results calls for further studies and clinical trails before asking all MS patients to take Melatonin suppliment every night.
Mohammad Ahmadzadeh, Jamshid Faraji,
Volume 16, Issue 11 (2-2014)
Abstract
Background: Wolfram syndrome is a rare neurodegenerative autosomal recessive disorder. That occurs in association with diabetes mellitus, diabetes insipidus, and optic nerve atrophy, hearing loss, urinary tract infection and nervous complication.
Case: The present report belong to a 24 years old girl who was effected by diabetes mellitus in 10 years old & has been effected by Diabetes insipidus, recurrent UTI, hearing loss and other type of disorders in 20 years old.
Conclusion: Strict control of blood glucose and regular fundoscopy, for early detection of optic atrophy are important. Step in management of this syndrome and quality of life is improved with hearing and vision aid tools.
Hamta Ahmad, Ansari Jamshid, Bayati Zahra,
Volume 19, Issue 7 (10-2016)
Abstract
Background: Breast cancer is both the prevailing malignancy and the most common cause of cancer death among women. Many factors may play a role in the susceptibility to the breast cancer and Oxygen Free Radicals may be one of these. There are various known antioxidant systems against oxidative stress, including ParaoxonaseI. The aim of this study was to investigate the association between rs854560 polymorphism in the PON1 gene in patients with breast cancer.
Materials and Methods: We performed genotyping analysis using polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) assay in a case–control study of 83 confirmed breast cancer patients and 100 cancer-free controls in Markazi Province.
Results: In our study of the PON1 gene L55M polymorphism, the LL genotype was found in 2 (2.40%) patients, whereas the LM genotype was found in 69 (83.13%) patients. The MM genotype was present in 12 (14.45%) patients. In the control group, LL, LM and MM genotypes were found in 4 (4%), 81 (81%), and 15 (15%) subjects, respectively. There was no statistically significant difference between patient and control groups in terms of the PON1 gene L55M polymorphism (p= 0.825). Allele distributions were different but this difference did not reach statistical significance (p= 0.920).
Conclusion: We found no association between M55L polymorphism and breast cancer.
Ahmad Hamta, Mahsa Mohammadi, Jamshid Ansari,
Volume 19, Issue 11 (2-2017)
Abstract
Background: Biological and epidemiological data indicate that the levels of vitamin D maybe affect the breast cancer risk. Vitamin D plays an important role in cell proliferation, apoptosis and tumor growth suppression. Vitamin D receptor is a critical mediator for the cellular reactions of vitamin D. Some of the epidemiological studies, reviewed the relationship between VDR gene polymorphism ApaI and breast cancer, but the controversial findings have been achieved.
Materials and Methods: In this study, a population-based case-control study including 140 patients and 160 healthy individuals of women in Markazi Province were evaluated using PCR-RFLP approach. Genomic DNA was extracted from blood samples using the salting-out procedure. Polymorphism of interest was determined by PCR-RFLP method using ApaI enzyme and statistical analysis was performed by SPSS software.
Results: Based on the results of this study, distribution of AA genotype in cancer and control groups was, 38.6 and 26.87, for AC genotype 55.00 and 66.87, and finally for CC genotype 6.43 and 6.26 respectively. The results of this study showed no association between ApaI polymorphism of the VDR gene and breast cancer(OR=0.903,CI=95%, 0.29-2.95.)
Conclusion: In this study, we found no association between ApaI polymorphism and breast cancer, which are consistent with the findings of some other researchs. It is necessary to examine a larger population to achieve more definitive results.
Mehri Jamilian, Jamilian Somayeh Jamshidi,
Volume 20, Issue 10 (1-2018)
Abstract
Abstract
Background: Selenium supplement has multiple important effects, including anti-inflammatory effect. The aim of this study was to assess the effects of selenium supplement on gene expression of inflammatory cytokines and vascular endothelial growth factor in gestational diabetes.
Materials and Methods: This randomized double blind placebo control trial was performed on 40 patients suffering from GDM aged 18–40 years old. Participants were randomly divided into interventional group receiving 200mg/day selenium supplements (n=20) and control group receiving placebo (n=20) for 6 weeks. Primary outcome was gene expression of inflammatory cytokines and VEGF which were assessed in lymphocyte of GDM patients by RT-PCR method.
Results: After 6 weeks intervention, in comparison with the control group, interventional group showed down regulation of gene expression of tumor necrosis factor alpha (TNF–α) (p=0.02) and transforming growth factor beta (TGF–β) (p=0.01) and up-regulation of gene expression of vascular endothelial (VEGF) (p = 0.03) in lymphocytes of GDM. There was not any significant change following intervention with selenium regarding gene expression of interleukin IL-1 β and IL-8 in lymphocytes of GDM patients.
Conclusion: 6 weeks supplementation with selenium in patients with GDM can cause down regulated gene expression of TNF-α and TGF–β, and up regulated gene expression of VEGF. Selenium supplement had not any effect on gene expression of IL-1 β and IL-8.
